ATE362371T1 - Somatostatin-analoge mit einer zyklisierten konformationsbeschränkten hauptkette - Google Patents

Somatostatin-analoge mit einer zyklisierten konformationsbeschränkten hauptkette

Info

Publication number
ATE362371T1
ATE362371T1 AT99957020T AT99957020T ATE362371T1 AT E362371 T1 ATE362371 T1 AT E362371T1 AT 99957020 T AT99957020 T AT 99957020T AT 99957020 T AT99957020 T AT 99957020T AT E362371 T1 ATE362371 T1 AT E362371T1
Authority
AT
Austria
Prior art keywords
main chain
somatostatin
somatostatin analogues
disclosed
somatostatin analogs
Prior art date
Application number
AT99957020T
Other languages
English (en)
Inventor
Vered Hornik
Michel Afargan
Gary Gellerman
Original Assignee
Develogen Israel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/100,360 external-priority patent/US6051554A/en
Application filed by Develogen Israel Ltd filed Critical Develogen Israel Ltd
Application granted granted Critical
Publication of ATE362371T1 publication Critical patent/ATE362371T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/28—Testing of electronic circuits, e.g. by signal tracer
    • G01R31/317—Testing of digital circuits
    • G01R31/3181—Functional testing
    • G01R31/31816—Soft error testing; Soft error rate evaluation; Single event testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/28—Testing of electronic circuits, e.g. by signal tracer
    • G01R31/317—Testing of digital circuits
    • G01R31/3181—Functional testing
    • G01R31/3185—Reconfiguring for testing, e.g. LSSD, partitioning
    • G01R31/318533—Reconfiguring for testing, e.g. LSSD, partitioning using scanning techniques, e.g. LSSD, Boundary Scan, JTAG
    • G01R31/318541—Scan latches or cell details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99957020T 1998-06-19 1999-06-15 Somatostatin-analoge mit einer zyklisierten konformationsbeschränkten hauptkette ATE362371T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/100,360 US6051554A (en) 1995-06-07 1998-06-19 Conformationally constrained backbone cyclized somatostatin analogs
US09/203,389 US6355613B1 (en) 1996-07-31 1998-12-02 Conformationally constrained backbone cyclized somatostatin analogs

Publications (1)

Publication Number Publication Date
ATE362371T1 true ATE362371T1 (de) 2007-06-15

Family

ID=26797065

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99957020T ATE362371T1 (de) 1998-06-19 1999-06-15 Somatostatin-analoge mit einer zyklisierten konformationsbeschränkten hauptkette

Country Status (14)

Country Link
US (3) US6355613B1 (de)
EP (1) EP1085896B1 (de)
JP (1) JP4637352B2 (de)
KR (1) KR100689402B1 (de)
AT (1) ATE362371T1 (de)
AU (1) AU747515B2 (de)
CA (1) CA2335488C (de)
CY (1) CY1106781T1 (de)
DE (1) DE69936100T2 (de)
DK (1) DK1085896T3 (de)
ES (1) ES2288029T3 (de)
IL (1) IL139956A0 (de)
NZ (1) NZ508956A (de)
WO (1) WO1999065508A1 (de)

