CY1121495T1 - Μεθοδος για αποστειρωτικη παραγωγη σωματιδιων λιπιδιου-νουκλεϊκου οξεος - Google Patents

Μεθοδος για αποστειρωτικη παραγωγη σωματιδιων λιπιδιου-νουκλεϊκου οξεος

Info

Publication number
CY1121495T1
CY1121495T1 CY20191100358T CY191100358T CY1121495T1 CY 1121495 T1 CY1121495 T1 CY 1121495T1 CY 20191100358 T CY20191100358 T CY 20191100358T CY 191100358 T CY191100358 T CY 191100358T CY 1121495 T1 CY1121495 T1 CY 1121495T1
Authority
CY
Cyprus
Prior art keywords
lipid
nucleic acid
acid particles
sterilizing production
sterilizing
Prior art date
Application number
CY20191100358T
Other languages
Greek (el)
English (en)
Inventor
Victor Knopov
Richard P. WITTE
Priya Karmali
Robin Lee
David Webb
Original Assignee
Nitto Denko Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Denko Corporation filed Critical Nitto Denko Corporation
Publication of CY1121495T1 publication Critical patent/CY1121495T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CY20191100358T 2011-11-04 2019-03-28 Μεθοδος για αποστειρωτικη παραγωγη σωματιδιων λιπιδιου-νουκλεϊκου οξεος CY1121495T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161556124P 2011-11-04 2011-11-04
PCT/IB2012/002916 WO2013064911A2 (en) 2011-11-04 2012-11-02 Single use system for sterilely producing lipid-nucleic acid particles

Publications (1)

Publication Number Publication Date
CY1121495T1 true CY1121495T1 (el) 2020-05-29

Family

ID=47178988

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100358T CY1121495T1 (el) 2011-11-04 2019-03-28 Μεθοδος για αποστειρωτικη παραγωγη σωματιδιων λιπιδιου-νουκλεϊκου οξεος

Country Status (22)

