DD140253A5 - Verfahren zur herstellung von 2,6-bis-(aminoacylamino)-benzo-eckige klammer auf 1,2-d:5,4-d'eckige klammer zu-bisthiazolen und 2-amino-6-(aminoacylamino)-benzo-eckige klammer auf 1,2-d:5,4-d'eckige klammer zu-bisthiazolen - Google Patents
Verfahren zur herstellung von 2,6-bis-(aminoacylamino)-benzo-eckige klammer auf 1,2-d:5,4-d'eckige klammer zu-bisthiazolen und 2-amino-6-(aminoacylamino)-benzo-eckige klammer auf 1,2-d:5,4-d'eckige klammer zu-bisthiazolen Download PDFInfo
- Publication number
- DD140253A5 DD140253A5 DD78207187A DD20718778A DD140253A5 DD 140253 A5 DD140253 A5 DD 140253A5 DD 78207187 A DD78207187 A DD 78207187A DD 20718778 A DD20718778 A DD 20718778A DD 140253 A5 DD140253 A5 DD 140253A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- benzo
- bis
- bisthiazole
- amino
- general formula
- Prior art date
Links
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940096529 carboxypolymethylene Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 239000002026 chloroform extract Substances 0.000 description 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- WEHWNAOGRSTTBQ-UHFFFAOYSA-N dipropylamine Chemical compound CCCNCCC WEHWNAOGRSTTBQ-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000004049 embossing Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 125000004705 ethylthio group Chemical group C(C)S* 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- OCDGBSUVYYVKQZ-UHFFFAOYSA-N gramine Chemical compound C1=CC=C2C(CN(C)C)=CNC2=C1 OCDGBSUVYYVKQZ-UHFFFAOYSA-N 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 230000002140 halogenating effect Effects 0.000 description 1
- 230000026030 halogenation Effects 0.000 description 1
- 238000005658 halogenation reaction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000000548 hind-foot Anatomy 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000005053 lamin Anatomy 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- AHNJTQYTRPXLLG-UHFFFAOYSA-N lithium;diethylazanide Chemical compound [Li+].CC[N-]CC AHNJTQYTRPXLLG-UHFFFAOYSA-N 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229940018564 m-phenylenediamine Drugs 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229940043265 methyl isobutyl ketone Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- KUHRIIPUCPOQMQ-UHFFFAOYSA-N n,n-diethyl-3-(ethyliminomethylideneamino)propan-1-amine Chemical compound CCN=C=NCCCN(CC)CC KUHRIIPUCPOQMQ-UHFFFAOYSA-N 0.000 description 1
- RRWLIXBKNJSFFJ-UHFFFAOYSA-N n-(2-ethylpiperidin-1-yl)acetamide Chemical compound CCC1CCCCN1NC(C)=O RRWLIXBKNJSFFJ-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000008023 pharmaceutical filler Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 150000003385 sodium Chemical class 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003557 thiazoles Chemical class 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- DQWPFSLDHJDLRL-UHFFFAOYSA-N triethyl phosphate Chemical compound CCOP(=O)(OCC)OCC DQWPFSLDHJDLRL-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772736652 DE2736652A1 (de) | 1977-08-13 | 1977-08-13 | 2,6-bis-(aminocylamino)-benzo- eckige klammer auf 1,2-d zu 5,4-d' eckige klammer zu -bisthiazole und 2-amino-6-(aminoacylamino)-benzo- eckige klammer auf 1,2-d zu 5,4-d' eckige klammer zu -bisthiazole, verfahren zu ihrer herstellung und arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD140253A5 true DD140253A5 (de) | 1980-02-20 |
Family
ID=6016379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD78207187A DD140253A5 (de) | 1977-08-13 | 1978-08-09 | Verfahren zur herstellung von 2,6-bis-(aminoacylamino)-benzo-eckige klammer auf 1,2-d:5,4-d'eckige klammer zu-bisthiazolen und 2-amino-6-(aminoacylamino)-benzo-eckige klammer auf 1,2-d:5,4-d'eckige klammer zu-bisthiazolen |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4344946A (en, 2012) |
| JP (1) | JPS5432495A (en, 2012) |
| AT (1) | AT356664B (en, 2012) |
| AU (1) | AU518652B2 (en, 2012) |
| BE (1) | BE869714A (en, 2012) |
| BG (1) | BG30774A3 (en, 2012) |
| CA (1) | CA1097635A (en, 2012) |
| CH (1) | CH639976A5 (en, 2012) |
| CS (1) | CS209542B2 (en, 2012) |
| DD (1) | DD140253A5 (en, 2012) |
| DE (1) | DE2736652A1 (en, 2012) |
| DK (1) | DK157762C (en, 2012) |
