CY1109504T1 - Αγωνιστες υποδοχεα γουανυλικης κυκλασης για την θεραπεια φλεγμονης ιστου και καρκινογενεσης - Google Patents

Αγωνιστες υποδοχεα γουανυλικης κυκλασης για την θεραπεια φλεγμονης ιστου και καρκινογενεσης

Info

Publication number
CY1109504T1
CY1109504T1 CY20091101078T CY091101078T CY1109504T1 CY 1109504 T1 CY1109504 T1 CY 1109504T1 CY 20091101078 T CY20091101078 T CY 20091101078T CY 091101078 T CY091101078 T CY 091101078T CY 1109504 T1 CY1109504 T1 CY 1109504T1
Authority
CY
Cyprus
Prior art keywords
treatment
cgmp
agonyl
receptor agonist
peptide
Prior art date
Application number
CY20091101078T
Other languages
English (en)
Inventor
Kunwar Shailubhai
Gregory Nikiforovich
Gary S Jacob
Original Assignee
Synergy Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27559539&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109504(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synergy Pharmaceuticals, Inc. filed Critical Synergy Pharmaceuticals, Inc.
Publication of CY1109504T1 publication Critical patent/CY1109504T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Αποκαλύπτεται μέθοδος θεραπείας φλεγμαίνοντος, προ-καρκινώδους ή καρκινώδους ιστού ή πολυπόδων σε ένα υποκείμενο θηλαστικό. Η θεραπεία περιλαμβάνει χορήγηση μίας σύνθεσης από τουλάχιστον ένα πεπτίδιο αγωνιστή ενός υποδοχέα γουανυλικής κυκλάσης ή/και άλλα μικρά μόρια που αυξάνουν ενδοκυτταρική παραγωγή του cGMP. Το τουλάχιστον ένα πεπτίδιο αγωνιστής ενός υποδοχέα γουανυλικής κυκλάσης μπορεί να χορηγηθεί είτε μόνο είτε σε συνδυασμό με έναν αναστολέα της εξαρτώμενης από cGMP φωσφοδιεστεράσης. Ο αναστολέας μπορεί να είναι ένα μικρό μόριο, πεπτίδιο, πρωτεΐνη ή άλλη ένωση που αναστέλλει την αποικοδόμηση του cGMP. Χωρίς να απαιτεί έναν συγκεκριμένο μηχανισμό δράσης, αυτή η θεραπεία μπορεί να αποκαταστήσει μία υγιή ισορροπία μεταξύ πολλαπλασιασμού και απόπτωσης στον πληθυσμό επιθηλιακών κυττάρων του υποκειμένου και επίσης να καταστείλει την καρκινογένεση. Έτσι, η μέθοδος μπορεί να χρησιμοποιηθεί για να θεραπεύσει μεταξύ άλλων, φλεγμονή, συμπεριλαμβανομένων γαστρεντερικών φλεγμονωδών διαταραχών, γενικής φλεγμονής οργάνου και άσθμα και καρκινογένεση του πνεύμονα, γαστρεντερικής οδού, κύστης, όρχεων, προστάτη και παγκρέατος ή πολύποδες.
CY20091101078T 2001-03-29 2009-10-15 Αγωνιστες υποδοχεα γουανυλικης κυκλασης για την θεραπεια φλεγμονης ιστου και καρκινογενεσης CY1109504T1 (el)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US27943701P 2001-03-29 2001-03-29
US27943801P 2001-03-29 2001-03-29
US30085001P 2001-06-27 2001-06-27
US30380601P 2001-07-10 2001-07-10
US30735801P 2001-07-25 2001-07-25
US34864602P 2002-01-17 2002-01-17
EP02721604.3A EP1379224B2 (en) 2001-03-29 2002-03-28 Guanylate cyclase receptor agonists for the treatment of tissue inflammation and carcinogenesis

Publications (1)

Publication Number Publication Date
CY1109504T1 true CY1109504T1 (el) 2014-08-13

Family

ID=27559539

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101078T CY1109504T1 (el) 2001-03-29 2009-10-15 Αγωνιστες υποδοχεα γουανυλικης κυκλασης για την θεραπεια φλεγμονης ιστου και καρκινογενεσης

Country Status (13)

Country Link
US (6) US7041786B2 (el)
EP (4) EP2301952B1 (el)
JP (3) JP4206272B2 (el)
CN (5) CN1551760A (el)
CA (3) CA2905585C (el)
CY (1) CY1109504T1 (el)
DE (1) DE60233040D1 (el)
DK (1) DK1379224T4 (el)
EA (1) EA006651B1 (el)
ES (3) ES2622468T3 (el)
HK (3) HK1136585A1 (el)
PT (1) PT1379224E (el)
WO (1) WO2002078683A1 (el)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1379224E (pt) 2001-03-29 2009-10-22 Synergy Pharmaceuticals Inc Agonistas do receptor da guanilato ciclase para o tratamento de inflamação de tecidos e carcinogénese
US20030232013A1 (en) * 2002-02-22 2003-12-18 Gary Sieckman Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides
US20080214437A1 (en) * 2002-09-06 2008-09-04 Mohapatra Shyam S Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases
US20060110359A1 (en) * 2002-09-06 2006-05-25 Juan Sanchez-Ramos Cellular delivery of natriuretic peptides
WO2004022003A2 (en) * 2002-09-06 2004-03-18 University Of South Florida Materials and methods for treatment of allergic diseases
US20050272650A1 (en) * 2004-02-17 2005-12-08 Mohapatra Shyam S Materials and methods for treatment of inflammatory and cell proliferation disorders
CA2498581C (en) 2002-09-10 2019-03-19 National Jewish Medical And Research Center Thioredoxin composition and uses thereof for liquefaction of mucus or sputum
US7304036B2 (en) 2003-01-28 2007-12-04 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1594517B1 (en) * 2003-01-28 2007-06-20 Microbia, Inc. Compositions for the treatment of gastrointestinal disorders
US7772188B2 (en) * 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7371727B2 (en) * 2003-01-28 2008-05-13 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20060281682A1 (en) * 2003-01-28 2006-12-14 Currie Mark G Methods and compositions for the treatment of gastrointestinal disorders
US8206704B2 (en) * 2003-02-10 2012-06-26 Thomas Jefferson University Use of GCC ligands
US7494979B2 (en) 2003-06-13 2009-02-24 Ironwood Pharmaceuticals, Inc. Method for treating congestive heart failure and other disorders
WO2005016244A2 (en) * 2003-06-13 2005-02-24 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US9107864B2 (en) 2004-06-07 2015-08-18 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
US8501198B2 (en) 2004-06-07 2013-08-06 Qu Biologics Inc. Tissue targeted antigenic activation of the immune response to treat cancers
WO2006012264A1 (en) 2004-06-25 2006-02-02 Thomas Jefferson University Compounds of the inventions of guanylyl cyclase c
US20090054319A1 (en) * 2005-03-17 2009-02-26 Microbia, Inc. Methods and Compositions for the Treatment of Hypertension and Gastrointestinal Disorders
WO2007022531A2 (en) * 2005-08-19 2007-02-22 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2007101161A2 (en) * 2006-02-24 2007-09-07 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2656990A1 (en) * 2006-04-28 2007-11-08 University Of South Florida Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor
JP2010518090A (ja) * 2007-02-09 2010-05-27 トランザイム・ファーマ，インコーポレイテッド 大環状グレリン受容体修飾因子およびその使用方法
US8969514B2 (en) * 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101772513B (zh) * 2007-06-04 2013-11-13 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
WO2009033773A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use endothelin 2, alone or combined with a nonapeptide, a peptide as a therapeutic agent
WO2009033738A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
NZ586957A (en) * 2008-02-01 2014-03-28 Chromocell Corp Cell lines and methods for making and using them
EP2296685B1 (en) 2008-06-04 2015-09-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
WO2010003308A1 (zh) * 2008-07-10 2010-01-14 卞化石 一氧化氮及其信息传递系统在制备恶性肿瘤靶向治疗药物中的应用
EP2321341B1 (en) * 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
CN109010254A (zh) 2008-08-15 2018-12-18 硬木药品公司 适合口服给药的鸟苷酸环化酶-c受体激动剂多肽的稳定的固体制剂
US20120039949A1 (en) * 2008-09-04 2012-02-16 Ironwood Pharmaceuticals, Inc. Stable Solid Formulations of GC-C Receptor Agonist Polypeptides Suitable for Oral Administration
