DE69936100D1 - Somatostatin-analoge mit einer zyklisierten konformationsbeschränkten hauptkette - Google Patents

Somatostatin-analoge mit einer zyklisierten konformationsbeschränkten hauptkette

Info

Publication number
DE69936100D1
DE69936100D1 DE69936100T DE69936100T DE69936100D1 DE 69936100 D1 DE69936100 D1 DE 69936100D1 DE 69936100 T DE69936100 T DE 69936100T DE 69936100 T DE69936100 T DE 69936100T DE 69936100 D1 DE69936100 D1 DE 69936100D1
Authority
DE
Germany
Prior art keywords
cycled
somatostatin
disclosed
somatostatin analogue
somatostatin analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69936100T
Other languages
English (en)
Other versions
DE69936100T2 (de
Inventor
Vered Hornik
Michel M Afargan
Gary Gellerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Peptor Ltd
Original Assignee
Peptor Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/100,360 external-priority patent/US6051554A/en
Application filed by Peptor Ltd filed Critical Peptor Ltd
Application granted granted Critical
Publication of DE69936100D1 publication Critical patent/DE69936100D1/de
Publication of DE69936100T2 publication Critical patent/DE69936100T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/28—Testing of electronic circuits, e.g. by signal tracer
    • G01R31/317—Testing of digital circuits
    • G01R31/3181—Functional testing
    • G01R31/31816—Soft error testing; Soft error rate evaluation; Single event testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/28—Testing of electronic circuits, e.g. by signal tracer
    • G01R31/317—Testing of digital circuits
    • G01R31/3181—Functional testing
    • G01R31/3185—Reconfiguring for testing, e.g. LSSD, partitioning
    • G01R31/318533—Reconfiguring for testing, e.g. LSSD, partitioning using scanning techniques, e.g. LSSD, Boundary Scan, JTAG
    • G01R31/318541—Scan latches or cell details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69936100T 1998-06-19 1999-06-15 Somatostatin-analoge mit einer zyklisierten konformationsbeschränkten hauptkette Expired - Lifetime DE69936100T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US203389 1988-06-07
US100360 1998-06-19
US09/100,360 US6051554A (en) 1995-06-07 1998-06-19 Conformationally constrained backbone cyclized somatostatin analogs
US09/203,389 US6355613B1 (en) 1996-07-31 1998-12-02 Conformationally constrained backbone cyclized somatostatin analogs
PCT/IL1999/000329 WO1999065508A1 (en) 1998-06-19 1999-06-15 Conformationally constrained backbone cyclized somatostatin analogs

Publications (2)

Publication Number Publication Date
DE69936100D1 true DE69936100D1 (de) 2007-06-28
DE69936100T2 DE69936100T2 (de) 2008-02-07

Family

ID=26797065

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69936100T Expired - Lifetime DE69936100T2 (de) 1998-06-19 1999-06-15 Somatostatin-analoge mit einer zyklisierten konformationsbeschränkten hauptkette

Country Status (14)

