CY1106781T1 - Περιορισμενα ως προς τη διαμορφωση κυκλοποιημενα στην κυρια αλυσιδα αναλογα σωματοστατινης - Google Patents

Περιορισμενα ως προς τη διαμορφωση κυκλοποιημενα στην κυρια αλυσιδα αναλογα σωματοστατινης

Info

Publication number
CY1106781T1
CY1106781T1 CY20071101021T CY071101021T CY1106781T1 CY 1106781 T1 CY1106781 T1 CY 1106781T1 CY 20071101021 T CY20071101021 T CY 20071101021T CY 071101021 T CY071101021 T CY 071101021T CY 1106781 T1 CY1106781 T1 CY 1106781T1
Authority
CY
Cyprus
Prior art keywords
main chain
somatostatin
somatostatin analogues
conformation
disclosed
Prior art date
Application number
CY20071101021T
Other languages
English (en)
Inventor
Vered Hornik
Michel M. Afargan
Gary Gellerman
Original Assignee
Develogen Israel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/100,360 external-priority patent/US6051554A/en
Application filed by Develogen Israel Ltd filed Critical Develogen Israel Ltd
Publication of CY1106781T1 publication Critical patent/CY1106781T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/28—Testing of electronic circuits, e.g. by signal tracer
    • G01R31/317—Testing of digital circuits
    • G01R31/3181—Functional testing
    • G01R31/31816—Soft error testing; Soft error rate evaluation; Single event testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/28—Testing of electronic circuits, e.g. by signal tracer
    • G01R31/317—Testing of digital circuits
    • G01R31/3181—Functional testing
    • G01R31/3185—Reconfiguring for testing, e.g. LSSD, partitioning
    • G01R31/318533—Reconfiguring for testing, e.g. LSSD, partitioning using scanning techniques, e.g. LSSD, Boundary Scan, JTAG
    • G01R31/318541—Scan latches or cell details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Αποκαλύπτονται νέα πεπτίδια τα οποία είναι περιορισμένα ως προς τη διαμόρφωση ανάλογα σωματοστασίνης με κυκλοποιημένη κύρια αλυσίδα, έχοντας υποδοχέα σωματοστασίνης υπότυπος επιλεκτικότητας. Αυτά τα στοιχεία της επιλεκτικότητας του υπότυπου υποδοχέα παρέχουν στοιχεία έχοντας βελτιώσει τη θεραπευτική χρήση. Μέθοδοι για σύνθεση των αναλόγων σωματοστασίνης και για προσεχτική εξέταση των αναλόγων σωματοστασίνης αποκαλύπτονται επίσης. Επίσης, αποκαλύπτονται φαρμακευτικές συνθέσεις περιλαμβάνοντας ανάλογα σωματοστάσης και μέθοδοι για τη χρήση τέτοιων ενώσεων.
CY20071101021T 1998-06-19 2007-08-01 Περιορισμενα ως προς τη διαμορφωση κυκλοποιημενα στην κυρια αλυσιδα αναλογα σωματοστατινης CY1106781T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/100,360 US6051554A (en) 1995-06-07 1998-06-19 Conformationally constrained backbone cyclized somatostatin analogs
US09/203,389 US6355613B1 (en) 1996-07-31 1998-12-02 Conformationally constrained backbone cyclized somatostatin analogs
PCT/IL1999/000329 WO1999065508A1 (en) 1998-06-19 1999-06-15 Conformationally constrained backbone cyclized somatostatin analogs

Publications (1)

Publication Number Publication Date
CY1106781T1 true CY1106781T1 (el) 2012-05-23

Family

ID=26797065

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101021T CY1106781T1 (el) 1998-06-19 2007-08-01 Περιορισμενα ως προς τη διαμορφωση κυκλοποιημενα στην κυρια αλυσιδα αναλογα σωματοστατινης

Country Status (14)

Country Link
US (3) US6355613B1 (el)
EP (1) EP1085896B1 (el)
JP (1) JP4637352B2 (el)
KR (1) KR100689402B1 (el)
AT (1) ATE362371T1 (el)
AU (1) AU747515B2 (el)
CA (1) CA2335488C (el)
CY (1) CY1106781T1 (el)
DE (1) DE69936100T2 (el)
DK (1) DK1085896T3 (el)
ES (1) ES2288029T3 (el)
IL (1) IL139956A0 (el)
NZ (1) NZ508956A (el)
WO (1) WO1999065508A1 (el)

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EP3405429B1 (en) * 2016-01-21 2021-07-28 Ramot at Tel-Aviv University Ltd. Formation of functionalized nanoparticles by supramolecular co-assembly
WO2017141106A1 (en) * 2016-02-16 2017-08-24 Strongbridge Biopharma plc Veldoreotide with poor solubitliy in physiological conditions for use in the treatment of acromegaly, acromegaly cancer, sst-r5 expressing tumors, type 2 diabetes, hyperglycemia, and hormone-related tumors
EP3464325A1 (en) 2016-06-07 2019-04-10 Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. Backbone cyclized inhibitory peptides of myeloid differentiation factor 88 (myd88)
US11261215B2 (en) 2017-09-19 2022-03-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Somatostatin prodrugs
US20220119474A1 (en) 2019-02-21 2022-04-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Par4 derived peptides, analogs and uses thereof
WO2022003673A1 (en) 2020-06-30 2022-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Humanin analogs and uses thereof
TW202400577A (zh) 2021-09-14 2024-01-01 美商美國禮來大藥廠 Sstr4促效劑鹽

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Also Published As

Publication number Publication date
ES2288029T3 (es) 2007-12-16
JP2002518339A (ja) 2002-06-25
US20050043226A1 (en) 2005-02-24
CA2335488C (en) 2011-08-23
DK1085896T3 (da) 2007-09-10
EP1085896A4 (en) 2005-04-06
AU4288499A (en) 2000-01-05
ATE362371T1 (de) 2007-06-15
US6930088B2 (en) 2005-08-16
AU747515B2 (en) 2002-05-16
IL139956A0 (en) 2002-02-10
NZ508956A (en) 2003-06-30
JP4637352B2 (ja) 2011-02-23
US7060679B2 (en) 2006-06-13
DE69936100T2 (de) 2008-02-07
CA2335488A1 (en) 1999-12-23
EP1085896A1 (en) 2001-03-28
WO1999065508A1 (en) 1999-12-23
KR100689402B1 (ko) 2007-03-08
KR20010071523A (ko) 2001-07-28
DE69936100D1 (de) 2007-06-28
EP1085896B1 (en) 2007-05-16
US6355613B1 (en) 2002-03-12
US20020052315A1 (en) 2002-05-02

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