CY1113003T1 - Ευσταθη παρασκευασματα laquinimod - Google Patents

Ευσταθη παρασκευασματα laquinimod

Info

Publication number
CY1113003T1
CY1113003T1 CY20121100127T CY121100127T CY1113003T1 CY 1113003 T1 CY1113003 T1 CY 1113003T1 CY 20121100127 T CY20121100127 T CY 20121100127T CY 121100127 T CY121100127 T CY 121100127T CY 1113003 T1 CY1113003 T1 CY 1113003T1
Authority
CY
Cyprus
Prior art keywords
laquinimod
stable preparations
pharmaceutically acceptable
preparations
stable
Prior art date
Application number
CY20121100127T
Other languages
English (en)
Inventor
Shulamit Patashnik
Daniella Licht
Adrian Gilbert
Original Assignee
Teva Pharmaceutical Industries, Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries, Ltd filed Critical Teva Pharmaceutical Industries, Ltd
Publication of CY1113003T1 publication Critical patent/CY1113003T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Abstract

Η εφεύρεση σχετίζεται με μία φαρμακευτική σύνθεση που περιλαμβάνει ένα φαρμακευτικά αποδεκτό άλας του N-ethyl-N- phenyl -1,2, -dihydro- 4 -hydroxy- 5 - chloro- 1 -methyl -2 -oxoquinoline-3-carboxamide, N-methylglucamine, και ένα φαρμακευτικά αποδεκτό φορέα.
CY20121100127T 2006-06-12 2012-02-07 Ευσταθη παρασκευασματα laquinimod CY1113003T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81324706P 2006-06-12 2006-06-12
EP07809468A EP2035001B1 (en) 2006-06-12 2007-06-12 Stable laquinimod preparations

Publications (1)

Publication Number Publication Date
CY1113003T1 true CY1113003T1 (el) 2016-04-13

Family

ID=38832466

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100127T CY1113003T1 (el) 2006-06-12 2012-02-07 Ευσταθη παρασκευασματα laquinimod

Country Status (28)

