CS235959B2 - Method of 3-ketoandrosterones production - Google Patents

Method of 3-ketoandrosterones production Download PDF

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Publication number
CS235959B2
CS235959B2 CS826085A CS608582A CS235959B2 CS 235959 B2 CS235959 B2 CS 235959B2 CS 826085 A CS826085 A CS 826085A CS 608582 A CS608582 A CS 608582A CS 235959 B2 CS235959 B2 CS 235959B2
Authority
CS
Czechoslovakia
Prior art keywords
chloroform
dien
solution
mixture
ethylthio
Prior art date
Application number
CS826085A
Other languages
Czech (cs)
English (en)
Inventor
Ravi Kannadikovilakom Varma
Original Assignee
E K Squibb And Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E K Squibb And Sons Inc filed Critical E K Squibb And Sons Inc
Priority to CS84576A priority Critical patent/CS235999B2/cs
Publication of CS235959B2 publication Critical patent/CS235959B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
CS826085A 1981-08-20 1982-08-19 Method of 3-ketoandrosterones production CS235959B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS84576A CS235999B2 (cs) 1981-08-20 1984-01-25 Způsob výroby 3-ketoandrostenů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/294,680 US4361559A (en) 1981-08-20 1981-08-20 Antiinflammatory 17,17-bis (substituted thio) androstenes

Publications (1)

Publication Number Publication Date
CS235959B2 true CS235959B2 (en) 1985-05-15

Family

ID=23134474

Family Applications (1)

Application Number Title Priority Date Filing Date
CS826085A CS235959B2 (en) 1981-08-20 1982-08-19 Method of 3-ketoandrosterones production

Country Status (24)

Country Link
US (1) US4361559A (no)
EP (1) EP0073026B1 (no)
JP (1) JPS5841900A (no)
KR (1) KR890000678B1 (no)
AT (1) ATE18671T1 (no)
AU (1) AU564228B2 (no)
CA (1) CA1213270A (no)
CS (1) CS235959B2 (no)
DD (3) DD215556A5 (no)
DE (1) DE3269987D1 (no)
DK (1) DK165838C (no)
ES (3) ES515110A0 (no)
FI (1) FI78916C (no)
GR (1) GR76251B (no)
HU (1) HU187783B (no)
IE (1) IE53732B1 (no)
IL (1) IL66564A (no)
NO (1) NO159601C (no)
NZ (1) NZ201343A (no)
PH (2) PH18594A (no)
PL (2) PL244113A1 (no)
PT (1) PT75442B (no)
SU (1) SU1189353A3 (no)
ZA (1) ZA825260B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447363A (en) * 1982-07-07 1984-05-08 E. R. Squibb & Sons, Inc. Androstene-17-dithioketals
US4435326A (en) * 1982-09-09 1984-03-06 E. R. Squibb & Sons, Inc. Intermediates useful in the preparation of 17,17-bis(substituted thio)androstenes
US4420428A (en) * 1982-12-27 1983-12-13 E. R. Squibb & Sons, Inc. 16-Ketoandrostene-17-dithioketals
US4427592A (en) * 1983-01-31 1984-01-24 E. R. Squibb & Sons, Inc. Androstene-17-dithioketals
US4481144A (en) * 1984-02-03 1984-11-06 E. R. Squibb & Sons, Inc. 17-Substituted thia-17-alkyl(or alkenyl or alkynyl)androstenes
US4499021A (en) * 1984-04-12 1985-02-12 E. R. Squibb & Sons, Inc. 17β(Substituted thio)-16-ketoandrostene-17α..-carboxylic acid derivatives
US4529548A (en) * 1984-05-07 1985-07-16 E. R. Squibb & Sons, Inc. 17β-(substituted thio)androstenes
US4529547A (en) * 1984-06-20 1985-07-16 E.R. Squibb & Sons, Inc. 17-(substituted thio)-17-(substituted dithio)androstenes
US4528138A (en) * 1984-06-20 1985-07-09 E. R. Squibb & Sons, Inc. 16-Keto-17-substituted thia-17-alkyl(or alkenyl or alkynyl) androstenes
US4891367A (en) * 1987-04-22 1990-01-02 Merrell Dow Pharmaceuticals Inc. 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US4868169A (en) * 1987-11-13 1989-09-19 E. R. Squibb & Sons, Inc. Steroid cream formulation
US4868168A (en) * 1987-11-13 1989-09-19 E. R. Squibb & Sons, Inc. Steroid ointment formulation
US5016635A (en) * 1988-11-29 1991-05-21 Sigmedics, Inc. Of Delaware Control of FNS via pattern variations of response EMG
US4883792A (en) * 1989-01-17 1989-11-28 Peter Timmins Steroid cream formulation
GB9103824D0 (en) * 1991-02-23 1991-04-10 Fisons Ag Formulation
IE922301A1 (en) * 1991-07-25 1993-01-27 Squibb & Sons Inc Selective thioketalization process, process for preparing¹thioenol ethers from thioketals, and process for the¹preparation of thioketals
NZ259401A (en) * 1992-12-24 1996-10-28 Rhone Poulenc Rorer Ltd (20s)-16<alpha>,17<alpha>-methylenedioxy-11<beta>-hydroxy-17<beta>-( sulphur substituted)androst- -an-3-one or -en-3-one derivatives
US5344651A (en) * 1993-07-23 1994-09-06 The Procter & Gamble Company Cyproterone acetate thioacetate
US5439901A (en) * 1993-07-23 1995-08-08 The Procter & Gamble Company Cyproterone thiopivalate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2840577A (en) * 1956-12-21 1958-06-24 Searle & Co 17-thio derivatives of estratrien-3-ol and of estratetraen-3-ol
US2949477A (en) * 1959-03-04 1960-08-16 Searle & Co 1, 3, 17-triacetoxyestra-1, 3, 5(10), 16-tetraene and congeners
US4091036A (en) * 1977-05-12 1978-05-23 E. R. Squibb & Sons, Inc. 17-Alkylthio (and arylthio)-1',2',3',4'-tetrahydroandrosteno [16 α, 17 α-b]naphthalenes and derivatives
US4094840A (en) * 1977-05-12 1978-06-13 E. R. Squibb & Sons, Inc. 17-Alkylthio (and arylthio) androsteno[16α,17α-b]benzodioxin-3-ones
US4133811A (en) * 1978-02-17 1979-01-09 E. R. Squibb & Sons, Inc. 13-Alkylthio (and arylthio)-11,17-epoxy-17-methyl-18-norandrostenes
US4146538A (en) * 1978-02-27 1979-03-27 E. R. Squibb & Sons, Inc. 17-Alkylthio (and arylthio) androsteno[17α,16α-b]benzopyran-3-ones and [16α,17α]naphthopyran-3-ones

