CY1115514T1 - Αντι-μολυσματικες πυραμιδινες και χρησεις αυτων - Google Patents

Αντι-μολυσματικες πυραμιδινες και χρησεις αυτων

Info

Publication number
CY1115514T1
CY1115514T1 CY20111101065T CY111101065T CY1115514T1 CY 1115514 T1 CY1115514 T1 CY 1115514T1 CY 20111101065 T CY20111101065 T CY 20111101065T CY 111101065 T CY111101065 T CY 111101065T CY 1115514 T1 CY1115514 T1 CY 1115514T1
Authority
CY
Cyprus
Prior art keywords
salts
compounds
compositions
polyminal
pyramidines
Prior art date
Application number
CY20111101065T
Other languages
Greek (el)
English (en)
Inventor
Charles A Flentge
Douglas K Hutchinson
David A Betebenner
David A Degoey
Pamela L Donner
Warren M Kati
Allan C Krueger
Dachun Liu
Yaya Liu
Kenton L Longenecker
Clarence J Maring
Christopher E Motter
John K Pratt
John T Randolph
Todd W Rockway
Kent D Stewart
Rolf Wagner
David M Barnes
Shuang Chen
Thaddeus S Ii Franczyk
Yi Gao
Anthony R Haight
John E Hengeveld
Brian J Kotecki
Xiaochun Lou
Geoff G Z Zhang
Original Assignee
Abbvie Bahamas Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Bahamas Limited filed Critical Abbvie Bahamas Limited
Publication of CY1115514T1 publication Critical patent/CY1115514T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CY20111101065T 2007-09-17 2011-11-03 Αντι-μολυσματικες πυραμιδινες και χρησεις αυτων CY1115514T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97288107P 2007-09-17 2007-09-17
US9679208P 2008-09-13 2008-09-13
EP20080832330 EP2203431B1 (en) 2007-09-17 2008-09-17 Anti-infective pyrimidines and uses thereof

Publications (1)

Publication Number Publication Date
CY1115514T1 true CY1115514T1 (el) 2016-04-13

Family

ID=40308557

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20111101065T CY1115514T1 (el) 2007-09-17 2011-11-03 Αντι-μολυσματικες πυραμιδινες και χρησεις αυτων
CY20141100943T CY1115893T1 (el) 2007-09-17 2014-11-12 Anti-μολυσματικες πυριμιδινες και χρησεις αυτων
CY2015013C CY2015013I1 (el) 2007-09-17 2015-03-26 Αντι-μολυσματικες πυραμιδινες και χρησεις αυτων

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY20141100943T CY1115893T1 (el) 2007-09-17 2014-11-12 Anti-μολυσματικες πυριμιδινες και χρησεις αυτων
CY2015013C CY2015013I1 (el) 2007-09-17 2015-03-26 Αντι-μολυσματικες πυραμιδινες και χρησεις αυτων

Country Status (22)

