CU24309B1 - Compuestos derivados tienopirimidina y composiciones farmacéuticas que los contienen - Google Patents
Compuestos derivados tienopirimidina y composiciones farmacéuticas que los contienenInfo
- Publication number
- CU24309B1 CU24309B1 CUP2014000143A CU20140143A CU24309B1 CU 24309 B1 CU24309 B1 CU 24309B1 CU P2014000143 A CUP2014000143 A CU P2014000143A CU 20140143 A CU20140143 A CU 20140143A CU 24309 B1 CU24309 B1 CU 24309B1
- Authority
- CU
- Cuba
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- tienopirimidine
- derivative compounds
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1363500A FR3015483B1 (fr) | 2013-12-23 | 2013-12-23 | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20140143A7 CU20140143A7 (es) | 2016-07-29 |
CU24309B1 true CU24309B1 (es) | 2018-01-10 |
Family
ID=50829005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2014000143A CU24309B1 (es) | 2013-12-23 | 2014-12-17 | Compuestos derivados tienopirimidina y composiciones farmacéuticas que los contienen |
Country Status (48)
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2965173A1 (en) | 2014-10-29 | 2016-05-06 | The Walter And Eliza Hall Institute Of Medical Research | Use of therapeutic agents |
EP3337805A4 (en) * | 2015-05-27 | 2019-04-03 | Pharmascience Inc. | INHIBITORS OF THE ENZYME FAMILY KINASES TEC |
FR3037959B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3037957B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3037956B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3037958B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR3046792B1 (fr) * | 2016-01-19 | 2018-02-02 | Les Laboratoires Servier | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
EP3454856A4 (en) | 2016-05-10 | 2019-12-25 | C4 Therapeutics, Inc. | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
MA45718A (fr) * | 2016-07-22 | 2019-05-29 | Servier Lab | Combinaison d'un inhibiteur de bcl-2 et d'un inhibiteur de mcl-1, utilisations et compositions pharmaceutiques associées |
TWI759316B (zh) * | 2016-07-22 | 2022-04-01 | 法商施維雅藥廠 | Bcl-2抑制劑及mcl1抑制劑之組合、其用途及醫藥組合物 |
TN2019000117A1 (en) * | 2016-10-28 | 2020-10-05 | Servier Lab | Liposomal formulation for use in the treatment of cancer |
WO2018126898A1 (zh) * | 2017-01-05 | 2018-07-12 | 河南美泰宝生物制药有限公司 | 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用 |
UY37560A (es) * | 2017-01-06 | 2018-07-31 | Servier Lab | Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta |
US10765680B2 (en) * | 2017-01-06 | 2020-09-08 | Les Laboratories Servier | Combination of a MCL-1 inhibitor and a taxane compound, uses and pharmaceutical compositions thereof |
EA039621B1 (ru) * | 2017-06-09 | 2022-02-17 | Ле Лаборатуар Сервье | Комбинация bcl-2 ингибитора и mcl-1 ингибитора, их применения и фармацевтические композиции |
WO2018234433A1 (en) * | 2017-06-22 | 2018-12-27 | Les Laboratoires Servier | COMBINATION OF MCL-1 INHIBITOR AND CARE TREATMENT STANDARD FOR HEMATOLOGICAL CANCERS, USES AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS |
GB201712282D0 (en) * | 2017-07-31 | 2017-09-13 | Nodthera Ltd | Selective inhibitors of NLRP3 inflammasome |
WO2019035927A1 (en) * | 2017-08-15 | 2019-02-21 | Abbvie Inc. | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE |
JP2020531433A (ja) * | 2017-08-15 | 2020-11-05 | アッヴィ・インコーポレイテッド | 大環状mcl−1阻害剤及び使用の方法 |
TW201920204A (zh) * | 2017-08-15 | 2019-06-01 | 美商艾伯維有限公司 | 大環mcl-1抑制劑以及使用方法 |
CN107573360B (zh) * | 2017-10-27 | 2019-08-09 | 都创(上海)医药科技有限公司 | 一种多靶点小分子化合物s63845的制备方法 |
CN111372936B (zh) * | 2017-11-23 | 2022-12-02 | 北京赛林泰医药技术有限公司 | Mcl-1选择性抑制剂及其制备和用途 |