Also Published As

Publication number Publication date
KR840001183A (ko) 1984-03-28
AU564228B2 (en) 1987-08-06
NZ201343A (en) 1985-08-16
IE53732B1 (en) 1989-02-01
EP0073026B1 (en) 1986-03-19
PT75442A (en) 1982-09-01
PL141303B1 (en) 1987-07-31
PT75442B (en) 1985-01-04
NO159601B (no) 1988-10-10
KR890000678B1 (ko) 1989-03-24
ES8308336A1 (es) 1983-08-16
EP0073026A1 (en) 1983-03-02
DK165838B (da) 1993-01-25
DD215086A5 (de) 1984-10-31
PL244113A1 (en) 1984-05-21
PL237936A1 (en) 1984-02-13
NO822823L (no) 1983-02-21
NO159601C (no) 1989-01-18
IL66564A0 (en) 1982-12-31
ZA825260B (en) 1983-05-25
SU1189353A3 (ru) 1985-10-30
AU8631882A (en) 1983-02-24
JPS5841900A (ja) 1983-03-11
CA1213270A (en) 1986-10-28
US4361559A (en) 1982-11-30
IE821951L (en) 1983-02-20
PH18594A (en) 1985-08-12
PH19857A (en) 1986-07-22
GR76251B (no) 1984-08-04
ES8406506A1 (es) 1984-07-01
FI78916C (fi) 1989-10-10
IL66564A (en) 1986-03-31
ATE18671T1 (de) 1986-04-15
ES515110A0 (es) 1983-08-16
ES8406505A1 (es) 1984-07-01
ES521951A0 (es) 1984-07-01
DE3269987D1 (en) 1986-04-24
DD215556A5 (de) 1984-11-14
FI822890A0 (fi) 1982-08-19
JPH035400B2 (no) 1991-01-25
DK165838C (da) 1993-06-21
HU187783B (en) 1986-02-28
FI78916B (fi) 1989-06-30
DD211567A5 (de) 1984-07-18
ES521952A0 (es) 1984-07-01
FI822890L (fi) 1983-02-21
DK372982A (da) 1983-02-21

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