Country Link
US (1) US8956572B2 (enExample)
EP (4) EP2773326B1 (enExample)
JP (3) JP6149041B2 (enExample)
KR (2) KR102056702B1 (enExample)
CN (2) CN103906503B (enExample)
AU (2) AU2012356239B2 (enExample)
CA (2) CA2853689C (enExample)
CY (1) CY1121495T1 (enExample)
DK (1) DK2773326T3 (enExample)
ES (1) ES2721325T3 (enExample)
HR (1) HRP20190481T1 (enExample)
HU (1) HUE043809T2 (enExample)
LT (1) LT2773326T (enExample)
PL (1) PL2773326T3 (enExample)
PT (1) PT2773326T (enExample)
RS (1) RS58562B1 (enExample)
RU (2) RU2642640C2 (enExample)
SI (1) SI2773326T1 (enExample)
SM (1) SMT201900197T1 (enExample)
TR (1) TR201904389T4 (enExample)
TW (3) TWI626952B (enExample)
WO (2) WO2013064911A2 (enExample)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3431485B2 (en) 2010-10-01 2024-09-04 ModernaTX, Inc. Engineered nucleic acids and methods of use thereof
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (en) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US9579338B2 (en) 2011-11-04 2017-02-28 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
US9320297B2 (en) * 2012-03-22 2016-04-26 Lemniscate Innovations Llc Spherification/reverse spherification automated and integrated system and method
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
RS62288B9 (sr) 2012-06-08 2021-12-31 Nitto Denko Corp Lipidi za formulacije za dostavu terapeutskih agenasa
CA2892529C (en) 2012-11-26 2023-04-25 Moderna Therapeutics, Inc. Terminally modified rna
WO2014123935A1 (en) 2013-02-05 2014-08-14 1Globe Health Institute Llc Biodegradable and clinically-compatible nanop articles as drug delivery carriers
WO2014152211A1 (en) 2013-03-14 2014-09-25 Moderna Therapeutics, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US11377470B2 (en) 2013-03-15 2022-07-05 Modernatx, Inc. Ribonucleic acid purification
DK3019619T3 (da) * 2013-07-11 2021-10-11 Modernatx Inc Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder
EP3041934A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Chimeric polynucleotides
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
WO2015048020A2 (en) * 2013-09-24 2015-04-02 Alnylam Pharmaceuticals, Inc. Compositions and methods for the manufacture of lipid nanoparticles
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
CN103599549A (zh) * 2013-11-22 2014-02-26 大连民族学院 一种siRNA/抗癌药物联合转运复合载体及其制备方法和应用
RS58337B1 (sr) * 2014-03-24 2019-03-29 Translate Bio Inc Irnk terapija za lečenje očnih oboljenja
DK4023249T3 (da) 2014-04-23 2025-01-13 Modernatx Inc Nukleinsyrevacciner
EP3164112A1 (en) * 2014-07-02 2017-05-10 Shire Human Genetic Therapies, Inc. Encapsulation of messenger rna
WO2016010840A1 (en) * 2014-07-16 2016-01-21 Novartis Ag Method of encapsulating a nucleic acid in a lipid nanoparticle host
WO2016011226A1 (en) 2014-07-16 2016-01-21 Moderna Therapeutics, Inc. Chimeric polynucleotides
US20170210788A1 (en) 2014-07-23 2017-07-27 Modernatx, Inc. Modified polynucleotides for the production of intrabodies
WO2016045732A1 (en) * 2014-09-25 2016-03-31 Biontech Rna Pharmaceuticals Gmbh Stable formulations of lipids and liposomes
SG11201705312PA (en) * 2014-12-29 2017-07-28 Bonac Corp Composition containing nucleic acid molecule stably
JP6764870B2 (ja) * 2015-02-24 2020-10-07 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア 連続フローマイクロ流体システム
JP2018525209A (ja) * 2015-04-28 2018-09-06 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア 使い捨てマイクロ流体カートリッジ
WO2016193206A1 (en) 2015-05-29 2016-12-08 Curevac Ag A method for producing and purifying rna, comprising at least one step of tangential flow filtration
CN113679689B (zh) * 2015-07-22 2023-09-01 日东电工株式会社 用于纳米粒冷冻干燥物形式的组合物及方法
