EA200870566A1 - 2-алкокси-3,4,5-тригидроксиалкиламидобензотиазепины, их получение, композиции, содержащие их, и применение - Google Patents
2-алкокси-3,4,5-тригидроксиалкиламидобензотиазепины, их получение, композиции, содержащие их, и применениеInfo
- Publication number
- EA200870566A1 EA200870566A1 EA200870566A EA200870566A EA200870566A1 EA 200870566 A1 EA200870566 A1 EA 200870566A1 EA 200870566 A EA200870566 A EA 200870566A EA 200870566 A EA200870566 A EA 200870566A EA 200870566 A1 EA200870566 A1 EA 200870566A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compositions containing
- trihydroxialkylamidobenzothiazepine
- alkoxi
- receiving
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
Abstract
2-Алкокси-3,4,5-тригидроксиалкиламидобензотиазепины, их получение, композиции, содержащие их, и применение. Изобретение предпочтительно относится к 2-алкокси-3,4,5-тригидроксиалкиламидобензотиазепинам, их получению, композициям, содержащим их, и их применению в качестве лекарственных средств, предпочтительно в качестве противораковых средств.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0604735A FR2901555A1 (fr) | 2006-05-24 | 2006-05-24 | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzothiazepine, leur preparation, compositions les contenant et utilisation |
PCT/FR2007/000867 WO2007135294A2 (fr) | 2006-05-24 | 2007-05-23 | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzothiazepine, leur préparation, compositions les contenant et utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200870566A1 true EA200870566A1 (ru) | 2009-04-28 |
Family
ID=37496965
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200870566A EA200870566A1 (ru) | 2006-05-24 | 2007-05-23 | 2-алкокси-3,4,5-тригидроксиалкиламидобензотиазепины, их получение, композиции, содержащие их, и применение |
Country Status (31)
Country | Link |
---|---|
US (1) | US7960373B2 (ru) |
EP (1) | EP2029596B1 (ru) |
JP (1) | JP2009537615A (ru) |
KR (1) | KR20090010214A (ru) |
CN (1) | CN101454278A (ru) |
AR (1) | AR061104A1 (ru) |
AT (1) | ATE458738T1 (ru) |
AU (1) | AU2007253197A1 (ru) |
BR (1) | BRPI0711892A2 (ru) |
CA (1) | CA2652361A1 (ru) |
CR (1) | CR10428A (ru) |
CY (1) | CY1110089T1 (ru) |
DE (1) | DE602007004982D1 (ru) |
DK (1) | DK2029596T3 (ru) |
DO (1) | DOP2007000103A (ru) |
EA (1) | EA200870566A1 (ru) |
EC (1) | ECSP088897A (ru) |
ES (1) | ES2341589T3 (ru) |
FR (1) | FR2901555A1 (ru) |
GT (1) | GT200800254A (ru) |
MA (1) | MA30560B1 (ru) |
MX (1) | MX2008014957A (ru) |
NO (1) | NO20085189L (ru) |
PE (1) | PE20080258A1 (ru) |
PL (1) | PL2029596T3 (ru) |
PT (1) | PT2029596E (ru) |
SI (1) | SI2029596T1 (ru) |
TN (1) | TNSN08442A1 (ru) |
TW (1) | TW200812990A (ru) |
UY (1) | UY30366A1 (ru) |
WO (1) | WO2007135294A2 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2878528B1 (fr) | 2004-11-29 | 2008-05-16 | Aventis Pharma Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4692522A (en) * | 1985-04-01 | 1987-09-08 | Merck & Co., Inc. | Benzofused lactams useful as cholecystokinin antagonists |
US4831135A (en) * | 1986-06-18 | 1989-05-16 | The Regents Of The University Of California | Bengamide anthelmintics |
US5283241A (en) * | 1992-08-28 | 1994-02-01 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
GB9411841D0 (en) | 1994-06-14 | 1994-08-03 | Pharma Mar Sa | New antitumoral compounds from jaspis sponge |
JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
CO5140099A1 (es) | 1998-11-17 | 2002-03-22 | Novartis Ag | Ciertas caprolactamas sustituidas, composiciones farmaceuticas que las contienen, y su uso en el tratamiento de tumores |
US6239127B1 (en) * | 1999-11-17 | 2001-05-29 | Novartis Ag | Certain substituted caprolactams, pharmaceutical compositions containing them and a process for their preparation |
ATE383341T1 (de) * | 2000-05-11 | 2008-01-15 | Novartis Pharma Gmbh | Substituierte caprolactam carbonate und ether sowie deren verwendung als anti-tumor wirkstoffe |
AU2002217020A1 (en) | 2000-11-14 | 2002-05-27 | Novartis Ag | Method for screening anti-proliferative compounds and inhibiting tumor growth |