Country Link
US (3) US8188104B2 (ru)
EP (3) EP2639226B1 (ru)
JP (3) JP5734655B2 (ru)
CN (4) CN104628654A (ru)
AT (1) ATE519746T1 (ru)
CA (2) CA2699986C (ru)
CY (3) CY1115514T1 (ru)
DK (3) DK2203431T3 (ru)
ES (3) ES2592961T3 (ru)
HK (2) HK1148273A1 (ru)
HR (2) HRP20110809T1 (ru)
HU (1) HUS1500013I1 (ru)
LT (1) LTC2203431I2 (ru)
LU (1) LU92666I2 (ru)
MX (1) MX2010002902A (ru)
NL (1) NL300729I2 (ru)
NO (1) NO2015011I1 (ru)
PL (3) PL2368882T3 (ru)
PT (3) PT2368882E (ru)
RU (2) RU2014147354A (ru)
SI (2) SI2368882T1 (ru)
WO (1) WO2009039134A1 (ru)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8178548B2 (en) 2007-09-17 2012-05-15 Abbott Laboratories Anti-infective agents and uses thereof
JP5734654B2 (ja) 2007-09-17 2015-06-17 アッヴィ・バハマズ・リミテッド C型肝炎を治療するためのウラシルまたはチミン誘導体
CN104628654A (zh) * 2007-09-17 2015-05-20 艾伯维巴哈马有限公司 抗感染嘧啶及其用途
ATE555096T1 (de) * 2008-07-23 2012-05-15 Hoffmann La Roche Heterocyclische verbindungen als viruzide
MX2011002846A (es) 2008-09-26 2011-04-07 Hoffmann La Roche Derivados de pirina o pirazina para tratar el virus de la hepatitis c.
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
WO2010084160A1 (en) 2009-01-21 2010-07-29 Oryzon Genomics S.A. Phenylcyclopropylamine derivatives and their medical use
JP5571167B2 (ja) * 2009-03-25 2014-08-13 アッヴィ・インコーポレイテッド 抗ウイルス組成物およびこの使用
CA2758838A1 (en) 2009-04-25 2010-10-28 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
TWI428332B (zh) 2009-06-09 2014-03-01 Hoffmann La Roche 雜環抗病毒化合物
WO2010149598A2 (en) 2009-06-24 2010-12-29 F. Hoffmann-La Roche Ag Heterocyclic antiviral compound
KR20120059626A (ko) 2009-09-21 2012-06-08 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
BR112012006572A2 (pt) 2009-09-25 2016-04-26 Oryzon Genomics Sa inibidores de demetilase-1 de lisina específicos e seu uso
WO2011042217A1 (en) 2009-10-09 2011-04-14 Oryzon Genomics S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
EP2501679A1 (en) * 2009-11-21 2012-09-26 F. Hoffmann-La Roche AG Heterocyclic antiviral compounds
KR20120104343A (ko) * 2009-12-14 2012-09-20 에프. 호프만-라 로슈 아게 헤테로환형 항바이러스성 화합물
SG181570A1 (en) * 2009-12-14 2012-07-30 Merck Patent Gmbh Inhibitors of sphingosine kinase
WO2011106105A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
WO2011106573A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
US9216952B2 (en) 2010-03-23 2015-12-22 Abbvie Inc. Process for preparing antiviral compound
US8722743B2 (en) 2010-04-19 2014-05-13 Oryzon Genomics S.A. Lysine specific demethylase-1 inhibitors and their use
CA2805748A1 (en) 2010-07-16 2012-01-19 Shashank Shekhar Process for preparing n-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide
EP2593226B1 (en) 2010-07-16 2018-11-14 AbbVie Ireland Unlimited Company Phosphine ligands for catalytic reactions
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
HUE037937T2 (hu) 2010-07-29 2021-11-29 Oryzon Genomics Sa Arilciklopropilamin-alapú LSD1-demetiláz inhibitorok és gyógyászati alkalmazásuk
WO2012020725A1 (ja) * 2010-08-10 2012-02-16 塩野義製薬株式会社 Npy y5受容体拮抗作用を有するヘテロ環誘導体
WO2012045883A1 (en) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
EP2712315B1 (en) 2011-02-08 2021-11-24 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
CN102675092B (zh) * 2011-03-14 2014-11-05 江苏中丹药物研究有限公司 一种制备2-芳基-2,2-二甲基乙酸甲酯的方法
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
KR102139537B1 (ko) 2011-10-20 2020-07-31 오리존 지노믹스 에스.에이. Lsd1 억제제로서 (헤테로)아릴 사이클로프로필아민 화합물
SI2776394T1 (sl) 2011-10-20 2019-05-31 Oryzon Genomics, S.A. Spojine (hetero)aril ciklopropilamina kot inhibitorji LSD1