CN108424417B (zh) * | 2017-12-21 | 2019-09-20 | 河南真实生物科技有限公司 | 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用 |
CN110964034B (zh) * | 2018-09-29 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 嘧啶并噻吩类衍生物、其制备方法及其在医药上的应用 |
AR116635A1 (es) | 2018-10-15 | 2021-05-26 | Servier Lab | Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen |
TW202038960A (zh) | 2018-11-14 | 2020-11-01 | 法商施維雅藥廠 | Mcl-1抑制劑及米哚妥林(midostaurin)之組合,其用途及醫藥組合物 |
CN111187277B (zh) * | 2018-11-14 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用 |
MA54379B1 (fr) | 2018-12-06 | 2023-12-29 | Servier Lab | Nouvelles formes cristallines d'un thienopyrimidine inhibiteur de mcl-1 |
CN113453679A (zh) | 2018-12-20 | 2021-09-28 | C4医药公司 | 靶向蛋白降解 |
EP3972651A2 (en) | 2019-05-20 | 2022-03-30 | Novartis AG | Mcl-1 inhibitor antibody-drug conjugates and methods of use |
WO2020254299A1 (en) | 2019-06-17 | 2020-12-24 | Les Laboratoires Servier | Combination of a mcl-1 inhibitor and a standard of care treatment for breast cancer, uses and pharmaceutical compositions thereof |
AR119494A1 (es) | 2019-07-29 | 2021-12-22 | Servier Lab | DERIVADOS DE 6,7-DIHIDRO-5H-PIRIDO[2,3-c]PIRIDAZIN-8-ILO, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN Y SUS USOS COMO AGENTES PROAPOPTÓTICOS |
AR119493A1 (es) | 2019-07-29 | 2021-12-22 | Servier Lab | Derivados de 3,6-diamino-piridazin-3-ilo, composiciones farmacéuticas que los contienen y sus usos como agentes proapoptóticos |
CN114746428A (zh) * | 2019-10-03 | 2022-07-12 | 加利福尼亚技术学院 | Mcl1抑制剂及其应用 |
CN113024577B (zh) * | 2019-12-09 | 2023-06-30 | 首药控股(北京)股份有限公司 | 一种抗凋亡蛋白选择性抑制剂的制备方法 |
CN113024578A (zh) * | 2019-12-09 | 2021-06-25 | 首药控股(北京)有限公司 | 一种mcl1选择性抑制剂的多晶型物及其制备方法 |
WO2022090443A1 (en) | 2020-10-30 | 2022-05-05 | Les Laboratoires Servier | Administration and dose regimen for a combination of a bcl-2 inhibitor and a mcl1 inhibitor |
KR20230138444A (ko) | 2020-11-24 | 2023-10-05 | 노파르티스 아게 | Mcl-1 억제제 항체-약물 접합체 및 사용 방법 |
EP4251209A1 (en) | 2020-11-24 | 2023-10-04 | Novartis AG | Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
UY39609A (es) | 2021-01-12 | 2022-08-31 | Servier Lab | Nuevos derivados de espirociclohexano, composiciones farmacéuticas que los contienen y sus usos como inhibidores antiapoptóticos |
KR20230170644A (ko) | 2021-02-02 | 2023-12-19 | 르 라보레또레 쎄르비에르 | 선택적 bcl-xl protac 화합물 및 사용 방법 |
WO2022216946A1 (en) * | 2021-04-07 | 2022-10-13 | California Institute Of Technology | Mcl1 inhibitors and uses thereof |
WO2022255888A1 (en) * | 2021-06-01 | 2022-12-08 | Captor Therapeutics S.A. | Targeted protein degradation using bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
CA3222752A1 (en) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-body drug conjugates |
TW202315637A (zh) | 2021-06-11 | 2023-04-16 | 美商基利科學股份有限公司 | Mcl-1抑制劑與抗癌劑之組合 |
WO2023225359A1 (en) | 2022-05-20 | 2023-11-23 | Novartis Ag | Antibody-drug conjugates of antineoplastic compounds and methods of use thereof |
TW202404645A (zh) | 2022-05-20 | 2024-02-01 | 瑞士商諾華公司 | Met bcl-xl抑制劑抗體-藥物結合物及其使用方法 |
WO2023225320A1 (en) | 2022-05-20 | 2023-11-23 | Novartis Ag | Epha2 bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
WO2024008941A1 (en) | 2022-07-08 | 2024-01-11 | Les Laboratoires Servier | New spirocyclohexane derivatives, pharmaceutical compositions containing them and their uses as anti-apoptotic inhibitors |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4008726A1 (de) * | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
CN1823071B (zh) * | 2003-06-11 | 2012-12-19 | 润生有限公司 | 用作钾通道抑制剂的噻吩并嘧啶衍生物 |