Country Link
US (3) US6355613B1 (de)
EP (1) EP1085896B1 (de)
JP (1) JP4637352B2 (de)
KR (1) KR100689402B1 (de)
AT (1) ATE362371T1 (de)
AU (1) AU747515B2 (de)
CA (1) CA2335488C (de)
CY (1) CY1106781T1 (de)
DE (1) DE69936100T2 (de)
DK (1) DK1085896T3 (de)
ES (1) ES2288029T3 (de)
IL (1) IL139956A0 (de)
NZ (1) NZ508956A (de)
WO (1) WO1999065508A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
US6355613B1 (en) 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
CA2284459C (en) 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
WO2002020610A2 (en) * 2000-09-07 2002-03-14 Biosynthema Inc. Conformationally constrained labeled peptides for imaging and therapy
AU2002243552C1 (en) * 2001-01-12 2006-08-31 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Pharmaceutical compositions which inhibit vascular proliferation and method of use thereof
CA2439498A1 (en) * 2001-03-08 2002-09-19 The Administrators Of The Tulane Educational Fund Somatostatin antagonists
HUP0303727A2 (hu) * 2001-04-09 2004-03-01 The Administrators Of The Tulane Educational Fund Szomatosztatin agonisták és ezek alkalmazása
EP1283216A1 (de) * 2001-08-10 2003-02-12 Mallinckrodt Inc. Alle somatostatinrezeptorsubtypen-bindende Somatostatinanaloge und deren Verwendung
AU2002359359A1 (en) * 2001-12-28 2003-07-24 Somatocor Pharmaceuticals, Inc. Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands
IL148921A0 (en) * 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
IL150384A0 (en) * 2002-06-24 2002-12-01 Peptor Ltd Radiolabelled somatostatin analogs backbone cyclized through metal complexation
US7550431B2 (en) 2003-07-31 2009-06-23 Tranzyme Pharma Inc. Spatially-defined macrocycles incorporating peptide bond surrogates
GB0318682D0 (en) 2003-08-08 2003-09-10 Novartis Ag Organic compounds
ITFI20040057A1 (it) * 2004-03-10 2004-06-10 Mauro Giuntini Analoghi della somatostatina
US20050287557A1 (en) * 2004-05-10 2005-12-29 Suad Efendic Methods for identifying compounds for treating diabetes mellitus
US20070025910A1 (en) 2005-07-29 2007-02-01 Norenberg Jeffrey P Anticancer therapy
US20090304768A1 (en) * 2006-02-15 2009-12-10 Intec Pharma Ltd Gastro-Retentive System for the Delivery of Macromolecules
CN1904150B (zh) * 2006-08-01 2010-07-28 华东师范大学 一种人胰高血糖素样肽-1衍生物及其固相化学合成
KR20100058555A (ko) * 2007-09-11 2010-06-03 몬도바이오테크 래보래토리즈 아게 치료제로서의 ｂｐｐ－ｂ의 용도
US20120270774A1 (en) 2009-08-28 2012-10-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection
EP2604281B1 (de) * 2011-12-14 2014-07-30 Centre National de la Recherche Scientifique (CNRS) Geklickte, somatostatinkonjugierte Analoga für biologische Anwendungen
EP2807182A1 (de) 2012-01-23 2014-12-03 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Stabilisierte peptid-helices zur hemmung der dimerisierung von chemokin-c-motiv-rezeptor 2 (ccr2)
US9371282B2 (en) 2013-05-17 2016-06-21 Centrexion Therapeutics Corporation Somatostatin receptor subtype 4 (SSTR4) agonists
WO2015087334A1 (en) 2013-12-15 2015-06-18 Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. Viperistatin-derived peptides and uses thereof
EP3135686A1 (de) * 2015-08-28 2017-03-01 Latvian Biomedical Research and Study Centre Neuartiges rekombinantes cyclisiertes menschliches wachstumshormon
US11389544B2 (en) * 2016-01-21 2022-07-19 Ramot At Tel-Aviv University Ltd. Formation of functionalized cancer targeting nanoparticles by supramolecular co-assembly
EP3416666B1 (de) * 2016-02-16 2021-10-27 Strongbridge Dublin Limited Pharmazeutische zusammensetzungen von wasserlöslichem veldoreotid mit schlechter löslichkeit in physilogischen bedingungen und herstellungsmethoden
US10662225B2 (en) 2016-06-07 2020-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Backbone cyclized inhibitory peptides of myeloid differentiation factor 88 (MyD88)
US11261215B2 (en) 2017-09-19 2022-03-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Somatostatin prodrugs
EP3927737A1 (de) 2019-02-21 2021-12-29 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Von par4 abgeleitete peptide, analoge und deren verwendungen
WO2022003673A1 (en) 2020-06-30 2022-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Humanin analogs and uses thereof
AR127055A1 (es) 2021-09-14 2023-12-13 Lilly Co Eli Sales agonistas de sstr4

