CZ289421B6 - Způsob přípravy amorfního atorvastatinu a jeho hydrátů - Google Patents

Způsob přípravy amorfního atorvastatinu a jeho hydrátů Download PDF

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Publication number
CZ289421B6
CZ289421B6 CZ1998122A CZ12298A CZ289421B6 CZ 289421 B6 CZ289421 B6 CZ 289421B6 CZ 1998122 A CZ1998122 A CZ 1998122A CZ 12298 A CZ12298 A CZ 12298A CZ 289421 B6 CZ289421 B6 CZ 289421B6
Authority
CZ
Czechia
Prior art keywords
atorvastatin
amorphous
solvent
tetrahydrofuran
preparation
Prior art date
Application number
CZ1998122A
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Czech (cs)
English (en)
Other versions
CZ12298A3 (cs
Inventor
Dieter Schweiss
Min Lin
Original Assignee
Warner-Lambert Company
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Publication date
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Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of CZ12298A3 publication Critical patent/CZ12298A3/cs
Publication of CZ289421B6 publication Critical patent/CZ289421B6/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CZ1998122A 1995-07-17 1996-07-16 Způsob přípravy amorfního atorvastatinu a jeho hydrátů CZ289421B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US145395P 1995-07-17 1995-07-17

Publications (2)

Publication Number Publication Date
CZ12298A3 CZ12298A3 (cs) 1998-12-16
CZ289421B6 true CZ289421B6 (cs) 2002-01-16

Family

ID=21696097

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ1998122A CZ289421B6 (cs) 1995-07-17 1996-07-16 Způsob přípravy amorfního atorvastatinu a jeho hydrátů

Country Status (37)

Country Link
US (1) US6274740B1 (https=)
EP (1) EP0839132B1 (https=)
JP (1) JP4064459B2 (https=)
KR (1) KR100400805B1 (https=)
CN (1) CN1087289C (https=)
AR (1) AR002849A1 (https=)
AT (1) ATE199542T1 (https=)
AU (1) AU700794B2 (https=)
BG (1) BG63631B1 (https=)
BR (1) BR9609714A (https=)
CA (1) CA2220455C (https=)
CO (1) CO4700441A1 (https=)
CZ (1) CZ289421B6 (https=)
DE (1) DE69611999T2 (https=)
DK (1) DK0839132T5 (https=)
EA (1) EA000625B1 (https=)
EE (1) EE03605B1 (https=)
ES (1) ES2156997T3 (https=)
GE (1) GEP20002027B (https=)
GR (1) GR3035859T3 (https=)
HR (1) HRP960312B1 (https=)
HU (1) HU220343B (https=)
IL (1) IL122161A (https=)
IN (1) IN185276B (https=)
MX (1) MX9708959A (https=)
NO (1) NO309322B1 (https=)
NZ (1) NZ313008A (https=)
PE (1) PE1698A1 (https=)
PL (1) PL191017B1 (https=)
PT (1) PT839132E (https=)
RO (1) RO120069B1 (https=)
SI (1) SI0839132T1 (https=)
SK (1) SK283204B6 (https=)
UA (1) UA50743C2 (https=)
UY (1) UY24286A1 (https=)
WO (1) WO1997003960A1 (https=)
ZA (1) ZA966043B (https=)

