AR104220A1 - Reducción de la aversión al sabor del cpc mediante la reducción de la activación del cpc de los receptores de trpa1, receptores de trpv1, o ambos - Google Patents

Reducción de la aversión al sabor del cpc mediante la reducción de la activación del cpc de los receptores de trpa1, receptores de trpv1, o ambos

Info

Publication number
AR104220A1
AR104220A1 ARP160100963A ARP160100963A AR104220A1 AR 104220 A1 AR104220 A1 AR 104220A1 AR P160100963 A ARP160100963 A AR P160100963A AR P160100963 A ARP160100963 A AR P160100963A AR 104220 A1 AR104220 A1 AR 104220A1
Authority
AR
Argentina
Prior art keywords
receivers
reduction
cpc
trpa1
trpv1
Prior art date
Application number
ARP160100963A
Other languages
English (en)
Inventor
Jean Lepont Pierig
Anne Marie - Hightower Carrita
Lin Yakang
Tatachar Sreekrishna Koti
Christian Haught John
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of AR104220A1 publication Critical patent/AR104220A1/es

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/121Ketones acyclic
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365Hydroxycarboxylic acids; Ketocarboxylic acids
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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    • A61K8/41Amines
    • A61K8/415Aminophenols
    • AHUMAN NECESSITIES
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/445Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof aromatic, i.e. the carboxylic acid directly linked to the aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
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    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
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    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Un método para detectar compuestos y composiciones que reducen la activación del cloruro de cetilpiridinio del receptor de TRPA1 o el receptor de TRPV1.
ARP160100963A 2015-04-09 2016-04-08 Reducción de la aversión al sabor del cpc mediante la reducción de la activación del cpc de los receptores de trpa1, receptores de trpv1, o ambos AR104220A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562145383P 2015-04-09 2015-04-09

Publications (1)

Publication Number Publication Date
AR104220A1 true AR104220A1 (es) 2017-07-05

Family

ID=55863204

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160100963A AR104220A1 (es) 2015-04-09 2016-04-08 Reducción de la aversión al sabor del cpc mediante la reducción de la activación del cpc de los receptores de trpa1, receptores de trpv1, o ambos

Country Status (10)

Country Link
US (2) US9993410B2 (es)
EP (2) EP3381453A3 (es)
CN (1) CN107438424A (es)
AR (1) AR104220A1 (es)
AU (1) AU2016245865B2 (es)
BR (1) BR112017021315A2 (es)
CA (1) CA2981612C (es)
MX (1) MX2017012946A (es)
RU (1) RU2017137525A (es)
WO (1) WO2016164676A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3381453A3 (en) 2015-04-09 2018-12-12 The Procter & Gamble Company Reduction in cpc taste aversion by reducing cpc activation of trpa1 receptors, tprv1 receptors, or both
EP4171227A4 (en) * 2020-06-30 2024-08-21 Isp Investments Llc ANTIMICROBIAL ORAL CARE COMPOSITION, METHOD OF PREPARING THE SAME AND METHOD OF USING THE SAME
CN113197293B (zh) * 2021-06-01 2022-09-09 云南中烟工业有限责任公司 一种利用肉桂醛调控葡萄糖溶液甜味值的方法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2946725A (en) 1957-03-25 1960-07-26 Procter & Gamble Dentifrice compositions
US3070510A (en) 1959-11-03 1962-12-25 Procter & Gamble Dentifrice containing resinous cleaning agents
US3111127A (en) 1961-06-27 1963-11-19 Brown & Williamson Tobacco Smoking tobacco product and method of making the same
US3538230A (en) 1966-12-05 1970-11-03 Lever Brothers Ltd Oral compositions containing silica xerogels as cleaning and polishing agents
US3678154A (en) 1968-07-01 1972-07-18 Procter & Gamble Oral compositions for calculus retardation
US3535421A (en) 1968-07-11 1970-10-20 Procter & Gamble Oral compositions for calculus retardation
US4178459A (en) 1971-02-04 1979-12-11 Wilkinson Sword Limited N-Substituted paramenthane carboxamides
US4150052A (en) 1971-02-04 1979-04-17 Wilkinson Sword Limited N-substituted paramenthane carboxamides
GB1315626A (en) 1971-02-04 1973-05-02 Wilkinson Sword Ltd Substituted p-menthanes and compositions containing them
US4136163A (en) 1971-02-04 1979-01-23 Wilkinson Sword Limited P-menthane carboxamides having a physiological cooling effect
US4157384A (en) 1972-01-28 1979-06-05 Wilkinson Sword Limited Compositions having a physiological cooling effect
BE795751A (fr) 1972-02-28 1973-08-21 Unilever Nv Compositions aromatisees contenant des composes qui donnent une sensation de froid
GB1421743A (en) 1972-04-18 1976-01-21 Wilkinson Sword Ltd Ingestible topical and other compositions
US4153679A (en) 1972-04-18 1979-05-08 Wilkinson Sword Limited Acyclic carboxamides having a physiological cooling effect
GB1436329A (en) 1972-08-07 1976-05-19 Unilever Ltd Esters of menthol and a heterocyclic carboxylic acid and their use in cosmetic preparations
GB1434728A (en) 1972-09-27 1976-05-05 Wilkinson Sword Ltd Compositions and articles containing phospine oxides having a physiological cooling effect and phosphine oxides for use therein
US3862307A (en) 1973-04-09 1975-01-21 Procter & Gamble Dentifrices containing a cationic therapeutic agent and improved silica abrasive
LU68016A1 (es) 1973-07-13 1975-04-11
US4051234A (en) 1975-06-06 1977-09-27 The Procter & Gamble Company Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies
US4206215A (en) 1976-02-25 1980-06-03 Sterling Drug Inc. Antimicrobial bis-[4-(substituted-amino)-1-pyridinium]alkanes
US4340583A (en) 1979-05-23 1982-07-20 J. M. Huber Corporation High fluoride compatibility dentifrice abrasives and compositions
JPS56139423A (en) * 1980-04-02 1981-10-30 Toyo Seiyaku Kasei Kk Hemostatic agent for dental oral use
JPS5888334A (ja) 1981-11-20 1983-05-26 Takasago Corp 3−l−メントキシプロパン−1、2−ジオ−ル
KR890700319A (ko) 1987-03-10 1989-04-24 원본 미기재 소금 맛 증진제
US5004597A (en) 1987-09-14 1991-04-02 The Procter & Gamble Company Oral compositions comprising stannous flouride and stannous gluconate
EP0310299A1 (en) 1987-09-28 1989-04-05 The Procter & Gamble Company Beta-amino acid ester derivatives of alcoholic actives having extended duration of activity
US5180577A (en) 1990-10-09 1993-01-19 Colgate-Palmolive Stabilized bis biguanide/anionic active ingredient compositions
FI915219A (fi) 1990-11-06 1992-05-07 Wrigley W M Jun Co Oekad smak medelst mentonketaler.
DE4110973A1 (de) 1991-04-05 1992-10-08 Haarmann & Reimer Gmbh Mittel mit physiologischem kuehleffekt und fuer diese mittel geeignete wirksame verbindungen
US5281410A (en) 1991-10-23 1994-01-25 The Proctor & Gamble Company Methods of reducing plaque and gingivitis with reduced staining
ATE158163T1 (de) 1992-05-18 1997-10-15 Procter & Gamble Zusammensetzungen mit kühleffekt
DE4226043A1 (de) 1992-08-06 1994-02-10 Haarmann & Reimer Gmbh Mittel mit physiologischem Kühleffekt und für diese Mittel geeignete wirksame Verbindungen
JP2978043B2 (ja) 1993-09-16 1999-11-15 高砂香料工業株式会社 (2s)−3−{(1r,2s,5r)−[ 5−メチル−2−(1−メチルエチル)シクロヘキシル ]オキシ}−1,2−プロパンジオール,その製造方法および用途
US5603920A (en) 1994-09-26 1997-02-18 The Proctor & Gamble Company Dentifrice compositions
US5578293A (en) 1994-12-06 1996-11-26 Colgate Palmolive Company Oral compositions containing stabilized stannous compounds having antiplaque and antitartar efficacy
US5589160A (en) 1995-05-02 1996-12-31 The Procter & Gamble Company Dentifrice compositions
US5658553A (en) 1995-05-02 1997-08-19 The Procter & Gamble Company Dentifrice compositions
US5651958A (en) 1995-05-02 1997-07-29 The Procter & Gamble Company Dentifrice compositions
US5725865A (en) 1995-08-29 1998-03-10 V. Mane Fils S.A. Coolant compositions
US5843466A (en) 1995-08-29 1998-12-01 V. Mane Fils S.A. Coolant compositions
US5716601A (en) 1996-03-22 1998-02-10 The Procter & Gamble Company Dentifrice compositions
GB9820233D0 (en) 1998-09-18 1998-11-11 Quest Int Improvements in or relating to insect repellents
NO990975A (no) * 1999-03-01 2000-02-21 Orix As Oralt preparat som er effektivt mot halitose
JP2001294546A (ja) 2000-02-28 2001-10-23 Takasago Internatl Corp (1’R,2’S,5’R)3−l−メントキシアルカン−1−オール冷感剤
DE60131804D1 (de) 2000-05-23 2008-01-24 Nestle Sa Verwendung von alpha-Ketoenaminderivaten als kühlende Mittel
DE10036184A1 (de) 2000-07-24 2002-02-14 Aventis Cropscience Gmbh Substituierte Sulfonylaminomethylbenzoesäure(derivate) und Verfahren zu ihrer Herstellung
US6365215B1 (en) 2000-11-09 2002-04-02 International Flavors & Fragrances Inc. Oral sensory perception-affecting compositions containing dimethyl sulfoxide, complexes thereof and salts thereof
MXPA04008173A (es) * 2002-02-22 2004-11-26 Pharmacia Corp Formulaciones de farmaco antibiotico oftalmico que contienen un compuesto de ciclodextrina y cloruro de cetil piridinio.
US6723305B2 (en) * 2002-03-04 2004-04-20 Colgate Palmolive Company Anti-microbial breath freshening mouthrinse
US20050031717A1 (en) 2003-07-09 2005-02-10 Desimone John A. Salt taste modification
ATE464283T1 (de) 2003-11-21 2010-04-15 Givaudan Sa N-substituierte p-menthancarbonsäureamide
US7189760B2 (en) 2004-04-02 2007-03-13 Millennium Specialty Chemicals Physiological cooling compositions containing highly purified ethyl ester of N-[[5-methyl-2-(1-methylethyl) cyclohexyl] carbonyl]glycine
PL1871738T3 (pl) 2005-03-29 2009-12-31 Edward T Wei Związki estrów N-alkilokarbonylo-aminokwasów i N-alkilokarbonylo-aminolaktonów i ich zastosowanie
US20080153845A1 (en) 2006-10-27 2008-06-26 Redpoint Bio Corporation Trpv1 antagonists and uses thereof
US8962057B2 (en) * 2009-04-29 2015-02-24 The Procter & Gamble Company Methods for improving taste and oral care compositions with improved taste
US9044429B2 (en) * 2010-01-15 2015-06-02 The Gillette Company Personal care compositions comprising a methyl naphthalenyl ketone or a derivative thereof
AU2011308857B2 (en) * 2010-10-01 2015-11-05 The Procter & Gamble Company Oral care compositions with improved flavor
CA2834828A1 (en) * 2011-05-12 2012-11-15 B.R.A.I.N. Biotechnology Research And Information Network Ag Small molecule inhibitors of trpa1
US20130315843A1 (en) * 2012-05-25 2013-11-28 The Procter & Gamble Company Composition for reduction of trpa1 and trpv1 sensations
EP3381453A3 (en) 2015-04-09 2018-12-12 The Procter & Gamble Company Reduction in cpc taste aversion by reducing cpc activation of trpa1 receptors, tprv1 receptors, or both

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AU2016245865B2 (en) 2019-04-11
AU2016245865A1 (en) 2017-10-26
MX2017012946A (es) 2018-01-30
RU2017137525A (ru) 2019-05-13
US10111819B2 (en) 2018-10-30
US20160296445A1 (en) 2016-10-13
EP3381453A3 (en) 2018-12-12
US20170333325A1 (en) 2017-11-23
EP3280411B1 (en) 2020-02-19
AU2016245865A8 (en) 2017-11-02
CN107438424A (zh) 2017-12-05
US9993410B2 (en) 2018-06-12
RU2017137525A3 (es) 2019-05-13
BR112017021315A2 (pt) 2018-06-26
CA2981612C (en) 2019-07-23
CA2981612A1 (en) 2016-10-13
EP3280411A1 (en) 2018-02-14
WO2016164676A1 (en) 2016-10-13

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