| ES (1) | ES472544A1 (en, 2012) |
| FI (1) | FI63415C (en, 2012) |
| FR (1) | FR2400027A1 (en, 2012) |
| GB (2) | GB2002383B (en, 2012) |
| GR (1) | GR65027B (en, 2012) |
| HU (1) | HU176066B (en, 2012) |
| IE (1) | IE47308B1 (en, 2012) |
| IL (1) | IL55335A0 (en, 2012) |
| IT (1) | IT1107969B (en, 2012) |
| LU (1) | LU80103A1 (en, 2012) |
| NL (1) | NL189611C (en, 2012) |
| NO (1) | NO153851C (en, 2012) |
| NZ (1) | NZ188122A (en, 2012) |
| PL (1) | PL118018B1 (en, 2012) |
| PT (1) | PT68418A (en, 2012) |
| RO (1) | RO75639A (en, 2012) |
| SE (1) | SE442511B (en, 2012) |
| SU (1) | SU847924A3 (en, 2012) |
| ZA (1) | ZA784569B (en, 2012) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2833671A1 (de) * | 1978-08-01 | 1980-02-21 | Boehringer Sohn Ingelheim | 2,6-bis- (aminoacylamino) - benzo - eckige klammer auf 1,2-d zu 5,4-d' eckige klammer zu -bisthiazole und 2-amino-6- (aminoacylamino) - benzo - eckige klammer auf 1,2-d zu 5,4-d' eckige klammer zu - bisthiazole, verfahren zu ihrer herstellung und arzneimittel |
| JPS59138758U (ja) * | 1983-03-08 | 1984-09-17 | 株式会社トクヤマ | 酸素検知装置 |
| US4628052A (en) * | 1985-05-28 | 1986-12-09 | Peat Raymond F | Pharmaceutical compositions containing dehydroepiandrosterone and other anesthetic steroids in the treatment of arthritis and other joint disabilities |
| WO2007144370A1 (en) | 2006-06-14 | 2007-12-21 | Boehringer Ingelheim International Gmbh | New chemical compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2562830A (en) * | 1951-07-31 | Derivatives | ||
| US2140540A (en) * | 1937-02-19 | 1938-12-20 | Du Pont Film Mfg Corp | Color photography |
| US2182815A (en) * | 1938-11-23 | 1939-12-12 | Du Pont Film Mfg Corp | Color-forming photographic compositions and processes |
| US3489558A (en) * | 1967-09-18 | 1970-01-13 | Ibm | Photoconductive benzobisthiazoles and their use in electrophotographic processes |
| US3501293A (en) * | 1967-09-18 | 1970-03-17 | Ibm | Photoconductive benzobisthiazoles and their use in electrophotographic processes |
| CH606335A5 (en, 2012) * | 1974-10-17 | 1978-10-31 | Ciba Geigy Ag |
-
1977
- 1977-08-13 DE DE19772736652 patent/DE2736652A1/de active Granted
-
1978
- 1978-08-02 GR GR56913A patent/GR65027B/el unknown
- 1978-08-03 AT AT562778A patent/AT356664B/de not_active IP Right Cessation
- 1978-08-09 DD DD78207187A patent/DD140253A5/de unknown
- 1978-08-09 CH CH845878A patent/CH639976A5/de not_active IP Right Cessation
- 1978-08-10 RO RO7894947A patent/RO75639A/ro unknown
- 1978-08-11 CS CS785273A patent/CS209542B2/cs unknown
- 1978-08-11 IL IL7855335A patent/IL55335A0/xx not_active IP Right Cessation
- 1978-08-11 FI FI782459A patent/FI63415C/fi not_active IP Right Cessation
- 1978-08-11 NL NLAANVRAGE7808391,A patent/NL189611C/xx not_active IP Right Cessation
- 1978-08-11 FR FR7823802A patent/FR2400027A1/fr active Granted
- 1978-08-11 IT IT50705/78A patent/IT1107969B/it active
- 1978-08-11 CA CA309,176A patent/CA1097635A/en not_active Expired
- 1978-08-11 PT PT68418A patent/PT68418A/pt unknown
- 1978-08-11 NO NO782734A patent/NO153851C/no unknown
- 1978-08-11 BE BE78189868A patent/BE869714A/xx not_active IP Right Cessation
- 1978-08-11 LU LU80103A patent/LU80103A1/de unknown
- 1978-08-11 JP JP9812178A patent/JPS5432495A/ja active Granted
- 1978-08-11 SE SE7808589A patent/SE442511B/sv not_active IP Right Cessation
- 1978-08-11 ZA ZA784569A patent/ZA784569B/xx unknown
- 1978-08-11 SU SU782646503A patent/SU847924A3/ru active
- 1978-08-11 IE IE1635/78A patent/IE47308B1/en not_active IP Right Cessation
- 1978-08-11 HU HU78BO1730A patent/HU176066B/hu not_active IP Right Cessation
- 1978-08-11 GB GB7833028A patent/GB2002383B/en not_active Expired
- 1978-08-11 DK DK356578A patent/DK157762C/da not_active IP Right Cessation
- 1978-08-11 NZ NZ188122A patent/NZ188122A/xx unknown
- 1978-08-11 GB GB8040967A patent/GB2062639B/en not_active Expired
- 1978-08-11 AU AU38822/78A patent/AU518652B2/en not_active Expired
- 1978-08-12 ES ES472544A patent/ES472544A1/es not_active Expired
- 1978-08-12 PL PL1978209009A patent/PL118018B1/pl unknown
- 1978-08-14 BG BG040662A patent/BG30774A3/xx unknown
-
1980
- 1980-08-28 US US06/182,077 patent/US4344946A/en not_active Expired - Lifetime
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