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HU226640B1 (en) * 1999-10-18 2009-05-28 Egis Gyogyszergyar Nyilvanosan Process for producing amorphous atorvastatin calcium salt
US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
SI20425A (sl) * 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
PL362981A1 (en) 2000-11-16 2004-11-02 Teva Pharmaceutical Industries Ltd. Hydrolysis of [r(r*,r*)]-2-(4-fluorophenyl)-beta,delta -dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
CA2622477A1 (en) 2000-12-27 2002-07-04 Teva Pharmaceutical Industries Ltd. Crystalline forms of atorvastatin
WO2002057228A1 (en) * 2001-01-17 2002-07-25 Biocon India Limited Atorvastatin calcium
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
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US7361772B2 (en) 2001-08-16 2008-04-22 Biocon Limited Process for the production of atorvastatin calcium
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CZ296967B6 (cs) * 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
HUP0500074A3 (en) 2002-03-18 2005-07-28 Biocon Ltd Bangalore Amorphous hmg-coa reductase inhibitors of desired particle size and process for producing them
RU2309141C2 (ru) * 2002-03-18 2007-10-27 Байокон Лимитид АМОРФНЫЕ ИНГИБИТОРЫ ГМГ-КоА-РЕДУКТАЗЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
WO2003099785A1 (en) * 2002-05-28 2003-12-04 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
US7179942B2 (en) 2002-07-05 2007-02-20 Bicon Limited Halo-substituted active methylene compounds
WO2004022053A1 (en) * 2002-09-03 2004-03-18 Morepen Laboratories Limited Atorvastatin calcium form vi or hydrates thereof
AU2004228607B2 (en) * 2003-04-11 2011-01-27 Lek Pharmaceuticals D.D. Process for the preparation of amorphous calcium salt of atorvastatin
ES2323366T3 (es) 2003-04-22 2009-07-14 Biocon Limited Procedimiento novedoso para la reduccion estereoselectiva de beta-cetoesteres.
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
AU2003272080A1 (en) 2003-09-18 2005-04-06 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
CZ298382B6 (cs) * 2004-03-10 2007-09-12 Zentiva, A. S. Zpusob prípravy amorfní formy hemivápenaté soli atorvastatinu a její stabilizace
WO2005092852A1 (en) 2004-03-17 2005-10-06 Ranbaxy Laboratories Limited Process for the production of atorvastatin calcium in amorphous form
CA2649054A1 (en) 2004-05-05 2005-11-10 Pfizer Products Inc. Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
CA2573969C (en) * 2004-07-16 2014-02-04 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
US7645888B2 (en) 2004-08-27 2010-01-12 Biocon Limited Process for the production of amorphous atorvastatin calcium
EP1793815A4 (en) * 2004-09-30 2010-12-29 Reddys Lab Ltd Dr AMORPHES ATORVASTATINCALCIUM
CN101039906A (zh) * 2004-10-18 2007-09-19 特瓦制药工业有限公司 通过将盐溶解于有机溶剂并除去该溶剂来制备无定形阿托伐他汀半钙的方法，所述有机溶剂为醇和酮和 /或酯的混合物
WO2006046109A1 (en) 2004-10-28 2006-05-04 Warner-Lambert Company Llc Process for forming amorphous atorvastatin
WO2006054308A2 (en) 2004-11-22 2006-05-26 Dexcel Pharma Technologies Ltd. Stable atorvastatin formulations
JP2008521878A (ja) * 2004-12-02 2008-06-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 非晶質アトルバスタチンの医薬組成物及びその製造のための方法
US20080108664A1 (en) 2005-12-23 2008-05-08 Liu Belle B Solid-state form of AMG 706 and pharmaceutical compositions thereof
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
EP1877375A1 (en) * 2006-03-01 2008-01-16 Teva Pharmaceutical Industries Ltd Process for preparing a crystalline form of atorvastatin hemi-calcium
WO2008053312A2 (en) * 2006-11-02 2008-05-08 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its intermediate
US7834195B2 (en) 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
WO2009007856A2 (en) * 2007-07-11 2009-01-15 Actavis Group Ptc Ehf Novel polymorph of atorvastatin calcium and use thereof for the preparation of amorphous atorvastatin calcium
US20090124817A1 (en) * 2007-11-09 2009-05-14 The Industry & Academic Cooperation In Chungnam National University Process for Preparing Amorphous Atorvastatin Calcium Nanoparticles
EP2075246A1 (en) 2007-12-27 2009-07-01 M. J. Institute of Research A process for preparation of amorphous form of atorvastatin hemi-calcium salt
WO2010066846A2 (en) * 2008-12-11 2010-06-17 Dsm Ip Assets B.V. Method for the isolation of atorvastatin
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
CZ201039A3 (cs) 2010-01-19 2011-07-27 Zentiva, K. S Zpusob prumyslové výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) s vysokým specifickým povrchem a jeho použití v lékové forme

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Also Published As

Publication number Publication date
IN185276B (https=) 2000-12-16
PL191017B1 (pl) 2006-03-31
BG102188A (en) 1998-08-31
NO309322B1 (no) 2001-01-15
SK283204B6 (sk) 2003-03-04
CA2220455C (en) 2002-09-24
EA199800128A1 (ru) 1998-08-27
ATE199542T1 (de) 2001-03-15
EP0839132A1 (en) 1998-05-06
EE9700369A (et) 1998-06-15
HRP960312B1 (en) 2001-10-31
IL122161A (en) 1999-07-14
HUP9903017A3 (en) 2001-01-29
SI0839132T1 (https=) 2001-06-30
DE69611999D1 (de) 2001-04-12
KR100400805B1 (ko) 2003-12-24
KR19990029045A (ko) 1999-04-15
UY24286A1 (es) 1997-01-17
UA50743C2 (uk) 2002-11-15
IL122161A0 (en) 1998-04-05
ES2156997T3 (es) 2001-08-01
EE03605B1 (et) 2002-02-15
ZA966043B (en) 1997-02-03
PT839132E (pt) 2001-06-29
PE1698A1 (es) 1998-02-19
CN1190956A (zh) 1998-08-19
SK5898A3 (en) 1998-08-05
HK1018054A1 (en) 1999-12-10
CN1087289C (zh) 2002-07-10
RO120069B1 (ro) 2005-08-30
JPH11510486A (ja) 1999-09-14
GR3035859T3 (en) 2001-08-31
MX9708959A (es) 1998-03-31
HU220343B (hu) 2001-12-28
EP0839132B1 (en) 2001-03-07
CA2220455A1 (en) 1997-02-06
WO1997003960A1 (en) 1997-02-06
NO980209L (no) 1998-01-16
GEP20002027B (en) 2000-04-10
BR9609714A (pt) 1999-02-23
BG63631B1 (bg) 2002-07-31
US6274740B1 (en) 2001-08-14
EA000625B1 (ru) 1999-12-29
DK0839132T3 (da) 2001-04-09
NZ313008A (en) 2000-01-28
CZ12298A3 (cs) 1998-12-16
AU6497896A (en) 1997-02-18
AR002849A1 (es) 1998-04-29
NO980209D0 (no) 1998-01-16
JP4064459B2 (ja) 2008-03-19
DE69611999T2 (de) 2001-07-26
AU700794B2 (en) 1999-01-14
PL324463A1 (en) 1998-05-25
DK0839132T5 (da) 2006-03-20
CO4700441A1 (es) 1998-12-29
HRP960312A2 (en) 1998-02-28

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MK4A Patent expired

Effective date: 20160716