CS221288B2 - Method of making the heterocyclic compounds - Google Patents
Method of making the heterocyclic compounds Download PDFInfo
- Publication number
- CS221288B2 CS221288B2 CS811644A CS164481A CS221288B2 CS 221288 B2 CS221288 B2 CS 221288B2 CS 811644 A CS811644 A CS 811644A CS 164481 A CS164481 A CS 164481A CS 221288 B2 CS221288 B2 CS 221288B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- dibenzo
- chloro
- enantiomers
- dihydro
- compounds
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title claims description 3
- 238000004519 manufacturing process Methods 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 21
- 239000002253 acid Substances 0.000 claims description 10
- 239000002585 base Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
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- 238000000034 method Methods 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 150000007513 acids Chemical class 0.000 claims description 4
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- 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
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- 150000004678 hydrides Chemical class 0.000 description 1
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- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
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- 239000005457 ice water Substances 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- INHCSSUBVCNVSK-UHFFFAOYSA-L lithium sulfate Inorganic materials [Li+].[Li+].[O-]S([O-])(=O)=O INHCSSUBVCNVSK-UHFFFAOYSA-L 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803008944 DE3008944A1 (de) | 1980-03-08 | 1980-03-08 | Dibenzimidazoazepine, ihre herstellung und verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS221288B2 true CS221288B2 (en) | 1983-04-29 |
Family
ID=6096617
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS811644A CS221288B2 (en) | 1980-03-08 | 1981-03-06 | Method of making the heterocyclic compounds |
| CS914104A CS410491A3 (en) | 1980-03-08 | 1991-12-27 | Heterocyclic derivatives, process of their preparation and pharmaceutical containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS914104A CS410491A3 (en) | 1980-03-08 | 1991-12-27 | Heterocyclic derivatives, process of their preparation and pharmaceutical containing them |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4313931A (en16) |
| EP (1) | EP0035749B1 (en16) |
| JP (1) | JPS56139484A (en16) |
| AU (1) | AU535359B2 (en16) |
| BG (1) | BG33886A3 (en16) |
| CA (1) | CA1150253A (en16) |
| CS (2) | CS221288B2 (en16) |
| DD (1) | DD156708A5 (en16) |
| DE (2) | DE3008944A1 (en16) |
| DK (1) | DK154299C (en16) |
| ES (1) | ES8301481A1 (en16) |
| FI (1) | FI70898C (en16) |
| GB (1) | GB2071095B (en16) |
| GR (1) | GR74805B (en16) |
| HK (1) | HK63186A (en16) |
| HU (1) | HU180628B (en16) |
| IE (1) | IE51015B1 (en16) |
| IL (1) | IL62309A (en16) |
| MX (1) | MX6869E (en16) |
| NO (1) | NO162073C (en16) |
| NZ (1) | NZ196446A (en16) |
| PH (1) | PH15839A (en16) |
| PL (1) | PL132141B1 (en16) |
| PT (1) | PT72631B (en16) |
| RO (1) | RO81652B (en16) |
| SU (1) | SU1015829A3 (en16) |
| UA (1) | UA8041A1 (en16) |
| YU (1) | YU42557B (en16) |
| ZA (1) | ZA811500B (en16) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ302483B6 (cs) * | 1999-11-12 | 2011-06-08 | Boehringer Ingelheim International Gmbh | Vodný roztok s obsahem epinastinu |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3134672A1 (de) * | 1981-09-02 | 1983-03-17 | Boehringer Ingelheim KG, 6507 Ingelheim | Heterocyclische verbindungen, ihre herstellung und verwendung |
| DE4102148A1 (de) * | 1991-01-25 | 1992-07-30 | Boehringer Ingelheim Kg | Verfahren zur herstellung von 3-amino-9,13b-dihydro-1h-dibenz-(c,f)imidazol(1,5-a)azepin-hydrochlorid |
| DE19542281C2 (de) * | 1995-11-14 | 1997-12-04 | Boehringer Ingelheim Kg | Verwendung von Epinastin für die Behandlung der Migräne |
| DE19958460A1 (de) * | 1999-12-03 | 2001-06-07 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Epinastine-Hydrochlorid in der hochschmelzenden Kristallmodifikation |
| US7776315B2 (en) * | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
| US20100310477A1 (en) * | 2000-11-28 | 2010-12-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Pharmaceutical compositions based on anticholingerics and additional active ingredients |
| RU2204563C2 (ru) * | 2001-06-22 | 2003-05-20 | Ярославский государственный технический университет | Гетероциклические о-дикарбонитрилы |
| DE10152973A1 (de) * | 2001-10-26 | 2003-05-08 | Boehringer Ingelheim Int | Neue trockene und wässrige Epinastin-Sirup-Formulierung |
| JP4298212B2 (ja) * | 2002-03-29 | 2009-07-15 | 大日本印刷株式会社 | 塩酸エピナスチン高融点型結晶の製造法 |
| MXPA04009753A (es) * | 2002-04-11 | 2005-06-08 | Konica Minolta Chemical Co Ltd | Metodo de produccion de 6-aminometil-6, 11-dihidro-5h-dibenz- [b,]azepina. |
| JP4514017B2 (ja) * | 2003-03-27 | 2010-07-28 | 大日本印刷株式会社 | 塩酸エピナスチンの製造方法 |
| US8758816B2 (en) * | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| JP5607291B2 (ja) * | 2004-11-24 | 2014-10-15 | メダ ファーマシューティカルズ インコーポレイテッド | アゼラスチンを含む組成物およびその使用方法 |
| US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
| KR20080034916A (ko) * | 2005-07-08 | 2008-04-22 | 센주 세이야꾸 가부시키가이샤 | 에피나스틴을 포함하는 경피 흡수 안과 제제 |
| US7247623B2 (en) * | 2005-08-19 | 2007-07-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with non-drying antihistamines |
| KR101386530B1 (ko) | 2006-12-29 | 2014-04-18 | 케이피엑스 라이프사이언스 주식회사 | 순도 및 수율이 향상된3-아미노-9,13ｂ디하이드로-1Ｈ-디벤즈-[ｃ,ｆ]이미다조[1,5-ａ]-아제핀 염산염의 제조방법 |
| WO2009063504A2 (en) * | 2007-09-24 | 2009-05-22 | Usv Limited | Novel crystal modification of epinastine or salts thereof and process for preparation thereof |
| WO2010021681A2 (en) * | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| JP2010120960A (ja) * | 2010-02-17 | 2010-06-03 | Dainippon Printing Co Ltd | 塩酸エピナスチンの製造方法 |
| JP6006634B2 (ja) * | 2011-12-28 | 2016-10-12 | 東和薬品株式会社 | イソウレア化合物を用いるエピナスチンの製造方法 |
| CN103172638B (zh) * | 2013-03-13 | 2015-09-16 | 北京朗依制药有限公司 | 一种盐酸依匹斯汀的制备方法 |
| CN104098575B (zh) * | 2013-04-15 | 2016-06-01 | 四川科瑞德凯华制药有限公司 | 一种盐酸依匹斯汀晶型及其制备方法和用途 |
| KR102041389B1 (ko) * | 2017-12-12 | 2019-11-27 | (주)프론트바이오 | N-(9,13b-디하이드로-1H-디벤조[c,f]이미다조[1,5-a]아제핀-3-일)-2-하이드록시벤즈아미드 및 2-((9,13b-디하이드로-1H-디벤조[c,f]이미다조[1,5-a]아제핀-3-일) 카바모일)페닐 아세테이트의 화합물, 이의 제조방법 및 이를 포함하는 항염증 및 진통제 조성물 |
| KR102080239B1 (ko) | 2019-08-06 | 2020-02-21 | 한양대학교 에리카산학협력단 | 에피나스틴의 신규 제조방법 |
| CN115974882A (zh) * | 2023-02-08 | 2023-04-18 | 广州艾格生物科技有限公司 | 一种盐酸依匹斯汀杂质的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789410A (fr) * | 1971-10-05 | 1973-01-15 | Akzo Nv | Nieuwe imidazolidine derivaten |
| NL7202963A (en16) * | 1972-03-07 | 1973-09-11 | ||
| NL7414038A (nl) * | 1974-10-28 | 1976-05-03 | Akzo Nv | Nieuwe tetracyclische pyrrolidino derivaten. |
-
1980
- 1980-03-08 DE DE19803008944 patent/DE3008944A1/de not_active Withdrawn
-
1981
- 1981-02-23 US US06/236,818 patent/US4313931A/en not_active Expired - Lifetime
- 1981-03-02 PH PH25292A patent/PH15839A/en unknown
- 1981-03-05 EP EP81101564A patent/EP0035749B1/de not_active Expired
- 1981-03-05 NO NO810762A patent/NO162073C/no not_active IP Right Cessation
- 1981-03-05 JP JP3190381A patent/JPS56139484A/ja active Granted
- 1981-03-05 UA UA3252241A patent/UA8041A1/uk unknown
- 1981-03-05 DD DD81228087A patent/DD156708A5/de not_active IP Right Cessation
- 1981-03-05 YU YU568/81A patent/YU42557B/xx unknown
- 1981-03-05 SU SU813252241A patent/SU1015829A3/ru active
- 1981-03-05 DE DE8181101564T patent/DE3163938D1/de not_active Expired
- 1981-03-06 MX MX819335U patent/MX6869E/es unknown
- 1981-03-06 BG BG051119A patent/BG33886A3/xx unknown
- 1981-03-06 ZA ZA00811500A patent/ZA811500B/xx unknown
- 1981-03-06 HU HU8181572A patent/HU180628B/hu unknown
- 1981-03-06 DK DK103581A patent/DK154299C/da not_active IP Right Cessation
- 1981-03-06 NZ NZ196446A patent/NZ196446A/en unknown
- 1981-03-06 ES ES500150A patent/ES8301481A1/es not_active Expired
- 1981-03-06 CA CA000372485A patent/CA1150253A/en not_active Expired
- 1981-03-06 IE IE485/81A patent/IE51015B1/en not_active IP Right Cessation
- 1981-03-06 GB GB8107114A patent/GB2071095B/en not_active Expired
- 1981-03-06 GR GR64337A patent/GR74805B/el unknown
- 1981-03-06 FI FI810712A patent/FI70898C/fi not_active IP Right Cessation
- 1981-03-06 PT PT72631A patent/PT72631B/pt unknown
- 1981-03-06 AU AU68158/81A patent/AU535359B2/en not_active Expired
- 1981-03-06 CS CS811644A patent/CS221288B2/cs unknown
- 1981-03-06 IL IL62309A patent/IL62309A/xx not_active IP Right Cessation
- 1981-03-06 PL PL1981230036A patent/PL132141B1/pl unknown
- 1981-03-07 RO RO103617A patent/RO81652B/ro unknown
-
1986
- 1986-08-28 HK HK631/86A patent/HK63186A/xx not_active IP Right Cessation
-
1991
- 1991-12-27 CS CS914104A patent/CS410491A3/cs unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ302483B6 (cs) * | 1999-11-12 | 2011-06-08 | Boehringer Ingelheim International Gmbh | Vodný roztok s obsahem epinastinu |
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