CY1687A - Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them - Google Patents

Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them

Info

Publication number
CY1687A
CY1687A CY1687A CY168793A CY1687A CY 1687 A CY1687 A CY 1687A CY 1687 A CY1687 A CY 1687A CY 168793 A CY168793 A CY 168793A CY 1687 A CY1687 A CY 1687A
Authority
CY
Cyprus
Prior art keywords
trimethoxybenzyl
dimethoxymethyl
bis
preparation
pharmaceutical compositions
Prior art date
Application number
CY1687A
Other languages
English (en)
Original Assignee
Wellcome Found
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found, Gen Hospital Corp filed Critical Wellcome Found
Publication of CY1687A publication Critical patent/CY1687A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Jib Cranes (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Cosmetics (AREA)
CY1687A 1984-07-18 1993-10-10 Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them CY1687A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848418303A GB8418303D0 (en) 1984-07-18 1984-07-18 Compounds

Publications (1)

Publication Number Publication Date
CY1687A true CY1687A (en) 1993-10-10

Family

ID=10564058

Family Applications (1)

Application Number Title Priority Date Filing Date
CY1687A CY1687A (en) 1984-07-18 1993-10-10 Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compositions containing them

Country Status (30)

Country Link
US (1) US4761418A (lt)
EP (1) EP0181055B1 (lt)
JP (1) JPH0662568B2 (lt)
AT (1) ATE60759T1 (lt)
AU (1) AU574481B2 (lt)
BG (1) BG60411B2 (lt)
CA (1) CA1273341A (lt)
CY (1) CY1687A (lt)
DD (1) DD235638A5 (lt)
DE (2) DE19675039I2 (lt)
DK (1) DK168093B1 (lt)
ES (1) ES8609260A1 (lt)
FI (1) FI85019C (lt)
GB (1) GB8418303D0 (lt)
GE (1) GEP19960468B (lt)
HK (1) HK47593A (lt)
HU (1) HU193996B (lt)
IE (1) IE58138B1 (lt)
IL (1) IL75833A (lt)
LT (1) LT2078B (lt)
LU (1) LU88801I2 (lt)
LV (1) LV5483A3 (lt)
MC (1) MC1690A1 (lt)
MX (1) MX9203667A (lt)
NL (1) NL940023I2 (lt)
NZ (1) NZ212766A (lt)
PL (1) PL146066B1 (lt)
SG (1) SG3493G (lt)
SU (1) SU1468414A3 (lt)
ZA (1) ZA855407B (lt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
CN1203061C (zh) * 1997-03-25 2005-05-25 艾弗拉药品公司 取代异喹啉类，其制备方法，药物组合物及其制药用途
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
US20050192243A1 (en) * 2003-10-28 2005-09-01 Savarese John J. Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) * 2006-06-20 2011-01-18 Farmabios S.P.A. Process for the preparation of mivacurium chloride
ATE554769T1 (de) * 2006-12-06 2012-05-15 Cornell Res Foundation Inc Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
WO2008107887A2 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0808581A2 (pt) * 2007-03-26 2014-09-16 Chemagis Ltd "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
US8357807B2 (en) * 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
US8293912B2 (en) * 2007-05-01 2012-10-23 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
BRPI0811687A2 (pt) * 2007-06-18 2015-02-18 Chemagis Ltd MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
US20100256381A1 (en) * 2007-07-09 2010-10-07 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
CA2702535A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
ITMI20080319A1 (it) 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
EP2283005A4 (en) * 2008-05-01 2011-08-31 Chemagis Ltd CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
CN102573794B (zh) 2009-08-19 2017-03-15 康奈尔大学 供生理注射用的半胱氨酸
WO2013021398A2 (en) * 2011-08-05 2013-02-14 Sequent Scientific Limited A process for preparation of mivacurium chloride
ES2625329T3 (es) * 2012-06-29 2017-07-19 Cornell University Agentes bloqueantes neuromusculares asimétricos reversibles de duración ultra-corta, corta o intermedia
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
CN107778237A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN107782821B (zh) * 2016-08-26 2021-11-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂的分析方法
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) * 2017-09-30 2018-09-07 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) * 2019-07-29 2022-04-29 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) * 2019-11-11 2021-03-09 武汉大安制药有限公司 一种5’-甲氧基劳丹素的拆分方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
MC1197A1 (fr) * 1977-08-01 1979-03-19 Massachusetts Gen Hospital Composes tetrahydro-isoquinoleiniques myorelaxants(agents de blocage de la plaque neuro-musculaire)et leur preparation
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
CA1153380A (en) * 1979-10-19 1983-09-06 Hassan A. El-Sayad Neuromuscular blocking tetrahydroisoquinolinium salts
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
DE3165714D1 (en) * 1980-12-17 1984-09-27 Wellcome Found Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体

Also Published As

Publication number Publication date
MX9203667A (es) 1992-07-31
HK47593A (en) 1993-05-21
LU88801I2 (fr) 1996-11-05
AU4510885A (en) 1986-01-23
ZA855407B (en) 1986-04-30
HU193996B (en) 1987-12-28
NL940023I1 (nl) 1995-01-02
JPH0662568B2 (ja) 1994-08-17
FI852807A0 (fi) 1985-07-17
LT2078B (lt) 1993-06-15
ATE60759T1 (de) 1991-02-15
DK324985D0 (da) 1985-07-17
PL146066B1 (en) 1988-12-31
ES8609260A1 (es) 1986-09-01
DD235638A5 (de) 1986-05-14
ES545319A0 (es) 1986-09-01
IL75833A (en) 1988-11-30
NL940023I2 (nl) 1998-06-02
NZ212766A (en) 1988-03-30
IL75833A0 (en) 1985-11-29
GEP19960468B (en) 1996-08-29
GB8418303D0 (en) 1984-08-22
DK324985A (da) 1986-01-19
EP0181055A1 (en) 1986-05-14
SG3493G (en) 1993-03-12
SU1468414A3 (ru) 1989-03-23
IE851791L (en) 1986-01-18
FI85019C (fi) 1992-02-25
LV5483A3 (lv) 1994-03-10
DE3581699D1 (de) 1991-03-14
DE19675039I2 (de) 2003-01-09
FI85019B (fi) 1991-11-15
MC1690A1 (fr) 1986-07-18
AU574481B2 (en) 1988-07-07
FI852807L (fi) 1986-01-19
HUT40626A (en) 1987-01-28
IE58138B1 (en) 1993-07-14
EP0181055B1 (en) 1991-02-06
DK168093B1 (da) 1994-02-07
JPS6187666A (ja) 1986-05-06
CA1273341A (en) 1990-08-28
PL254571A1 (en) 1986-07-15
BG60411B2 (bg) 1995-02-28
US4761418A (en) 1988-08-02

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