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
ES2529143B1 (es) 2011-10-21 2015-10-26 Abbvie Inc. Combinación de al menos dos agentes antivirales de acción directa, ribavirina pero no interferón para uso de tratamiento del vhc
GB2515942A (en) * 2011-10-21 2015-01-07 Abbvie Inc Combination treatment (e.g. with ABT-072 or ABT-333) of DAAs for use in treating HCV
CN104884440A (zh) 2012-08-21 2015-09-02 艾伯维公司 用于制备抗病毒化合物的方法
MX2015004973A (es) * 2012-10-18 2015-07-17 Abbvie Inc Formulaciones de compuestos derivados de pirimidindiona.
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
WO2015197028A1 (en) * 2014-06-28 2015-12-30 Sunshine Lake Pharma Co., Ltd. Compounds as hepatitis c virus (hcv) inhibitors and uses thereof in medicine
WO2016105547A1 (en) 2014-12-24 2016-06-30 Concert Pharmaceuticals, Inc. Deuterated dasabuvir
EA039557B1 (ru) * 2016-03-17 2022-02-10 Фмк Корпорейшн Способ превращения s-энантиомера в его рацемическую форму
EP3448392A4 (en) 2016-04-28 2020-01-15 Emory University ALCYNE-CONTAINING NUCLEOTIDES AND NUCLEOSIDES THERAPEUTIC COMPOSITIONS AND USES THEREOF
CN108290844B (zh) * 2016-05-27 2021-04-30 深圳市塔吉瑞生物医药有限公司 一种取代的萘环化合物及药物组合物及其应用
CN110483496B (zh) * 2019-07-17 2021-05-04 杭州市西溪医院 一类具有尿嘧啶-苯并噻唑结构衍生物、其制备方法及抗hcv药物的应用
CN111518036A (zh) * 2020-04-29 2020-08-11 杭州勇诚睿生物科技有限公司 一种达沙布韦关键中间体的制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239888A (en) * 1974-11-04 1980-12-16 Pfizer Inc. 1-Phenyluracils
JPS60243017A (ja) * 1984-05-16 1985-12-03 Kyowa Hakko Kogyo Co Ltd 抗けいれん組成物
US5084084A (en) * 1989-07-14 1992-01-28 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
AU627906B2 (en) * 1989-07-14 1992-09-03 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
ATE169915T1 (de) * 1990-02-15 1998-09-15 Takeda Chemical Industries Ltd Pyrimidindionderivate, deren herstellung und verwendung
NL9001075A (ru) * 1990-05-04 1991-12-02 Duphar Int Res
EP0489480A1 (en) * 1990-12-05 1992-06-10 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
JPH05213755A (ja) 1992-02-07 1993-08-24 Nikko Kyodo Co Ltd 肝臓障害治療薬
DE19528305A1 (de) 1995-08-02 1997-02-06 Bayer Ag Substituierte Phenyluracile
SI1237878T1 (sl) 1999-12-06 2007-08-31 Hoffmann La Roche 4-pirimidinil-n-acil-l-fenilanin
US6380387B1 (en) * 1999-12-06 2002-04-30 Hoffmann-La Roche Inc. 4-Pyrimidinyl-n-acyl-l phenylalanines
IL167958A (en) * 2000-02-04 2010-11-30 Sumitomo Chemical Co 2-thio 3-hydroxypyridine derivatives
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1480982A4 (en) * 2002-02-14 2007-08-01 Pharmasset Inc MODIFIED FLUORINATED NUCLEOSIDE ANALOGUES
WO2004048343A1 (en) * 2002-11-28 2004-06-10 Schering Aktiengesellschaft Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
KR100589964B1 (ko) * 2003-06-13 2006-06-19 주식회사 엘지생명과학 C형 간염 바이러스의 억제제
EP1651631A1 (en) * 2003-08-01 2006-05-03 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against flaviviridae
US7163937B2 (en) 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
KR20070083484A (ko) * 2004-07-14 2007-08-24 피티씨 테라퓨틱스, 인크. C형 간염 치료 방법
WO2007058392A1 (ja) * 2005-11-21 2007-05-24 Japan Tobacco Inc. ヘテロ環化合物およびその医薬用途
CN104628654A (zh) * 2007-09-17 2015-05-20 艾伯维巴哈马有限公司 抗感染嘧啶及其用途
US8178548B2 (en) 2007-09-17 2012-05-15 Abbott Laboratories Anti-infective agents and uses thereof
JP5734654B2 (ja) 2007-09-17 2015-06-17 アッヴィ・バハマズ・リミテッド C型肝炎を治療するためのウラシルまたはチミン誘導体
ATE555096T1 (de) 2008-07-23 2012-05-15 Hoffmann La Roche Heterocyclische verbindungen als viruzide

