ES8308336A1 - Un procedimiento para preparar compuestos de 3-cetoandroste-no. - Google Patents

Un procedimiento para preparar compuestos de 3-cetoandroste-no.

Info

Publication number
ES8308336A1
ES8308336A1 ES515110A ES515110A ES8308336A1 ES 8308336 A1 ES8308336 A1 ES 8308336A1 ES 515110 A ES515110 A ES 515110A ES 515110 A ES515110 A ES 515110A ES 8308336 A1 ES8308336 A1 ES 8308336A1
Authority
ES
Spain
Prior art keywords
ketoandrostenes
bis
pharmaceutical compositions
substituted thio
thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515110A
Other languages
English (en)
Other versions
ES515110A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES515110A0 publication Critical patent/ES515110A0/es
Publication of ES8308336A1 publication Critical patent/ES8308336A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE 3-CETOANDROSTENO, DE FORMULA (I), EN LA QUE R<1 Y R<2 SON ALCOHILO, CICLOALCOHILO O ARILO; Y R<3, R<4, R<5 Y R<6 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA R<2SH, EN LAS QUE R<1 A R<6 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN PRESENCIA DE UN ACIDO DE LEWIS, TAL COMO ETERATO DE TRIFLUORURO DE BORO, EN UN DISOLVENTE INERTE, A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIINFLAMATORIA.
ES515110A 1981-08-20 1982-08-19 Un procedimiento para preparar compuestos de 3-cetoandroste-no. Expired ES8308336A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/294,680 US4361559A (en) 1981-08-20 1981-08-20 Antiinflammatory 17,17-bis (substituted thio) androstenes

Publications (2)

Publication Number Publication Date
ES515110A0 ES515110A0 (es) 1983-08-16
ES8308336A1 true ES8308336A1 (es) 1983-08-16

Family

ID=23134474

Family Applications (3)

Application Number Title Priority Date Filing Date
ES515110A Expired ES8308336A1 (es) 1981-08-20 1982-08-19 Un procedimiento para preparar compuestos de 3-cetoandroste-no.
ES521952A Granted ES521952A0 (es) 1981-08-20 1983-04-29 Un procedimiento para preparar derivados de androsteno.
ES521951A Expired ES8406505A1 (es) 1981-08-20 1983-04-29 Un procedimiento para preparar derivados de androsteno.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES521952A Granted ES521952A0 (es) 1981-08-20 1983-04-29 Un procedimiento para preparar derivados de androsteno.
ES521951A Expired ES8406505A1 (es) 1981-08-20 1983-04-29 Un procedimiento para preparar derivados de androsteno.

Country Status (24)

Country Link
US (1) US4361559A (es)
EP (1) EP0073026B1 (es)
JP (1) JPS5841900A (es)
KR (1) KR890000678B1 (es)
AT (1) ATE18671T1 (es)
AU (1) AU564228B2 (es)
CA (1) CA1213270A (es)
CS (1) CS235959B2 (es)
DD (3) DD215556A5 (es)
DE (1) DE3269987D1 (es)
DK (1) DK165838C (es)
ES (3) ES8308336A1 (es)
FI (1) FI78916C (es)
GR (1) GR76251B (es)
HU (1) HU187783B (es)
IE (1) IE53732B1 (es)
IL (1) IL66564A (es)
NO (1) NO159601C (es)
NZ (1) NZ201343A (es)
PH (2) PH18594A (es)
PL (2) PL141303B1 (es)
PT (1) PT75442B (es)
SU (1) SU1189353A3 (es)
ZA (1) ZA825260B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447363A (en) * 1982-07-07 1984-05-08 E. R. Squibb & Sons, Inc. Androstene-17-dithioketals
US4435326A (en) * 1982-09-09 1984-03-06 E. R. Squibb & Sons, Inc. Intermediates useful in the preparation of 17,17-bis(substituted thio)androstenes
US4420428A (en) * 1982-12-27 1983-12-13 E. R. Squibb & Sons, Inc. 16-Ketoandrostene-17-dithioketals
US4427592A (en) * 1983-01-31 1984-01-24 E. R. Squibb & Sons, Inc. Androstene-17-dithioketals
US4481144A (en) * 1984-02-03 1984-11-06 E. R. Squibb & Sons, Inc. 17-Substituted thia-17-alkyl(or alkenyl or alkynyl)androstenes
US4499021A (en) * 1984-04-12 1985-02-12 E. R. Squibb & Sons, Inc. 17β(Substituted thio)-16-ketoandrostene-17α..-carboxylic acid derivatives
US4529548A (en) * 1984-05-07 1985-07-16 E. R. Squibb & Sons, Inc. 17β-(substituted thio)androstenes
US4528138A (en) * 1984-06-20 1985-07-09 E. R. Squibb & Sons, Inc. 16-Keto-17-substituted thia-17-alkyl(or alkenyl or alkynyl) androstenes
US4529547A (en) * 1984-06-20 1985-07-16 E.R. Squibb & Sons, Inc. 17-(substituted thio)-17-(substituted dithio)androstenes
US4891367A (en) * 1987-04-22 1990-01-02 Merrell Dow Pharmaceuticals Inc. 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US4868168A (en) * 1987-11-13 1989-09-19 E. R. Squibb & Sons, Inc. Steroid ointment formulation
US4868169A (en) * 1987-11-13 1989-09-19 E. R. Squibb & Sons, Inc. Steroid cream formulation
US5016635A (en) * 1988-11-29 1991-05-21 Sigmedics, Inc. Of Delaware Control of FNS via pattern variations of response EMG
US4883792A (en) * 1989-01-17 1989-11-28 Peter Timmins Steroid cream formulation
GB9103824D0 (en) * 1991-02-23 1991-04-10 Fisons Ag Formulation
IE922301A1 (en) * 1991-07-25 1993-01-27 Squibb & Sons Inc Selective thioketalization process, process for preparing¹thioenol ethers from thioketals, and process for the¹preparation of thioketals
CA2149777C (en) * 1992-12-24 2004-05-25 Michael John Ashton New steroids
US5439901A (en) * 1993-07-23 1995-08-08 The Procter & Gamble Company Cyproterone thiopivalate
US5344651A (en) * 1993-07-23 1994-09-06 The Procter & Gamble Company Cyproterone acetate thioacetate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2840577A (en) * 1956-12-21 1958-06-24 Searle & Co 17-thio derivatives of estratrien-3-ol and of estratetraen-3-ol
US2949477A (en) * 1959-03-04 1960-08-16 Searle & Co 1, 3, 17-triacetoxyestra-1, 3, 5(10), 16-tetraene and congeners
US4091036A (en) * 1977-05-12 1978-05-23 E. R. Squibb & Sons, Inc. 17-Alkylthio (and arylthio)-1',2',3',4'-tetrahydroandrosteno [16 α, 17 α-b]naphthalenes and derivatives
US4094840A (en) * 1977-05-12 1978-06-13 E. R. Squibb & Sons, Inc. 17-Alkylthio (and arylthio) androsteno[16α,17α-b]benzodioxin-3-ones
US4133811A (en) * 1978-02-17 1979-01-09 E. R. Squibb & Sons, Inc. 13-Alkylthio (and arylthio)-11,17-epoxy-17-methyl-18-norandrostenes
US4146538A (en) * 1978-02-27 1979-03-27 E. R. Squibb & Sons, Inc. 17-Alkylthio (and arylthio) androsteno[17α,16α-b]benzopyran-3-ones and [16α,17α]naphthopyran-3-ones

Also Published As

Publication number Publication date
PT75442B (en) 1985-01-04
DK165838C (da) 1993-06-21
PH19857A (en) 1986-07-22
PL244113A1 (en) 1984-05-21
IE53732B1 (en) 1989-02-01
AU8631882A (en) 1983-02-24
IE821951L (en) 1983-02-20
FI78916B (fi) 1989-06-30
DK372982A (da) 1983-02-21
PH18594A (en) 1985-08-12
GR76251B (es) 1984-08-04
SU1189353A3 (ru) 1985-10-30
IL66564A (en) 1986-03-31
ES521951A0 (es) 1984-07-01
DE3269987D1 (en) 1986-04-24
ZA825260B (en) 1983-05-25
NO822823L (no) 1983-02-21
CS235959B2 (en) 1985-05-15
IL66564A0 (en) 1982-12-31
PL141303B1 (en) 1987-07-31
NO159601B (no) 1988-10-10
CA1213270A (en) 1986-10-28
EP0073026A1 (en) 1983-03-02
ATE18671T1 (de) 1986-04-15
NZ201343A (en) 1985-08-16
DD215556A5 (de) 1984-11-14
PL237936A1 (en) 1984-02-13
PT75442A (en) 1982-09-01
DK165838B (da) 1993-01-25
ES8406506A1 (es) 1984-07-01
JPH035400B2 (es) 1991-01-25
FI78916C (fi) 1989-10-10
NO159601C (no) 1989-01-18
JPS5841900A (ja) 1983-03-11
US4361559A (en) 1982-11-30
KR840001183A (ko) 1984-03-28
ES515110A0 (es) 1983-08-16
DD211567A5 (de) 1984-07-18
EP0073026B1 (en) 1986-03-19
FI822890A0 (fi) 1982-08-19
KR890000678B1 (ko) 1989-03-24
DD215086A5 (de) 1984-10-31
AU564228B2 (en) 1987-08-06
HU187783B (en) 1986-02-28
FI822890L (fi) 1983-02-21
ES521952A0 (es) 1984-07-01
ES8406505A1 (es) 1984-07-01

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