CS240994B2 - Production method of nizatidine - Google Patents

Production method of nizatidine Download PDF

Info

Publication number
CS240994B2
CS240994B2 CS84812A CS81284A CS240994B2 CS 240994 B2 CS240994 B2 CS 240994B2 CS 84812 A CS84812 A CS 84812A CS 81284 A CS81284 A CS 81284A CS 240994 B2 CS240994 B2 CS 240994B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
acid
product
reaction
nizatidine
Prior art date
Application number
CS84812A
Other languages
Czech (cs)
English (en)
Other versions
CS81284A2 (en
Inventor
Charles W Ryan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23843341&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS240994(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS81284A2 publication Critical patent/CS81284A2/cs
Publication of CS240994B2 publication Critical patent/CS240994B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Credit Cards Or The Like (AREA)
CS84812A 1983-02-07 1984-02-06 Production method of nizatidine CS240994B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46429683A 1983-02-07 1983-02-07

Publications (2)

Publication Number Publication Date
CS81284A2 CS81284A2 (en) 1985-06-13
CS240994B2 true CS240994B2 (en) 1986-03-13

Family

ID=23843341

Family Applications (1)

Application Number Title Priority Date Filing Date
CS84812A CS240994B2 (en) 1983-02-07 1984-02-06 Production method of nizatidine

Country Status (27)

Country Link
EP (1) EP0116452B1 (ro)
JP (1) JPS59152378A (ro)
KR (1) KR860000767B1 (ro)
AT (1) ATE84530T1 (ro)
AU (1) AU559639B2 (ro)
BG (1) BG45216A3 (ro)
CA (1) CA1221369A (ro)
CS (1) CS240994B2 (ro)
DD (1) DD216459A5 (ro)
DE (1) DE3486032T2 (ro)
DK (2) DK164501C (ro)
EG (1) EG17702A (ro)
ES (1) ES8601941A1 (ro)
FI (1) FI840474A (ro)
GB (1) GB2134521B (ro)
GR (1) GR81755B (ro)
HU (2) HU190527B (ro)
IE (1) IE56763B1 (ro)
IL (1) IL70880A (ro)
NZ (1) NZ207046A (ro)
PH (1) PH19941A (ro)
PL (1) PL138793B1 (ro)
PT (1) PT78063A (ro)
RO (1) RO87706A (ro)
SU (1) SU1303028A3 (ro)
UA (1) UA6020A1 (ro)
ZA (1) ZA84869B (ro)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1277325C (en) * 1985-12-18 1990-12-04 Bruce A. Slomski Synthesis of nizatidine
ES2038922B1 (es) * 1991-12-30 1994-04-16 Fermentaciones Y Sintesis Espa Procedimiento para la obtencion de nizatidina.
US5470865A (en) * 1994-08-30 1995-11-28 Eli Lilly And Company Pharmaceutical composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Also Published As

Publication number Publication date
DE3486032T2 (de) 1993-05-19
DK164501C (da) 1992-11-23
JPH0576473B2 (ro) 1993-10-22
DK164906B (da) 1992-09-07
EP0116452A2 (en) 1984-08-22
ATE84530T1 (de) 1993-01-15
FI840474A0 (fi) 1984-02-06
ES529492A0 (es) 1985-11-01
DK164501B (da) 1992-07-06
GB2134521B (en) 1986-10-01
KR840007591A (ko) 1984-12-08
GB2134521A (en) 1984-08-15
HU194198B (en) 1988-01-28
HU190527B (en) 1986-09-29
NZ207046A (en) 1986-06-11
GB8403109D0 (en) 1984-03-07
PL138793B1 (en) 1986-11-29
DK51984D0 (da) 1984-02-06
FI840474A (fi) 1984-08-08
AU2421584A (en) 1984-08-16
RO87706B (ro) 1985-10-01
GR81755B (ro) 1984-12-12
ZA84869B (en) 1985-09-25
EP0116452B1 (en) 1993-01-13
IE840274L (en) 1984-08-07
DK164906C (da) 1993-01-25
IE56763B1 (en) 1991-12-04
DK51984A (da) 1984-08-08
JPS59152378A (ja) 1984-08-31
DK21292A (da) 1992-02-19
CA1221369A (en) 1987-05-05
RO87706A (ro) 1985-10-31
EG17702A (en) 1991-03-30
UA6020A1 (uk) 1994-12-29
BG45216A3 (bg) 1989-04-14
PT78063A (en) 1984-03-01
PH19941A (en) 1986-08-14
KR860000767B1 (ko) 1986-06-23
IL70880A (en) 1987-01-30
EP0116452A3 (en) 1987-04-29
DD216459A5 (de) 1984-12-12
ES8601941A1 (es) 1985-11-01
DE3486032D1 (de) 1993-02-25
IL70880A0 (en) 1984-05-31
SU1303028A3 (ru) 1987-04-07
AU559639B2 (en) 1987-03-19
CS81284A2 (en) 1985-06-13
PL246097A1 (en) 1985-06-04
DK21292D0 (da) 1992-02-19

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