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US6355613B1 (en) 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
CA2284459C (en) * 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
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AU2001288847A1 (en) * 2000-09-07 2002-03-22 Biosyntema Inc. Conformationally constrained labeled peptides for imaging and therapy
CA2433785C (en) * 2001-01-12 2009-08-04 Michael Dewitt Culler Pharmaceutical compositions which inhibit vascular proliferation and method of use thereof
DE60226419D1 (de) * 2001-03-08 2008-06-19 Univ Tulane Somatostatin-antagonisten
MXPA03009048A (es) * 2001-04-09 2004-02-12 Univ Tulane Agonistas de la somatostatina.
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AU2002359359A1 (en) * 2001-12-28 2003-07-24 Somatocor Pharmaceuticals, Inc. Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands
IL148921A0 (en) * 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
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JP4928263B2 (ja) 2003-07-31 2012-05-09 トランザイム・ファーマ ペプチド結合サロゲートを組み入れた空間的に規定された大環状分子
GB0318682D0 (en) 2003-08-08 2003-09-10 Novartis Ag Organic compounds
ITFI20040057A1 (it) * 2004-03-10 2004-06-10 Mauro Giuntini Analoghi della somatostatina
US20050287557A1 (en) * 2004-05-10 2005-12-29 Suad Efendic Methods for identifying compounds for treating diabetes mellitus
US20070025910A1 (en) 2005-07-29 2007-02-01 Norenberg Jeffrey P Anticancer therapy
WO2007093999A1 (en) * 2006-02-15 2007-08-23 Intec Pharma Ltd. A gastro-retentive system for the delivery of macromolecules
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RU2010114010A (ru) * 2007-09-11 2011-10-20 Мондобайотек Лабораториз Аг (Li) Применение октреотида в качестве терапевтического средства
US20120270774A1 (en) 2009-08-28 2012-10-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection
EP2604281B1 (de) * 2011-12-14 2014-07-30 Centre National de la Recherche Scientifique (CNRS) Geklickte, somatostatinkonjugierte Analoga für biologische Anwendungen
EP2807182A1 (de) 2012-01-23 2014-12-03 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Stabilisierte peptid-helices zur hemmung der dimerisierung von chemokin-c-motiv-rezeptor 2 (ccr2)
US9371282B2 (en) 2013-05-17 2016-06-21 Centrexion Therapeutics Corporation Somatostatin receptor subtype 4 (SSTR4) agonists
WO2015087334A1 (en) 2013-12-15 2015-06-18 Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. Viperistatin-derived peptides and uses thereof
EP3135686A1 (de) * 2015-08-28 2017-03-01 Latvian Biomedical Research and Study Centre Neuartiges rekombinantes cyclisiertes menschliches wachstumshormon
EP3405429B1 (de) * 2016-01-21 2021-07-28 Ramot at Tel-Aviv University Ltd. Bildung von funktionalisierten nanopartikeln durch supramolekulare co-assemblierung
WO2017141106A1 (en) * 2016-02-16 2017-08-24 Strongbridge Biopharma plc Veldoreotide with poor solubitliy in physiological conditions for use in the treatment of acromegaly, acromegaly cancer, sst-r5 expressing tumors, type 2 diabetes, hyperglycemia, and hormone-related tumors
EP3464325A1 (de) 2016-06-07 2019-04-10 Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. Rückgrat-zyklisierte inhibitorpeptide des myeloiden differenzierungsfaktors 88 (myd88)
US11261215B2 (en) 2017-09-19 2022-03-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Somatostatin prodrugs
US20220119474A1 (en) 2019-02-21 2022-04-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Par4 derived peptides, analogs and uses thereof
WO2022003673A1 (en) 2020-06-30 2022-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Humanin analogs and uses thereof
TW202400577A (zh) 2021-09-14 2024-01-01 美商美國禮來大藥廠 Sstr4促效劑鹽

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Also Published As

Publication number Publication date
ES2288029T3 (es) 2007-12-16
JP2002518339A (ja) 2002-06-25
US20050043226A1 (en) 2005-02-24
CA2335488C (en) 2011-08-23
DK1085896T3 (da) 2007-09-10
EP1085896A4 (de) 2005-04-06
CY1106781T1 (el) 2012-05-23
AU4288499A (en) 2000-01-05
US6930088B2 (en) 2005-08-16
AU747515B2 (en) 2002-05-16
IL139956A0 (en) 2002-02-10
NZ508956A (en) 2003-06-30
JP4637352B2 (ja) 2011-02-23
US7060679B2 (en) 2006-06-13
DE69936100T2 (de) 2008-02-07
CA2335488A1 (en) 1999-12-23
EP1085896A1 (de) 2001-03-28
WO1999065508A1 (en) 1999-12-23
KR100689402B1 (ko) 2007-03-08
KR20010071523A (ko) 2001-07-28
DE69936100D1 (de) 2007-06-28
EP1085896B1 (de) 2007-05-16
US6355613B1 (en) 2002-03-12
US20020052315A1 (en) 2002-05-02

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