CY1113056T1 - Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18 - Google Patents

Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18

Info

Publication number
CY1113056T1
CY1113056T1 CY20121100583T CY121100583T CY1113056T1 CY 1113056 T1 CY1113056 T1 CY 1113056T1 CY 20121100583 T CY20121100583 T CY 20121100583T CY 121100583 T CY121100583 T CY 121100583T CY 1113056 T1 CY1113056 T1 CY 1113056T1
Authority
CY
Cyprus
Prior art keywords
binding protein
preparation
recombinant binding
recombinant
composition
Prior art date
Application number
CY20121100583T
Other languages
English (en)
Inventor
Urs Wieber
Thierry Ziegler
Original Assignee
Ares Trading S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading S.A. filed Critical Ares Trading S.A.
Publication of CY1113056T1 publication Critical patent/CY1113056T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)

Abstract

Η εφεύρεση σχετίζεται με μία διαδικασία για την παρασκευή της ανασυνδυασμένης συνδετικής πρωτεΐνης IL-18 (IL-18ΒΡ) και με μία σύνθεση η οποία περιέχει την IL-18ΒΡ η οποία χαρακτηρίζεται από ένα ειδικό προφίλ γλυκοζυλίωσης.
CY20121100583T 2005-06-03 2012-06-29 Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18 CY1113056T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68763105P 2005-06-03 2005-06-03
EP05104878 2005-06-03
EP05106429 2005-07-13
EP10184728A EP2267024B1 (en) 2005-06-03 2006-06-01 Production of recombinant Il-18 binding protein

Publications (1)

Publication Number Publication Date
CY1113056T1 true CY1113056T1 (el) 2016-04-13

Family

ID=44352415

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20111101026T CY1111969T1 (el) 2005-06-03 2011-10-27 Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18
CY20121100583T CY1113056T1 (el) 2005-06-03 2012-06-29 Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20111101026T CY1111969T1 (el) 2005-06-03 2011-10-27 Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18

Country Status (15)

Country Link
US (2) US7691611B2 (el)
EP (2) EP2267024B1 (el)
JP (2) JP5199073B2 (el)
AT (2) ATE557038T1 (el)
AU (1) AU2006254103B2 (el)
CA (1) CA2609060C (el)
CY (2) CY1111969T1 (el)
DK (2) DK2267024T3 (el)
ES (2) ES2385639T3 (el)
IL (1) IL187838A (el)
NO (1) NO342802B1 (el)
PL (2) PL2267024T3 (el)
PT (2) PT1885753E (el)
SI (2) SI2267024T1 (el)
WO (1) WO2006128908A1 (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ520392A (en) * 2000-02-10 2005-04-29 Abbott Lab Antibodies that bind human interleukin-18 and methods of making and using
KR101180139B1 (ko) * 2003-03-11 2012-09-13 메르크 세로노 에스.에이. Ｍｃｍｖ ｉｅ2 프로모터를 포함하는 발현 벡터
JP5074030B2 (ja) * 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用
CA2541523A1 (en) 2003-10-21 2005-05-06 Applied Research Systems Ars Holding N.V. Minimal dna sequence acting as a chromatin insulator and its use in protein expression
CA2544146C (en) * 2003-11-05 2012-10-02 Ares Trading S.A. Process for the purification of il-18 binding protein
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
DK1720979T3 (da) 2004-03-01 2007-12-10 Ares Trading Sa Anvendelse af et serumfrit celledyrkningsmedium til fremstilling af IL-18BP I pattedyrceller
AU2005259269B2 (en) * 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
EP1891088B1 (en) 2005-06-10 2011-10-19 Ares Trading S.A. Process for the purification of il-18 binding protein
US20160145589A1 (en) 2011-06-24 2016-05-26 Green Cross Corporation Composition and formulation comprising recombinant human iduronate-2-sulfatase and preparation method thereof
LT2837680T (lt) * 2011-07-01 2020-07-10 Amgen Inc. Žinduolių ląstelių kultūra
KR101380740B1 (ko) 2012-06-29 2014-04-11 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 이듀로네이트-2-설파타제의 정제
US20140004097A1 (en) * 2012-06-29 2014-01-02 Shire Human Genetic Therapies, Inc. Method of producing recombinant iduronate-2-sulfatase
US9150841B2 (en) 2012-06-29 2015-10-06 Shire Human Genetic Therapies, Inc. Cells for producing recombinant iduronate-2-sulfatase
US8956830B2 (en) 2013-03-14 2015-02-17 Momenta Pharmaceuticals, Inc. Methods of cell culture
US9677105B2 (en) * 2013-03-14 2017-06-13 Momenta Pharmaceuticals, Inc. Methods of cell culture
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
MX362922B (es) 2013-03-26 2019-02-25 Coherus Biosciences Inc Método de producción de proteínas.
EP3041864B1 (en) 2013-09-05 2021-07-21 AB2 Bio SA Il-18 binding protein (il-18bp) in inflammatory diseases
USD759075S1 (en) * 2014-04-11 2016-06-14 Nutonian, Inc. Display screen with graphical user interface
USD759076S1 (en) * 2014-04-18 2016-06-14 Nutonian, Inc. Display screen with graphical user interface
AU2016227644B2 (en) 2015-03-05 2022-06-16 Ab2 Bio Sa IL-18 Binding Protein (IL-18BP) and antibodies in inflammatory diseases
KR101789509B1 (ko) * 2015-11-05 2017-10-26 주식회사 프로젠 재조합 인간 갑상선 자극 호르몬을 포함하는 조성물 및 상기 재조합 인간 갑상선 자극 호르몬의 생산 방법
CA3075679A1 (en) 2017-10-16 2019-04-25 Regeneron Pharmaceuticals, Inc. Perfusion bioreactor and related methods of use