US11564893B2 (en) 2015-08-17 2023-01-31 Modernatx, Inc. Methods for preparing particles and related compositions
US9938572B1 (en) * 2015-09-08 2018-04-10 Raindance Technologies, Inc. System and method for forming an emulsion
DK3350157T3 (da) 2015-09-17 2022-02-14 Modernatx Inc Forbindelser og sammensætninger til intracellulær afgivelse af terapeutiske midler
US12109274B2 (en) 2015-09-17 2024-10-08 Modernatx, Inc. Polynucleotides containing a stabilizing tail region
MA46316A (fr) 2015-10-22 2021-03-24 Modernatx Inc Vaccin contre le cytomégalovirus humain
MD3386484T2 (ro) 2015-12-10 2022-11-30 Modernatx Inc Compoziții și metode de livrare a unor agenți terapeutici
AU2016377681B2 (en) 2015-12-22 2021-05-13 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
EP4039699A1 (en) 2015-12-23 2022-08-10 ModernaTX, Inc. Methods of using ox40 ligand encoding polynucleotides
JP7349788B2 (ja) 2016-01-06 2023-09-25 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア 分岐ミキサー並びにその使用及び製造方法
US20190241658A1 (en) 2016-01-10 2019-08-08 Modernatx, Inc. Therapeutic mRNAs encoding anti CTLA-4 antibodies
US10689873B2 (en) 2016-03-10 2020-06-23 Lonza Ltd Customizable facility
JP7009378B2 (ja) 2016-03-10 2022-02-10 ロンザ リミテッド カスタマイズ可能施設
US20200315967A1 (en) * 2016-06-24 2020-10-08 Modernatx, Inc. Lipid nanoparticles
EP3478838A1 (en) * 2016-06-30 2019-05-08 Arbutus Biopharma Corporation Compositions and methods for delivering messenger rna
IL264374B2 (en) * 2016-08-02 2024-03-01 Lonza Ag Customizable facility
WO2018035387A1 (en) 2016-08-17 2018-02-22 The Broad Institute, Inc. Novel crispr enzymes and systems
US11352647B2 (en) 2016-08-17 2022-06-07 The Broad Institute, Inc. Crispr enzymes and systems
JP7079250B2 (ja) * 2016-08-18 2022-06-01 ブレマー，トロイ リポソーム構築物を用いた黄斑細胞及び網膜細胞への尿素の送達
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
EP3315125A1 (en) * 2016-10-31 2018-05-02 Silence Therapeutics (London) Ltd Lipid nanoparticle formulation
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
CA3055653A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Lipid nanoparticle formulation
AU2018234692B2 (en) 2017-03-15 2022-06-02 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
ES2911186T3 (es) 2017-03-15 2022-05-18 Modernatx Inc Formas cristalinas de aminolípidos
WO2018191750A2 (en) 2017-04-14 2018-10-18 The Broad Institute Inc. Novel delivery of large payloads
WO2018232120A1 (en) 2017-06-14 2018-12-20 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
US11786607B2 (en) 2017-06-15 2023-10-17 Modernatx, Inc. RNA formulations
CA3069019A1 (en) * 2017-07-10 2019-01-17 Immunovaccine Technologies Inc. Pharmaceutical compositions, methods for preparation using lipid vesicle particles of defined size, and uses thereof
CA3071968A1 (en) 2017-08-04 2019-02-07 Kyowa Kirin Co., Ltd. Nucleic acid-containing lipid nanoparticle
JP2019043216A (ja) 2017-08-30 2019-03-22 いすゞ自動車株式会社 ステアリング装置
MX2020002348A (es) 2017-08-31 2020-10-08 Modernatx Inc Métodos de elaboración de nanopartículas lipídicas.
RU2022103533A (ru) 2017-10-20 2022-03-10 Бионтек Рна Фармасьютикалс Гмбх (Biontech Rna Pharmaceuticals Gmbh) Приготовление и хранение липосомальных РНК-составов, подходящих для терапии
WO2019135816A2 (en) 2017-10-23 2019-07-11 The Broad Institute, Inc. Novel nucleic acid modifiers
JP6968452B2 (ja) 2017-11-01 2021-11-17 国立大学法人大阪大学 所望の粒径を有する脂質粒子を製造するための方法および装置の開発
EP3706713A4 (en) * 2017-11-09 2021-06-16 ImmunoVaccine Technologies Inc. PHARMACEUTICAL COMPOSITIONS, METHOD OF MANUFACTURING THEREOF, INCLUDING SIZING OF LIPID VESICLE PARTICLES, AND USES