US20050187389A1 (en) | 2004-01-13 | 2005-08-25 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
US20050288906A1 (en) | 2004-06-29 | 2005-12-29 | Drennen James K Iii | Spectroscopic pharmacy verification and inspection system |
JP2008505084A (ja) | 2004-06-29 | 2008-02-21 | アムゲン インコーポレイティッド | フラノピリミジン |
WO2006036266A1 (en) * | 2004-07-16 | 2006-04-06 | Sunesis Pharmaceuticals, Inc. | Thienopyrimidines useful as aurora kinase inhibitors |
GB0423653D0 (en) * | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
US7576080B2 (en) * | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
EP2078721B1 (en) * | 2005-10-21 | 2014-01-22 | Dow AgroSciences LLC | Thieno-pyrimidine compounds having fungicidal activity |
CA2671845C (en) * | 2006-12-07 | 2015-03-24 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
DE102007027800A1 (de) | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
EP2212333A1 (en) * | 2007-10-16 | 2010-08-04 | Wyeth LLC | Thienopyrimidine and pyrazolopyrimidine compounds and their use as mtor kinase and pi3 kinase inhibitors |
KR101703941B1 (ko) | 2008-11-10 | 2017-02-07 | 내셔날 헬스 리서치 인스티튜트 | 티로신 키나아제 억제제로서의 접합 이환 및 삼환 피리미딘 화합물 |
MY162132A (en) * | 2010-06-23 | 2017-05-31 | Hanmi Science Co Ltd | Novel fused pyrimidine derivatives for inhibition of tyrosine kinase activity |
WO2012044993A1 (en) * | 2010-09-30 | 2012-04-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders |
CN102464667B (zh) * | 2010-11-03 | 2014-06-04 | 中国科学院上海药物研究所 | 一类五元杂环并嘧啶类化合物及其制备方法和用途 |
AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
FR2986002B1 (fr) | 2012-01-24 | 2014-02-21 | Servier Lab | Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2013
- 2013-12-23 FR FR1363500A patent/FR3015483B1/fr not_active Expired - Fee Related
-
2014
- 2014-12-08 JO JOP/2014/0353A patent/JO3193B1/ar active
- 2014-12-09 IL IL236143A patent/IL236143A/en active IP Right Grant
- 2014-12-10 PH PH12014000375A patent/PH12014000375B1/en unknown
- 2014-12-10 CR CR20140569A patent/CR20140569A/es unknown
- 2014-12-11 CA CA2875226A patent/CA2875226C/en active Active
- 2014-12-11 TN TN2014000516A patent/TN2014000516A1/fr unknown
- 2014-12-12 AP AP2014008127A patent/AP2014008127A0/xx unknown
- 2014-12-12 AU AU2014274644A patent/AU2014274644B2/en active Active
- 2014-12-15 DO DO2014000282A patent/DOP2014000282A/es unknown
- 2014-12-15 PE PE2014002444A patent/PE20151064A1/es active IP Right Grant
- 2014-12-17 CU CUP2014000143A patent/CU24309B1/xx unknown
- 2014-12-18 CL CL2014003444A patent/CL2014003444A1/es unknown
- 2014-12-18 ZA ZA2014/09365A patent/ZA201409365B/en unknown
- 2014-12-18 MX MX2014015854A patent/MX351581B/es active IP Right Grant
- 2014-12-18 MY MYPI2014703853A patent/MY185221A/en unknown
- 2014-12-19 NI NI201400150A patent/NI201400150A/es unknown
- 2014-12-19 GE GEAP201413667A patent/GEP201706619B/en unknown
- 2014-12-19 UA UAA201413661A patent/UA120341C2/uk unknown
- 2014-12-19 US US14/576,683 patent/US9670227B2/en active Active
- 2014-12-19 CN CN201410800069.2A patent/CN104725397B/zh active Active
- 2014-12-19 JP JP2014257658A patent/JP5922215B2/ja active Active
- 2014-12-22 EA EA201401292A patent/EA029601B1/ru unknown
- 2014-12-22 RS RS20160802A patent/RS55213B1/sr unknown
- 2014-12-22 UY UY0001035915A patent/UY35915A/es active IP Right Grant
- 2014-12-22 ES ES14199533.2T patent/ES2594377T3/es active Active
- 2014-12-22 SA SA114360144A patent/SA114360144B1/ar unknown
- 2014-12-22 DK DK14199533.2T patent/DK2886545T3/en active
- 2014-12-22 LT LTEP14199533.2T patent/LT2886545T/lt unknown
- 2014-12-22 BR BR102014032336-8A patent/BR102014032336B1/pt active IP Right Grant
- 2014-12-22 MD MDA20140137A patent/MD4516C1/ro active IP Right Grant
- 2014-12-22 EP EP14199533.2A patent/EP2886545B1/en active Active
- 2014-12-22 RU RU2014151850/04A patent/RU2605403C2/ru active
- 2014-12-22 PL PL14199533T patent/PL2886545T3/pl unknown
- 2014-12-22 GT GT201400297A patent/GT201400297A/es unknown
- 2014-12-22 ME MEP-2016-207A patent/ME02521B/me unknown
- 2014-12-22 AR ARP140104847A patent/AR098906A1/es unknown
- 2014-12-22 SI SI201430061A patent/SI2886545T1/sl unknown
- 2014-12-22 SG SG10201408563UA patent/SG10201408563UA/en unknown
- 2014-12-22 HU HUE14199533A patent/HUE029654T2/en unknown
- 2014-12-22 WO PCT/EP2014/078947 patent/WO2015097123A1/en active Application Filing
- 2014-12-22 TW TW103144845A patent/TWI508969B/zh active
- 2014-12-22 PT PT141995332T patent/PT2886545T/pt unknown
- 2014-12-23 CO CO14282098A patent/CO7210068A1/es unknown
- 2014-12-23 KR KR1020140187349A patent/KR101636401B1/ko active IP Right Grant
-
2015
- 2015-10-28 HK HK15110667.4A patent/HK1209750A1/xx unknown
- 2015-12-16 HK HK15112389.7A patent/HK1211583A1/xx unknown
-
2016
- 2016-09-20 HR HRP20161203TT patent/HRP20161203T8/hr unknown
- 2016-09-22 CY CY20161100949T patent/CY1118058T1/el unknown
-
2017
- 2017-04-20 US US15/492,306 patent/US10278972B2/en active Active
-
2019
- 2019-03-08 US US16/296,766 patent/US20190201404A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CU24309B1 (es) | Compuestos derivados tienopirimidina y composiciones farmacéuticas que los contienen | |
SV2017005590A (es) | Nuevos derivados hidroxiacido un proceso para su preparacion y composiciones farmaceuticas que los contienen | |
SV2017005588A (es) | Nuevos derivados aminoacido, un proceso para su preparacion y composiciones farmaceuticas que los contienen | |
ECSP18053634A (es) | Nuevos derivados de amonio, un proceso para su preparación y composiciones farmacéuticas que los contienen | |
SV2018005791A (es) | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen | |
ECSP17083003A (es) | Nuevos derivados bicíclicos, un proceso para su preparación y composiciones farmacéuticas que los contienen | |
CR20170564A (es) | Nuevos derivados hidroxiéster, un proceso para su preparación y composiciones farmacéuticas que los contienen | |
CR20170118A (es) | Derivados espirodiamina como inhibidores de la aldosterona sintasa | |
SV2014004770A (es) | Nuevos derivados de pirrol, su procedimiento de preparación y los composiciones farmacéuticas que los contienen | |
SV2014004771A (es) | Nuevos derivados fosfatos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
CR20140275A (es) | Triazolopiridinas sustituidas | |
UY35485A (es) | Compuestos heterocíclicos y usos de los mismos | |
CR20140089A (es) | Nuevos derivados bicíclicos de dihidroquinolina-2-ona | |
EA201401054A1 (ru) | N-циклиламиды в качестве нематоцидов | |
UY35467A (es) | Compuestos orgánicos | |
DOP2015000059A (es) | Amino-quinolinas como inhibidores de cinasa | |
CR20150440A (es) | Nuevos derivados de piridina | |
UY35653A (es) | Nuevos derivados de indol y de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
CU20180028A7 (es) | DERIVADOS DE IMIDAZO[4,5-b]PIRIDINA, ÚTILES COMO INHIBIDORES DUALES DE DYRK1/CLK1 Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN | |
UY35664A (es) | Nuevos compuestos isoindolina o isoquinolina, un proceso para su preparación y composiciones farmacéuticas que los contienen | |
ECSP15050110A (es) | Derivados de triazina | |
SV2014004879A (es) | Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen |