CS235976B2 - Method of pyrimidine derivatives production - Google Patents
Method of pyrimidine derivatives production Download PDFInfo
- Publication number
- CS235976B2 CS235976B2 CS829474A CS947482A CS235976B2 CS 235976 B2 CS235976 B2 CS 235976B2 CS 829474 A CS829474 A CS 829474A CS 947482 A CS947482 A CS 947482A CS 235976 B2 CS235976 B2 CS 235976B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- group
- methyl
- ethyl
- pyridyl
- residue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Liquid Crystal Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33478481A | 1981-12-28 | 1981-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS235976B2 true CS235976B2 (en) | 1985-05-15 |
Family
ID=23308823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS829474A CS235976B2 (en) | 1981-12-28 | 1982-12-21 | Method of pyrimidine derivatives production |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0083186B1 (de) |
| JP (1) | JPS58118585A (de) |
| KR (1) | KR860000106B1 (de) |
| AT (1) | ATE34173T1 (de) |
| AU (1) | AU558153B2 (de) |
| CA (1) | CA1206151A (de) |
| CS (1) | CS235976B2 (de) |
| DD (1) | DD203720A5 (de) |
| DE (1) | DE3278473D1 (de) |
| DK (1) | DK574782A (de) |
| ES (1) | ES8403895A1 (de) |
| FI (1) | FI824407A7 (de) |
| GB (1) | GB2111995B (de) |
| GR (1) | GR78415B (de) |
| HU (1) | HU192951B (de) |
| IE (1) | IE54313B1 (de) |
| IL (1) | IL67496A (de) |
| NZ (1) | NZ202797A (de) |
| PH (1) | PH19797A (de) |
| PL (1) | PL239796A1 (de) |
| PT (1) | PT76004B (de) |
| SU (1) | SU1195906A3 (de) |
| ZA (1) | ZA829247B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4468399A (en) * | 1981-12-28 | 1984-08-28 | Eli Lilly And Company | 2-[2-(2-Aminoalkyl-4-thiazolylmethylthio)alkyl]-amino-5-substituted-4-pyrimidones |
| GB8320505D0 (en) * | 1983-07-29 | 1983-09-01 | Smith Kline French Lab | Chemical compounds |
| US4772704A (en) * | 1983-09-21 | 1988-09-20 | Bristol-Myers Company | 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity |
| GB8421427D0 (en) * | 1984-08-23 | 1984-09-26 | Smith Kline French Lab | Chemical compounds |
| TW245716B (de) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
| RU2250767C1 (ru) * | 2004-07-12 | 2005-04-27 | Казанский государственный медицинский университет | Способ лечения язвенной болезни желудка и двенадцатиперстной кишки |
| CN102260254A (zh) * | 2010-05-31 | 2011-11-30 | 中国农业科学院植物保护研究所 | 新颖2-硝基亚氨基嘧啶衍生物的合成 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1421792A (en) * | 1973-05-17 | 1976-01-21 | Smith Kline French Lab | Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them |
| IN146736B (de) * | 1975-10-02 | 1979-08-25 | Smith Kline French Lab | |
| US4200578A (en) * | 1978-12-18 | 1980-04-29 | Bristol-Myers Company | Thiazole derivatives |
| US4521418A (en) * | 1979-02-21 | 1985-06-04 | Smith Kline & French Laboratories Limited | Guanidinothiazolyl derivatives |
| AU531142B2 (en) * | 1979-04-04 | 1983-08-11 | Smith Kline & French Laboratories Limited | 2 amino- pyimindones |
| US4375547A (en) * | 1980-10-02 | 1983-03-01 | Eli Lilly And Company | N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine |
-
1982
- 1982-12-14 CA CA000417662A patent/CA1206151A/en not_active Expired
- 1982-12-14 NZ NZ202797A patent/NZ202797A/en unknown
- 1982-12-15 AU AU91539/82A patent/AU558153B2/en not_active Ceased
- 1982-12-15 ZA ZA829247A patent/ZA829247B/xx unknown
- 1982-12-15 PH PH28281A patent/PH19797A/en unknown
- 1982-12-16 IL IL67496A patent/IL67496A/xx unknown
- 1982-12-20 AT AT82306785T patent/ATE34173T1/de active
- 1982-12-20 DE DE8282306785T patent/DE3278473D1/de not_active Expired
- 1982-12-20 PT PT76004A patent/PT76004B/pt unknown
- 1982-12-20 GB GB08236116A patent/GB2111995B/en not_active Expired