WO2019094983A1 (en) 2017-11-13 2019-05-16 The Broad Institute, Inc. Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway
US10968257B2 (en) 2018-04-03 2021-04-06 The Broad Institute, Inc. Target recognition motifs and uses thereof
WO2019204451A1 (en) * 2018-04-17 2019-10-24 Carnegie Mellon University Enhanced lipid nanoparticle drug delivery using a negatively charged polymer
CA3108920A1 (en) * 2018-08-29 2020-03-05 Translate Bio, Inc. Improved process of preparing mrna-loaded lipid nanoparticles
CA3113025A1 (en) 2018-09-19 2020-03-26 Modernatx, Inc. Peg lipids and uses thereof
EP4509118A3 (en) 2018-09-19 2025-05-14 ModernaTX, Inc. High-purity peg lipids and uses thereof
US12263248B2 (en) 2018-09-19 2025-04-01 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
US12090235B2 (en) 2018-09-20 2024-09-17 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
EP3852911B1 (en) * 2018-09-21 2025-01-22 Acuitas Therapeutics, Inc. Systems and methods for manufacturing lipid nanoparticles and liposomes
KR20210093232A (ko) 2018-10-09 2021-07-27 더 유니버시티 오브 브리티시 콜롬비아 유기용매와 세제가 없는 형질감염 적격 소포를 포함하는 조성물과 시스템 및 관련 방법
AU2019362031A1 (en) * 2018-10-19 2021-04-08 Translate Bio, Inc. Pumpless encapsulation of messenger RNA
BR112021014845A2 (pt) * 2019-01-31 2021-11-03 Modernatx Inc Métodos de preparação de nanopartículas lipídicas
US12215382B2 (en) 2019-03-01 2025-02-04 The General Hospital Corporation Liver protective MARC variants and uses thereof
WO2020191102A1 (en) 2019-03-18 2020-09-24 The Broad Institute, Inc. Type vii crispr proteins and systems
US11737979B2 (en) 2019-03-19 2023-08-29 Arcturus Therapeutics, Inc. Method of making lipid-encapsulated RNA nanoparticles
CN118203546A (zh) 2019-05-07 2024-06-18 米尼翁大学 生产脂质体的方法
WO2020236972A2 (en) 2019-05-20 2020-11-26 The Broad Institute, Inc. Non-class i multi-component nucleic acid targeting systems
HUE068356T2 (hu) 2019-08-14 2024-12-28 Acuitas Therapeutics Inc Javított lipid nanorészecskék nukleinsavak bejuttatására
EP4025196A4 (en) 2019-09-06 2023-07-12 Generation Bio Co. Lipid nanoparticle compositions comprising closed-ended dna and cleavable lipids and methods of use thereof
JP7271374B2 (ja) * 2019-09-10 2023-05-11 株式会社東芝 分析方法、分析基体、分析キット及び分析装置。
CA3154618A1 (en) 2019-09-19 2021-03-25 Modernatx, Inc. Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
US12297426B2 (en) 2019-10-01 2025-05-13 The Broad Institute, Inc. DNA damage response signature guided rational design of CRISPR-based systems and therapies
CN114787127B (zh) 2019-11-22 2024-04-26 世代生物公司 可电离脂质及其纳米颗粒组合物
KR102409145B1 (ko) * 2020-03-23 2022-06-15 프레스티지바이오로직스 주식회사 항체 의약품 제조 공정을 위한 버퍼 조제 및 이송 시스템
CN111467321A (zh) * 2020-03-26 2020-07-31 深圳市新合生物医疗科技有限公司 一种mRNA核酸类药物胞内递送系统、制备方法和应用
JP7746280B2 (ja) 2020-03-27 2025-09-30 ジェネレーション バイオ カンパニー 新規脂質及びそれらのナノ粒子組成物
MX2023000614A (es) 2020-07-16 2023-02-13 Acuitas Therapeutics Inc Lipidos cationicos para usarse en nanoparticulas lipidicas.
BR112023002642A2 (pt) * 2020-08-14 2023-04-04 Arcturus Therapeutics Inc Método para liofilizar nanopartículas lipídicas
IL301253A (en) 2020-09-13 2023-05-01 Arcturus Therapeutics Inc As a mass of large RNA lipid nanoparticles
US20220218622A1 (en) * 2020-10-14 2022-07-14 George Mason Research Foundation, Inc. Ionizable lipids and methods of manufacture and use thereof
CN112843019A (zh) * 2021-01-27 2021-05-28 江苏普瑞康生物医药科技有限公司 一种核酸脂质纳米粒组合物，包含其的药物制剂，及其制备方法和应用
JP2024509743A (ja) * 2021-02-16 2024-03-05 ザ・ジョンズ・ホプキンス・ユニバーシティ ｉｎ ｖｉｔｒｏおよびｉｎ ｖｉｖｏトランスフェクションのための規定サイズのプラスミドＤＮＡ／脂質粒子の調製方法
WO2022175366A1 (en) 2021-02-17 2022-08-25 Secoya Technologies Method for producing lipid nanoparticles and lipid nanoparticles resulting therefrom
US11524023B2 (en) 2021-02-19 2022-12-13 Modernatx, Inc. Lipid nanoparticle compositions and methods of formulating the same
JP7656363B2 (ja) * 2021-04-22 2025-04-03 インベンテージ ラボ インコーポレイテッド 脂質ナノ粒子の製造方法およびその製造装置
IL309145A (en) 2021-06-14 2024-02-01 Generation Bio Co Cationic lipids and their compositions
EP4412591A1 (en) * 2021-10-06 2024-08-14 leon-nanodrugs GmbH Method for preparing lipid nanoparticles
WO2023081526A1 (en) 2021-11-08 2023-05-11 Orna Therapeutics, Inc. Lipid nanoparticle compositions for delivering circular polynucleotides
CN116549626A (zh) * 2022-01-27 2023-08-08 深圳瑞吉生物科技有限公司 一种载核酸脂质纳米颗粒冻干制剂及其制备方法与应用
US20250327041A1 (en) 2022-02-24 2025-10-23 Io Biotech Aps Nucleotide delivery of cancer therapy
EP4503923A1 (en) 2022-04-04 2025-02-12 The Regents of the University of California Genetic complementation compositions and methods
KR102475540B1 (ko) * 2022-04-26 2022-12-08 주식회사 무진메디 약물이 담지된 지질 나노입자 제조 방법 및 제조 장치
EP4536197A1 (en) 2022-06-07 2025-04-16 Generation Bio Co. Lipid nanoparticle compositions and uses thereof
TW202425959A (zh) 2022-11-08 2024-07-01 美商歐納醫療公司 遞送多核苷酸的脂質及奈米顆粒組合物
TW202428289A (zh) 2022-11-08 2024-07-16 美商歐納醫療公司 環狀rna組合物
WO2024102762A1 (en) 2022-11-08 2024-05-16 Orna Therapeutics, Inc. Lipids and lipid nanoparticle compositions for delivering polynucleotides
AU2023406303A1 (en) 2022-12-01 2025-05-29 Generation Bio Co. Lipid nanoparticles comprising nucleic acids, ionizable lipids, sterols, lipid anchored polymers and helper lipids, their uses
EP4626401A1 (en) 2022-12-01 2025-10-08 Generation Bio Co. Stealth lipid nanoparticle compositions for cell targeting
AU2023406321A1 (en) 2022-12-01 2025-05-29 Generation Bio Co. Novel polyglycerol-conjugated lipids and lipid nanoparticle compositions comprising the same
EP4626402A1 (en) 2022-12-01 2025-10-08 Generation Bio Co. Lipid nanoparticles comprising nucleic acids and lipid-anchored polymers
AU2023398825A1 (en) 2022-12-15 2025-06-26 Orna Therapeutics, Inc. Circular rna compositions and methods
WO2024136254A1 (ko) * 2022-12-20 2024-06-27 (주)인벤티지랩 저농도 이온화 지질을 포함하는 지질나노입자 및 이의 제조 방법
WO2024205657A2 (en) 2023-03-29 2024-10-03 Orna Therapeutics, Inc. Lipids and lipid nanoparticle compositions for delivering polynucleotides
WO2024233308A2 (en) 2023-05-05 2024-11-14 Orna Therapeutics, Inc. Circular rna compositions and methods
WO2025049690A1 (en) 2023-08-29 2025-03-06 Orna Therapeutics, Inc. Circular polyethylene glycol lipids
EP4520345A1 (en) 2023-09-06 2025-03-12 Myneo Nv Product
WO2025052180A2 (en) 2023-09-07 2025-03-13 Axelyf ehf. Lipids and lipid nanoparticles
WO2025051994A1 (en) 2023-09-07 2025-03-13 Coave Therapeutics Ionizable lipid nanoparticles
WO2025072383A1 (en) 2023-09-25 2025-04-03 The Broad Institute, Inc. Viral open reading frames, uses thereof, and methods of detecting the same
WO2025097055A2 (en) 2023-11-02 2025-05-08 The Broad Institute, Inc. Compositions and methods of use of t cells in immunotherapy
WO2025101501A1 (en) 2023-11-07 2025-05-15 Orna Therapeutics, Inc. Circular rna compositions
WO2025114520A1 (en) 2023-12-01 2025-06-05 Coave Therapeutics Ionizable lipid nanoparticles
EP4570361A1 (en) * 2023-12-11 2025-06-18 Sartorius Stedim Biotech GmbH Device assembly and method for a production-scale tangential flow filtration
WO2025129158A1 (en) 2023-12-15 2025-06-19 The Broad Institute, Inc. Engineered arc delivery vesicles and uses thereof
WO2025166238A1 (en) 2024-01-31 2025-08-07 Orna Therapeutics, Inc. Fast-shedding polyethylene glycol lipids
WO2025250808A1 (en) 2024-05-29 2025-12-04 The Brigham And Women’S Hospital, Inc. Anti-crispr delivery compositions and methods

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285638A4 (en) * 1986-09-18 1989-06-14 Liposome Technology Inc METHOD FOR PRODUCING A HIGH DENSITY LIPOSOME.
US4781871A (en) * 1986-09-18 1988-11-01 Liposome Technology, Inc. High-concentration liposome processing method
US4895452A (en) 1988-03-03 1990-01-23 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
EP0706374B1 (en) * 1993-06-30 1997-12-10 Genentech, Inc. Method for preparing liposomes
US5981501A (en) 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
DE69634084T2 (de) 1995-06-07 2005-12-08 Inex Pharmaceuticals Corp. Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
US6395302B1 (en) 1996-11-19 2002-05-28 Octoplus B.V. Method for the preparation of microspheres which contain colloidal systems
DE69841002D1 (de) * 1997-05-14 2009-09-03 Univ British Columbia Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln
US6534018B1 (en) 1998-11-13 2003-03-18 Optime Therapeutics, Inc. Method and apparatus for liposome production
US6855296B1 (en) 1998-11-13 2005-02-15 Optime Therapeutics, Inc. Method and apparatus for liposome production
US7094423B1 (en) 1999-07-15 2006-08-22 Inex Pharmaceuticals Corp. Methods for preparation of lipid-encapsulated therapeutic agents
AU771706B2 (en) * 1999-07-15 2004-04-01 University Of British Columbia, The Methods and apparatus for preparation of lipid vesicles
EP1203614A1 (de) 2000-11-03 2002-05-08 Polymun Scientific Immunbiologische Forschung GmbH Verfahren und Vorrichtung zur Herstellung von Lipidvesikeln
ATE381963T1 (de) * 2001-10-26 2008-01-15 Octoplus Technologies B V Verfahren zur herstellung von gereinigten partikeln
US7223887B2 (en) 2001-12-18 2007-05-29 The University Of British Columbia Multivalent cationic lipids and methods of using same in the production of lipid particles
WO2003059280A2 (en) 2002-01-09 2003-07-24 Elan Pharmaceuticals, Inc. Efficient liposomal encapsulation
US6712963B2 (en) 2002-06-14 2004-03-30 Scilog, Llc Single-use manifold for automated, aseptic transfer of solutions in bioprocessing applications
US7901708B2 (en) 2002-06-28 2011-03-08 Protiva Biotherapeutics, Inc. Liposomal apparatus and manufacturing methods
FR2856940B1 (fr) * 2003-07-04 2007-02-09 Stedim Sa Systeme clos a usage unique de melange, de stockage et d'homogeneisation de liquides en conditions propres ou steriles
WO2005090403A2 (en) * 2004-03-12 2005-09-29 Biovest International, Inc. Method and apparatus for antibody purification
CA2569405C (en) 2004-06-04 2011-05-03 Xcellerex, Inc. Disposable bioreactor systems and methods
US7410587B2 (en) 2004-08-03 2008-08-12 Scilog, Inc. Liquid handling for filtration and preparative chromatography
US7404969B2 (en) * 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
JP5639338B2 (ja) 2005-07-27 2014-12-10 プロチバ バイオセラピューティクス インコーポレイティッド リポソームの製造システムおよび製造方法
US8101741B2 (en) * 2005-11-02 2012-01-24 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
US20090252836A1 (en) 2006-04-11 2009-10-08 Wingturf Co., Ltd. Method of Gas Treatment
EP1920765A1 (en) 2006-11-07 2008-05-14 Medigene AG Liposome preparation by single-pass process
US20110117125A1 (en) 2008-01-02 2011-05-19 Tekmira Pharmaceuticals Corporation Compositions and methods for the delivery of nucleic acids
JP5322476B2 (ja) 2008-03-31 2013-10-23 テルモ株式会社 リポソームの製造装置およびリポソームの製造方法
US8231787B2 (en) 2008-05-06 2012-07-31 Spf Innovations, Llc Tangential flow filtration system
US20110224447A1 (en) * 2008-08-18 2011-09-15 Bowman Keith A Novel Lipid Nanoparticles and Novel Components for Delivery of Nucleic Acids
EP2349210B1 (en) 2008-10-16 2015-03-18 Marina Biotech, Inc. Processes and compositions for liposomal and efficient delivery of gene silencing therapeutics
JP2012509272A (ja) * 2008-11-17 2012-04-19 エンゾン ファーマシューティカルズ，インコーポレーテッド 核酸送達系のための放出性カチオン脂質
WO2010080724A1 (en) * 2009-01-12 2010-07-15 Merck Sharp & Dohme Corp. Novel lipid nanoparticles and novel components for delivery of nucleic acids
JP5684729B2 (ja) * 2009-01-20 2015-03-18 メッド コート エービーＭｅｄ Ｃｏａｔ Ａｂ 新規コーティング組成物とその使用
FR2943560B1 (fr) * 2009-03-24 2011-05-27 Jean Pascal Zambaux Bioreacteur jetable et systeme d'agitation a usage unique
JP5823405B2 (ja) * 2009-11-04 2015-11-25 ザ ユニバーシティ オブ ブリティッシュ コロンビア 核酸含有脂質粒子および関連方法
EP3403647A1 (en) * 2009-12-01 2018-11-21 Translate Bio, Inc. Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
EP2525781A1 (en) * 2010-01-22 2012-11-28 Schering Corporation Novel cationic lipids for oligonucleotide delivery
EP3391877A1 (en) 2010-04-08 2018-10-24 The Trustees of Princeton University Preparation of lipid nanoparticles
KR102038300B1 (ko) * 2011-06-08 2019-10-31 닛토덴코 가부시키가이샤 표적 약물 전달체 및 ｓｉＲＮＡ 활성을 증가시키는 화합물

