CY1109420T1 - Ενωσεις εστερα ν-αλκυλκαρβονυλ-αμινοξεος και ν-αλκυλκαρβονυλ-αμινο λακτονης και χρηση αυτων - Google Patents

Ενωσεις εστερα ν-αλκυλκαρβονυλ-αμινοξεος και ν-αλκυλκαρβονυλ-αμινο λακτονης και χρηση αυτων

Info

Publication number
CY1109420T1
CY1109420T1 CY20091100988T CY091100988T CY1109420T1 CY 1109420 T1 CY1109420 T1 CY 1109420T1 CY 20091100988 T CY20091100988 T CY 20091100988T CY 091100988 T CY091100988 T CY 091100988T CY 1109420 T1 CY1109420 T1 CY 1109420T1
Authority
CY
Cyprus
Prior art keywords
alkylcarbonyl
amino acid
lactone
ester compounds
compounds
Prior art date
Application number
CY20091100988T
Other languages
Greek (el)
English (en)
Inventor
Edward T Wei
Original Assignee
Wei, Edward T.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wei, Edward T. filed Critical Wei, Edward T.
Publication of CY1109420T1 publication Critical patent/CY1109420T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/08—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
CY20091100988T 2005-03-29 2009-09-23 Ενωσεις εστερα ν-αλκυλκαρβονυλ-αμινοξεος και ν-αλκυλκαρβονυλ-αμινο λακτονης και χρηση αυτων CY1109420T1 (el)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US66716605P 2005-03-29 2005-03-29
US68338405P 2005-05-20 2005-05-20
US70250505P 2005-07-25 2005-07-25
US20372805A 2005-08-13 2005-08-13
US77237406P 2006-02-09 2006-02-09
EP06710144A EP1871738B1 (en) 2005-03-29 2006-03-23 N-alkylcarbonyl-amino acid ester and n-alkylcarbonyl-amino lactone compounds and their use

Publications (1)

Publication Number Publication Date
CY1109420T1 true CY1109420T1 (el) 2014-08-13

Family

ID=36498694

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100988T CY1109420T1 (el) 2005-03-29 2009-09-23 Ενωσεις εστερα ν-αλκυλκαρβονυλ-αμινοξεος και ν-αλκυλκαρβονυλ-αμινο λακτονης και χρηση αυτων

Country Status (19)

Country Link
US (2) US20110082204A1 (https=)
EP (2) EP1871738B1 (https=)
JP (2) JP2008538115A (https=)
KR (1) KR20070116133A (https=)
CN (1) CN101184725B (https=)
AU (1) AU2006228280B2 (https=)
BR (1) BRPI0609784C1 (https=)
CA (1) CA2602075C (https=)
CY (1) CY1109420T1 (https=)
DE (1) DE602006007831D1 (https=)
DK (1) DK1871738T3 (https=)
ES (1) ES2328847T3 (https=)
IL (1) IL186297A0 (https=)
MX (1) MX2007011831A (https=)
PL (1) PL1871738T3 (https=)
PT (1) PT1871738E (https=)
SI (1) SI1871738T1 (https=)
WO (1) WO2006103401A2 (https=)
ZA (1) ZA200709252B (https=)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2618560T3 (es) * 2005-03-29 2017-06-21 Axalbion Sa Éster isopropílico del ácido [((1R,2S,5R)-2-isopropil-5-metil-ciclohexanocarbonil)-amino]-acético y compuestos relacionados y su uso en terapia
DE102006047162A1 (de) * 2006-09-29 2008-04-03 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit Kombinationen aus (R)-2-[((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-propionsäure methyl ester und einer oder mehreren Lichtschutzfiltersubstanzen
DE102006047164A1 (de) * 2006-09-29 2008-04-03 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an 2-Isopropyl-5-Methyl-Cyclohexancarbonyl-D-Alaninmethylester und einem oder mehreren Hautbefeuchtungsmitteln
EP1913976A1 (de) * 2006-10-18 2008-04-23 Symrise GmbH & Co. KG N-alpha-(Menthancarbonyl)aminosäureamide und deren Verwendung als physiologische Kühlwirkstoffe
JP2010509299A (ja) * 2006-11-08 2010-03-25 ウェイ，エドワード，タク Ｎ−アルキルカルボニル−ｄ−アミノ酸ヒドロキシアルキルエステル化合物およびそれらの使用
EP2014333A1 (en) * 2007-07-12 2009-01-14 Hakiman Shargh Research Company Use of cooling agents for treatment or prevention of lacrimation or eye burning
GB2451503B (en) * 2007-08-01 2011-10-12 Lrc Products Stimulating gel comprising a cyclic carboxamide coolant
WO2009081107A1 (en) * 2007-12-21 2009-07-02 Paget, Hugh, Charles, Edward P-menthawe-3-carboxylic acid esters to treat airways diseases
DE102008015424A1 (de) * 2008-03-20 2009-09-24 Beiersdorf Ag Kühlende kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridyn-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5- methylcyclohexancarboxamid mit Menthoxypropandiol
DE102008015426A1 (de) * 2008-03-20 2009-09-24 Beiersdorf Ag Kühlende kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridyn-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexancarboxamid zu Reduktion von Hautrötungen
MX2011001724A (es) 2008-08-15 2011-03-21 Procter & Gamble Sintesis de derivados de ciclohexano utiles como agentes de sensacion en productos de consumo.
BRPI0917997A2 (pt) 2008-08-15 2015-11-17 Procter & Gamble solução de mentanocarboxamidas para uso em produtos destinados ao consumidor
EP2346475B2 (en) 2008-11-20 2023-04-19 The Procter & Gamble Company Personal care compositions providing enhanced cooling sensation
AU2010255540A1 (en) * 2009-06-05 2012-01-19 Edward Tak Wei Treatment of eye discomfort by topical administration of a cooling agent to the external surface of the eyelid
US9446267B2 (en) 2009-10-06 2016-09-20 Symrise Ag Products comprising a flavoring agent composition
EP2364689B1 (de) 2009-10-06 2019-12-11 Symrise AG Mentholhaltige Zahnputz-Zusammensetzung mit reduzierter Bitterwahrnehmung
US20120014883A1 (en) 2010-07-19 2012-01-19 Douglas Craig Scott Compositions Comprising Derivatives Of Essential Oil Compounds And Use In Personal Care Products
US9937115B2 (en) 2010-10-01 2018-04-10 The Procter & Gamble Company Oral care compositions with improved flavor
CN103339103B (zh) * 2010-12-06 2015-06-17 魏德烽 [((1r,2s,5r)-2-异丙基-5-甲基-环己烷羰基)-氨基]乙酸异丙酯和相关化合物及它们在治疗中的应用
WO2012098342A1 (en) 2011-01-18 2012-07-26 Paget, Hugh, Charles, Edward (r)-1,2-propanediol for use as a solvent in therapeutic cooling agent compositions
US8426463B2 (en) * 2011-04-04 2013-04-23 Edward T. Wei [((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester and related compounds and their use in therapy
US20130042482A1 (en) 2011-08-16 2013-02-21 Valerie Jean Bradford Skin Engaging Member Comprising An Anti-Irritation Agent
ES2689171T3 (es) 2011-09-01 2018-11-08 The Procter & Gamble Company Composiciones para el cuidado bucal con reología mejorada
US20150272161A1 (en) * 2011-12-21 2015-10-01 Wm. Wrigley Jr. Company Chewing gum products containing (r)-2-[((1r,2s,5r)-2-isopropyl-5-methylclohexanecarbonyl)-amino]-acetic acid isopropyl ester
US20130315843A1 (en) 2012-05-25 2013-11-28 The Procter & Gamble Company Composition for reduction of trpa1 and trpv1 sensations
CA2882090C (en) 2012-09-28 2018-07-10 The Gillette Company A skin engaging member comprising at least one thermally resilient sensate
BR112015006847B1 (pt) 2012-09-28 2020-02-04 Gillette Co um elemento auxiliar de barbeamento ou depilação de contato com a pele que compreende ao menos uma substância sensibilizante termicamente resiliente
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
JP6352413B2 (ja) 2013-10-22 2018-07-04 エドワード タク ウェイＷＥＩ， Ｅｄｗａｒｄ Ｔａｋ 感覚的不快感の治療向け局所薬としてのジ−イソプロピル−アルカン（ｄａｐａ）化合物
WO2015059433A1 (en) 2013-10-22 2015-04-30 Edward Tak Wei 1-di(sec-butyl)-phosphinoyl-pentane (dapa-2-5) as a topical agent for the treatment of discomfort from non-keratinized stratified epithelial (nkse) tissue
US9884130B2 (en) 2013-11-13 2018-02-06 The Procter & Gamble Company Compositions for delivery of oral comfort sensations
CN106029175A (zh) 2014-02-27 2016-10-12 宝洁公司 具有减少的苦味感受的口腔护理组合物
US20150272847A1 (en) 2014-03-26 2015-10-01 The Gillette Company Skin Engaging Shaving Aid Comprising A Thermally Resilient Sensate And A TRPA1 Receptor Inhibitor
US20150273711A1 (en) 2014-03-26 2015-10-01 The Gillette Company Razor Comprising A Molded Shaving Aid Composition Comprising A Thermally Resilient Sensate
AU2015249706A1 (en) 2014-04-23 2016-11-03 The Procter & Gamble Company Cyclohexanecarboxamide with cooling properties
WO2016025414A1 (en) 2014-08-15 2016-02-18 The Procter & Gamble Company Oral care compositions and regimens
MX2017002099A (es) 2014-08-15 2017-05-04 Procter & Gamble Composiciones para el cuidado bucal con una experiencia sensorial mejorada.
MX2017002100A (es) 2014-08-15 2017-05-04 Procter & Gamble Dentifrico con sustancias quimicas incrementales.
AU2015353904B2 (en) 2014-11-26 2018-12-20 The Gillette Company Llc A skin engaging member comprising ethylene vinyl acetate
US9951295B2 (en) 2015-02-19 2018-04-24 The Procter & Gamble Company Compositions for deposition on biological surfaces
AR104220A1 (es) 2015-04-09 2017-07-05 Procter & Gamble Reducción de la aversión al sabor del cpc mediante la reducción de la activación del cpc de los receptores de trpa1, receptores de trpv1, o ambos
CN107920571A (zh) * 2015-06-30 2018-04-17 Wm.雷格利 Jr.公司 长效清凉制剂
EP3365324A1 (en) 2015-10-22 2018-08-29 The Procter and Gamble Company Synthesis of cyclohexane carboxamide derivatives useful as sensates in consumer products
JP2018533567A (ja) * 2015-10-22 2018-11-15 ザ プロクター アンド ギャンブル カンパニー クロマトグラフィー分離方法
WO2017106279A1 (en) 2015-12-18 2017-06-22 The Procter & Gamble Company Synthesis of cyclohexane ester derivatives useful as sensates in consumer products
CA3018598A1 (en) 2016-04-01 2017-10-05 The Procter & Gamble Company Oral care compositions containing gel networks and potassium nitrate
BR112018069979A2 (pt) 2016-04-01 2019-02-05 Procter & Gamble composições para tratamento bucal contendo nitrato de potássio e peróxido
MX2018011991A (es) 2016-04-01 2019-02-13 Procter & Gamble Composiciones para el cuidado bucal con una exhibicion de saborizante eficaz.
CA3018552A1 (en) 2016-04-01 2017-10-05 The Procter & Gamble Company Oral care compositions containing a gel network phase and potassium nitrate
WO2017173198A1 (en) 2016-04-01 2017-10-05 The Procter & Gamble Company Oral care compositions containing a gel network phase
US20170334082A1 (en) 2016-05-18 2017-11-23 The Gillette Company Llc Skin Engaging Member Comprising Ethylene Vinyl Acetate
US10538881B2 (en) 2016-10-25 2020-01-21 The Procter & Gamble Company Fibrous structures
CA3036897C (en) 2016-10-25 2021-11-16 The Procter & Gamble Company Fibrous structures
US20180117780A1 (en) 2016-11-03 2018-05-03 The Gillette Company Llc Skin engaging member comprising ethylene vinyl acetate
US10898425B2 (en) 2016-11-17 2021-01-26 The Gillette Company Llc Skin engaging member comprising ethylene vinyl acetate and a fragrance
WO2018144678A1 (en) * 2017-02-03 2018-08-09 The Johns Hopkins University Mini-cancers utilization for personalized cancer drug regimens
CN112423729B (zh) 2018-05-28 2023-07-11 宝洁公司 清凉感觉剂在口腔中的沉积功效改善的口腔护理组合物
KR102132713B1 (ko) 2018-12-04 2020-07-13 주식회사 오스테온 모발 또는 두피 상태 개선용 조성물
GB201908219D0 (en) * 2019-06-10 2019-07-24 Axalbion Sa Therapeutic use of a compound
EP4216915A1 (en) 2020-09-28 2023-08-02 The Procter & Gamble Company Oral care composition comprising hops and flavor
JP7592526B2 (ja) * 2021-03-19 2024-12-02 株式会社マンダム Ｔｒｐｖ１活性抑制剤、およびその利用
US12397518B2 (en) * 2021-04-29 2025-08-26 Coopervision International Limited WS12-releasing contact lens
MX2023012062A (es) 2021-05-11 2023-10-23 Procter & Gamble Composiciones para el cuidado bucal que comprenden copolimero de bloque.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150052A (en) * 1971-02-04 1979-04-17 Wilkinson Sword Limited N-substituted paramenthane carboxamides
US4136163A (en) * 1971-02-04 1979-01-23 Wilkinson Sword Limited P-menthane carboxamides having a physiological cooling effect
GB1351761A (en) * 1971-02-04 1974-05-01 Wilkinson Sword Ltd Substituted p-menthane carboxamides and compositions containing them
PH10359A (en) * 1971-02-04 1977-01-05 Wilkinson Sword Ltd N-substituted-p-methane-3-carboxamides having physiological cooling activity and compositions containing them
US4178459A (en) * 1971-02-04 1979-12-11 Wilkinson Sword Limited N-Substituted paramenthane carboxamides
US3889804A (en) * 1973-03-14 1975-06-17 Gorham Int Inc Disposable towel
JP2978043B2 (ja) * 1993-09-16 1999-11-15 高砂香料工業株式会社 （２ｓ）−３−｛（１ｒ，２ｓ，５ｒ）−［ ５−メチル−２−（１−メチルエチル）シクロヘキシル ］オキシ｝−１，２−プロパンジオール，その製造方法および用途
US7189760B2 (en) * 2004-04-02 2007-03-13 Millennium Specialty Chemicals Physiological cooling compositions containing highly purified ethyl ester of N-[[5-methyl-2-(1-methylethyl) cyclohexyl] carbonyl]glycine
US20080227857A1 (en) * 2005-03-29 2008-09-18 Edward Tak Wei N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use