US20120028897A1 (en) * 2008-12-02 2012-02-02 Currie Mark G Methods and compositions for the treatment of fluid retention disorders
CA2994066A1 (en) * 2008-12-03 2010-06-10 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase c agonists and methods of use
BRPI0923861B8 (pt) 2008-12-31 2021-05-25 Ardelyx Inc compostos e composições farmacêuticas para inibir o antiporte nhe-mediado no tratamento de distúrbios associados com a retenção de fluido ou com a sobrecarga de sal e distúrbios do trato gastrointestinal
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US8748573B2 (en) * 2009-08-06 2014-06-10 Ironwood Pharmaceuticals, Inc. Formulations comprising linaclotide
WO2011020054A1 (en) 2009-08-13 2011-02-17 Ironwood Pharmaceuticals Inc. Method for modulating the pharmacodynamic effect of orally administered guanylate cyclase receptor agonists
CN104447996A (zh) 2009-10-23 2015-03-25 米伦纽姆医药公司 抗gcc抗体分子及其相关组合物和方法
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
WO2011095450A1 (en) 2010-02-02 2011-08-11 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
PL2536742T3 (pl) 2010-02-17 2017-11-30 Ironwood Pharmaceuticals, Inc. Leczenie zaburzeń żołądkowo-jelitowych
PT2603232T (pt) 2010-08-11 2020-01-09 Ironwood Pharmaceuticals Inc Formulações estáveis de linaclotida
AU2011302006A1 (en) 2010-09-15 2013-03-07 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase C agonists and methods of use
US9616097B2 (en) * 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP5948683B2 (ja) * 2011-02-28 2016-07-06 国立研究開発法人国立循環器病研究センター 悪性腫瘍転移抑制用医薬
KR102034748B1 (ko) 2011-03-01 2019-10-21 시너지 파마슈티컬즈 인코포레이티드 구아닐레이트 사이클라제 c 작용제의 제조 방법
US10184942B2 (en) 2011-03-17 2019-01-22 University Of South Florida Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer
US20140255518A1 (en) * 2011-04-29 2014-09-11 Thomas Jefferson University Hospitals, Inc. Treatment and Prevention of Gastrointestinal Syndrome
EP2776055B1 (en) 2011-08-17 2016-12-14 Ironwood Pharmaceuticals, Inc. Treatments for gastrointestinal disorders
SA113340502B1 (ar) 2012-04-27 2015-09-17 ميلينيوم فارماسيوتيكالز، انك جزيئات أجسام مضادة لـ gcc وطرق لاستخدام هذه الجزيئات
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CA2880338A1 (en) 2012-08-21 2014-02-27 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
JP6672139B2 (ja) 2013-03-15 2020-03-25 オアプロ セラピューティクス インコーポレイテッドＯｒｐｒｏ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 粘液の粘性の正常化のための組成物
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
CA2905435A1 (en) * 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US10272079B2 (en) 2013-04-12 2019-04-30 Ardelyx, Inc. NHE3-binding compounds and methods for inhibiting phosphate transport
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
CN114404588A (zh) 2013-08-09 2022-04-29 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
US20160235807A1 (en) * 2013-10-09 2016-08-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for downregulation of pro-inflammatory cytokines
MY188934A (en) 2013-10-18 2022-01-13 Univ Heidelberg Ruprecht Karls Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
US20150273088A1 (en) * 2014-03-28 2015-10-01 Washington University Zaprinast analogues as glutaminase inhibitors and methods to predict response thereto
EP3137108A4 (en) 2014-05-02 2017-09-27 Qu Biologics Inc Anti-microbial immunomodulation
CA3001727A1 (en) * 2015-11-18 2017-05-26 Synergy Pharmaceuticals, Inc. Compositions and method for the treatment and detection of colon cancer
US10653744B2 (en) 2016-01-11 2020-05-19 Bausch Health Ireland Limited Formulations and methods for treating ulcerative colitis
WO2018129552A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
AU2018206479B2 (en) 2017-01-09 2022-07-14 Ardelyx, Inc. Inhibitors of NHE-mediated antiport
CN107349417A (zh) * 2017-04-01 2017-11-17 南阳市中心医院 一种治疗食管鳞癌的ecm复合物以及其在制备治疗食管鳞癌的药物中的用途
CA3073181A1 (en) * 2017-08-18 2019-02-21 Thomas Jefferson University Protection of normal tissue in cancer treatment
WO2019215753A2 (en) 2018-05-07 2019-11-14 Mylan Laboratories Ltd Process for preparation of pure plecanatide
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
TW202112816A (zh) 2019-06-12 2021-04-01 瑞士商諾華公司 利鈉肽受體1抗體及使用方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1319099C (en) 1987-01-23 1993-06-15 James A. Nathanson Atriopeptins, guanylate cyclase activators, and phosphodiesterase inhibitors as treatment for glaucoma, hydrocephalus and cerebral edema (cranial fluid volume dysfunction)
US5106834A (en) * 1988-12-27 1992-04-21 G. D. Searle & Co. Linear free-sulfhydryl-containing oligopeptide derivatives as antihypertensive agents
AU3237193A (en) * 1991-12-11 1993-07-19 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5969097A (en) * 1992-06-23 1999-10-19 G. D. Searle & Co. Human guanylin
AU6358594A (en) * 1993-03-09 1994-09-26 Middlesex Sciences, Inc. Macromolecular microparticles and methods of production
US5601990A (en) * 1994-09-13 1997-02-11 Thomas Jefferson University Methods of diagnosing colorectal tumors and metastasis thereof
US5518888A (en) * 1993-10-26 1996-05-21 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US5879656A (en) * 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
ES2216004T3 (es) * 1993-10-26 2004-10-16 Thomas Jefferson University Composiciones que se unen especificamente a celulas cancerosas colorectales y procedimientos de uso de las mismas.
US5489670A (en) * 1993-10-29 1996-02-06 G. D. Searle & Co. Human uroguanylin
DE19744027A1 (de) * 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Substituierte Pyrazolo[3,4-b]pyridine, ihre Herstellung und Verwendung in Arzneimitteln
US6203513B1 (en) 1997-11-20 2001-03-20 Optonol Ltd. Flow regulating implant, method of manufacture, and delivery device
US6235782B1 (en) * 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
DE19903087A1 (de) * 1999-01-27 2000-08-10 Forssmann Wolf Georg Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern
AU7700400A (en) 1999-10-06 2001-05-10 Pharmacia Corporation Uroguanylin as an intestinal cancer inhibiting agent
JP4088412B2 (ja) 2000-12-26 2008-05-21 トヨタ自動車株式会社 内燃機関の空燃比制御装置
JP2004521123A (ja) * 2001-02-02 2004-07-15 ファルマシア・コーポレーション 腸癌阻害のためのウログアニリンおよびシクロオキシゲナーゼ−２阻害薬の組合わせ
EP1367968A4 (en) 2001-03-16 2006-12-13 Glaukos Corp APPLICATOR AND METHOD FOR SETTING A TRABECULAR SHUNT FOR GLUCKOM TREATMENT
PT1379224E (pt) 2001-03-29 2009-10-22 Synergy Pharmaceuticals Inc Agonistas do receptor da guanilato ciclase para o tratamento de inflamação de tecidos e carcinogénese
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
DE10292434D2 (de) 2001-06-05 2004-07-29 Yueksel Savas Verwendung eines Peptids, welches Guanylat Cyclase C aktiviert, für die Behandlung von Atemwegserkrankungen über die Luftwege, Arzneimittel, Inhalationsvorrichtung und Diagnoseverfahren
US6991726B2 (en) 2002-07-01 2006-01-31 Usfilter Corporation Filter having a media retaining plate
CA2493010C (en) 2002-07-19 2011-09-13 Yale University Uveoscleral drainage device
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1594517B1 (en) 2003-01-28 2007-06-20 Microbia, Inc. Compositions for the treatment of gastrointestinal disorders
US7073363B2 (en) 2003-05-20 2006-07-11 Schumag Ag Method for processing drawn material and drawn material production installation
US7494979B2 (en) 2003-06-13 2009-02-24 Ironwood Pharmaceuticals, Inc. Method for treating congestive heart failure and other disorders
WO2005016244A2 (en) * 2003-06-13 2005-02-24 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7291125B2 (en) 2003-11-14 2007-11-06 Transcend Medical, Inc. Ocular pressure regulation
TWI393170B (zh) 2004-11-18 2013-04-11 尼康股份有限公司 A position measuring method, a position control method, a measuring method, a loading method, an exposure method, an exposure apparatus, and a device manufacturing method
WO2007022531A2 (en) 2005-08-19 2007-02-22 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20070101158A1 (en) 2005-10-28 2007-05-03 Elliott Robert C Security region in a non-volatile memory
US20090192083A1 (en) 2006-02-24 2009-07-30 Currie Mark G Methods and compositions for the treatment of gastrointestinal disorders
US7692307B2 (en) 2006-12-08 2010-04-06 Intel Corporation Compliant structure for an electronic device, method of manufacturing same, and system containing same
US8779090B2 (en) 2007-02-26 2014-07-15 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of heart failure and other disorders
US20120040025A9 (en) 2007-05-04 2012-02-16 Currie Mark G Compositions and Methods for Treating Disorders Associated with Salt or Fluid Retention
CN101772513B (zh) 2007-06-04 2013-11-13 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
EP2296685B1 (en) 2008-06-04 2015-09-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
CA2994066A1 (en) 2008-12-03 2010-06-10 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase c agonists and methods of use

