CY1110751T1 - Φαρμακευτικο σκευασμα που περιλαμβανει μικροκαψουλες απο στατινες εναιωρημενες σε αλκυλεστερες πολυακορεστων λιπαρων οξεων (pufa) - Google Patents

Φαρμακευτικο σκευασμα που περιλαμβανει μικροκαψουλες απο στατινες εναιωρημενες σε αλκυλεστερες πολυακορεστων λιπαρων οξεων (pufa)

Info

Publication number
CY1110751T1
CY1110751T1 CY20101100790T CY101100790T CY1110751T1 CY 1110751 T1 CY1110751 T1 CY 1110751T1 CY 20101100790 T CY20101100790 T CY 20101100790T CY 101100790 T CY101100790 T CY 101100790T CY 1110751 T1 CY1110751 T1 CY 1110751T1
Authority
CY
Cyprus
Prior art keywords
pufa
microcellulars
aluylic
statines
distributed
Prior art date
Application number
CY20101100790T
Other languages
English (en)
Inventor
Paolo Carminati
Antonio Parente
Original Assignee
Gp Pharm S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gp Pharm S.A. filed Critical Gp Pharm S.A.
Publication of CY1110751T1 publication Critical patent/CY1110751T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η εφεύρεση σχετίζεται με φαρμακευτική σύνθεση που περιλαμβάνει εναιώρημα που αποτελείται από έλαιο με υψηλή συγκέντρωση αλκυλεστέρων πολυακόρεστων λιπαρών οξέων (PUFA) και με μικροκάψουλες που περιλαμβάνουν τουλάχιστον ένα πολυμερές και μία στατίνη.
CY20101100790T 2004-10-19 2010-08-30 Φαρμακευτικο σκευασμα που περιλαμβανει μικροκαψουλες απο στατινες εναιωρημενες σε αλκυλεστερες πολυακορεστων λιπαρων οξεων (pufa) CY1110751T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200402492A ES2255426B1 (es) 2004-10-19 2004-10-19 Formulacion farmaceutica que comprende microcapsulas de estatinas suspendidas en ester alquilicos de acidos grasos poliinsaturados (pufa).
EP05802903A EP1803440B1 (en) 2004-10-19 2005-10-13 Pharmaceutical formulation comprising microcapsules of statins suspended in alkyl esters of polyunsaturated fatty asids (pufa)

Publications (1)

Publication Number Publication Date
CY1110751T1 true CY1110751T1 (el) 2015-06-10

Family

ID=36227494

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100790T CY1110751T1 (el) 2004-10-19 2010-08-30 Φαρμακευτικο σκευασμα που περιλαμβανει μικροκαψουλες απο στατινες εναιωρημενες σε αλκυλεστερες πολυακορεστων λιπαρων οξεων (pufa)

Country Status (22)

Country Link
US (1) US20090196920A1 (el)
EP (1) EP1803440B1 (el)
JP (1) JP4976302B2 (el)
KR (1) KR101413339B1 (el)
CN (2) CN102727462A (el)
AT (1) ATE469641T1 (el)
AU (1) AU2005298587B2 (el)
BR (1) BRPI0516152A (el)
CA (1) CA2583756C (el)
CY (1) CY1110751T1 (el)
DE (1) DE602005021668D1 (el)
DK (1) DK1803440T3 (el)
EA (1) EA012371B1 (el)
ES (2) ES2255426B1 (el)
IL (1) IL182466A (el)
MX (1) MX2007004655A (el)
NZ (1) NZ554265A (el)
PL (1) PL1803440T3 (el)
PT (1) PT1803440E (el)
SI (1) SI1803440T1 (el)
WO (1) WO2006045865A1 (el)
ZA (1) ZA200703509B (el)

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Also Published As

Publication number Publication date
ES2347055T3 (es) 2010-10-25
CN102727462A (zh) 2012-10-17
DE602005021668D1 (de) 2010-07-15
PT1803440E (pt) 2010-08-31
JP2008517040A (ja) 2008-05-22
PL1803440T3 (pl) 2010-12-31
AU2005298587A1 (en) 2006-05-04
ES2255426B1 (es) 2007-08-16
DK1803440T3 (da) 2010-10-04
ZA200703509B (en) 2008-09-25
MX2007004655A (es) 2008-03-10
EA012371B1 (ru) 2009-10-30
CA2583756C (en) 2013-12-24
EP1803440A1 (en) 2007-07-04
US20090196920A1 (en) 2009-08-06
EA200700614A1 (ru) 2007-10-26
AU2005298587B2 (en) 2010-08-05
JP4976302B2 (ja) 2012-07-18
CA2583756A1 (en) 2006-05-04
SI1803440T1 (sl) 2010-10-29
IL182466A0 (en) 2007-07-24
IL182466A (en) 2013-06-27
NZ554265A (en) 2010-12-24
CN101043873A (zh) 2007-09-26
BRPI0516152A (pt) 2008-08-26
EP1803440B1 (en) 2010-06-02
WO2006045865A1 (es) 2006-05-04
ATE469641T1 (de) 2010-06-15
KR20070083715A (ko) 2007-08-24
KR101413339B1 (ko) 2014-06-27
ES2255426A1 (es) 2006-06-16

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