CS203092B2 - Method of preparing substituted purines - Google Patents

Method of preparing substituted purines Download PDF

Info

Publication number
CS203092B2
CS203092B2 CS755957A CS595775A CS203092B2 CS 203092 B2 CS203092 B2 CS 203092B2 CS 755957 A CS755957 A CS 755957A CS 595775 A CS595775 A CS 595775A CS 203092 B2 CS203092 B2 CS 203092B2
Authority
CS
Czechoslovakia
Prior art keywords
hydrogen
amino
formula
alkyl
compound
Prior art date
Application number
CS755957A
Other languages
Czech (cs)
English (en)
Inventor
Howard J Schaeffer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10402412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS203092(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Priority to CS773125A priority Critical patent/CS203095B2/cs
Priority to CS773124A priority patent/CS203094B2/cs
Publication of CS203092B2 publication Critical patent/CS203092B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
CS755957A 1974-09-02 1975-09-02 Method of preparing substituted purines CS203092B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS773125A CS203095B2 (cs) 1974-09-02 1977-05-12 Způsob přípravy substituovaných purinů
CS773124A CS203094B2 (cs) 1974-09-02 1977-05-12 Způsob přípravy substituovaných purinů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB38278/74A GB1523865A (en) 1974-09-02 1974-09-02 Purine compunds and salts thereof

Publications (1)

Publication Number Publication Date
CS203092B2 true CS203092B2 (en) 1981-02-27

Family

ID=10402412

Family Applications (2)

Application Number Title Priority Date Filing Date
CS755957A CS203092B2 (en) 1974-09-02 1975-09-02 Method of preparing substituted purines
CS773087A CS203093B2 (en) 1974-09-02 1975-09-02 Method of preparing substituted purines

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS773087A CS203093B2 (en) 1974-09-02 1975-09-02 Method of preparing substituted purines

Country Status (35)