Country Link
US (3) US7989473B2 (el)
EP (1) EP2035001B1 (el)
JP (1) JP5226678B2 (el)
KR (4) KR20160013273A (el)
CN (1) CN101466379B (el)
AR (1) AR061348A1 (el)
AT (1) ATE532515T1 (el)
AU (1) AU2007258366B2 (el)
BR (1) BRPI0713694A2 (el)
CA (2) CA2899472C (el)
CY (1) CY1113003T1 (el)
DK (1) DK2035001T3 (el)
EA (1) EA018031B1 (el)
ES (1) ES2377149T3 (el)
HK (1) HK1121971A1 (el)
HR (1) HRP20120093T1 (el)
IL (1) IL195724A (el)
MX (1) MX2008015808A (el)
NO (1) NO342485B1 (el)
NZ (1) NZ573846A (el)
PL (1) PL2035001T3 (el)
PT (1) PT2035001E (el)
RS (1) RS52169B (el)
SI (1) SI2035001T1 (el)
TW (1) TWI400073B (el)
UA (1) UA96449C2 (el)
WO (1) WO2007146248A2 (el)
ZA (1) ZA200810790B (el)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314124B2 (en) 2004-02-06 2012-11-20 Active Biotech Ab Crystalline salts of quinoline compounds and methods for preparing them
JP5832716B2 (ja) 2005-10-19 2015-12-16 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドナトリウムの結晶，及びその製造方法
KR20160013273A (ko) 2006-06-12 2016-02-03 테바 파마슈티컬 인더스트리즈 리미티드 안정한 라퀴니모드 제제
PT2682120T (pt) * 2007-12-20 2016-11-07 Teva Pharma Preparações de laquinimod estáveis
KR20110048571A (ko) * 2008-09-03 2011-05-11 테바 파마슈티컬 인더스트리즈 리미티드 면역 기능을 지닌 ２―옥소―１,２―다이하이드로―퀴놀린 조절제
DE102009008851A1 (de) 2009-02-13 2010-08-19 Amw Gmbh Transdermales System mit Immunmodulator
DE102010048788A1 (de) 2009-02-13 2011-05-19 Amw Gmbh Transdermales System mit Immunmodulator
EP3028572A1 (en) * 2009-06-19 2016-06-08 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with laquinimod
EA025468B1 (ru) * 2009-07-30 2016-12-30 Тева Фармасьютикал Индастриз Лтд. Лечение болезни крона с применением лаквинимода
PL3064206T3 (pl) * 2009-08-10 2020-02-28 Active Biotech Ab Leczenie choroby Huntingtona z zastosowaniem lakwinimodu
DE102010026879A1 (de) 2010-02-11 2011-08-11 AMW GmbH, 83627 Transdermales System mit Immunmodulator
CA2791709A1 (en) * 2010-03-03 2011-09-09 Teva Pharmaceutical Industries Ltd. Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
JP2013521305A (ja) * 2010-03-03 2013-06-10 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドを用いるループス関節炎の治療
CA2791691A1 (en) * 2010-03-03 2011-09-09 Teva Pharmaceutical Industries Ltd. Treatment of lupus nephritis using laquinimod
SG186948A1 (en) 2010-07-09 2013-02-28 Teva Pharma Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof
US20120010239A1 (en) * 2010-07-09 2012-01-12 Ulf Tomas Fristedt 5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide, salts and uses thereof
SG10201509831XA (en) * 2010-12-07 2015-12-30 Teva Pharma Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients
IN2014MN00333A (el) * 2011-07-28 2015-09-25 Teva Pharma
JP2014521659A (ja) * 2011-07-28 2014-08-28 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドおよびインターフェロンβを組み合わせた多発性硬化症の治療
WO2013055907A1 (en) * 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
AR089862A1 (es) 2012-02-03 2014-09-24 Teva Pharma USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA
WO2013123419A1 (en) 2012-02-16 2013-08-22 Teva Pharmaceutical Industries Ltd. N-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinoline carboxamide, preparation and uses thereof
US20130259856A1 (en) 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201350467A (zh) * 2012-05-08 2013-12-16 Teva Pharma Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
US20130345257A1 (en) * 2012-06-26 2013-12-26 The Regents Of The University Of California Composition for lupus nephritis and methods of making and using the same
AR091706A1 (es) * 2012-07-11 2015-02-25 Teva Pharma Formulaciones de laquinimod sin agentes alcalinizantes
TW201410243A (zh) * 2012-08-13 2014-03-16 Teva Pharma 用於治療大麻素受體型１（ｃｂ１）媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
AU2013341506A1 (en) * 2012-11-07 2015-06-04 Teva Pharmaceutical Industries Ltd. Amine salts of Laquinimod
MX2015010296A (es) * 2013-02-15 2016-05-05 Teva Pharma Tratamiento de formas progresivas de esclerosis multiple con laquinimod.
JP2016513665A (ja) 2013-03-14 2016-05-16 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドの経皮製剤
CA2901849A1 (en) 2013-03-14 2014-09-25 Teva Pharmaceutical Industries Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
US20150094332A1 (en) * 2013-09-27 2015-04-02 Teva Pharmaceutical Industries, Ltd. Laquinimod Combination Therapy For Treatment Of Multiple Sclerosis
CA2933380A1 (en) * 2013-12-20 2015-06-25 Esther Lukasiewicz Hagai Use of laquinimod to delay huntington's disease progression
WO2015109083A1 (en) * 2014-01-17 2015-07-23 Teva Pharmaceutical Industries Ltd. Treatment of crohn's disease using low doses of laquinimod
SG11201608674UA (en) 2014-04-29 2016-11-29 Teva Pharma Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status
CN110193014B (zh) * 2019-06-06 2021-05-11 温州医科大学 一种注射用拉喹莫德胶束冻干制剂及制备方法、拉喹莫德注射制剂

