ES8406505A1 - Un procedimiento para preparar derivados de androsteno. - Google Patents
Un procedimiento para preparar derivados de androsteno.Info
- Publication number
- ES8406505A1 ES8406505A1 ES521951A ES521951A ES8406505A1 ES 8406505 A1 ES8406505 A1 ES 8406505A1 ES 521951 A ES521951 A ES 521951A ES 521951 A ES521951 A ES 521951A ES 8406505 A1 ES8406505 A1 ES 8406505A1
- Authority
- ES
- Spain
- Prior art keywords
- ketoandrostenes
- bis
- pharmaceutical compositions
- substituted thio
- thio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ANDROSTENO.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UN ACIDO DE LEWIS, DE UN DISOLVENTE ORGANICO EN ATMOSFERA INERTE A TEMPERATURA ENTRE 0J Y 30JC Y DE DIALCOHIL-ACETAL DE DIMETIL-FORMAMIDA TAL COMO DIMETIL-ACETAL DE DIMETILFORMAMIDA, PARA OBTENER UN COMPUESTO DE FORMULA (I), DONDE R1 Y R2 SON EL MISMO GRUPO ALCOHILO, CICLOALCOHILO, O ARILO; R3 ES HIDROXI, ALCOXI, ARILOXI, ALCOHILTIO Y OTROS.TIENE APLICACION FARMACEUTICA POR SU ACTIVIDAD ANTIINFLAMATORIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/294,680 US4361559A (en) | 1981-08-20 | 1981-08-20 | Antiinflammatory 17,17-bis (substituted thio) androstenes |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8406505A1 true ES8406505A1 (es) | 1984-07-01 |
ES521951A0 ES521951A0 (es) | 1984-07-01 |
Family
ID=23134474
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES515110A Expired ES8308336A1 (es) | 1981-08-20 | 1982-08-19 | Un procedimiento para preparar compuestos de 3-cetoandroste-no. |
ES521952A Expired ES8406506A1 (es) | 1981-08-20 | 1983-04-29 | Un procedimiento para preparar derivados de androsteno. |
ES521951A Granted ES521951A0 (es) | 1981-08-20 | 1983-04-29 | Un procedimiento para preparar derivados de androsteno. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES515110A Expired ES8308336A1 (es) | 1981-08-20 | 1982-08-19 | Un procedimiento para preparar compuestos de 3-cetoandroste-no. |
ES521952A Expired ES8406506A1 (es) | 1981-08-20 | 1983-04-29 | Un procedimiento para preparar derivados de androsteno. |
Country Status (24)
Country | Link |
---|---|
US (1) | US4361559A (es) |
EP (1) | EP0073026B1 (es) |
JP (1) | JPS5841900A (es) |
KR (1) | KR890000678B1 (es) |
AT (1) | ATE18671T1 (es) |
AU (1) | AU564228B2 (es) |
CA (1) | CA1213270A (es) |
CS (1) | CS235959B2 (es) |
DD (3) | DD215086A5 (es) |
DE (1) | DE3269987D1 (es) |
DK (1) | DK165838C (es) |
ES (3) | ES8308336A1 (es) |
FI (1) | FI78916C (es) |
GR (1) | GR76251B (es) |
HU (1) | HU187783B (es) |
IE (1) | IE53732B1 (es) |
IL (1) | IL66564A (es) |
NO (1) | NO159601C (es) |
NZ (1) | NZ201343A (es) |
PH (2) | PH18594A (es) |
PL (2) | PL141303B1 (es) |
PT (1) | PT75442B (es) |
SU (1) | SU1189353A3 (es) |
ZA (1) | ZA825260B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4447363A (en) * | 1982-07-07 | 1984-05-08 | E. R. Squibb & Sons, Inc. | Androstene-17-dithioketals |
US4435326A (en) * | 1982-09-09 | 1984-03-06 | E. R. Squibb & Sons, Inc. | Intermediates useful in the preparation of 17,17-bis(substituted thio)androstenes |
US4420428A (en) * | 1982-12-27 | 1983-12-13 | E. R. Squibb & Sons, Inc. | 16-Ketoandrostene-17-dithioketals |
US4427592A (en) * | 1983-01-31 | 1984-01-24 | E. R. Squibb & Sons, Inc. | Androstene-17-dithioketals |
US4481144A (en) * | 1984-02-03 | 1984-11-06 | E. R. Squibb & Sons, Inc. | 17-Substituted thia-17-alkyl(or alkenyl or alkynyl)androstenes |
US4499021A (en) * | 1984-04-12 | 1985-02-12 | E. R. Squibb & Sons, Inc. | 17β(Substituted thio)-16-ketoandrostene-17α..-carboxylic acid derivatives |
US4529548A (en) * | 1984-05-07 | 1985-07-16 | E. R. Squibb & Sons, Inc. | 17β-(substituted thio)androstenes |
US4529547A (en) * | 1984-06-20 | 1985-07-16 | E.R. Squibb & Sons, Inc. | 17-(substituted thio)-17-(substituted dithio)androstenes |
US4528138A (en) * | 1984-06-20 | 1985-07-09 | E. R. Squibb & Sons, Inc. | 16-Keto-17-substituted thia-17-alkyl(or alkenyl or alkynyl) androstenes |
US4891367A (en) * | 1987-04-22 | 1990-01-02 | Merrell Dow Pharmaceuticals Inc. | 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
US4868168A (en) * | 1987-11-13 | 1989-09-19 | E. R. Squibb & Sons, Inc. | Steroid ointment formulation |
US4868169A (en) * | 1987-11-13 | 1989-09-19 | E. R. Squibb & Sons, Inc. | Steroid cream formulation |
US5016635A (en) * | 1988-11-29 | 1991-05-21 | Sigmedics, Inc. Of Delaware | Control of FNS via pattern variations of response EMG |
US4883792A (en) * | 1989-01-17 | 1989-11-28 | Peter Timmins | Steroid cream formulation |
GB9103824D0 (en) * | 1991-02-23 | 1991-04-10 | Fisons Ag | Formulation |
IE922301A1 (en) * | 1991-07-25 | 1993-01-27 | Squibb & Sons Inc | Selective thioketalization process, process for preparing¹thioenol ethers from thioketals, and process for the¹preparation of thioketals |
ATE154607T1 (de) * | 1992-12-24 | 1997-07-15 | Rhone Poulenc Rorer Ltd | Neue steroide |
US5439901A (en) * | 1993-07-23 | 1995-08-08 | The Procter & Gamble Company | Cyproterone thiopivalate |
US5344651A (en) * | 1993-07-23 | 1994-09-06 | The Procter & Gamble Company | Cyproterone acetate thioacetate |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2840577A (en) * | 1956-12-21 | 1958-06-24 | Searle & Co | 17-thio derivatives of estratrien-3-ol and of estratetraen-3-ol |
US2949477A (en) * | 1959-03-04 | 1960-08-16 | Searle & Co | 1, 3, 17-triacetoxyestra-1, 3, 5(10), 16-tetraene and congeners |
US4094840A (en) * | 1977-05-12 | 1978-06-13 | E. R. Squibb & Sons, Inc. | 17-Alkylthio (and arylthio) androsteno[16α,17α-b]benzodioxin-3-ones |
US4091036A (en) * | 1977-05-12 | 1978-05-23 | E. R. Squibb & Sons, Inc. | 17-Alkylthio (and arylthio)-1',2',3',4'-tetrahydroandrosteno [16 α, 17 α-b]naphthalenes and derivatives |
US4133811A (en) * | 1978-02-17 | 1979-01-09 | E. R. Squibb & Sons, Inc. | 13-Alkylthio (and arylthio)-11,17-epoxy-17-methyl-18-norandrostenes |
US4146538A (en) * | 1978-02-27 | 1979-03-27 | E. R. Squibb & Sons, Inc. | 17-Alkylthio (and arylthio) androsteno[17α,16α-b]benzopyran-3-ones and [16α,17α]naphthopyran-3-ones |
-
1981
- 1981-08-20 US US06/294,680 patent/US4361559A/en not_active Expired - Lifetime
-
1982
- 1982-07-19 CA CA000407557A patent/CA1213270A/en not_active Expired
- 1982-07-21 NZ NZ201343A patent/NZ201343A/en unknown
- 1982-07-22 AU AU86318/82A patent/AU564228B2/en not_active Ceased
- 1982-07-22 ZA ZA825260A patent/ZA825260B/xx unknown
- 1982-08-10 PH PH27702A patent/PH18594A/en unknown
- 1982-08-12 GR GR69029A patent/GR76251B/el unknown
- 1982-08-12 IE IE1951/82A patent/IE53732B1/en not_active IP Right Cessation
- 1982-08-17 PL PL1982237936A patent/PL141303B1/pl unknown
- 1982-08-17 PL PL24411382A patent/PL244113A1/xx unknown
- 1982-08-18 IL IL66564A patent/IL66564A/xx not_active IP Right Cessation
- 1982-08-18 HU HU822683A patent/HU187783B/hu not_active IP Right Cessation
- 1982-08-19 PT PT75442A patent/PT75442B/pt not_active IP Right Cessation
- 1982-08-19 DE DE8282107589T patent/DE3269987D1/de not_active Expired
- 1982-08-19 EP EP82107589A patent/EP0073026B1/en not_active Expired
- 1982-08-19 NO NO822823A patent/NO159601C/no unknown
- 1982-08-19 JP JP57144576A patent/JPS5841900A/ja active Granted
- 1982-08-19 FI FI822890A patent/FI78916C/fi not_active IP Right Cessation
- 1982-08-19 KR KR8203735A patent/KR890000678B1/ko active
- 1982-08-19 SU SU823480340A patent/SU1189353A3/ru active
- 1982-08-19 CS CS826085A patent/CS235959B2/cs unknown
- 1982-08-19 AT AT82107589T patent/ATE18671T1/de not_active IP Right Cessation
- 1982-08-19 ES ES515110A patent/ES8308336A1/es not_active Expired
- 1982-08-19 DK DK372982A patent/DK165838C/da not_active IP Right Cessation
- 1982-08-20 DD DD82257409A patent/DD215086A5/de not_active IP Right Cessation
- 1982-08-20 DD DD82242677A patent/DD211567A5/de not_active IP Right Cessation
- 1982-08-20 DD DD82257403A patent/DD215556A5/de not_active IP Right Cessation
-
1983
- 1983-04-29 ES ES521952A patent/ES8406506A1/es not_active Expired
- 1983-04-29 ES ES521951A patent/ES521951A0/es active Granted
-
1984
- 1984-06-29 PH PH30900A patent/PH19857A/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000201 |