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588585A (en) 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US4737462A (en) 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US5116943A (en) 1985-01-18 1992-05-26 Cetus Corporation Oxidation-resistant muteins of Il-2 and other protein
US5266476A (en) 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
US5017691A (en) 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US4879111A (en) 1986-04-17 1989-11-07 Cetus Corporation Treatment of infections with lymphokines
US4965195A (en) 1987-10-26 1990-10-23 Immunex Corp. Interleukin-7
US4904584A (en) 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
RU2166955C2 (ru) 1991-01-18 2001-05-20 Эмген Инк. Способ лечения и профилактики заболеваний, обусловленных повышением уровня фактора, вызывающего некроз опухолевых клеток
JP4306813B2 (ja) * 1995-09-19 2009-08-05 アスビオファーマ株式会社 動物細胞の新規培養方法
PL187400B1 (pl) 1996-02-20 2004-06-30 Applied Research Systems Białka hybrydowe tworzące heterodimery
DE69740038D1 (el) 1996-07-12 2010-12-16 Genentech Inc
IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
EP1194539A2 (en) 1999-06-25 2002-04-10 Universität Zürich Hetero-associating coiled-coil peptides and screening method therefor
JP4944324B2 (ja) 1999-07-13 2012-05-30 ボルダー バイオテクノロジー， インコーポレイテッド 免疫グロブリン融合タンパク質
IL131047A0 (en) 1999-07-22 2001-01-28 Yeda Res & Dev Use of il-18 inhibitors
UA74557C2 (en) * 1999-09-03 2006-01-16 Applied Research Systems A method for producing a heterologous secreted protein from chinese hamster ovaries cells grown on microcarriers
ME00546B (me) 2000-02-21 2011-10-10 Serono Lab Korišćenje inhibitora il-18
PT1278540E (pt) 2000-05-05 2008-07-03 Inst Nat Sante Rech Med Utilização de inibidores da il-18 para o tratamento e/ou prevenção de aterosclerose
IL140110A0 (en) * 2000-12-05 2002-02-10 Applied Research Systems Improvement of homogeneity and secretion of recombinant proteins in mammalian systems
DE60224004T2 (de) 2001-01-29 2009-07-23 Laboratoires Serono S.A., Coinsins Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten
SI1392830T1 (sl) 2001-03-08 2006-06-30 Ares Trading Sa Mutanti interlevkina-18, njihova proizvodnja in uporaba
US20030008822A1 (en) 2001-05-16 2003-01-09 Charles Dinarello Use of IL-18 inhibitors for the treatment or prevention of sepsis
HU230294B1 (hu) 2001-05-25 2015-12-28 Ares Trading S.A. IL-18-inhibitorok alkalmazása központi idegrendszeri sérülések kezelésére vagy megelőzésére
UA78516C2 (en) 2001-08-10 2007-04-10 Applied Research Systems Use of inhibitors of il-18 for treatment and/or prevention of hypersensitivity disorders, and in particular of delayed-type hypersensitivity
AU2003219162B2 (en) 2002-03-22 2008-01-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of IL-18 inhibitors for the treatment and/or prevention of peripheral vascular diseases
AU2003293351A1 (en) 2002-08-14 2004-03-19 Avidis Sa Production of multimeric fusion proteins using a c4bp scaffold
DE60329116D1 (de) 2002-10-11 2009-10-15 Zymogenetics Inc Herstellung von homotrimeren fusionsproteinen
CN101857851A (zh) * 2002-12-23 2010-10-13 布里斯托尔-迈尔斯斯奎布公司 用于蛋白质生产的哺乳动物细胞培养方法
KR101180139B1 (ko) 2003-03-11 2012-09-13 메르크 세로노 에스.에이. Ｍｃｍｖ ｉｅ2 프로모터를 포함하는 발현 벡터
JP5074030B2 (ja) 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用
CA2541523A1 (en) 2003-10-21 2005-05-06 Applied Research Systems Ars Holding N.V. Minimal dna sequence acting as a chromatin insulator and its use in protein expression
CA2544146C (en) 2003-11-05 2012-10-02 Ares Trading S.A. Process for the purification of il-18 binding protein
DK1720979T3 (da) 2004-03-01 2007-12-10 Ares Trading Sa Anvendelse af et serumfrit celledyrkningsmedium til fremstilling af IL-18BP I pattedyrceller
AU2005259269B2 (en) * 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
EP1891088B1 (en) * 2005-06-10 2011-10-19 Ares Trading S.A. Process for the purification of il-18 binding protein