Also Published As

Publication number Publication date
US8853267B2 (en) 2014-10-07
BRPI0609784A2 (pt) 2010-04-27
CA2602075A1 (en) 2006-10-05
EP2161252A1 (en) 2010-03-10
EP1871738A2 (en) 2008-01-02
US20110152366A1 (en) 2011-06-23
EP1871738B1 (en) 2009-07-15
BRPI0609784A8 (pt) 2017-07-11
US20110082204A1 (en) 2011-04-07
BRPI0609784B8 (pt) 2020-07-21
PL1871738T3 (pl) 2009-12-31
WO2006103401A2 (en) 2006-10-05
BRPI0609784B1 (pt) 2020-07-07
CN101184725B (zh) 2012-03-21
DK1871738T3 (da) 2009-09-21
PT1871738E (pt) 2009-09-11
ES2328847T3 (es) 2009-11-18
JP2011068656A (ja) 2011-04-07
ZA200709252B (en) 2009-04-29
BRPI0609784C1 (pt) 2021-05-25
JP2008538115A (ja) 2008-10-09
SI1871738T1 (sl) 2009-12-31
AU2006228280B2 (en) 2012-08-30
KR20070116133A (ko) 2007-12-06
MX2007011831A (es) 2007-11-21
CN101184725A (zh) 2008-05-21
HK1106761A1 (en) 2008-03-20
IL186297A0 (en) 2008-01-20
DE602006007831D1 (de) 2009-08-27
CA2602075C (en) 2014-04-29
WO2006103401A3 (en) 2007-03-08
AU2006228280A1 (en) 2006-10-05

Similar Documents

Publication Publication Date Title
CY1109420T1 (el) Ενωσεις εστερα ν-αλκυλκαρβονυλ-αμινοξεος και ν-αλκυλκαρβονυλ-αμινο λακτονης και χρηση αυτων
ATE417610T1 (de) Zusammensetzung enthaltend 6-ä3-(1-adamantyl)-4- methoxyphenylü-2-naphthanoesäure zur behandlung dermatologischer erkrankungen
CY1116057T1 (el) Παραγωγα κιναζολιν-4(3η)-ονης που χρησιμοποιουνται ως αναστολεις κινασης ρι3
EA200801580A1 (ru) Новые производные пирониндола и способ их получения
ATE416177T1 (de) Hetaryloxy-substituierte phenylaminopyrimidine als rho-kinasehemmer
CY1110812T1 (el) Παραγωγα διφαινυλοξυοξικου οξεος για τη θεραπεια αναπνευστικων διαταραχων
ATE453642T1 (de) Substituierte phenylaminopyrimidine
IL189104A (en) Pharmaceutical preparation containing lasalazide or sodium balasalazide for use in the treatment of gastrointestinal disorders.
ATE538651T1 (de) Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
NO20063047L (no) Vandige ciclesonidsuspensjoner for forstoving
ATE555116T1 (de) Ahcy-hydrolasehemmer zur behandlung von hyperhomocysteinämie
DE602005017503D1 (de) Biphenyloxyessigsäure - derivate zur behandlung von atemwegserkränkungen
NO20076405L (no) Anvendelse av 24-nor-UDCA
ATE336996T1 (de) Verwendung von flavonoid-derivaten zur behandlung von atopischem ekzem
ATE456955T1 (de) Verwendung von cyclodextrin zur behandlung und vorbeugung von entzündlichen bronchialerkrankungen
CY1116234T1 (el) Υποκατεστημενα 2-οξυ-κινολινο-3-καρβοξαμιδια σαν διαμορφωτες kcnq2/3
CY1111778T1 (el) Παραγωγα θειοξανθενιου ως μοναδικοι αντιμολυσματικοι παραγοντες για χρηση στην αντιμετωπιση των μολυσματικων ασθενειων
ATE524488T1 (de) Lysobactinamide
MY145448A (en) Acylated nonadepsipeptides used as lysobactin derivatives
ATE527997T1 (de) Verwendung von aminapthon zur herstellung eines medikaments zur behandlung von arteriopathien
ATE455789T1 (de) Substituierte nonadepsipeptide
ATE410443T1 (de) Heterocyclyl-substituierte nonadepsipeptide
ATE460168T1 (de) Nicht-radioaktives strontiummittel zur behandlung von krebs
ATE524463T1 (de) 4-chromenonyl-1,4-dihydropyridincarbonitrile und ihre verwendung
ATE477820T1 (de) Pharmazeutische zusammensetzungen zur oralen verabreichung bei der behandlung von adipositas- patienten