CY1121157T1 - Μειωση της ανοσογονικοτητας εναντι παραγοντα viii σε ατομα τα οποια υποβαλλονται σε θεραπεια με παραγοντα viii - Google Patents

Μειωση της ανοσογονικοτητας εναντι παραγοντα viii σε ατομα τα οποια υποβαλλονται σε θεραπεια με παραγοντα viii

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Publication number
CY1121157T1
CY1121157T1 CY20181101133T CY181101133T CY1121157T1 CY 1121157 T1 CY1121157 T1 CY 1121157T1 CY 20181101133 T CY20181101133 T CY 20181101133T CY 181101133 T CY181101133 T CY 181101133T CY 1121157 T1 CY1121157 T1 CY 1121157T1
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Cyprus
Prior art keywords
fviii
factors viii
people
treated
reduction
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CY20181101133T
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English (en)
Inventor
Haiyan Jiang
Tongyao Liu
Sriram KRISHNAMOORTHY
Neil JOSEPHSON
Pierce GLENN
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Bioverativ Therapeutics Inc.
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Publication date
Application filed by Bioverativ Therapeutics Inc. filed Critical Bioverativ Therapeutics Inc.
Publication of CY1121157T1 publication Critical patent/CY1121157T1/el

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Abstract

Η παρούσα αποκάλυψη παρέχει μεθόδους χορήγησης χιμαιρικών και υβριδικών πολυπεπτιδίων Παράγοντα VIII (FVIII) που περιέχουν FVIII και Fc σε υποκείμενα που κινδυνεύουν να αναπτύξουν ανασταλτικές FVIII ανοσοαποκρίσεις, όπου συμπεριλαμβάνονται αντισώματα έναντι-FVIII και/ή κυτταρομεσολαβούμενη ανοσία. Η χορήγηση είναι επαρκής για να προάγει την πήξη και να επάγει ανοσολογική ανοχή στο FVIII. Το χιμαιρικό πολυπεπτίδιο μπορεί να περιλαμβάνει πλήρους μήκους FVIII ή ένα FVIII πολυπεπτίδιο που περιέχει μία διαγραφή, π.χ., μία πλήρη ή μερική διαγραφή της Β επικράτειας.
CY20181101133T 2012-01-12 2018-11-01 Μειωση της ανοσογονικοτητας εναντι παραγοντα viii σε ατομα τα οποια υποβαλλονται σε θεραπεια με παραγοντα viii CY1121157T1 (el)

Applications Claiming Priority (3)

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US201261586103P 2012-01-12 2012-01-12
US201261668961P 2012-07-06 2012-07-06
PCT/US2013/021332 WO2013106789A1 (en) 2012-01-12 2013-01-12 Methods of reducing immunogenicity against factor viii in individuals undergoing factor viii therapy

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CY1121157T1 true CY1121157T1 (el) 2020-05-29

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US (3) US10221455B2 (el)
EP (3) EP3453402B1 (el)
JP (4) JP6234378B2 (el)
CN (2) CN104254614A (el)
AU (2) AU2016210768B2 (el)
BR (1) BR112014017111A8 (el)
CA (1) CA2863329C (el)
CY (1) CY1121157T1 (el)
DK (1) DK2802668T3 (el)
EA (2) EA029560B1 (el)
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BR112019011198A2 (pt) * 2016-12-02 2019-12-17 Bioverativ Therapeutics Inc métodos de indução de tolerância imune a fatores de coagulação
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TW202039546A (zh) 2019-01-16 2020-11-01 美商巴克斯歐塔公司 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
CN114008069A (zh) 2019-04-17 2022-02-01 科迪亚克生物科学公司 外来体和aav的组合物
JP2022537200A (ja) 2019-06-19 2022-08-24 バイオベラティブ セラピューティクス インコーポレイテッド 血友病および低骨ミネラル密度を処置するための方法および組成物
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