Also Published As

Publication number Publication date
EP2267024A1 (en) 2010-12-29
JP5837476B2 (ja) 2015-12-24
AU2006254103A1 (en) 2006-12-07
ES2385639T3 (es) 2012-07-27
NO342802B1 (no) 2018-08-06
SI2267024T1 (sl) 2012-09-28
US20100137195A1 (en) 2010-06-03
PL1885753T3 (pl) 2011-12-30
DK2267024T3 (da) 2012-06-25
EP2267024B1 (en) 2012-05-09
IL187838A (en) 2011-07-31
JP2008541748A (ja) 2008-11-27
AU2006254103B2 (en) 2012-09-06
CA2609060C (en) 2014-07-15
PT1885753E (pt) 2011-10-06
DK1885753T3 (da) 2011-10-03
PT2267024E (pt) 2012-06-01
ATE557038T1 (de) 2012-05-15
US20080199913A1 (en) 2008-08-21
CY1111969T1 (el) 2015-11-04
PL2267024T3 (pl) 2012-10-31
US7691611B2 (en) 2010-04-06
WO2006128908A1 (en) 2006-12-07
ATE517917T1 (de) 2011-08-15
CA2609060A1 (en) 2006-12-07
EP1885753B1 (en) 2011-07-27
IL187838A0 (en) 2008-03-20
ES2370417T3 (es) 2011-12-15
JP5199073B2 (ja) 2013-05-15
EP1885753A1 (en) 2008-02-13
JP2013048633A (ja) 2013-03-14
SI1885753T1 (sl) 2011-12-30
NO20076672L (no) 2008-02-22

Similar Documents

Publication Publication Date Title
CY1113056T1 (el) Παρασκευη ανασυνδυασμενης συνδετικης πρωτεϊνης il-18
HK1120052A1 (en) Process for the preparation of glycosylated interferon beta
LTPA2019520I1 (lt) Rekombinantiniai anti-IL-23 antikūnai
EP1897951A3 (en) Composition and methods for producing steviol and steviol glycosides
NO20070687L (no) Ny karbamylert EPO og fremgangsmate for deres fremstilling
WO2007136752A3 (en) Erythropoietin compositions
HK1130834A1 (en) Polynucleotide for production of recombinant protein by silkworm
ZA200705874B (en) Process for producing polypeptide mixtures using hydrogenolysis
CY1112312T1 (el) Διεργασια για τον καθαρισμο της πρωτεϊνης δεσμευσης της ιl-18
HK1119188A1 (en) Recombinant production of heparin binding proteins
ZA200711011B (en) A recombinant method for production of an erythropoiesis stimulating protein
EP2261243A3 (en) Hemopexin-like structure as polypeptide-scaffold
DE602006009439D1 (de) Wanderbettverfahrenverfahren zur Herstellung von Phenylalkanen
PL1627881T3 (pl) Sposób otrzymywania topiramatu
EP1799234A4 (en) INCREASED PRODUCTION OF CO-EXPRESSION RECOMBINED HEMOGLOBIN WITH HEMOGLOBIN ALPHA STABILIZATION PROTEIN
EP1935981A4 (en) PROCESS FOR PRODUCING RECOMBINANT PROTEIN
GB0711250D0 (en) Furanose derivatives
ZA200711006B (en) A process comprising codon optimization for the production of recombinant activated human protein c for the treatment of sepsis
ZA200805149B (en) Recombinant production of heparin binding proteins
ATE469962T1 (de) Proanthocyanidin-tannin-zusammensetzung, herstellungsverfahren dafür und verwendung davon
PL380041A1 (pl) Sposób wytwarzania kwasów , -alkilenodiamino-N,N'-bis(1-arylometylofosfonowych)