CY1111969T1 - Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18 - Google Patents

Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18

Info

Publication number
CY1111969T1
CY1111969T1 CY20111101026T CY111101026T CY1111969T1 CY 1111969 T1 CY1111969 T1 CY 1111969T1 CY 20111101026 T CY20111101026 T CY 20111101026T CY 111101026 T CY111101026 T CY 111101026T CY 1111969 T1 CY1111969 T1 CY 1111969T1
Authority
CY
Cyprus
Prior art keywords
binding protein
preparation
recombinant binding
recombinant
composition
Prior art date
Application number
CY20111101026T
Other languages
English (en)
Inventor
Urs Weber
Thierry Ziegler
Original Assignee
Ares Trading S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading S.A. filed Critical Ares Trading S.A.
Publication of CY1111969T1 publication Critical patent/CY1111969T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Η εφεύρεση σχετίζεται με μία διαδικασία για την παρασκευή της ανασυνδυασμένης συνδετικής πρωτεΐνης IL-18 (IL-18BP) και με μία σύνθεση η οποία περιέχει την IL-18BP η οποία χαρακτηρίζεται από ένα ειδικό προφίλ γλυκοζυλίωσης.
CY20111101026T 2005-06-03 2011-10-27 Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18 CY1111969T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68763105P 2005-06-03 2005-06-03
EP05104878 2005-06-03
EP05106429 2005-07-13
EP06763472A EP1885753B1 (en) 2005-06-03 2006-06-01 Production of recombinant Il-18 binding protein

Publications (1)

Publication Number Publication Date
CY1111969T1 true CY1111969T1 (el) 2015-11-04

Family

ID=44352415

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20111101026T CY1111969T1 (el) 2005-06-03 2011-10-27 Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18
CY20121100583T CY1113056T1 (el) 2005-06-03 2012-06-29 Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20121100583T CY1113056T1 (el) 2005-06-03 2012-06-29 Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18

Country Status (15)

Country Link
US (2) US7691611B2 (el)
EP (2) EP1885753B1 (el)
JP (2) JP5199073B2 (el)
AT (2) ATE517917T1 (el)
AU (1) AU2006254103B2 (el)
CA (1) CA2609060C (el)
CY (2) CY1111969T1 (el)
DK (2) DK1885753T3 (el)
ES (2) ES2385639T3 (el)
IL (1) IL187838A (el)
NO (1) NO342802B1 (el)
PL (2) PL1885753T3 (el)
PT (2) PT1885753E (el)
SI (2) SI1885753T1 (el)
WO (1) WO2006128908A1 (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ520392A (en) * 2000-02-10 2005-04-29 Abbott Lab Antibodies that bind human interleukin-18 and methods of making and using
PT1601776E (pt) 2003-03-11 2008-09-17 Serono Lab Vectores de expressão que compreendem o promotor ie2 do mcmv
DK1622939T3 (da) * 2003-05-13 2012-04-10 Merck Serono Sa Aktive varianter af det IL-18-bindende protein og medicinske anvendelser deraf
EP1675956B1 (en) 2003-10-21 2010-10-13 Merck Serono SA Minimal dna sequence acting as a chromatin insulator and its use in protein expression
DK1689777T3 (da) 2003-11-05 2007-06-11 Ares Trading Sa Fremgangsmåde til oprensning af il18-bindende protein
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
PT1720979E (pt) 2004-03-01 2007-10-25 Ares Trading Sa Utilização de um meio de cultura de células sem soro para a produção de il-18bp em células de mamífero
DE602005009827D1 (de) 2004-06-29 2008-10-30 Ares Trading Sa Verfahren zur aufreinigung von il-18-bindendem protein
SI1891088T1 (sl) 2005-06-10 2012-02-29 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina
US20160145589A1 (en) 2011-06-24 2016-05-26 Green Cross Corporation Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof
CN107988166B (zh) * 2011-07-01 2022-03-15 美国安进公司 哺乳动物细胞培养
US9150841B2 (en) 2012-06-29 2015-10-06 Shire Human Genetic Therapies, Inc. Cells for producing recombinant iduronate-2-sulfatase
KR101380740B1 (ko) 2012-06-29 2014-04-11 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 이듀로네이트-2-설파타제의 정제
US20140004097A1 (en) * 2012-06-29 2014-01-02 Shire Human Genetic Therapies, Inc. Method of producing recombinant iduronate-2-sulfatase
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
US8956830B2 (en) 2013-03-14 2015-02-17 Momenta Pharmaceuticals, Inc. Methods of cell culture
US9677105B2 (en) 2013-03-14 2017-06-13 Momenta Pharmaceuticals, Inc. Methods of cell culture
AU2014241259B9 (en) 2013-03-26 2018-12-20 Coherus Biosciences, Inc. Protein production method
PL3041864T3 (pl) 2013-09-05 2021-12-20 Ab2 Bio Sa Białko wiążące il-18 (il-18bp) w chorobach zapalnych
USD759075S1 (en) * 2014-04-11 2016-06-14 Nutonian, Inc. Display screen with graphical user interface
USD759076S1 (en) * 2014-04-18 2016-06-14 Nutonian, Inc. Display screen with graphical user interface
RU2755691C2 (ru) 2015-03-05 2021-09-20 Аб2 Био Са Il-18-связывающие белок (il-18bp) и антитела при воспалительных заболеваниях
KR101789509B1 (ko) * 2015-11-05 2017-10-26 주식회사 프로젠 재조합 인간 갑상선 자극 호르몬을 포함하는 조성물 및 상기 재조합 인간 갑상선 자극 호르몬의 생산 방법
EP4039786A1 (en) 2017-10-16 2022-08-10 Regeneron Pharmaceuticals, Inc. Perfusion bioreactor and related methods of use

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588585A (en) 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US4737462A (en) 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US5116943A (en) 1985-01-18 1992-05-26 Cetus Corporation Oxidation-resistant muteins of Il-2 and other protein
US5266476A (en) 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
US5017691A (en) 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US4879111A (en) 1986-04-17 1989-11-07 Cetus Corporation Treatment of infections with lymphokines
US4965195A (en) 1987-10-26 1990-10-23 Immunex Corp. Interleukin-7
US4904584A (en) 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
CA2100329C (en) 1991-01-18 2009-09-29 David F. Carmichael Methods for treating tumor necrosis factor mediated diseases
JP4306813B2 (ja) * 1995-09-19 2009-08-05 アスビオファーマ株式会社 動物細胞の新規培養方法
EA002474B1 (ru) 1996-02-20 2002-06-27 Апплайд Резеч Системз Арс Холдинг Н.В. Гибридный белок, образующий гетеродимеры, способ его получения и использования
NZ333325A (en) 1996-07-12 2000-06-23 Genentech Inc Recombinant chimeric heteromultimer adhesins comprising extracellular domains of ErbB receptors
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2377513A1 (en) 1999-06-25 2001-01-04 Universitat Zurich Hetero-associating coiled-coil peptides
NZ517184A (en) 1999-07-13 2004-02-27 Bolder Biotechnology Inc Immunoglobulin fusion proteins that are cytokines or growth factors joined to an Immunoglobulin domain
IL131047A0 (en) 1999-07-22 2001-01-28 Yeda Res & Dev Use of il-18 inhibitors
UA74557C2 (en) 1999-09-03 2006-01-16 Applied Research Systems A method for producing a heterologous secreted protein from chinese hamster ovaries cells grown on microcarriers
KR20020086540A (ko) 2000-02-21 2002-11-18 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. Ｉｌ-18 저해물질의 용도
MXPA02010895A (es) 2000-05-05 2003-03-27 Applied Research Systems Uso de inhibidores de interleucina 18 para el tratamiento y/o prevencion de aterosclerosis.
IL140110A0 (en) * 2000-12-05 2002-02-10 Applied Research Systems Improvement of homogeneity and secretion of recombinant proteins in mammalian systems
ES2295332T3 (es) 2001-01-29 2008-04-16 Laboratoires Serono Sa Uso de inhibidores de il-18 para el tratamiento y/o prevencion de cardiopatias.
ES2251610T3 (es) 2001-03-08 2006-05-01 Ares Trading S.A. Mutantes de interleuquina-18, su produccion y su uso.
JP4502580B2 (ja) 2001-05-16 2010-07-14 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド 敗血症の治療または予防のためのｉｌ−１８阻害剤の使用
PL216228B1 (pl) 2001-05-25 2014-03-31 Ares Trading Sa Zastosowanie białka wiążącego IL-18
UA78516C2 (en) 2001-08-10 2007-04-10 Applied Research Systems Use of inhibitors of il-18 for treatment and/or prevention of hypersensitivity disorders, and in particular of delayed-type hypersensitivity
KR20050004809A (ko) 2002-03-22 2005-01-12 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 말초 맥관 질환 치료 및/또는 예방에 사용되는 ｉｌ-18저해제
CN1726283A (zh) 2002-08-14 2006-01-25 阿维迪斯公司 利用c4bp支架制备多聚体融合蛋白
DE60329116D1 (de) 2002-10-11 2009-10-15 Zymogenetics Inc Herstellung von homotrimeren fusionsproteinen
WO2004058800A2 (en) * 2002-12-23 2004-07-15 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
PT1601776E (pt) * 2003-03-11 2008-09-17 Serono Lab Vectores de expressão que compreendem o promotor ie2 do mcmv
DK1622939T3 (da) 2003-05-13 2012-04-10 Merck Serono Sa Aktive varianter af det IL-18-bindende protein og medicinske anvendelser deraf
EP1675956B1 (en) * 2003-10-21 2010-10-13 Merck Serono SA Minimal dna sequence acting as a chromatin insulator and its use in protein expression
DK1689777T3 (da) * 2003-11-05 2007-06-11 Ares Trading Sa Fremgangsmåde til oprensning af il18-bindende protein
PT1720979E (pt) 2004-03-01 2007-10-25 Ares Trading Sa Utilização de um meio de cultura de células sem soro para a produção de il-18bp em células de mamífero
DE602005009827D1 (de) * 2004-06-29 2008-10-30 Ares Trading Sa Verfahren zur aufreinigung von il-18-bindendem protein
SI1891088T1 (sl) 2005-06-10 2012-02-29 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina

Also Published As

Publication number Publication date
WO2006128908A1 (en) 2006-12-07
ATE517917T1 (de) 2011-08-15
AU2006254103B2 (en) 2012-09-06
CA2609060A1 (en) 2006-12-07
EP2267024B1 (en) 2012-05-09
PT1885753E (pt) 2011-10-06
SI2267024T1 (sl) 2012-09-28
PT2267024E (pt) 2012-06-01
US20100137195A1 (en) 2010-06-03
PL2267024T3 (pl) 2012-10-31
JP2008541748A (ja) 2008-11-27
JP2013048633A (ja) 2013-03-14
US20080199913A1 (en) 2008-08-21
CA2609060C (en) 2014-07-15
EP2267024A1 (en) 2010-12-29
ATE557038T1 (de) 2012-05-15
SI1885753T1 (sl) 2011-12-30
DK1885753T3 (da) 2011-10-03
NO20076672L (no) 2008-02-22
JP5837476B2 (ja) 2015-12-24
IL187838A (en) 2011-07-31
DK2267024T3 (da) 2012-06-25
JP5199073B2 (ja) 2013-05-15
ES2385639T3 (es) 2012-07-27
CY1113056T1 (el) 2016-04-13
AU2006254103A1 (en) 2006-12-07
IL187838A0 (en) 2008-03-20
EP1885753A1 (en) 2008-02-13
EP1885753B1 (en) 2011-07-27
NO342802B1 (no) 2018-08-06
ES2370417T3 (es) 2011-12-15
PL1885753T3 (pl) 2011-12-30
US7691611B2 (en) 2010-04-06

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