MD4584B1 - (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzil)carbamoil)-2,3,4,5,7,9,13,13a-octahidro-2,5-metanopirido[1ʹ,2ʹ:4,5]pirazino[2,1-b][1,3]oxazepin-8-olat de sodiu - Google Patents

(2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzil)carbamoil)-2,3,4,5,7,9,13,13a-octahidro-2,5-metanopirido[1ʹ,2ʹ:4,5]pirazino[2,1-b][1,3]oxazepin-8-olat de sodiu Download PDF

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Publication number
MD4584B1
MD4584B1 MDA20170006A MD20170006A MD4584B1 MD 4584 B1 MD4584 B1 MD 4584B1 MD A20170006 A MDA20170006 A MD A20170006A MD 20170006 A MD20170006 A MD 20170006A MD 4584 B1 MD4584 B1 MD 4584B1
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Moldova
Prior art keywords
methanopyrido
oxazepin
trifluorobenzyl
pyrazino
octahydro
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MDA20170006A
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Russian (ru)
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MD20170006A2 (ro
MD4584C1 (ro
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Эрнест А. КАРРА
Ирэн ЧЭНЬ
Вахид Зиа
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Gilead Sciences, Inc.
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Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of MD20170006A2 publication Critical patent/MD20170006A2/ro
Publication of MD4584B1 publication Critical patent/MD4584B1/ro
Publication of MD4584C1 publication Critical patent/MD4584C1/ro

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/66—Phosphorus compounds
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61P31/18—Antivirals for RNA viruses for HIV
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

Prezenta invenţie se referă la Forma I a (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzil)carbamoil)-2,3,4,5,7,9,13,13a-octahidro-2,5-metanopirido[1',2':4,5]pirazino[2,1-b][1,3]oxazepin-8-olatului de sodiu cu formula (II)Invenţia de asemenea se referă la compoziţii farmaceutice ce conţin compusul menţionat şi la metode de tratament sau prevenire profilactică a unei infecţii cu HIV.
MDA20170006A 2014-06-20 2015-06-19 (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzil)carbamoil)-2,3,4,5,7,9,13,13a-octahidro-2,5-metanopirido[1ʹ,2ʹ:4,5]pirazino[2,1-b][1,3]oxazepin-8-olat de sodiu MD4584C1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462015245P 2014-06-20 2014-06-20
PCT/US2015/036757 WO2015196116A1 (en) 2014-06-20 2015-06-19 Sodium (2r, 5s, 13ar) -7, 9-dioxo-10- ( (2,4,6-trifluorobenzyl) carbamoyl) -2, 3, 4, 5, 7, 9, 13, 13a-octahydro-2, 5-methanopyrido [1',2' : 4.5] pyrazino [2, 1-b] oxazepin-8-olate

Publications (3)

Publication Number Publication Date
MD20170006A2 MD20170006A2 (ro) 2017-06-30
MD4584B1 true MD4584B1 (ro) 2018-07-31
MD4584C1 MD4584C1 (ro) 2019-02-28

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ID=53674269

Family Applications (2)

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MDA20180037A MD20180037A2 (ro) 2014-06-20 2015-06-19 (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzil)carbamoil)-2,3,4,5,7,9,13,13a-octahidro-2,5-metanopirido[1ʹ,2ʹ:4,5]pirazino[2,1-b][1,3]oxazepin-8-olat de sodiu
MDA20170006A MD4584C1 (ro) 2014-06-20 2015-06-19 (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzil)carbamoil)-2,3,4,5,7,9,13,13a-octahidro-2,5-metanopirido[1ʹ,2ʹ:4,5]pirazino[2,1-b][1,3]oxazepin-8-olat de sodiu

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MDA20180037A MD20180037A2 (ro) 2014-06-20 2015-06-19 (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzil)carbamoil)-2,3,4,5,7,9,13,13a-octahidro-2,5-metanopirido[1ʹ,2ʹ:4,5]pirazino[2,1-b][1,3]oxazepin-8-olat de sodiu

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US (3) US9708342B2 (ro)
EP (3) EP4523758A3 (ro)
JP (4) JP6334007B2 (ro)
KR (1) KR101899803B1 (ro)
CN (2) CN106459085B (ro)
AP (1) AP2016009591A0 (ro)
AR (1) AR100903A1 (ro)
AU (2) AU2015276860B2 (ro)
BR (2) BR122021025861B1 (ro)
CA (1) CA2950307C (ro)
CL (1) CL2016003249A1 (ro)
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CY (1) CY1120025T1 (ro)
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DO (1) DOP2016000327A (ro)
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MD (2) MD20180037A2 (ro)
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MX (2) MX383272B (ro)
MY (1) MY186696A (ro)
NO (1) NO2717902T3 (ro)
NZ (1) NZ727155A (ro)
PE (1) PE20170150A1 (ro)
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SV (1) SV2016005339A (ro)
TR (1) TR201802179T4 (ro)
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UA (1) UA118480C2 (ro)
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