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011182A (en) 1975-03-21 1977-03-08 American Home Products Corporation Cyclic undecapeptide analogs of somatostatin and intermediates
US3988304A (en) 1975-08-25 1976-10-26 American Home Products Corporation Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof
US4054558A (en) 1976-05-24 1977-10-18 American Home Products Corporation Cyclic dodecapeptide and intermediates therefor
SU798098A1 (ru) 1977-12-14 1981-01-23 Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp Циклический аналог брадикинина,обла-дАющий СпОСОбНОСТью СОздАВАТь пРОлОНги-РОВАННый дЕпРЕССОРНый эффЕКТ B эКСпЕРиМЕН-TE ,A ТАКжЕ ВАСКул РНую пРОНи-цАЕМОСТь B эКСпЕРиМЕНТЕ
US4191754A (en) 1979-02-28 1980-03-04 Merck & Co., Inc. Bicyclic somatostatin analogs
US4235886A (en) 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4310518A (en) 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
DE19375086I2 (de) * 1979-11-27 2003-01-09 Novartis Ag Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung
US4369179A (en) * 1979-12-14 1983-01-18 Ciba-Geigy Corporation Acylpeptides
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
US4923963A (en) 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
EP0334244A3 (de) 1988-03-25 1991-05-29 The Procter & Gamble Company Peptide-Antagonisten von Bradykinin
WO1989009783A1 (en) 1988-04-08 1989-10-19 Scripps Clinic And Research Foundation Polypeptides stabilized by covalent hydrogen bond replacements
IE63490B1 (en) 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
HU207104B (en) * 1991-01-25 1993-03-01 Biosignal Kutato Fejlesztoe Kf Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
EP0588905A1 (de) 1991-06-03 1994-03-30 Mallinckrodt Medical, Inc. Radioaktiv markierte somatostatinderivate, ihre herstellung und verwendung
DE4119544C1 (de) 1991-06-13 1992-10-15 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig, De
US5364851A (en) 1991-06-14 1994-11-15 International Synthecon, Llc Conformationally restricted biologically active peptides, methods for their production and uses thereof
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
IL99628A (en) 1991-10-02 2004-07-25 Yissum Res Dev Co Processes for the preparation of cyclic peptides, and pharmaceutical compositions containing them
US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
DE69330494T2 (de) 1992-02-05 2002-03-28 Mallinckrodt Inc Radioaktiv markierte somatostatin
US5411943A (en) * 1992-02-25 1995-05-02 Biomeasure, Inc. Hepatoma treatment with somatostatin analogs
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5371070A (en) 1992-11-09 1994-12-06 The Salk Institute For Biological Studies Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
NZ250653A (en) 1993-01-12 1995-12-21 Sandoz Ltd Somatostatin derivatives and pharmaceutical or diagnostic imaging compositions
SG48977A1 (en) * 1993-06-23 1998-05-18 Diatide Inc Radiolabeled peptides
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
IL109943A (en) 1994-06-08 2006-08-01 Develogen Israel Ltd Conformationally constrained backbone cyclized peptide analogs
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
US6051554A (en) * 1995-06-07 2000-04-18 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US6025372A (en) * 1997-04-04 2000-02-15 Merck & Co., Inc. Somatostatin agonists
US6335613B1 (en) * 2000-12-04 2002-01-01 Abb T&D Technology Ltd. Versatile power flow transformers for compensating power flow in a transmission line

Also Published As

Publication number Publication date
EP1085896B1 (de) 2007-05-16
CA2335488A1 (en) 1999-12-23
US7060679B2 (en) 2006-06-13
KR20010071523A (ko) 2001-07-28
AU4288499A (en) 2000-01-05
AU747515B2 (en) 2002-05-16
DE69936100T2 (de) 2008-02-07
US20050043226A1 (en) 2005-02-24
WO1999065508A1 (en) 1999-12-23
ES2288029T3 (es) 2007-12-16
JP2002518339A (ja) 2002-06-25
ATE362371T1 (de) 2007-06-15
EP1085896A4 (de) 2005-04-06
US6930088B2 (en) 2005-08-16
US20020052315A1 (en) 2002-05-02
EP1085896A1 (de) 2001-03-28
CY1106781T1 (el) 2012-05-23
IL139956A0 (en) 2002-02-10
KR100689402B1 (ko) 2007-03-08
JP4637352B2 (ja) 2011-02-23
NZ508956A (en) 2003-06-30
DK1085896T3 (da) 2007-09-10
US6355613B1 (en) 2002-03-12
CA2335488C (en) 2011-08-23

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