Also Published As

Publication number Publication date
PT2773326T (pt) 2019-04-23
JP6133883B2 (ja) 2017-05-24
HUE043809T2 (hu) 2019-09-30
AU2012356239B2 (en) 2016-09-22
CN103906504B (zh) 2017-11-17
EP3485875A1 (en) 2019-05-22
PL2773326T3 (pl) 2019-06-28
SMT201900197T1 (it) 2019-05-10
SI2773326T1 (sl) 2019-04-30
RU2014122432A (ru) 2015-12-10
WO2013093648A3 (en) 2013-10-24
RU2014122433A (ru) 2015-12-10
US8956572B2 (en) 2015-02-17
KR102056702B1 (ko) 2019-12-17
TW201731491A (zh) 2017-09-16
EP2773326B1 (en) 2019-02-20
HRP20190481T1 (hr) 2019-05-03
TW201325634A (zh) 2013-07-01
JP2017165748A (ja) 2017-09-21
TW201323020A (zh) 2013-06-16
DK2773326T3 (en) 2019-04-15
KR102046968B1 (ko) 2019-12-02
US20130164400A1 (en) 2013-06-27
JP2015502345A (ja) 2015-01-22
KR20140097276A (ko) 2014-08-06
TWI626952B (zh) 2018-06-21
WO2013093648A2 (en) 2013-06-27
CN103906503B (zh) 2016-12-14
TWI618548B (zh) 2018-03-21
CA2853685A1 (en) 2013-05-10
TR201904389T4 (tr) 2019-04-22
JP2014534232A (ja) 2014-12-18
CA2853685C (en) 2019-09-03
AU2012356239A1 (en) 2014-05-29
ES2721325T3 (es) 2019-07-31
RU2647476C2 (ru) 2018-03-15
RS58562B1 (sr) 2019-05-31
AU2012330819B2 (en) 2017-08-31
LT2773326T (lt) 2019-04-25
RU2642640C2 (ru) 2018-01-25
JP6442551B2 (ja) 2018-12-19
WO2013064911A3 (en) 2013-10-24
AU2012330819A1 (en) 2014-05-15
WO2013064911A2 (en) 2013-05-10
EP2773328A2 (en) 2014-09-10
CA2853689A1 (en) 2013-06-27
EP3673898A1 (en) 2020-07-01
TWI615156B (zh) 2018-02-21
KR20140101748A (ko) 2014-08-20
CN103906504A (zh) 2014-07-02
JP6149041B2 (ja) 2017-06-14
CA2853689C (en) 2020-06-30
EP2773326A2 (en) 2014-09-10
CN103906503A (zh) 2014-07-02

Similar Documents

Publication Publication Date Title
CY1121495T1 (el) Μεθοδος για αποστειρωτικη παραγωγη σωματιδιων λιπιδιου-νουκλεϊκου οξεος
EP2671862A4 (en) METHOD FOR PRODUCING AN UNSATURATED ALDEHYDE AND / OR UNSATURATED CARBOXYLIC ACID
IL232941B (en) Microbial-based process for high-quality protein concentrate
EP2708507A4 (en) METHOD FOR PRODUCING NANOCARBON AND PRODUCTION DEVICE
EP2762558A4 (en) METHOD FOR THE PRODUCTION OF WOVEN FABRICS AND ORGANS
DE112011105262A5 (de) Optoelektronische Vorrichtung und Verfahren zur Herstellung von optoelektronischen Vorrichtungen
EP2682033A4 (en) TOILET PAPER MANUFACTURING METHOD AND TOILET PAPER
EP2731509A4 (en) DEVICE AND METHOD FOR RE-POSITIONING BODY PARTS
EP2712928A4 (en) Method for producing natural -carotene by fermentation and use thereof
EP2704655C0 (de) Verfahren zur inaktivierung von molekülen und vorrichtung zu dessen durchführung
EP2888403A4 (en) METHOD FOR PRODUCING A PAPER PRODUCT AND PAPER PRODUCT
EP2488604A4 (en) METHOD AND DEVICE FOR PRODUCING BIO-CARBON
EP2415349A4 (en) PROCESS FOR PREPARING SPREADED MILK AND SPELLED MILK
EP2814866A4 (en) METHOD FOR MANUFACTURING POLYMER AND DEVICE FOR MANUFACTURING POLYMER
LU92438B1 (de) Vorrichtung und Verfahren zur Behandlung von biologischem Gewebe mit einem Niederdruckplasma
DE102011111523B8 (de) Verfahren und Vorrichtung zur Kantenentkeimung von Verpackungsmaterial
DE112013001147A5 (de) Verfahren und Vorrichtung zur Herstellung von Preformen
BR112013024213B8 (pt) Método de fabricação de instrumento médico e instrumento médico
EP2754010A4 (en) APPARATUS, AND METHOD FOR READING CORRESPONDING CONTENT
BR112014011092A2 (pt) método de recuperação de etileno durante o processo de produção de vac e seu dispositivo
EP2762884A4 (en) MOLECULAR TEMPLATE AND METHOD FOR THE PRODUCTION THEREOF
DE112013003816A5 (de) Verfahren zur Herstellung eines Leuchtmittels
EP2773323A4 (en) NANO-SUSPENSION METHOD
EP2808388A4 (en) EXPRESSION VECTOR AND METHOD FOR PRODUCING PROTEIN
EP2741790A4 (en) MEDICAL ADHESIVE AND METHOD FOR THE PRODUCTION THEREOF