Also Published As

Publication number Publication date
EP2301952A3 (en) 2011-07-06
DE60233040D1 (de) 2009-09-03
CN107029209A (zh) 2017-08-11
JP2004532208A (ja) 2004-10-21
CN102643333B (zh) 2019-04-23
JP2009001582A (ja) 2009-01-08
CN102643333A (zh) 2012-08-22
DK1379224T3 (da) 2009-11-09
EA200301070A1 (ru) 2004-04-29
JP2012149071A (ja) 2012-08-09
US20110212884A1 (en) 2011-09-01
EP2301952A2 (en) 2011-03-30
EP2103624A1 (en) 2009-09-23
US8114831B2 (en) 2012-02-14
ES2330312T5 (es) 2014-01-31
CA2441970A1 (en) 2002-10-10
EA006651B1 (ru) 2006-02-24
EP2944648B1 (en) 2019-11-13
US20140121169A1 (en) 2014-05-01
EP2103624B1 (en) 2015-03-18
US20200325176A1 (en) 2020-10-15
CA2905585A1 (en) 2002-10-10
JP4206272B2 (ja) 2009-01-07
CN1551760A (zh) 2004-12-01
ES2539132T3 (es) 2015-06-26
ES2622468T3 (es) 2017-07-06
US7799897B2 (en) 2010-09-21
CN103641892B (zh) 2015-06-17
US20030073628A1 (en) 2003-04-17
EP2944648A1 (en) 2015-11-18
US7041786B2 (en) 2006-05-09
WO2002078683A1 (en) 2002-10-10
ES2330312T3 (es) 2009-12-09
CN103638514A (zh) 2014-03-19
US20060154868A1 (en) 2006-07-13
HK1196135A1 (en) 2014-12-05
HK1217714A1 (zh) 2017-01-20
HK1136585A1 (en) 2010-07-02
EP1379224A1 (en) 2004-01-14
CN103641892A (zh) 2014-03-19
CA2795396C (en) 2015-11-17
EP2301952B1 (en) 2017-01-18
EP1379224B1 (en) 2009-07-22
PT1379224E (pt) 2009-10-22
US8637451B2 (en) 2014-01-28
CA2795396A1 (en) 2002-10-10
US20120142614A1 (en) 2012-06-07
CA2441970C (en) 2013-01-22
EP1379224B2 (en) 2013-10-02
CA2905585C (en) 2020-02-18
EP1379224A4 (en) 2005-06-22
DK1379224T4 (da) 2013-12-02

