CY1121799T1 - Παραγωγα πυριμιδο[4,5-β]ινδολης και χρηση εξ αυτων στην επεκταση των αιμοποιητικων αρχεγονων κυτταρων - Google Patents
Παραγωγα πυριμιδο[4,5-β]ινδολης και χρηση εξ αυτων στην επεκταση των αιμοποιητικων αρχεγονων κυτταρωνInfo
- Publication number
- CY1121799T1 CY1121799T1 CY20191100713T CY191100713T CY1121799T1 CY 1121799 T1 CY1121799 T1 CY 1121799T1 CY 20191100713 T CY20191100713 T CY 20191100713T CY 191100713 T CY191100713 T CY 191100713T CY 1121799 T1 CY1121799 T1 CY 1121799T1
- Authority
- CY
- Cyprus
- Prior art keywords
- indole derivatives
- hemapopoietic
- pyrimide
- expansion
- cells
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Παράγωγα πυριμιδο[4,5-b)]ινδόλης παρέχονται. Αυτές οι ενώσεις είναι χρήσιμες για επέκταση πληθυσμών αιμοποιητικών αρχέγονων κυττάρων, ειδικότερα, πληθυσμών ανθρώπινων αιμοποιητικών αρχέγονων κυττάρων. Οι ενώσεις είναι επίσης χρήσιμες στην ιατρική αγωγή παθήσεων που ενέχουν αιμοποιητικά αρχέγονα κύτταρα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261591521P | 2012-01-27 | 2012-01-27 | |
PCT/CA2013/050052 WO2013110198A1 (en) | 2012-01-27 | 2013-01-25 | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121799T1 true CY1121799T1 (el) | 2020-07-31 |
Family
ID=48872865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100713T CY1121799T1 (el) | 2012-01-27 | 2019-07-05 | Παραγωγα πυριμιδο[4,5-β]ινδολης και χρηση εξ αυτων στην επεκταση των αιμοποιητικων αρχεγονων κυτταρων |
Country Status (24)
Country | Link |
---|---|
US (3) | US9409906B2 (el) |
EP (1) | EP2807165B1 (el) |
JP (1) | JP6250556B2 (el) |
KR (1) | KR102098122B1 (el) |
CN (1) | CN104144931B (el) |
AU (1) | AU2013212457B2 (el) |
BR (1) | BR112014018524B1 (el) |
CA (1) | CA2862140C (el) |
CY (1) | CY1121799T1 (el) |
DK (1) | DK2807165T3 (el) |
ES (1) | ES2733946T3 (el) |
HK (1) | HK1203945A1 (el) |
HR (1) | HRP20191189T1 (el) |
HU (1) | HUE044070T4 (el) |
IL (1) | IL233587B (el) |
LT (1) | LT2807165T (el) |
NZ (1) | NZ627188A (el) |
PL (1) | PL2807165T3 (el) |
PT (1) | PT2807165T (el) |
RS (1) | RS59002B1 (el) |
SG (1) | SG11201404241SA (el) |
SI (1) | SI2807165T1 (el) |
TR (1) | TR201909582T4 (el) |
WO (1) | WO2013110198A1 (el) |
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AU2014249192B2 (en) | 2013-03-11 | 2017-12-21 | The Regents Of The University Of Michigan | BET bromodomain inhibitors and therapeutic methods using the same |
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EP3134409B1 (en) * | 2014-04-22 | 2020-02-12 | Université de Montréal | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells |
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WO2019161494A1 (en) * | 2018-02-20 | 2019-08-29 | Universite De Montreal | Expansion of nk and dc cells in vivo mediating immune response |
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2013
- 2013-01-25 SG SG11201404241SA patent/SG11201404241SA/en unknown
- 2013-01-25 LT LTEP13740815.9T patent/LT2807165T/lt unknown
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- 2013-01-25 NZ NZ627188A patent/NZ627188A/en unknown
- 2013-01-25 PT PT13740815T patent/PT2807165T/pt unknown
- 2013-01-25 BR BR112014018524-7A patent/BR112014018524B1/pt active IP Right Grant
- 2013-01-25 HU HUE13740815A patent/HUE044070T4/hu unknown
- 2013-01-25 US US14/374,953 patent/US9409906B2/en active Active
- 2013-01-25 CA CA2862140A patent/CA2862140C/en active Active
- 2013-01-25 CN CN201380007006.5A patent/CN104144931B/zh active Active
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- 2013-01-25 JP JP2014553589A patent/JP6250556B2/ja active Active
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- 2013-01-25 AU AU2013212457A patent/AU2013212457B2/en active Active
- 2013-01-25 PL PL13740815T patent/PL2807165T3/pl unknown
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2014
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2015
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