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3024257A (en) 1961-04-10 1962-03-06 Frosst & Co Charles E Stable preparations of alkali metal salts of estrone sulfate
FR2340735A1 (fr) 1976-02-11 1977-09-09 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
IE52670B1 (en) 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
DE3437232A1 (de) * 1984-10-10 1986-04-17 Mack Chem Pharm Stabilisierte injektionsloesungen von piroxicam
SE8902076D0 (sv) 1989-06-09 1989-06-09 Pharmacia Ab Derivatives of quinoline-3-carboxanilide
HUT60458A (en) 1991-02-01 1992-09-28 Sandoz Ag Process for producing benzyloxyphenyl derivatives and pharmaceutical compositions comprising same
US5540934A (en) 1994-06-22 1996-07-30 Touitou; Elka Compositions for applying active substances to or through the skin
CH687615A5 (de) * 1994-09-07 1997-01-15 R W Johnson Pharmaceutical Res Tropen-Verpackung.
US5912349A (en) 1997-01-31 1999-06-15 Pharmacia & Upjohn Company Process for the preparation of roquinimex
US20030124187A1 (en) * 1997-02-14 2003-07-03 Smithkline Beecham Laboratoires Pharmaceutiques, Pharmaceutical formulations comprising amoxycillin and clavulanate
SE9801474D0 (sv) 1998-04-27 1998-04-27 Active Biotech Ab Quinoline Derivatives
US6077851A (en) 1998-04-27 2000-06-20 Active Biotech Ab Quinoline derivatives
US6121287A (en) 1998-07-15 2000-09-19 Active Biotech Ab Quinoline derivatives
SE9802550D0 (sv) 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
SE9802549D0 (sv) 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
US6133285A (en) 1998-07-15 2000-10-17 Active Biotech Ab Quinoline derivatives
DK1187601T3 (da) 1999-06-07 2005-11-21 Altana Pharma Ag Hidtil ukendt præparat og administrationsform som omfatter en syrelabil protonpumpeinhibitor
SE0002320D0 (sv) 1999-10-25 2000-06-21 Active Biotech Ab Malignant tumors
PL199781B1 (pl) 1999-10-25 2008-10-31 Active Biotech Ab Nowe związki pochodne chinoliny, zastosowanie związków pochodnych chinoliny, zawierające je kompozycje farmaceutyczne i sposób ich wytwarzania
JP2002031610A (ja) 2000-07-14 2002-01-31 Ajinomoto Co Inc 生体分子複合体の界面残基を同定する方法
US6307050B1 (en) 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6802422B2 (en) * 2000-12-12 2004-10-12 Multi-Comp, Inc. Sealed blister assembly
US6706733B2 (en) 2001-05-08 2004-03-16 Dainippon Ink And Chemicals, Inc. Quinolinone derivative formulation and its production method
US20030119826A1 (en) 2001-09-24 2003-06-26 Pharmacia Corporation Neuroprotective treatment methods using selective iNOS inhibitors
US6875869B2 (en) 2002-06-12 2005-04-05 Active Biotech Ab Process for the manufacture of quinoline derivatives
US7560557B2 (en) 2002-06-12 2009-07-14 Active Biotech Ag Process for the manufacture of quinoline derivatives
SE0201778D0 (sv) 2002-06-12 2002-06-12 Active Biotech Ab Process for the manufacture of quinoline derivatives
US8980870B2 (en) * 2002-09-24 2015-03-17 Boehringer Ingelheim International Gmbh Solid telmisartan pharmaceutical formulations
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US20060188568A1 (en) * 2003-10-30 2006-08-24 Lupin Limited Stable formulations of ace inhibitors and methods for preparation thereof
US8314124B2 (en) 2004-02-06 2012-11-20 Active Biotech Ab Crystalline salts of quinoline compounds and methods for preparing them
SE0400235D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
JP5832716B2 (ja) 2005-10-19 2015-12-16 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドナトリウムの結晶，及びその製造方法
KR20160013273A (ko) 2006-06-12 2016-02-03 테바 파마슈티컬 인더스트리즈 리미티드 안정한 라퀴니모드 제제
US20080087929A1 (en) * 2006-10-11 2008-04-17 Infineon Technologies Ag Static random access memory with thin oxide capacitor
PT2682120T (pt) 2007-12-20 2016-11-07 Teva Pharma Preparações de laquinimod estáveis
KR20110048571A (ko) 2008-09-03 2011-05-11 테바 파마슈티컬 인더스트리즈 리미티드 면역 기능을 지닌 ２―옥소―１,２―다이하이드로―퀴놀린 조절제
EP3028572A1 (en) 2009-06-19 2016-06-08 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with laquinimod
EA025468B1 (ru) 2009-07-30 2016-12-30 Тева Фармасьютикал Индастриз Лтд. Лечение болезни крона с применением лаквинимода
PL3064206T3 (pl) 2009-08-10 2020-02-28 Active Biotech Ab Leczenie choroby Huntingtona z zastosowaniem lakwinimodu
CA2791709A1 (en) 2010-03-03 2011-09-09 Teva Pharmaceutical Industries Ltd. Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
CA2791691A1 (en) 2010-03-03 2011-09-09 Teva Pharmaceutical Industries Ltd. Treatment of lupus nephritis using laquinimod
JP2013521305A (ja) 2010-03-03 2013-06-10 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドを用いるループス関節炎の治療
SG186948A1 (en) 2010-07-09 2013-02-28 Teva Pharma Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof
US20120010239A1 (en) 2010-07-09 2012-01-12 Ulf Tomas Fristedt 5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide, salts and uses thereof