Country Link
US (3) US4360522A (ru)
JP (1) JPS5154589A (ru)
AR (4) AR220299A1 (ru)
AT (1) AT354462B (ru)
AU (1) AU503160B2 (ru)
BE (1) BE833006A (ru)
BG (4) BG26536A4 (ru)
CA (1) CA1062257A (ru)
CH (7) CH626363A5 (ru)
CS (2) CS203092B2 (ru)
CY (1) CY1033A (ru)
DD (1) DD122092A5 (ru)
DE (1) DE2539963A1 (ru)
DK (1) DK146595C (ru)
ES (3) ES440631A1 (ru)
FI (1) FI60709C (ru)
FR (1) FR2282892A1 (ru)
GB (1) GB1523865A (ru)
HK (1) HK84379A (ru)
HU (1) HU176730B (ru)
IE (1) IE42282B1 (ru)
IL (1) IL48035A (ru)
KE (1) KE3002A (ru)
LU (1) LU73304A1 (ru)
MC (1) MC1068A1 (ru)
MY (1) MY8200191A (ru)
NL (1) NL175061C (ru)
NO (1) NO144216C (ru)
NZ (1) NZ178556A (ru)
RO (4) RO74275A (ru)
SE (1) SE428562C (ru)
SU (7) SU904523A3 (ru)
YU (4) YU39947B (ru)
ZA (1) ZA755574B (ru)
ZM (1) ZM12875A1 (ru)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146715A (en) 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
AU521577B2 (en) * 1977-02-24 1982-04-22 Wellcome Foundation Limited, The 9-hydroxyethoxymethyl guanine phosphates
US4287188A (en) 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
KR830005852A (ko) * 1980-07-18 1983-09-14 미첼 페터 잭슨 피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU547311B2 (en) * 1980-10-15 1985-10-17 Wellcome Foundation Limited, The Treating viral infections in fish
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4603219A (en) * 1981-05-21 1986-07-29 Syntex (U.S.A.) Inc. 1,3-dibenzyloxy-2-acetoxymethoxypropane, intermediate for 9-(1,3-dihydroxy-2-propoxymethyl)guanine
PL141198B1 (en) * 1981-08-11 1987-07-31 Wellcome Found Process for preparing derivatives of purine
AU564576B2 (en) * 1981-09-24 1987-08-20 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Purine derivatives
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
ATE24836T1 (de) * 1982-02-12 1987-01-15 Ens Bio Logicals Inc Antivirale zusammensetzungen.
SE8203856D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine ii
SE8203855D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine i
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DK472683A (da) * 1982-10-14 1984-04-15 Wellcome Found Fremgangsmaade til fremstilling af purinderivater
US5059604A (en) * 1982-10-14 1991-10-22 Burroughs Wellcome Co. 2-amino purine derivatives
US4745119A (en) * 1982-10-14 1988-05-17 Burroughs Wellcome Co. Method for using purine derivatives
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4649140A (en) * 1982-10-14 1987-03-10 Burroughs Wellcome Co. Purine derivatives
US4612314A (en) * 1982-12-22 1986-09-16 Syntex (U.S.A.) Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
ES520140A0 (es) * 1983-02-25 1984-04-01 Ind Farma Especial Un procedimiento para la preparacion de acicloguanosina.
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
JPS6023380A (ja) * 1983-06-24 1985-02-05 メルク・エンド・カムパニー・インコーポレーテッド 抗ウイルス剤
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
JPS6094992A (ja) * 1983-10-28 1985-05-28 Sankyo Co Ltd グリゼオ−ル酸誘導体
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
US4918219A (en) * 1983-10-31 1990-04-17 Warner-Lambert Company Glycerine derivatives
ZA848080B (en) * 1983-10-31 1985-06-26 Warner Lambert Co Purine derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
US4617304A (en) * 1984-04-10 1986-10-14 Merck & Co., Inc. Purine derivatives
IL74881A0 (en) * 1984-04-13 1985-07-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
JPH0625061B2 (ja) 1984-07-03 1994-04-06 ザ ウエルカム フアウンデ−シヨン リミテツド 抗ウイルス性化合物
WO1986000901A1 (en) * 1984-07-20 1986-02-13 Gauntt Charles O Immunoregulatory and anti-viral compound
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US5683990A (en) * 1985-03-16 1997-11-04 Glaxo Wellcome Inc. Treatment of human viral infections
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
DE3667058D1 (en) 1985-05-02 1989-12-28 Wellcome Found Antiviral compounds
DE3529497A1 (de) * 1985-08-17 1987-02-26 Boehringer Mannheim Gmbh N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
IT1207507B (it) * 1985-10-21 1989-05-25 Baldacci Lab Spa Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.
JP2930589B2 (ja) * 1986-10-06 1999-08-03 ザ ユニバーシィティ オブ バージニア アルミニ パテンツ ファンデーション 外科手術中における改善された心臓保護のためのアデノシン，ヒポキサンチン及びリボース含有溶液の使用
US4916225A (en) * 1986-11-25 1990-04-10 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr 9-substituted guanines
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
US4829055A (en) * 1987-01-23 1989-05-09 Naficy Sadeque S Method of treatment for herpes infections of external tissues
US5565566A (en) * 1987-04-24 1996-10-15 Discovery Therapeutics, Inc. N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US6306647B1 (en) 1987-06-16 2001-10-23 Ajinomoto Co., Inc. Process for producing and purifying 2′,3′-dideoxynucleosides, and process for producing 2′,3′-dideoxy-2′,3′-didehydronucleosides
