CS227345B2 - Method of preparing 1,1-dioxopenicillanoyloxymethyl-penicillanate - Google Patents

Method of preparing 1,1-dioxopenicillanoyloxymethyl-penicillanate Download PDF

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Publication number
CS227345B2
CS227345B2 CS822014A CS201482A CS227345B2 CS 227345 B2 CS227345 B2 CS 227345B2 CS 822014 A CS822014 A CS 822014A CS 201482 A CS201482 A CS 201482A CS 227345 B2 CS227345 B2 CS 227345B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
hydrogen
bromine
chlorine
acid
Prior art date
Application number
CS822014A
Other languages
Czech (cs)
English (en)
Inventor
Vytautas J Jasys
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to CS828597A priority Critical patent/CS227350B2/cs
Priority to CS828596A priority patent/CS227349B2/cs
Publication of CS227345B2 publication Critical patent/CS227345B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
CS822014A 1981-03-23 1982-03-23 Method of preparing 1,1-dioxopenicillanoyloxymethyl-penicillanate CS227345B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS828597A CS227350B2 (cs) 1981-03-23 1982-11-30 Způsob výroby derivátů 1,1-dioxopenicilanové kyseliny
CS828596A CS227349B2 (cs) 1981-03-23 1982-11-30 Způsob výroby 1,1-dioxopenicilanoyloxymethyl-6-(2-amino-2-fenylacetamido)- penicilanótů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24645681A 1981-03-23 1981-03-23

Publications (1)

Publication Number Publication Date
CS227345B2 true CS227345B2 (en) 1984-04-16

Family

ID=22930766

Family Applications (1)

Application Number Title Priority Date Filing Date
CS822014A CS227345B2 (en) 1981-03-23 1982-03-23 Method of preparing 1,1-dioxopenicillanoyloxymethyl-penicillanate

Country Status (32)

Country Link
EP (1) EP0061274B1 (xx)
JP (3) JPS57169493A (xx)
KR (1) KR860001368B1 (xx)
AU (1) AU531892B2 (xx)
BG (2) BG38939A3 (xx)
CA (1) CA1213581A (xx)
CS (1) CS227345B2 (xx)
DD (1) DD202163A5 (xx)
DE (1) DE3267505D1 (xx)
DK (3) DK162392C (xx)
EG (1) EG15803A (xx)
ES (2) ES8305768A1 (xx)
FI (1) FI74284C (xx)
GB (1) GB2095250A (xx)
GR (1) GR75935B (xx)
GT (1) GT198274393A (xx)
HK (1) HK52487A (xx)
HU (2) HU189917B (xx)
IE (1) IE52835B1 (xx)
IL (1) IL65308A (xx)
IN (1) IN159362B (xx)
MY (1) MY8700499A (xx)
NO (1) NO159658C (xx)
NZ (1) NZ200066A (xx)
PH (1) PH17602A (xx)
PL (3) PL138851B1 (xx)
PT (1) PT74621B (xx)
RO (2) RO87946A (xx)
SG (1) SG23387G (xx)
SU (2) SU1277898A3 (xx)
YU (2) YU42761B (xx)
ZA (1) ZA821899B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0084730A1 (en) * 1982-01-22 1983-08-03 Beecham Group Plc Esters of penicillin derivatives with beta-lactamase inhibitors, their preparation and their use
PH20068A (en) * 1982-12-06 1986-09-18 Pfizer Process and intermediates for sultamicillin and analogs
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
ES2039299B1 (es) * 1991-10-04 1994-05-16 Asturpharma S A Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.
ES2100125B1 (es) * 1995-06-02 1998-04-01 Asturpharma S A Procedimiento de preparacion de esteres de metanodiol de acido dioxopenicilanico.
CN112724162B (zh) * 2020-12-28 2022-06-10 华南农业大学 一种阿莫西林-舒巴坦杂合分子的合成方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE49880B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd Penicillin derivatives
KR830001903B1 (ko) * 1979-02-13 1983-09-19 레오 파마슈티칼 프로덕츠 리미티드 페니실란산유도체의 제조방법
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
ZA80646B (en) * 1979-03-05 1981-02-25 Pfizer Process and intermediates for penicillanic acid,1,1-dioxide and esters thereof
IE50650B1 (en) * 1979-10-11 1986-06-11 Leo Pharm Prod Ltd Method for producing penicillanic acid derivatives

Also Published As

Publication number Publication date
YU61982A (en) 1985-03-20
BG37380A3 (en) 1985-05-15
DK165746B (da) 1993-01-11
YU43585B (en) 1989-08-31
PL139261B1 (en) 1987-01-31
AU531892B2 (en) 1983-09-08
PL235578A1 (en) 1983-06-20
RO84278B (ro) 1984-07-30
AU8176482A (en) 1982-11-04
EP0061274B1 (en) 1985-11-21
IE52835B1 (en) 1988-03-16
JPS63146886A (ja) 1988-06-18
ES518970A0 (es) 1984-03-01
PT74621A (en) 1982-04-01
MY8700499A (en) 1987-12-31
FI74284B (fi) 1987-09-30
RO84278A (ro) 1984-05-23
GR75935B (xx) 1984-08-02
IE820659L (en) 1982-09-23
PL240664A1 (en) 1983-09-12
SU1277898A3 (ru) 1986-12-15
ZA821899B (en) 1983-01-26
DK21892A (da) 1992-02-20
HU189917B (en) 1986-08-28
DK127182A (da) 1982-09-24
HUT34985A (en) 1985-05-28
BG38939A3 (en) 1986-03-14
DK162392C (da) 1992-03-09
KR830009113A (ko) 1983-12-17
DK21892D0 (da) 1992-02-20
YU42761B (en) 1988-12-31
ES8403132A1 (es) 1984-03-01
KR860001368B1 (ko) 1986-09-17
FI74284C (fi) 1988-01-11
DD202163A5 (de) 1983-08-31
CA1213581A (en) 1986-11-04
IL65308A (en) 1985-03-31
IN159362B (xx) 1987-05-09
JPH0331717B2 (xx) 1991-05-08
EP0061274A1 (en) 1982-09-29
ES510655A0 (es) 1983-04-16
DK121491D0 (da) 1991-06-21
JPS57169493A (en) 1982-10-19
DK165746C (da) 1993-06-07
DE3267505D1 (en) 1986-01-02
ES8305768A1 (es) 1983-04-16
GT198274393A (es) 1983-09-08
HU187667B (en) 1986-02-28
NO159658C (no) 1989-01-25
PT74621B (en) 1984-11-26
IL65308A0 (en) 1982-05-31
PL138851B1 (en) 1986-11-29
NO159658B (no) 1988-10-17
RO87946A (ro) 1985-12-20
YU181084A (en) 1987-06-30
SG23387G (en) 1987-07-10
GB2095250A (en) 1982-09-29
PL134250B1 (en) 1985-08-31
DK162392B (da) 1991-10-21
RO87946B (ro) 1985-12-02
JPS6345287A (ja) 1988-02-26
HK52487A (en) 1987-07-17
NZ200066A (en) 1985-08-16
PL240663A1 (en) 1983-09-12
EG15803A (en) 1990-08-30
FI820991L (fi) 1982-09-24
PH17602A (en) 1984-10-05
NO820898L (no) 1982-09-24
DK121491A (da) 1991-06-21
DK167119B1 (da) 1993-08-30
SU1277897A3 (ru) 1986-12-15

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