US6545148B2 (en) * | 2001-03-12 | 2003-04-08 | Novartis Ag | Process for preparing certain substituted caprolactams |
JP2004262793A (ja) | 2003-02-28 | 2004-09-24 | Noyaku Bio Technology Kaihatsu Gijutsu Kenkyu Kumiai | 化合物n−9011、その製造法及び用途 |
JP2006528611A (ja) * | 2003-07-25 | 2006-12-21 | ノバルティス アクチエンゲゼルシャフト | 置換ラクタムおよびそれらの抗がん剤としての使用 |
US7153846B2 (en) * | 2003-10-24 | 2006-12-26 | Sanofi-Aventis Deutschland Gmbh | Bengamide derivatives, process for preparing them, and their use |
DE10349669B3 (de) | 2003-10-24 | 2005-05-25 | Aventis Pharma Deutschland Gmbh | Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
FR2878525B1 (fr) * | 2004-11-29 | 2007-02-23 | Aventis Pharma Sa | Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation |
FR2878528B1 (fr) * | 2004-11-29 | 2008-05-16 | Aventis Pharma Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
-
2006
- 2006-05-24 FR FR0604735A patent/FR2901555A1/fr active Pending
-
2007
- 2007-05-17 TW TW096117613A patent/TW200812990A/zh unknown
- 2007-05-21 PE PE2007000623A patent/PE20080258A1/es not_active Application Discontinuation
- 2007-05-23 EA EA200870566A patent/EA200870566A1/ru unknown
- 2007-05-23 AR ARP070102223A patent/AR061104A1/es unknown
- 2007-05-23 AU AU2007253197A patent/AU2007253197A1/en not_active Abandoned
- 2007-05-23 EP EP07765943A patent/EP2029596B1/fr active Active
- 2007-05-23 KR KR1020087028522A patent/KR20090010214A/ko not_active Application Discontinuation
- 2007-05-23 DE DE602007004982T patent/DE602007004982D1/de active Active
- 2007-05-23 ES ES07765943T patent/ES2341589T3/es active Active
- 2007-05-23 BR BRPI0711892-9A patent/BRPI0711892A2/pt not_active IP Right Cessation
- 2007-05-23 SI SI200730237T patent/SI2029596T1/sl unknown
- 2007-05-23 PT PT07765943T patent/PT2029596E/pt unknown
- 2007-05-23 MX MX2008014957A patent/MX2008014957A/es active IP Right Grant
- 2007-05-23 CN CNA2007800189562A patent/CN101454278A/zh active Pending
- 2007-05-23 DK DK07765943.1T patent/DK2029596T3/da active
- 2007-05-23 AT AT07765943T patent/ATE458738T1/de active
- 2007-05-23 WO PCT/FR2007/000867 patent/WO2007135294A2/fr active Application Filing
- 2007-05-23 JP JP2009511546A patent/JP2009537615A/ja not_active Withdrawn
- 2007-05-23 CA CA002652361A patent/CA2652361A1/fr not_active Abandoned
- 2007-05-23 PL PL07765943T patent/PL2029596T3/pl unknown
- 2007-05-24 UY UY30366A patent/UY30366A1/es not_active Application Discontinuation
- 2007-05-24 DO DO2007000103A patent/DOP2007000103A/es unknown
-
2008
- 2008-11-04 TN TNP2008000442A patent/TNSN08442A1/en unknown
- 2008-11-06 CR CR10428A patent/CR10428A/es unknown
- 2008-11-10 US US12/267,691 patent/US7960373B2/en not_active Expired - Fee Related
- 2008-11-19 EC EC2008008897A patent/ECSP088897A/es unknown
- 2008-11-24 GT GT200800254A patent/GT200800254A/es unknown
- 2008-12-05 MA MA31453A patent/MA30560B1/fr unknown
- 2008-12-12 NO NO20085189A patent/NO20085189L/no not_active Application Discontinuation
-
2010
- 2010-05-21 CY CY20101100455T patent/CY1110089T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AR061104A1 (es) | 2008-08-06 |
ES2341589T3 (es) | 2010-06-22 |
UY30366A1 (es) | 2008-01-02 |
JP2009537615A (ja) | 2009-10-29 |
PT2029596E (pt) | 2010-05-28 |
MA30560B1 (fr) | 2009-07-01 |
WO2007135294A2 (fr) | 2007-11-29 |
AU2007253197A1 (en) | 2007-11-29 |
EP2029596A2 (fr) | 2009-03-04 |
BRPI0711892A2 (pt) | 2012-01-10 |
DE602007004982D1 (de) | 2010-04-08 |
FR2901555A1 (fr) | 2007-11-30 |
MX2008014957A (es) | 2008-12-10 |
PL2029596T3 (pl) | 2010-07-30 |
DK2029596T3 (da) | 2010-06-14 |
ECSP088897A (es) | 2008-12-30 |
US7960373B2 (en) | 2011-06-14 |
CR10428A (es) | 2008-12-01 |
SI2029596T1 (sl) | 2010-07-30 |
TNSN08442A1 (en) | 2010-04-14 |
PE20080258A1 (es) | 2008-05-12 |
US20090093459A1 (en) | 2009-04-09 |
KR20090010214A (ko) | 2009-01-29 |
CY1110089T1 (el) | 2015-01-14 |
ATE458738T1 (de) | 2010-03-15 |
GT200800254A (es) | 2009-03-13 |
TW200812990A (en) | 2008-03-16 |
NO20085189L (no) | 2009-02-11 |
DOP2007000103A (es) | 2007-11-15 |
CA2652361A1 (fr) | 2007-11-29 |
CN101454278A (zh) | 2009-06-10 |
WO2007135294A3 (fr) | 2008-01-17 |
EP2029596B1 (fr) | 2010-02-24 |
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