Also Published As

Publication number Publication date
ES2368879T3 (es) 2011-11-23
EP2368882B1 (en) 2014-08-13
LTC2203431I2 (lt) 2017-01-25
EP2639226A1 (en) 2013-09-18
EP2368882A1 (en) 2011-09-28
EP2203431B1 (en) 2011-08-10
PT2639226T (pt) 2016-12-09
JP5931683B2 (ja) 2016-06-08
EP2639226B1 (en) 2016-08-31
DK2639226T3 (en) 2016-12-19
PT2368882E (pt) 2014-11-27
ES2592961T3 (es) 2016-12-02
DK2203431T3 (da) 2011-11-21
RU2010114827A (ru) 2011-10-27
NL300729I1 (ru) 2016-01-07
HRP20141102T1 (en) 2015-03-13
CN104628655A (zh) 2015-05-20
HK1148273A1 (en) 2011-09-02
CA2699986C (en) 2014-06-17
CN101842360B (zh) 2014-12-17
CY2015013I2 (el) 2016-04-13
CA2849420C (en) 2016-07-12
PL2639226T3 (pl) 2017-02-28
CA2849420A1 (en) 2009-03-26
US20090186912A1 (en) 2009-07-23
CY2015013I1 (el) 2016-04-13
US9139536B2 (en) 2015-09-22
NL300729I2 (ru) 2016-01-07
JP2013056886A (ja) 2013-03-28
PT2203431E (pt) 2011-10-12
RU2539570C2 (ru) 2015-01-20
CN102746240A (zh) 2012-10-24
CY1115893T1 (el) 2017-01-25
NO2015011I2 (no) 2015-04-22
HUS1500013I1 (hu) 2016-11-28
NO2015011I1 (no) 2015-05-04
CN104628654A (zh) 2015-05-20
SI2368882T1 (sl) 2015-02-27
SI2203431T1 (sl) 2011-12-30
RU2014147354A3 (ru) 2018-07-30
JP2010539187A (ja) 2010-12-16
JP5734655B2 (ja) 2015-06-17
CN102746240B (zh) 2017-10-03
US20120244119A1 (en) 2012-09-27
DK2368882T3 (en) 2014-12-01
CN101842360A (zh) 2010-09-22
PL2368882T3 (pl) 2015-04-30
CA2699986A1 (en) 2009-03-26
HK1156033A1 (en) 2012-06-01
LU92666I2 (fr) 2015-11-24
EP2203431A1 (en) 2010-07-07
ES2523864T3 (es) 2014-12-02
WO2009039134A1 (en) 2009-03-26
US20140294766A1 (en) 2014-10-02
US8188104B2 (en) 2012-05-29
JP2015187106A (ja) 2015-10-29
ATE519746T1 (de) 2011-08-15
MX2010002902A (es) 2010-06-02
RU2014147354A (ru) 2015-07-10
HRP20110809T1 (hr) 2011-12-31
PL2203431T3 (pl) 2012-01-31
US8501238B2 (en) 2013-08-06

Similar Documents

Publication Publication Date Title
CY1115893T1 (el) Anti-μολυσματικες πυριμιδινες και χρησεις αυτων
PH12013500365A1 (en) Anti-infective agents and uses thereof
CY1119669T1 (el) Παραγωγα 1-φαινυλ-2-πυριδινυλ-αλκυλ-αλκοολων ως αναστολεις φωσφοδιεστερασης
BRPI0516911A (pt) método para a preparação de um composto e composto de anilina
CY1118658T1 (el) Συνθεση 18f-ραδιοεπισημασμενων στυρυλοπυριδινων απο τοσυλικες προδρομες ενωσεις και σταθερες φαρμακευτικες συνθεσεις αυτων
MX2010002904A (es) N-fenil-dioxo-hidropirimidinas utiles como inhibidores de virus de hepatitis c (hcv).
MY148253A (en) Azaadamantane derivatives and methods of use
EA201001205A1 (ru) Соединения, содержащие циклобутоксигруппу
WO2010111436A3 (en) Antiviral compounds and uses thereof
CY1113282T1 (el) Αντιικα νουκλεοζιτικα αναλογα
ECSP10010722A (es) Compuestos orgánicos
EA201170772A1 (ru) Органические соединения
CY1109998T1 (el) Ενδυναμωτες υποδοχεων γλουταμινικου
EA200970156A1 (ru) Пиридизиноновые производные
EA201401193A1 (ru) Триарильные соединения и композиции, их содержащие
EA201190293A1 (ru) Пролекарства триптолида
CY1111367T1 (el) Νεα παραγωγα της διοσμετινης, η μεθοδος παρασκευης τους και οι φαρμακευτικες συνθεσεις που τα περιεχουν
EA200900090A1 (ru) Бензиламины, способ их получения и их применение в качестве противовоспалительных средств
MX2009006750A (es) Derivados de azaadamantano espirociclicos y metodos de uso.
CY1116875T1 (el) Διϋδροετορφινες και η παρασκευη αυτων
ATE417849T1 (de) Pyrazoloä4,3-düpyrimidine
EA201001855A1 (ru) Соединения, содержащие циклобутоксигруппу
CY1116596T1 (el) Αλατα ισοφωσφοραμιδικης μουσταρδας και αναλογα αυτων
ATE527248T1 (de) Polymorphe von enantioreinem erdostein
BR112012024329A2 (pt) composição endoparasiticidas