PL1871738T3 - Związki estrów N-alkilokarbonylo-aminokwasów i N-alkilokarbonylo-aminolaktonów i ich zastosowanie - Google Patents

Związki estrów N-alkilokarbonylo-aminokwasów i N-alkilokarbonylo-aminolaktonów i ich zastosowanie

Info

Publication number
PL1871738T3
PL1871738T3 PL06710144T PL06710144T PL1871738T3 PL 1871738 T3 PL1871738 T3 PL 1871738T3 PL 06710144 T PL06710144 T PL 06710144T PL 06710144 T PL06710144 T PL 06710144T PL 1871738 T3 PL1871738 T3 PL 1871738T3
Authority
PL
Poland
Prior art keywords
alkylcarbonyl
amino
acid ester
amino acid
lactone compounds
Prior art date
Application number
PL06710144T
Other languages
English (en)
Inventor
Edward T Wei
Original Assignee
Edward T Wei
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edward T Wei filed Critical Edward T Wei
Publication of PL1871738T3 publication Critical patent/PL1871738T3/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/08—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
PL06710144T 2005-03-29 2006-03-23 Związki estrów N-alkilokarbonylo-aminokwasów i N-alkilokarbonylo-aminolaktonów i ich zastosowanie PL1871738T3 (pl)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US66716605P 2005-03-29 2005-03-29
US68338405P 2005-05-20 2005-05-20
US70250505P 2005-07-25 2005-07-25
US20372805A 2005-08-13 2005-08-13
US77237406P 2006-02-09 2006-02-09
EP06710144A EP1871738B1 (en) 2005-03-29 2006-03-23 N-alkylcarbonyl-amino acid ester and n-alkylcarbonyl-amino lactone compounds and their use
PCT/GB2006/001093 WO2006103401A2 (en) 2005-03-29 2006-03-23 N-alkylcarbonyl-amino acid ester and n-alkylcarbonyl-amino lactone compounds and their use

Publications (1)

Publication Number Publication Date
PL1871738T3 true PL1871738T3 (pl) 2009-12-31

Family

ID=36498694

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06710144T PL1871738T3 (pl) 2005-03-29 2006-03-23 Związki estrów N-alkilokarbonylo-aminokwasów i N-alkilokarbonylo-aminolaktonów i ich zastosowanie

Country Status (20)

Country Link
US (2) US20110082204A1 (pl)
EP (2) EP2161252A1 (pl)
JP (2) JP2008538115A (pl)
KR (1) KR20070116133A (pl)
CN (1) CN101184725B (pl)
AU (1) AU2006228280B2 (pl)
BR (1) BRPI0609784C1 (pl)
CA (1) CA2602075C (pl)
CY (1) CY1109420T1 (pl)
DE (1) DE602006007831D1 (pl)
DK (1) DK1871738T3 (pl)
ES (1) ES2328847T3 (pl)
HK (1) HK1106761A1 (pl)
IL (1) IL186297A0 (pl)
MX (1) MX2007011831A (pl)
PL (1) PL1871738T3 (pl)
PT (1) PT1871738E (pl)
SI (1) SI1871738T1 (pl)
WO (1) WO2006103401A2 (pl)
ZA (1) ZA200709252B (pl)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2618560T3 (es) * 2005-03-29 2017-06-21 Axalbion Sa Éster isopropílico del ácido [((1R,2S,5R)-2-isopropil-5-metil-ciclohexanocarbonil)-amino]-acético y compuestos relacionados y su uso en terapia
DE102006047164A1 (de) * 2006-09-29 2008-04-03 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an 2-Isopropyl-5-Methyl-Cyclohexancarbonyl-D-Alaninmethylester und einem oder mehreren Hautbefeuchtungsmitteln
DE102006047162A1 (de) * 2006-09-29 2008-04-03 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit Kombinationen aus (R)-2-[((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-propionsäure methyl ester und einer oder mehreren Lichtschutzfiltersubstanzen
EP1913976A1 (de) * 2006-10-18 2008-04-23 Symrise GmbH & Co. KG N-alpha-(Menthancarbonyl)aminosäureamide und deren Verwendung als physiologische Kühlwirkstoffe
DE602007009283D1 (de) * 2006-11-08 2010-10-28 Edward T Wei En und ihre verwendung
EP2014333A1 (en) * 2007-07-12 2009-01-14 Hakiman Shargh Research Company Use of cooling agents for treatment or prevention of lacrimation or eye burning
GB2451503B (en) * 2007-08-01 2011-10-12 Lrc Products Stimulating gel comprising a cyclic carboxamide coolant
CN101903023A (zh) * 2007-12-21 2010-12-01 爱德华·塔克·韦 治疗呼吸道疾病的对薄荷烷3-羧酸酯
DE102008015426A1 (de) * 2008-03-20 2009-09-24 Beiersdorf Ag Kühlende kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridyn-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexancarboxamid zu Reduktion von Hautrötungen
DE102008015424A1 (de) * 2008-03-20 2009-09-24 Beiersdorf Ag Kühlende kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridyn-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5- methylcyclohexancarboxamid mit Menthoxypropandiol
MX2011001724A (es) 2008-08-15 2011-03-21 Procter & Gamble Sintesis de derivados de ciclohexano utiles como agentes de sensacion en productos de consumo.
MX2011001725A (es) 2008-08-15 2011-03-21 Procter & Gamble Solucion en mentano carboxamida para usar en productos de consumo.
BRPI0920909B1 (pt) 2008-11-20 2017-04-18 Procter & Gamble método de acentuação e/ou modulação da atividade de um ou mais agentes refrigerantes não mentol e composições de cuidados pessoais para uso oral
EP2437719A1 (en) * 2009-06-05 2012-04-11 Edward Tak Wei Treatment of eye discomfort by topical administration of a cooling agent to the external surface of the eyelid
US9446267B2 (en) 2009-10-06 2016-09-20 Symrise Ag Products comprising a flavoring agent composition
EP2364689B1 (de) 2009-10-06 2019-12-11 Symrise AG Mentholhaltige Zahnputz-Zusammensetzung mit reduzierter Bitterwahrnehmung
WO2012012385A2 (en) 2010-07-19 2012-01-26 The Procter & Gamble Company Compositions comprising derivatives of essential oil compounds and use in personal care products
AU2011308857B2 (en) 2010-10-01 2015-11-05 The Procter & Gamble Company Oral care compositions with improved flavor
AU2011340295B2 (en) * 2010-12-06 2016-11-03 Axalbion Sa [((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester and related compounds and their use in therapy
JP2014508740A (ja) 2011-01-18 2014-04-10 ウェイ，エドワード，タク 治療用冷却剤組成物における溶媒としての使用のための（ｒ）−１，２−プロパンジオール
US8426463B2 (en) * 2011-04-04 2013-04-23 Edward T. Wei [((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester and related compounds and their use in therapy
US20130042482A1 (en) 2011-08-16 2013-02-21 Valerie Jean Bradford Skin Engaging Member Comprising An Anti-Irritation Agent
AU2012302149B2 (en) 2011-09-01 2015-08-13 The Procter & Gamble Company Oral care compositions with improved rheology
WO2013096405A1 (en) 2011-12-21 2013-06-27 Wm. Wrigley Jr. Company Chewing gum products containing [(2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester
US20130315843A1 (en) 2012-05-25 2013-11-28 The Procter & Gamble Company Composition for reduction of trpa1 and trpv1 sensations
CA2882090C (en) 2012-09-28 2018-07-10 The Gillette Company A skin engaging member comprising at least one thermally resilient sensate
EP2900332B1 (en) 2012-09-28 2017-08-02 The Gillette Company LLC A skin engaging shaving aid member comprising at least one thermally resilient sensate
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
CA2959231C (en) 2013-10-22 2022-06-21 Edward Tak Wei Di-isopropyl-phosphinoyl-alkane (dapa) compounds as topical agents for the treatment of sensory discomfort
AU2013403623A1 (en) 2013-10-22 2016-06-09 Edward Tak Wei 1-di(sec-butyl)-phosphinoyl-pentane (DAPA-2-5) as a topical agent for the treatment of discomfort from non-keratinized stratified epithelial (NKSE) tissue
US9884130B2 (en) 2013-11-13 2018-02-06 The Procter & Gamble Company Compositions for delivery of oral comfort sensations
CN106029175A (zh) 2014-02-27 2016-10-12 宝洁公司 具有减少的苦味感受的口腔护理组合物
US20150273711A1 (en) 2014-03-26 2015-10-01 The Gillette Company Razor Comprising A Molded Shaving Aid Composition Comprising A Thermally Resilient Sensate
US20150272847A1 (en) 2014-03-26 2015-10-01 The Gillette Company Skin Engaging Shaving Aid Comprising A Thermally Resilient Sensate And A TRPA1 Receptor Inhibitor
EP3134081B1 (en) 2014-04-23 2020-04-22 The Procter and Gamble Company Cyclohexanecarboxamide with cooling properties
CN106572950A (zh) 2014-08-15 2017-04-19 宝洁公司 口腔护理组合物和方案
AU2015301623B2 (en) 2014-08-15 2018-10-18 The Procter & Gamble Company Oral care compositions with an enhanced sensory experience
CN111939090A (zh) 2014-08-15 2020-11-17 宝洁公司 具有增量化学物质的牙粉
MX2017006347A (es) 2014-11-26 2017-08-21 Gillette Co Llc Un miembro de acoplamiento con la piel que comprende acetato de etilenvinilo.
US9951295B2 (en) 2015-02-19 2018-04-24 The Procter & Gamble Company Compositions for deposition on biological surfaces
US9993410B2 (en) 2015-04-09 2018-06-12 The Procter & Gamble Company Reduction in CPC taste aversion by reducing CPC activation of TRPA1, TPRV1, or both
US20180184680A1 (en) * 2015-06-30 2018-07-05 Wm. Wrigley Jr. Company Long-lasting cooling formulations
EP3365324A1 (en) * 2015-10-22 2018-08-29 The Procter and Gamble Company Synthesis of cyclohexane carboxamide derivatives useful as sensates in consumer products
EP3364940B1 (en) 2015-10-22 2019-08-07 The Procter and Gamble Company Method of chromatographic separation
EP3390352A1 (en) 2015-12-18 2018-10-24 The Procter and Gamble Company Synthesis of cyclohexane ester derivatives useful as sensates in consumer products
WO2017173197A1 (en) 2016-04-01 2017-10-05 The Procter & Gamble Company Oral care compositions containing a gel network phase and potassium nitrate
MX2018011989A (es) 2016-04-01 2019-02-13 Procter & Gamble Composiciones para el cuidado bucal que contienen una fase de red de gel.
EP3435960A1 (en) 2016-04-01 2019-02-06 The Procter and Gamble Company Oral care compositions containing potassium nitrate and peroxide
CN108883039A (zh) 2016-04-01 2018-11-23 宝洁公司 具有有效风味显示的口腔护理组合物
CA3018598A1 (en) 2016-04-01 2017-10-05 The Procter & Gamble Company Oral care compositions containing gel networks and potassium nitrate
US20170334082A1 (en) 2016-05-18 2017-11-23 The Gillette Company Llc Skin Engaging Member Comprising Ethylene Vinyl Acetate
WO2018081189A1 (en) 2016-10-25 2018-05-03 The Procter & Gamble Company Fibrous structures
US10745865B2 (en) 2016-10-25 2020-08-18 The Procter & Gamble Company Creped fibrous structures
WO2018085479A1 (en) 2016-11-03 2018-05-11 The Gillette Company Llc Skin engaging member comprising ethylene vinyl acetate
US10898425B2 (en) 2016-11-17 2021-01-26 The Gillette Company Llc Skin engaging member comprising ethylene vinyl acetate and a fragrance
WO2018144678A1 (en) * 2017-02-03 2018-08-09 The Johns Hopkins University Mini-cancers utilization for personalized cancer drug regimens
MX2020012655A (es) 2018-05-28 2022-05-11 Procter & Gamble Composicion para el cuidado bucal con eficacia de deposito mejorada de un agente de sensacion de frescura en la cavidad bucal.
KR102132713B1 (ko) 2018-12-04 2020-07-13 주식회사 오스테온 모발 또는 두피 상태 개선용 조성물
MX2023003549A (es) 2020-09-28 2023-04-21 Procter & Gamble Composiciones para el cuidado bucal que comprenden lupulo y saborizante.
US20220370334A1 (en) 2021-05-11 2022-11-24 The Procter & Gamble Company Oral Care Compositions Comprising Block Copolymer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178459A (en) * 1971-02-04 1979-12-11 Wilkinson Sword Limited N-Substituted paramenthane carboxamides
PH10359A (en) * 1971-02-04 1977-01-05 Wilkinson Sword Ltd N-substituted-p-methane-3-carboxamides having physiological cooling activity and compositions containing them
GB1351761A (en) * 1971-02-04 1974-05-01 Wilkinson Sword Ltd Substituted p-menthane carboxamides and compositions containing them
US4150052A (en) * 1971-02-04 1979-04-17 Wilkinson Sword Limited N-substituted paramenthane carboxamides
US4136163A (en) * 1971-02-04 1979-01-23 Wilkinson Sword Limited P-menthane carboxamides having a physiological cooling effect
US3889804A (en) * 1973-03-14 1975-06-17 Gorham Int Inc Disposable towel
JP2978043B2 (ja) * 1993-09-16 1999-11-15 高砂香料工業株式会社 （２ｓ）−３−｛（１ｒ，２ｓ，５ｒ）−［ ５−メチル−２−（１−メチルエチル）シクロヘキシル ］オキシ｝−１，２−プロパンジオール，その製造方法および用途
US7189760B2 (en) * 2004-04-02 2007-03-13 Millennium Specialty Chemicals Physiological cooling compositions containing highly purified ethyl ester of N-[[5-methyl-2-(1-methylethyl) cyclohexyl] carbonyl]glycine
US20080227857A1 (en) * 2005-03-29 2008-09-18 Edward Tak Wei N-Alkylcarbonyl-Amino Acid Ester and N-Alkylcarbonyl-Amino Lactone Compounds and Their Use

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