CS219880B2 - Method of isolation of the polysaccharide - Google Patents
Method of isolation of the polysaccharide Download PDFInfo
- Publication number
- CS219880B2 CS219880B2 CS772084A CS208477A CS219880B2 CS 219880 B2 CS219880 B2 CS 219880B2 CS 772084 A CS772084 A CS 772084A CS 208477 A CS208477 A CS 208477A CS 219880 B2 CS219880 B2 CS 219880B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- molecular weight
- coriolus
- fungus
- extraction
- temperature
- Prior art date
Links
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 13
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 title claims description 38
- 150000004676 glycans Chemical class 0.000 title claims description 4
- 238000002955 isolation Methods 0.000 title claims description 3
- 239000000243 solution Substances 0.000 claims abstract description 22
- 241000222356 Coriolus Species 0.000 claims abstract description 16
- 241000233866 Fungi Species 0.000 claims abstract description 16
- 230000000259 anti-tumor effect Effects 0.000 claims abstract description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 28
- 238000000605 extraction Methods 0.000 claims description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 238000001223 reverse osmosis Methods 0.000 claims description 10
- 241000221198 Basidiomycota Species 0.000 claims description 9
- 241000222355 Trametes versicolor Species 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 230000000644 propagated effect Effects 0.000 claims description 2
- 239000006286 aqueous extract Substances 0.000 claims 1
- 239000000284 extract Substances 0.000 abstract description 21
- 239000000126 substance Substances 0.000 abstract description 19
- -1 nitrogen-containing polysaccharide Chemical class 0.000 abstract description 11
- 239000012670 alkaline solution Substances 0.000 abstract description 7
- 239000012528 membrane Substances 0.000 description 15
- 238000000108 ultra-filtration Methods 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- 238000000746 purification Methods 0.000 description 9
- 208000006268 Sarcoma 180 Diseases 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 8
- 230000005764 inhibitory process Effects 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 238000007912 intraperitoneal administration Methods 0.000 description 6
- 230000003285 pharmacodynamic effect Effects 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 235000014633 carbohydrates Nutrition 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000005194 fractionation Methods 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 241000222357 Trametes hirsuta Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000921 elemental analysis Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- KJCVRFUGPWSIIH-UHFFFAOYSA-N 1-naphthol Chemical compound C1=CC=C2C(O)=CC=CC2=C1 KJCVRFUGPWSIIH-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000974482 Aricia saepiolus Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 241000222341 Polyporaceae Species 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 238000002523 gelfiltration Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000013627 low molecular weight specie Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000005185 salting out Methods 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000768983 Callitettix biformis Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 102100030497 Cytochrome c Human genes 0.000 description 1
- 108010075031 Cytochromes c Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 241001676647 Trametes pubescens Species 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 241000002830 Volutella consors Species 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000005907 cancer growth Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000010200 folin Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000005965 immune activity Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000003439 radiotherapeutic effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8066476A JPS536412A (en) | 1976-07-07 | 1976-07-07 | Preparation of n-containing polysaccharides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS219880B2 true CS219880B2 (en) | 1983-03-25 |
Family
ID=13724621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS772084A CS219880B2 (en) | 1976-07-07 | 1977-03-29 | Method of isolation of the polysaccharide |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US4202969A (OSRAM) |
| JP (1) | JPS536412A (OSRAM) |
| AR (1) | AR213963A1 (OSRAM) |
| AT (1) | AT360145B (OSRAM) |
| AU (1) | AU497455B2 (OSRAM) |
| BE (1) | BE852987A (OSRAM) |
| BG (1) | BG33007A3 (OSRAM) |
| BR (1) | BR7703439A (OSRAM) |
| CA (1) | CA1072034A (OSRAM) |
| CH (1) | CH628649A5 (OSRAM) |
| CS (1) | CS219880B2 (OSRAM) |
| DD (1) | DD130249A5 (OSRAM) |
| DE (2) | DE2759978C2 (OSRAM) |
| DK (1) | DK145505C (OSRAM) |
| ES (1) | ES457722A1 (OSRAM) |
| FR (1) | FR2361910A1 (OSRAM) |
| GB (1) | GB1571075A (OSRAM) |
| HU (1) | HU175947B (OSRAM) |
| IN (1) | IN145169B (OSRAM) |
| IT (1) | IT1075700B (OSRAM) |
| MX (1) | MX4243E (OSRAM) |
| NL (1) | NL169616C (OSRAM) |
| PH (1) | PH12242A (OSRAM) |
| PL (1) | PL102730B1 (OSRAM) |
| RO (1) | RO70328A (OSRAM) |
| SE (1) | SE436170B (OSRAM) |
| SU (1) | SU730277A3 (OSRAM) |
| YU (1) | YU39795B (OSRAM) |
| ZA (1) | ZA773442B (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851395A (en) * | 1976-07-07 | 1989-07-25 | Kureha Kagaku Kogyo Kabushiki Kausha | Nitrogen-containing polysaccharide |
| JPS536413A (en) * | 1976-07-07 | 1978-01-20 | Kureha Chem Ind Co Ltd | Preparation of n-containing polysaccharides |
| JPS5315495A (en) * | 1976-07-22 | 1978-02-13 | Kureha Chem Ind Co Ltd | Preparation of polysaccharides |
| JPS5394012A (en) * | 1977-01-27 | 1978-08-17 | Kureha Chem Ind Co Ltd | Novel polysaccharide and its preparation |
| FR2444464A1 (fr) * | 1978-12-19 | 1980-07-18 | Fabre Sa Pierre | Proteoglycanes bacteriens purifies, procede pour leur preparation et vaccin les contenant |
| JPS5626198A (en) * | 1979-08-08 | 1981-03-13 | Takara Shuzo Co Ltd | Preparation of antitumor substance |
| JPS5932480B2 (ja) * | 1981-02-10 | 1984-08-09 | 呉羽化学工業株式会社 | 新規な糖蛋白複合体 |
| NZ199752A (en) * | 1981-02-27 | 1984-11-09 | Otsuka Pharma Co Ltd | Glycoproteins and immunoactive compositions |
| US4614733A (en) * | 1981-12-31 | 1986-09-30 | Kureha Kagaku Kogyo Kabushiki Kaisha | Polysaccharides pharmaceutical compositions and the use thereof |
| US4417415A (en) * | 1982-04-26 | 1983-11-29 | Battelle Development Corporation | Process for culturing a microalga, and extracting a polysaccharide therefrom |
| JPS5913729A (ja) * | 1982-07-15 | 1984-01-24 | Mutsunori Fujiwara | 含窒素多糖体の製造方法 |
| JPS5926109U (ja) * | 1982-08-10 | 1984-02-18 | 福井鋲螺株式会社 | 拡開性取付具 |
| DE3448149C2 (OSRAM) * | 1983-08-11 | 1990-01-04 | Kureha Kagaku Kogyo K.K., Tokio/Tokyo, Jp | |
| JPH0825890B2 (ja) * | 1987-06-18 | 1996-03-13 | 呉羽化学工業株式会社 | 抗ウイルス剤 |
| KR900007498B1 (ko) * | 1987-06-18 | 1990-10-11 | 구레하 가가꾸 고교 가부시끼가이샤 | 다당류 및 그것을 활성성분으로 함유하는 항바이러스 약제 |
| CA1339308C (en) * | 1987-06-18 | 1997-08-19 | Koichi Niimura | Polysaccharides and antiviral drug containing polysaccharides as active ingredient |
| JPH0643336B2 (ja) * | 1988-06-30 | 1994-06-08 | 呉羽化学工業株式会社 | 血管増殖抑制剤 |
| JP2782443B2 (ja) * | 1988-12-26 | 1998-07-30 | 將純 吉原 | 抗エイズウィルス剤 |
| CA2156767A1 (en) * | 1994-08-25 | 1996-02-26 | Kenichi Matsunaga | Binding agent for growth factor |
| US7048932B2 (en) * | 2002-05-22 | 2006-05-23 | The Chinese University Of Hong Kong | Preparation and standardization of immunomodulatory peptide-linked glucans with verifiable oral absorbability from coriolus versicolor |
| US7829098B2 (en) * | 2005-11-08 | 2010-11-09 | Vita Green Health Products Co., Ltd | Herbal powder extracts and methods of preparing and using the same |
| US7854936B2 (en) * | 2008-01-14 | 2010-12-21 | Active Organics, Inc. | Anti-inflammatory hydrolysate of C. versicolor |
| WO2012046145A2 (en) | 2010-10-06 | 2012-04-12 | Purapharm International (Hk) Limited | Coriolus versicolor extracts, methods of preparation and uses thereof |
| CN103113442B (zh) * | 2013-02-28 | 2015-04-22 | 华南理工大学 | 一种从冬虫夏草菌丝体中提取虫草多糖和腺苷的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3436311A (en) * | 1966-02-28 | 1969-04-01 | Pillsbury Co | Fungal polysaccharide composition and method for making same |
| DE1915687C2 (de) * | 1968-03-28 | 1982-03-18 | Kaken Kagaku K.K., Tokyo | Pharmazeutisches Präparat mit Antitumorwirkung |
| US3759896A (en) * | 1968-03-28 | 1973-09-18 | T Yamamoto | Process for manufacture of polysaccharides with antitumor action |
| US3436346A (en) * | 1968-06-10 | 1969-04-01 | Pillsbury Co | Process for preparing filterable aqueous polysaccharide solutions |
| BE757248A (fr) * | 1969-10-15 | 1971-04-08 | Kureha Chemical Ind Co Ltd | Substance a propriete anticancereuse et procedes pour sa preparation |
| US3754925A (en) * | 1970-03-24 | 1973-08-28 | Takeda Chemical Industries Ltd | New thermo gelable polysaccharide containing foodstuffs |
| US4051314A (en) * | 1970-10-14 | 1977-09-27 | Kureha Kagaku Kogyo Kabushiki Kaisha | Polysaccharides and method for producing same |
| US3933788A (en) * | 1971-11-11 | 1976-01-20 | Kelco Company | Polysaccharide and bacterial fermentation process for its preparation |
| JPS4924211A (OSRAM) * | 1972-07-01 | 1974-03-04 | ||
| JPS544960B2 (OSRAM) * | 1972-07-17 | 1979-03-12 | ||
| JPS57793B2 (OSRAM) * | 1972-09-16 | 1982-01-07 | ||
| FR2261755A1 (en) * | 1974-02-25 | 1975-09-19 | Thomas Andre | Glyco protein and mucopolysaccharides extraction - from naturally occuring materials fr use in cosmetics |
| JPS5290614A (en) * | 1975-12-18 | 1977-07-30 | Kureha Chem Ind Co Ltd | Preparation of anti-tumor substance |
| PH14773A (en) * | 1976-01-01 | 1981-12-09 | Kureha Chemical Ind Co Ltd | Protein-bound polysaccharides |
| JPS536413A (en) * | 1976-07-07 | 1978-01-20 | Kureha Chem Ind Co Ltd | Preparation of n-containing polysaccharides |
| JPS5315495A (en) * | 1976-07-22 | 1978-02-13 | Kureha Chem Ind Co Ltd | Preparation of polysaccharides |
| JPS5446830A (en) * | 1977-09-16 | 1979-04-13 | Kureha Chem Ind Co Ltd | Pesticide for plant viral disease |
-
1976
- 1976-07-07 JP JP8066476A patent/JPS536412A/ja active Granted
-
1977
- 1977-03-21 YU YU737/77A patent/YU39795B/xx unknown
- 1977-03-21 SE SE7703195A patent/SE436170B/xx not_active IP Right Cessation
- 1977-03-26 DE DE2759978A patent/DE2759978C2/de not_active Expired
- 1977-03-26 DE DE2713458A patent/DE2713458C2/de not_active Expired
- 1977-03-28 IN IN464/CAL/1977A patent/IN145169B/en unknown
- 1977-03-29 BE BE176205A patent/BE852987A/xx not_active IP Right Cessation
- 1977-03-29 GB GB13271/77A patent/GB1571075A/en not_active Expired
- 1977-03-29 CS CS772084A patent/CS219880B2/cs unknown
- 1977-03-30 NL NLAANVRAGE7703434,A patent/NL169616C/xx not_active IP Right Cessation
- 1977-03-30 AT AT219277A patent/AT360145B/de not_active IP Right Cessation
- 1977-03-30 CA CA275,105A patent/CA1072034A/en not_active Expired
- 1977-03-31 RO RO7789869A patent/RO70328A/ro unknown
- 1977-03-31 CH CH403577A patent/CH628649A5/de not_active IP Right Cessation
- 1977-04-05 FR FR7710263A patent/FR2361910A1/fr active Granted
- 1977-04-05 DK DK151877A patent/DK145505C/da not_active IP Right Cessation
- 1977-04-11 DD DD7700198342A patent/DD130249A5/xx unknown
- 1977-04-12 ES ES457722A patent/ES457722A1/es not_active Expired
- 1977-04-12 AU AU24167/77A patent/AU497455B2/en not_active Expired
- 1977-04-13 PL PL1977197374A patent/PL102730B1/pl unknown
- 1977-04-15 IT IT22507/77A patent/IT1075700B/it active
- 1977-04-19 US US05/788,992 patent/US4202969A/en not_active Expired - Lifetime
- 1977-04-20 SU SU772472207A patent/SU730277A3/ru active
- 1977-05-20 PH PH19793A patent/PH12242A/en unknown
- 1977-05-27 BR BR7703439A patent/BR7703439A/pt unknown
- 1977-06-07 ZA ZA00773442A patent/ZA773442B/xx unknown
- 1977-06-08 MX MX775785U patent/MX4243E/es unknown
- 1977-06-17 AR AR268091A patent/AR213963A1/es active
- 1977-07-06 BG BG036817A patent/BG33007A3/xx unknown
- 1977-07-07 HU HU77KU518A patent/HU175947B/hu unknown
-
1984
- 1984-03-06 US US06/585,037 patent/US4699787A/en not_active Expired - Fee Related
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