- 1982-12-20 EP EP82306785A patent/EP0083186B1/de not_active Expired
- 1982-12-21 IE IE3031/82A patent/IE54313B1/en unknown
- 1982-12-21 CS CS829474A patent/CS235976B2/cs unknown
- 1982-12-21 FI FI824407A patent/FI824407A7/fi not_active Application Discontinuation
- 1982-12-23 GR GR70164A patent/GR78415B/el unknown
- 1982-12-24 SU SU823526201A patent/SU1195906A3/ru active
- 1982-12-27 ES ES518592A patent/ES8403895A1/es not_active Expired
- 1982-12-27 HU HU824173A patent/HU192951B/hu not_active IP Right Cessation
- 1982-12-27 DK DK574782A patent/DK574782A/da not_active Application Discontinuation
- 1982-12-28 JP JP57234881A patent/JPS58118585A/ja active Pending
- 1982-12-28 PL PL23979682A patent/PL239796A1/xx unknown
- 1982-12-28 DD DD82246677A patent/DD203720A5/de unknown
- 1982-12-28 KR KR8205837A patent/KR860000106B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2111995A (en) | 1983-07-13 |
| ZA829247B (en) | 1984-07-25 |
| ES518592A0 (es) | 1984-04-01 |
| DK574782A (da) | 1983-06-29 |
| PL239796A1 (en) | 1984-05-21 |
| PT76004A (en) | 1983-01-01 |
| ES8403895A1 (es) | 1984-04-01 |
| KR840002831A (ko) | 1984-07-21 |
| PH19797A (en) | 1986-07-02 |
| EP0083186B1 (de) | 1988-05-11 |
| DE3278473D1 (en) | 1988-06-16 |
| IE54313B1 (en) | 1989-08-16 |
| CA1206151A (en) | 1986-06-17 |
| ATE34173T1 (de) | 1988-05-15 |
| NZ202797A (en) | 1985-08-30 |
| EP0083186A2 (de) | 1983-07-06 |
| JPS58118585A (ja) | 1983-07-14 |
| FI824407L (fi) | 1983-06-29 |
| HU192951B (en) | 1987-08-28 |
| AU9153982A (en) | 1983-07-07 |
| FI824407A7 (fi) | 1983-06-29 |
| GB2111995B (en) | 1985-07-24 |
| FI824407A0 (fi) | 1982-12-21 |
| AU558153B2 (en) | 1987-01-22 |
| GR78415B (de) | 1984-09-27 |
| IL67496A (en) | 1986-11-30 |
| EP0083186A3 (en) | 1984-05-23 |
| DD203720A5 (de) | 1983-11-02 |
| SU1195906A3 (ru) | 1985-11-30 |
| KR860000106B1 (ko) | 1986-02-19 |
| IE823031L (en) | 1983-06-28 |
| PT76004B (en) | 1985-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112533904B (zh) | 黑皮质素亚型-2受体(mc2r)拮抗剂及其用途 | |
| DE60118704T2 (de) | Pyrimidin-derivate als selective inhibitoren von cox-2 | |
| KR850001795B1 (ko) | 2,4-이치환된 티아졸 유도체의 제조방법 | |
| AU2002363177B2 (en) | Aminobenzamide derivatives as glycogen synthase kinase 3Beta inhibitors | |
| DE69208263T2 (de) | Substituierte aminopyrimidine als angiotensin ii antagonisten | |
| CS200545B2 (en) | Method of producing derivatives of guanidine | |
| DD201901A5 (de) | Verfahren zur herstellung neuer derivate von 4-amino-6,7-dimethoxy-2-piperazinochinazolin | |
| KR20040048920A (ko) | 글리코겐 신타아제 키나제 3-베타 저해제(ｇｓｋ저해제)로서의 헤테로아릴 아민 | |
| DE3689748T2 (de) | Benzimidazolderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung. | |
| SI9520084A (en) | Use of heterocyclic compounds as dopamines-d3 ligands | |
| DE69724098T2 (de) | Chinolin- und benzimidazolderivate als bradykinin agonisten | |
| NO841168L (no) | Fremgangsmaate for fremstilling av pyrimidinderivater | |
| AU2001259691B2 (en) | Modulators of TNF-alpha signaling | |
| JP2023541203A (ja) | Ｔｙｋ２阻害剤およびその使用 | |
| DE2658267A1 (de) | Pyrimid-4-on- und -thion-derivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel | |
| EP0196005A1 (de) | Pyridazinone, ihre Herstellung und diese Verbindungen enthaltende Arzneimittel | |
| AU2001259691A1 (en) | Modulators of TNF-alpha signaling | |
| PT77855B (en) | Pyridine derivatives | |
| NZ207914A (en) | Indeno-pyridazinones and pharmaceutical compositions | |
| US3169966A (en) | Aminopyrazoles | |
| EP0068833A2 (de) | Pyrimidinonderivate und diese enthaltende pharmazeutische Zusammensetzungen | |
| CS235976B2 (en) | Method of pyrimidine derivatives production | |
| DD202552A5 (de) | Heterocyclische derivate | |
| CN114728949B (zh) | 作为激酶抑制剂的杂环化合物及其用途 | |
| JP2018531266A (ja) | ピリドン誘導体およびキナーゼ阻害剤としてのその使用 |