Also Published As

Publication number Publication date
CN101466379B (zh) 2012-10-31
DK2035001T3 (da) 2012-02-27
ES2377149T3 (es) 2012-03-22
EA018031B1 (ru) 2013-05-30
NO342485B1 (no) 2018-05-28
EP2035001A2 (en) 2009-03-18
RS52169B (en) 2012-08-31
EA200870599A1 (ru) 2009-06-30
US8383645B2 (en) 2013-02-26
ATE532515T1 (de) 2011-11-15
TWI400073B (zh) 2013-07-01
JP5226678B2 (ja) 2013-07-03
SI2035001T1 (sl) 2012-03-30
PT2035001E (pt) 2012-02-06
UA96449C2 (en) 2011-11-10
HK1121971A1 (en) 2009-05-08
US20070293537A1 (en) 2007-12-20
NO20090175L (no) 2009-03-11
EP2035001A4 (en) 2009-09-23
CA2899472C (en) 2019-04-30
CA2654982C (en) 2015-11-10
KR20140091778A (ko) 2014-07-22
HRP20120093T1 (hr) 2012-03-31
TW200815006A (en) 2008-04-01
KR20150065951A (ko) 2015-06-15
CA2899472A1 (en) 2007-12-21
ZA200810790B (en) 2010-03-31
KR101495327B1 (ko) 2015-02-24
IL195724A0 (en) 2009-09-01
IL195724A (en) 2015-09-24
AU2007258366A1 (en) 2007-12-21
PL2035001T3 (pl) 2012-05-31
EP2035001B1 (en) 2011-11-09
CN101466379A (zh) 2009-06-24
JP2009539984A (ja) 2009-11-19
US7989473B2 (en) 2011-08-02
AU2007258366B2 (en) 2012-10-25
WO2007146248A2 (en) 2007-12-21
MX2008015808A (es) 2009-02-17
KR20090017694A (ko) 2009-02-18
US20120302600A1 (en) 2012-11-29
BRPI0713694A2 (pt) 2012-10-30
US20110251235A1 (en) 2011-10-13
NZ573846A (en) 2012-01-12
CA2654982A1 (en) 2007-12-21
WO2007146248A3 (en) 2008-12-24
AR061348A1 (es) 2008-08-20
KR20160013273A (ko) 2016-02-03

Similar Documents

Publication Publication Date Title
CY1113003T1 (el) Ευσταθη παρασκευασματα laquinimod
CY1111470T1 (el) Νεες φαρμακευτικες συνθεσεις που περιεχουν φλιβανσερινη πολυμορφη α
CY1109010T1 (el) γ-ΚΡΥΣΤΑΛΛΙΚΗ ΜΟΡΦΗ ΤΗΣ ΥΔΡΟΧΛΩΡΙΚΗΣ ΙΒΑΒΡΑΔΙΝΗΣ, ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ ΤΗΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΗΝ ΠΕΡΙΕΧΟΥΝ
RS50660B (sr) Dihidrotetrabenazini i farmaceutske kompozicije koje ih sadrže
BR0306870A (pt) Composição farmacêutica oral, e, método para preparar a mesma
TW200833370A (en) Pharmaceutical composition containing low substituted hydroxypropylcellulose
EA200702589A1 (ru) 2,6-хинолинильные производные, способы их получения и их применение
CY1115919T1 (el) Ενωσεις ενεργοποιησης τελομερασης και μεθοδοι χρησης αυτων
MA32841B1 (fr) Composés de cycloundeca depsipeptides et leur utilisation comme médicament
CY1110213T1 (el) Παραγωγα αζολοπυριδιν-2-ονης ως αναστολεις λιπασων και φωσφολιπασων
CY1108711T1 (el) Συνθεσεις βενζοθειαζολιου και η χρηση αυτων
SE0300457D0 (sv) Novel compounds
ATE460934T1 (de) Pharmazeutische zubereitungen von ciprofloxacin
EA200701180A1 (ru) Способ и промежуточные продукты для получения канфосфамида и его солей, фармацевтические композиции, содержащие некоторые промежуточные продукты и их применение в качестве противораковых средств
EA200870157A1 (ru) Производные 2-карбамид-4-фенилтиазола, их получение и их применение в терапии
UY27628A1 (es) "2'-halo -3',5'-dialcoxi-fen-1'il-2-imidazolidinas y su uso como un fármaco"
NO20085267L (no) Derivater av 2-alkoksy -3,4,5-trihydroksy-alkyl amider, fremstilling og anvendelse derav, samt sammensetninger inneholdende samme
NO20020914D0 (no) Alkoksy-substituerte benzimidazolforbindelser, preparater inneholdende slike samt anvendelser derav
BRPI0410638A (pt) derivados de azitromicina
CY1108865T1 (el) Υποκατεστημενες 2,5-διαμινομευθυλο-1η-πυρρολες
EA200600172A1 (ru) Фармацевтическая композиция для интраназального введения пирибедила
NO20085285L (no) 2-alkosy-3,4,5-tnhydroksyalkylamidbenzazepiner, deres fremstilling og bruk samt preparater inneholdende disse
EA200870566A1 (ru) 2-алкокси-3,4,5-тригидроксиалкиламидобензотиазепины, их получение, композиции, содержащие их, и применение
ATE454144T1 (de) Behandlung von malignen neoplasien
UY27824A1 (es) Nueva formulación para la administración parenteral de crobenetina.