CZ418597A3 - 1,6-disubstituované izochromany pro léčbu bolestí hlavy při migréně - Google Patents

1,6-disubstituované izochromany pro léčbu bolestí hlavy při migréně Download PDF

Info

Publication number
CZ418597A3
CZ418597A3 CZ974185A CZ418597A CZ418597A3 CZ 418597 A3 CZ418597 A3 CZ 418597A3 CZ 974185 A CZ974185 A CZ 974185A CZ 418597 A CZ418597 A CZ 418597A CZ 418597 A3 CZ418597 A3 CZ 418597A3
Authority
CZ
Czechia
Prior art keywords
defined above
ethyl
isochroman
alkyl
piperazinyl
Prior art date
Application number
CZ974185A
Other languages
Czech (cs)
English (en)
Inventor
Michael D. Ennis
Ruth E. Tenbrink
Original Assignee
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Publication of CZ418597A3 publication Critical patent/CZ418597A3/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76Benzo[c]pyrans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CZ974185A 1995-06-30 1996-06-07 1,6-disubstituované izochromany pro léčbu bolestí hlavy při migréně CZ418597A3 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74195P 1995-06-30 1995-06-30
US1123496P 1996-02-06 1996-02-06

Publications (1)

Publication Number Publication Date
CZ418597A3 true CZ418597A3 (cs) 1998-06-17

Family

ID=26668092

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ974185A CZ418597A3 (cs) 1995-06-30 1996-06-07 1,6-disubstituované izochromany pro léčbu bolestí hlavy při migréně

Country Status (12)

Country Link
EP (1) EP0836599A1 (pt)
JP (1) JPH11509532A (pt)
AU (1) AU6252296A (pt)
BR (1) BR9609631A (pt)
CA (1) CA2225282A1 (pt)
CZ (1) CZ418597A3 (pt)
FI (1) FI974640A (pt)
MX (1) MX9710260A (pt)
NO (1) NO976112L (pt)
PL (1) PL324319A1 (pt)
SK (1) SK164297A3 (pt)
WO (1) WO1997002259A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2370270A (en) * 2000-12-20 2002-06-26 Lilly Co Eli Pharmaceutical compounds
US7335660B2 (en) 2001-12-19 2008-02-26 Eli Lilly And Company Isochroman compounds for treatment of CNS disorders
GB0130339D0 (en) * 2001-12-19 2002-02-06 Lilly Co Eli Isochroman compounds
US7110576B2 (en) 2002-12-30 2006-09-19 Pitney Bowes Inc. System and method for authenticating a mailpiece sender
KR100823805B1 (ko) 2004-05-05 2008-04-21 에프. 호프만-라 로슈 아게 5-ht6 수용체, 5-ht2a 수용체 또는 둘다를 조절하기에유용한 아릴설포닐 벤조다이옥산
CN101111472A (zh) 2004-12-21 2008-01-23 弗·哈夫曼-拉罗切有限公司 1,2,3,4-四氢化萘和茚满衍生物及其作为5-ht拮抗剂的用途
DK1831159T3 (da) 2004-12-21 2010-03-22 Hoffmann La Roche Tetralin og indanderivater samt anvendelser deraf
KR100965190B1 (ko) 2004-12-21 2010-06-24 에프. 호프만-라 로슈 아게 크로만 유도체 및 중추 신경계 장애의 치료에서 그의 용도
WO2006066745A1 (en) 2004-12-21 2006-06-29 F.Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
KR20070088798A (ko) 2004-12-21 2007-08-29 에프. 호프만-라 로슈 아게 크로만 유도체 및 그의 5-ht 수용체 리간드로서의 용도
BRPI0618206A2 (pt) 2005-11-03 2011-08-23 Hoffmann La Roche arilsulfonil cromanos como inibidores de 5-ht6, bem como composição farmacêutica, uso e processo para produção dos mesmos
AU2007263084A1 (en) 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
EP2076489A1 (en) 2006-06-20 2009-07-08 F. Hoffmann-Roche AG Arylsulfonamidyl tetralin derivatives and uses thereof
CA2654822A1 (en) 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonyl naphthalene derivatives and uses thereof
KR20110125258A (ko) * 2009-03-05 2011-11-18 스미또모 가가꾸 가부시끼가이샤 할로겐 치환 벤젠디메탄올의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552004A (en) * 1976-05-26 1979-09-05 Takeda Chemical Industries Ltd Isochroman derivatives
AU684874B2 (en) * 1993-12-28 1998-01-08 Pharmacia & Upjohn Company Heterocyclic compounds for the treatment of cns and cardiovascular disorders

Also Published As

Publication number Publication date
SK164297A3 (en) 1998-09-09
FI974640A0 (fi) 1997-12-30
NO976112L (no) 1998-03-02
MX9710260A (es) 1998-03-29
NO976112D0 (no) 1997-12-29
JPH11509532A (ja) 1999-08-24
AU6252296A (en) 1997-02-05
EP0836599A1 (en) 1998-04-22
WO1997002259A1 (en) 1997-01-23
FI974640A (fi) 1997-12-30
BR9609631A (pt) 1999-03-02
CA2225282A1 (en) 1997-01-23
PL324319A1 (en) 1998-05-25

Similar Documents

Publication Publication Date Title
AU2013254657B2 (en) Novel compounds
AU701420B2 (en) Novel piperazides derived from arylpiperazine, processes for their preparation, their use as medicaments and pharmaceutical compositions comprising them
KR101025358B1 (ko) 히스타민-3 수용체 길항제
TW536537B (en) Benzoxazine antimicrobial agents
CZ418597A3 (cs) 1,6-disubstituované izochromany pro léčbu bolestí hlavy při migréně
JP5189110B2 (ja) ドーパミンd4受容体拮抗剤であるピペラジニル−プロピル−ピラゾール誘導体及びそれを含む医薬組成物
US20020103205A1 (en) Muscarinic antagonists
US20030153507A1 (en) HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
JPWO2005037269A1 (ja) 新規ピペリジン誘導体
HU211336A9 (en) Heterocyclic derivatives
AU684874B2 (en) Heterocyclic compounds for the treatment of cns and cardiovascular disorders
JP2001525406A (ja) 新規な化合物
WO2007042660A2 (fr) Dérivés de la 1-amino-phtalazine substituee, leur préparation et leur application en thérapeutique
JP2015524481A (ja) (s)−3−(4−((4−(モルホリノメチル)ベンジル)オキシ)−1−オキソイソインドリン−2−イル)ピペリジン−2,6−ジオン及びその医薬として許容し得る形態の製造プロセス
JP2006527769A (ja) Cb1モジュレーターとしての2,3位置換5,6−ジアリール−ピラジン誘導体
AU2021410119A1 (en) Tetrahydroquinoline derivative and medicinal use thereof
JP3035356B2 (ja) ピロリジニルヒドロキサム酸化合物及びその製造方法
HU225747B1 (en) New benzenesulphonamide compounds, their preparation thereof and pharmaceutical compositions containing them
US20040034036A1 (en) N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-yl-benzenesulfonamide
OA11235A (en) Quatenary ammonium compounds as tachykinin antagonists
MXPA04012345A (es) Derivados de pirimidina 2,5-substituida como antagonistas ix del receptor ccr-3.
AU707950B2 (en) Heterocyclic compounds for treating myocardial ischemia
JPH06306025A (ja) ジアリールアルカン誘導体
KR19990028550A (ko) 편두통 치료용의 1,6-이치환된 이소크로만
KR940009533B1 (ko) 헥사하이드로디벤조디옥산에서 유도된 암모늄염의 제조방법

Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic