CS214691B2 - Method of making the vindesine - Google Patents

Method of making the vindesine Download PDF

Info

Publication number
CS214691B2
CS214691B2 CS80235A CS23580A CS214691B2 CS 214691 B2 CS214691 B2 CS 214691B2 CS 80235 A CS80235 A CS 80235A CS 23580 A CS23580 A CS 23580A CS 214691 B2 CS214691 B2 CS 214691B2
Authority
CS
Czechoslovakia
Prior art keywords
vindesine
triphenylphosphine
solution
tetrahydrofuran
vlb
Prior art date
Application number
CS80235A
Other languages
Czech (cs)
English (en)
Inventor
Gloris C Paschal
Geral L Thompson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS214691B2 publication Critical patent/CS214691B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
CS80235A 1979-01-15 1980-01-10 Method of making the vindesine CS214691B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/003,442 US4210584A (en) 1979-01-15 1979-01-15 Vindesine synthesis

Publications (1)

Publication Number Publication Date
CS214691B2 true CS214691B2 (en) 1982-05-28

Family

ID=21705894

Family Applications (1)

Application Number Title Priority Date Filing Date
CS80235A CS214691B2 (en) 1979-01-15 1980-01-10 Method of making the vindesine

Country Status (34)

Country Link
US (1) US4210584A (es)
EP (1) EP0014053B1 (es)
JP (1) JPS5598195A (es)
KR (1) KR830002840B1 (es)
AR (1) AR223694A1 (es)
AT (1) AT371127B (es)
AU (1) AU5452280A (es)
BE (1) BE881078A (es)
BG (1) BG33295A3 (es)
CA (1) CA1148945A (es)
CH (1) CH645383A5 (es)
CS (1) CS214691B2 (es)
DD (1) DD148779A5 (es)
DE (1) DE3065852D1 (es)
DK (1) DK148961C (es)
ES (2) ES8101611A1 (es)
FI (1) FI800071A (es)
FR (1) FR2446290A1 (es)
GB (1) GB2040934B (es)
GR (1) GR72464B (es)
HU (1) HU182083B (es)
IE (1) IE49376B1 (es)
IL (1) IL59119A (es)
IT (1) IT1140506B (es)
LU (1) LU82079A1 (es)
MY (1) MY8500570A (es)
NZ (1) NZ192574A (es)
PH (1) PH15343A (es)
PL (1) PL124350B1 (es)
PT (1) PT70681A (es)
RO (1) RO77532A (es)
SU (1) SU906381A3 (es)
YU (1) YU5680A (es)
ZA (1) ZA80157B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60112895A (ja) * 1983-11-24 1985-06-19 Nippon Oil & Fats Co Ltd 金属圧延用潤滑油
FR2651348B1 (es) * 1989-08-04 1993-01-22 Adir
TW258739B (es) * 1992-04-04 1995-10-01 Hoechst Ag
JP2003513756A (ja) * 1999-11-12 2003-04-15 アンジオテック ファーマシューティカルズ，インコーポレイテッド 放射性治療と細胞周期インヒビターとの組合せの組成物
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
CN106831826B (zh) * 2016-12-31 2018-07-06 广州白云山汉方现代药业有限公司 一种从长春花中制备长春地辛的方法
CN106831827B (zh) * 2016-12-31 2019-03-29 广州白云山汉方现代药业有限公司 一种长春地辛的分离纯化方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2756235A (en) * 1954-08-27 1956-07-24 Lilly Co Eli Method of producing lysergic acid amide

Also Published As

Publication number Publication date
SU906381A3 (ru) 1982-02-15
CH645383A5 (fr) 1984-09-28
PL124350B1 (en) 1983-01-31
DD148779A5 (de) 1981-06-10
JPS6332796B2 (es) 1988-07-01
LU82079A1 (fr) 1980-04-23
GB2040934B (en) 1983-03-09
IE49376B1 (en) 1985-10-02
PH15343A (en) 1982-12-02
ES487682A0 (es) 1980-12-16
AT371127B (de) 1983-06-10
EP0014053B1 (en) 1983-12-14
PT70681A (en) 1980-02-01
YU5680A (en) 1983-02-28
DK14780A (da) 1980-07-16
IT1140506B (it) 1986-10-01
ATA14080A (de) 1982-10-15
AU5452280A (en) 1980-07-24
HU182083B (en) 1983-12-28
ES8101612A1 (es) 1980-12-16
DE3065852D1 (en) 1984-01-19
IE800060L (en) 1980-07-15
BG33295A3 (en) 1983-01-14
CA1148945A (en) 1983-06-28
KR830002840B1 (ko) 1983-12-27
IT8019210A0 (it) 1980-01-14
AR223694A1 (es) 1981-09-15
FI800071A (fi) 1980-07-16
IL59119A (en) 1983-06-15
ES8101611A1 (es) 1980-12-16
DK148961C (da) 1986-05-20
US4210584A (en) 1980-07-01
IL59119A0 (en) 1980-05-30
EP0014053A1 (en) 1980-08-06
FR2446290B1 (es) 1983-06-24
GB2040934A (en) 1980-09-03
ZA80157B (en) 1981-08-26
JPS5598195A (en) 1980-07-25
RO77532A (ro) 1982-02-26
MY8500570A (en) 1985-12-31
NZ192574A (en) 1982-03-16
GR72464B (es) 1983-11-10
BE881078A (fr) 1980-07-10
DK148961B (da) 1985-12-02
FR2446290A1 (fr) 1980-08-08
KR830001961A (ko) 1983-05-21
ES487726A0 (es) 1980-12-16
PL221359A1 (es) 1980-12-15

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