Similar Documents

Publication Publication Date Title
CY1109504T1 (el) Αγωνιστες υποδοχεα γουανυλικης κυκλασης για την θεραπεια φλεγμονης ιστου και καρκινογενεσης
ES2567708T3 (es) Inhibidores peptídicos de la vía de transducción de la señal de JNK con permeabilidad celular
van Rijn et al. Survival of human glioma cells treated with various combination of temozolomide and X-rays
Modi et al. Mode of action of granulocyte-colony stimulating factor (G-CSF) as a novel therapy for stroke in a mouse model
CY1122817T1 (el) Νεα αντι-il 13 αντισωματα και χρησεις αυτων
EA200300628A1 (ru) Соединения, специфические к аденозиновому a, aи aрецептору, и их применение
GT200000057A (es) Compuestos para tratar la obesidad.
EA200971130A1 (ru) Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
CY1105078T1 (el) Ανταγωνιστες τεκ
CY1116069T1 (el) Θεραπευτικη αγωγη της διαμεσης κυστιτιδας με υψηλη δοση θειικης χονδροϊτινης
CY2607B2 (el) Συνεργιστικος συνδυασμος αναστολεων pde και αγωνιστων αδενυλικης κυκλασης ή αγωνιστων γουανυλικης κυκλασης
CY1109786T1 (el) Μεθοδοι για την θεραπευτικη αγωγη ρευματικων ασθενειων με την χρησιμοποιηση ενος διαλυτου μοριου ctla4
ATE230614T1 (de) Krebsbehandlung mit aminophospholipide bindenden, therapeutischen konjugaten
BR0316169A (pt) Derivados de indolil pirazinona úteis para tratamento de distúrbios e doenças hiperproliferativos associados com angiogênese
CY1106285T1 (el) Χρηση αναστολεων της τυροσινης κινασης του egfr για τη θepαπεια του καρκινου του μαστου
CY1113610T1 (el) Συνθεσεις και μεθοδοι για αγωγη μιτοχονδριακων παθησεων
ECSP066294A (es) Un conjugado citotóxico ca6 antígeno-específico y métodos para utilizar el mismo
ATE450269T1 (de) Peptid pyyä3-36ü zur behandlung von stoffwechselkrankheiten
CY1109340T1 (el) Μεθοδοι θεραπειας bcl-2 διαταραχης χρησιμοποιωντας bcl-2 αντιπληροφοριακα ολιγομερη
CY1106723T1 (el) Ν-τελικα μονοπεγυλιωμενα συζευγματα ανθρωπινης αυξητικης ορμονης, διεργασιες για την παρασκευη τους και μεθοδοι χρησης αυτων
PT939627E (pt) Pentafluorobenzenossulfonamidas e analogos
BRPI0213844B8 (pt) anticorpo monoclonal humanizado purificado, composição e kit para induzir seletivamente a apoptose em células alvo que expressam dr-4, para inibir a proliferação de células alvo que expressam dr4, para tratar um paciente com câncer, para tratar um paciente tendo uma doença inflamatória ou autoimune
DE602004012858D1 (de) 2-aminobenzothiazole als cb1 rezeptor inverse agonisten
ES2181298T3 (es) Analogos de tiroxina que poseen una actividad hormonal no significativa para el tratamiento de tumores malignos.
PA8484801A1 (es) Agonistas de receptores 5-ht1 y metoclopramida para el tratamiento de la migraña