US4835104A (en) * 1987-06-16 1989-05-30 Ajinomoto Co., Inc., Patent & Licensing Department Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides
GB8719367D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
GB8725939D0 (en) * 1987-11-05 1987-12-09 Wellcome Found Therapeutic compounds
CA1302887C (en) * 1987-11-24 1992-06-09 Yves Langelier Combination of acyclovir or a derivative thereof and bacitracin
JPH01121424U (ru) * 1988-02-10 1989-08-17
US5164395A (en) * 1988-06-27 1992-11-17 Burroughs Wellcome Co. Antiviral acetyl pyridine derivative or said acetyl pyridine derivative in combination with acyclovir
GB8815241D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Antiviral combinations & compounds therefor
GB8816760D0 (en) * 1988-07-14 1988-08-17 Wellcome Found Therapeutic compounds
DE68907013D1 (de) * 1988-10-24 1993-07-15 Wellcome Found Guaninderivate mit antiviraler wirkung und deren pharmazeutisch vertraegliche salze.
EP0457773A4 (en) * 1989-01-31 1993-03-10 Whitby Research Incorporated N?6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
GB8907173D0 (en) * 1989-03-30 1989-05-10 Beecham Group Plc Novel compounds
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
GB9001886D0 (en) * 1990-01-26 1990-03-28 Beecham Group Plc Pharmaceutical formulation
DE4008858A1 (de) * 1990-03-20 1991-09-26 Hoechst Ag Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
CA2033447C (en) * 1990-12-31 1999-08-31 Robert Deziel Synergistic combination for treating herpes infections
US5580571A (en) * 1991-10-15 1996-12-03 Hostetler; Karl Y. Nucleoside analogues
US5879700A (en) * 1991-10-15 1999-03-09 Hostetler; Karl Y. Nucleoside analogue phosphates for topical use
CA2091732C (en) * 1992-07-08 1998-07-21 Anica Markovac A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine
DK169121B1 (da) 1992-09-09 1994-08-22 Gea Farmaceutisk Fabrik As Antiviralt virksom farmaceutisk olie-i-vand-emulsion indeholdende 9-[(2-hydroxyethoxy)methyl]guanin (acyclovir) eller et salt eller en ester deraf
DE59310344D1 (de) * 1992-09-24 2003-07-24 Hoechst Ag N1-Substituierte 1H-1,2,3-Triazolo[4,5-d]pyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
US6015573A (en) * 1993-05-12 2000-01-18 Hostetler; Karl Y. Nucleoside phosphate therapy for viral infection
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
IT1264599B1 (it) * 1993-06-14 1996-10-04 Solar Chem Sa Processo per la sintesi della 9-(2-idrossietossimetil)- guanina
US5567816A (en) * 1994-07-26 1996-10-22 Syntex (U.S.A.) Inc. Preparation of acyclovir using 1,3 dioxolane
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US6083953A (en) * 1994-07-28 2000-07-04 Syntex (U.S.A.) Inc. 2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative
US5565565A (en) * 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
IN179493B (ru) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
US5789589A (en) * 1996-04-22 1998-08-04 Drug Innovation & Design, Inc. Guanine analog phosphates
US6440980B1 (en) * 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
DE69807464T2 (de) * 1997-05-15 2003-05-15 Drug Innovation & Design Inc Diester-derivate von acyclovir
US6180790B1 (en) 1997-05-15 2001-01-30 Drug Innovation And Design, Inc. Methods of preparing acyclovir prodrugs
YU31104A (sh) * 2001-10-16 2006-08-17 Avanir Pharmaceuticals Inhibicija virusa n-dokozanolom
US20070129334A1 (en) * 2001-10-30 2007-06-07 Conforma Therapeutics Corporation Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
US7241890B2 (en) * 2001-10-30 2007-07-10 Conforma Therapeutics Corporation Purine analogs having HSP90-inhibiting activity
US7078524B2 (en) 2002-11-22 2006-07-18 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
US20040224916A1 (en) 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
US20040200730A1 (en) * 2003-04-14 2004-10-14 Kyo Jibiki Hydrometallurgical copper recovery process
WO2005112937A1 (en) 2004-05-19 2005-12-01 Emisphere Technologies, Inc. Acyclovir formulations
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
WO2007106561A2 (en) * 2006-03-14 2007-09-20 Alt Solutions, Inc. Prevention and treatment of cancer and other diseases
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2376514A2 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
AR074897A1 (es) 2008-12-23 2011-02-23 Pharmasset Inc Fosforamidatos de nucleosidos
PA8855801A1 (es) 2008-12-23 2010-07-27 Sintesis de nucleosidos de purina
US8859756B2 (en) 2010-03-31 2014-10-14 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
GB201819418D0 (en) 2018-11-29 2019-01-16 Daniel Calladine Ltd Anti-viral compositions
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4146715A (en) * 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines

Also Published As

Publication number Publication date
US4323573A (en) 1982-04-06
AR212914A1 (es) 1978-11-15
CH626363A5 (ru) 1981-11-13
AR220299A1 (es) 1980-10-31
SE428562B (sv) 1983-07-11
RO76939A (ro) 1981-06-22
FI752465A (ru) 1976-03-03
SU858569A3 (ru) 1981-08-23
CH623586A5 (ru) 1981-06-15
YU119982A (en) 1982-08-31
CS203093B2 (en) 1981-02-27
US4360522A (en) 1982-11-23
AU8445975A (en) 1977-03-10
SU686618A3 (ru) 1979-09-15
DE2539963A1 (de) 1976-03-18
RO74275A (ro) 1981-09-24
BG26536A4 (ru) 1979-04-12
SU700064A3 (ru) 1979-11-25
YU120182A (en) 1982-08-31
AR220508A1 (es) 1980-11-14
YU222075A (en) 1982-08-31
ES455978A1 (es) 1978-01-16
DK146595C (da) 1984-04-24
DD122092A5 (ru) 1976-09-12
BG24815A3 (en) 1978-05-12
DE2539963C2 (ru) 1987-01-22
ZM12875A1 (en) 1977-09-21
IE42282L (en) 1976-03-02
ES440631A1 (es) 1977-06-16
YU40079B (en) 1985-06-30
HK84379A (en) 1979-12-14
DK392675A (da) 1976-03-03
MY8200191A (en) 1982-12-31
IL48035A0 (en) 1975-11-25
CH628897A5 (de) 1982-03-31
ES455979A1 (es) 1978-01-16
CH629805A5 (de) 1982-05-14
SU784777A3 (ru) 1980-11-30
BE833006A (fr) 1976-03-02
SU799664A3 (ru) 1981-01-23
ATA676375A (de) 1979-06-15
YU120082A (en) 1982-08-31
AR220885A1 (es) 1980-12-15
NZ178556A (en) 1978-09-25
NO144216C (no) 1981-07-15
FR2282892A1 (fr) 1976-03-26
CH626364A5 (ru) 1981-11-13
KE3002A (en) 1979-12-14
SU751325A3 (ru) 1980-07-23
JPS5154589A (en) 1976-05-13
MC1068A1 (fr) 1976-05-21
IL48035A (en) 1981-07-31
NL175061B (nl) 1984-04-16
AU503160B2 (en) 1979-08-23
YU40080B (en) 1985-06-30
SE7509675L (sv) 1976-03-03
NO144216B (no) 1981-04-06
NO753009L (ru) 1976-03-03
CA1062257A (en) 1979-09-11
RO74276A (ro) 1981-06-26
GB1523865A (en) 1978-09-06
BG25094A3 (en) 1978-07-12
BG26389A3 (ru) 1979-03-15
SU904523A3 (ru) 1982-02-07
RO74274A (ro) 1981-09-24
ZA755574B (en) 1977-04-27
US4294831A (en) 1981-10-13
CY1033A (en) 1980-08-01
HU176730B (en) 1981-04-28
CH629206A5 (de) 1982-04-15
AT354462B (de) 1979-01-10
IE42282B1 (en) 1980-07-16
NL7510342A (nl) 1976-03-04
SE428562C (sv) 1985-08-20
FI60709C (fi) 1982-03-10
CH623587A5 (ru) 1981-06-15
NL175061C (nl) 1984-09-17
JPS6147839B2 (ru) 1986-10-21
YU39947B (en) 1985-06-30
FI60709B (fi) 1981-11-30
FR2282892B1 (ru) 1980-04-25
DK146595B (da) 1983-11-14
LU73304A1 (ru) 1976-08-13

Similar Documents

Publication Publication Date Title
CS203092B2 (en) Method of preparing substituted purines
US4199574A (en) Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4146715A (en) 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines
EP1017394B1 (en) Cyclin dependent kinase inhibiting purine derivatives
US4287188A (en) Purine derivatives
EP0215759A1 (en) Antiviral carbocyclic analogs of xylofuranosylpurines
SK391891A3 (en) Xanthine derivatives and pharmaceutical composition comprising same
CA2326357A1 (en) Cyclin dependent kinase inhibitors
JPS63297381A (ja) ９−〔２−（ヒドロキシメチル）シクロアルキルメチル〕グアニン類
PL150841B1 (en) Purine compounds.
US4060616A (en) Purine derivatives with repeating unit
US4863927A (en) 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
US5648489A (en) Syntheses of acyclic guanine nucleosides
CA1086316A (en) Purine acyclic nucleosides
GB1561380A (en) Esters of hydroxyalkoxyalkyl purines their preparation and pharmaceutical compositions containing them
CS203095B2 (cs) Způsob přípravy substituovaných purinů
KR830000709B1 (ko) 9-(하이드록시알킬) 푸린류의 제조방법
CS199665B2 (cs) Způsob přípravy 9-substituovaných purinů
CS199666B2 (cs) Způsob přípravy 9-substituovaných purinů
SI8211200A8 (sl) Postopek za pridobivanje 9-(2-hidroksi-etoksimetil)gvaninskih derivatov purina
KR20000051515A (ko) 항바이러스 활성을 가지는 2-아미노퓨린