CY1120025T1 - (2r,5s,13ar)-7,9-διοξο-10-((2,4,6-τριφθοροβενζυλ) καρβαμοϋλ)-2,3,4,5,7,9,13,13α-οκταϋδρο-2,5-μεθανοπυριδο[1',2':4.5]πυραζινο[2,1-β]οξαζεπιν-8-ολεϊκο νατριο - Google Patents

(2r,5s,13ar)-7,9-διοξο-10-((2,4,6-τριφθοροβενζυλ) καρβαμοϋλ)-2,3,4,5,7,9,13,13α-οκταϋδρο-2,5-μεθανοπυριδο[1',2':4.5]πυραζινο[2,1-β]οξαζεπιν-8-ολεϊκο νατριο

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Publication number
CY1120025T1
CY1120025T1 CY20181100305T CY181100305T CY1120025T1 CY 1120025 T1 CY1120025 T1 CY 1120025T1 CY 20181100305 T CY20181100305 T CY 20181100305T CY 181100305 T CY181100305 T CY 181100305T CY 1120025 T1 CY1120025 T1 CY 1120025T1
Authority
CY
Cyprus
Prior art keywords
trifluorobenzyl
octahydro
dioxo
pyrazine
carbamoyl
Prior art date
Application number
CY20181100305T
Other languages
English (en)
Inventor
Ernest A. CARRA
Irene Chen
Vahid Zia
Original Assignee
Gilead Sciences, Inc.
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53674269&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1120025(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of CY1120025T1 publication Critical patent/CY1120025T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

Η παρούσα εφεύρεση αφορά σε (2R,5S,13aR)-7,9-διοξo-10 -((2,4,6-τριφθοροβενζυλ)καρβαμοϋλ)-2,3,4,5,7,9,13,13a-οκταϋδρο-2,5-μεθανοπυριδο[1’,2’:4,5]πυραζινο[2,1-b][1,3]οξαζεπιν-8-ολικού νατρίου Μορφή I.
CY20181100305T 2014-06-20 2018-03-13 (2r,5s,13ar)-7,9-διοξο-10-((2,4,6-τριφθοροβενζυλ) καρβαμοϋλ)-2,3,4,5,7,9,13,13α-οκταϋδρο-2,5-μεθανοπυριδο[1',2':4.5]πυραζινο[2,1-β]οξαζεπιν-8-ολεϊκο νατριο CY1120025T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462015245P 2014-06-20 2014-06-20
PCT/US2015/036757 WO2015196116A1 (en) 2014-06-20 2015-06-19 Sodium (2r, 5s, 13ar) -7, 9-dioxo-10- ( (2,4,6-trifluorobenzyl) carbamoyl) -2, 3, 4, 5, 7, 9, 13, 13a-octahydro-2, 5-methanopyrido [1',2' : 4.5] pyrazino [2, 1-b] oxazepin-8-olate

Publications (1)

Publication Number Publication Date
CY1120025T1 true CY1120025T1 (el) 2018-12-12

Family

ID=53674269

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CY20181100305T CY1120025T1 (el) 2014-06-20 2018-03-13 (2r,5s,13ar)-7,9-διοξο-10-((2,4,6-τριφθοροβενζυλ) καρβαμοϋλ)-2,3,4,5,7,9,13,13α-οκταϋδρο-2,5-μεθανοπυριδο[1',2':4.5]πυραζινο[2,1-β]οξαζεπιν-8-ολεϊκο νατριο

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US (3) US9708342B2 (el)
EP (2) EP3321270A1 (el)
JP (4) JP6334007B2 (el)
KR (1) KR101899803B1 (el)
CN (2) CN106459085B (el)
AP (1) AP2016009591A0 (el)
AR (1) AR100903A1 (el)
AU (2) AU2015276860B2 (el)
BR (2) BR122021025861B1 (el)
CA (1) CA2950307C (el)
CL (1) CL2016003249A1 (el)
CR (1) CR20160589A (el)
CU (1) CU24478B1 (el)
CY (1) CY1120025T1 (el)
DK (1) DK3157932T3 (el)
DO (1) DOP2016000327A (el)
EA (2) EA030967B1 (el)
EC (1) ECSP16095566A (el)
ES (1) ES2660862T3 (el)
HR (1) HRP20180455T1 (el)
HU (1) HUE036928T2 (el)
IL (1) IL249161B (el)
LT (1) LT3157932T (el)
MA (2) MA40239B1 (el)
MD (2) MD4584C1 (el)
ME (1) ME03037B (el)
MX (2) MX369555B (el)
MY (1) MY186696A (el)
NO (1) NO2717902T3 (el)
NZ (1) NZ727155A (el)
PE (1) PE20170150A1 (el)
PH (1) PH12016502499B1 (el)
PL (1) PL3157932T3 (el)
PT (1) PT3157932T (el)
RS (1) RS56950B1 (el)
SG (1) SG11201610211QA (el)
SI (1) SI3157932T1 (el)
SV (1) SV2016005339A (el)
TR (1) TR201802179T4 (el)
TW (2) TWI673274B (el)
UA (1) UA118480C2 (el)
UY (1) UY36177A (el)
WO (1) WO2015196116A1 (el)
ZA (1) ZA201608744B (el)

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