CS199631B2 - Method of producing new chromogen enzyme substrate - Google Patents

Method of producing new chromogen enzyme substrate Download PDF

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Publication number
CS199631B2
CS199631B2 CS764543A CS454376A CS199631B2 CS 199631 B2 CS199631 B2 CS 199631B2 CS 764543 A CS764543 A CS 764543A CS 454376 A CS454376 A CS 454376A CS 199631 B2 CS199631 B2 CS 199631B2
Authority
CS
Czechoslovakia
Prior art keywords
group
lysine
substrates
reaction
terminal
Prior art date
Application number
CS764543A
Other languages
Czech (cs)
English (en)
Inventor
Ekenstam Bo Thuressonaf Af
Leif E Aurell
Karl G Claeson
Birgitta G Karlsson
Stig I Gustavsson
Gun A Clausson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of CS199631B2 publication Critical patent/CS199631B2/cs

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10Anilides
    • C12Q2337/12Para-Nitroanilides p-NA

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CS764543A 1975-07-11 1976-07-08 Method of producing new chromogen enzyme substrate CS199631B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7507974A SE407571B (sv) 1975-07-11 1975-07-11 Nya kromogena enzymsubstrat for serinproteaser

Publications (1)

Publication Number Publication Date
CS199631B2 true CS199631B2 (en) 1980-07-31

Family

ID=20325115

Family Applications (1)

Application Number Title Priority Date Filing Date
CS764543A CS199631B2 (en) 1975-07-11 1976-07-08 Method of producing new chromogen enzyme substrate

Country Status (23)

Country Link
US (1) US4214049A (ja)
JP (1) JPS5224581A (ja)
AT (1) AT349648B (ja)
AU (1) AU497546B2 (ja)
BE (1) BE843969A (ja)
CA (1) CA1081212A (ja)
CH (1) CH622285A5 (ja)
CS (1) CS199631B2 (ja)
DD (1) DD127320A5 (ja)
DE (1) DE2629067A1 (ja)
DK (1) DK146937C (ja)
ES (1) ES449738A1 (ja)
FI (1) FI56524C (ja)
FR (1) FR2317278A1 (ja)
GB (1) GB1510925A (ja)
IL (1) IL49830A (ja)
IT (1) IT1062604B (ja)
NL (1) NL187693C (ja)
NO (1) NO142812C (ja)
PL (1) PL103098B1 (ja)
SE (1) SE407571B (ja)
SU (1) SU700060A3 (ja)
ZA (1) ZA763585B (ja)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
AT387393B (de) * 1978-07-18 1989-01-10 Kabi Ab Verfahren zur herstellung von neuen tripeptidderivaten
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
JPS5537120A (en) * 1978-09-06 1980-03-15 Kanji Tsuchiya Method and device for preparation of food from oilseed
JPS5559149A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
JPS59499B2 (ja) * 1978-11-02 1984-01-07 味の素株式会社 ペプチド誘導体
US4327178A (en) 1979-05-01 1982-04-27 University Of Miami Urinary kallikrein assay: specific substrates and assay method
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
CA1161432A (en) * 1980-02-12 1984-01-31 Lars G. Svendsen Tripeptide derivatives and their application in assaying enzymes
DE3108322A1 (de) 1980-03-18 1981-12-24 Immuno Aktiengesellschaft für chemisch-medizinische Produkte, 1220 Wien Chromogenes enzymsubstrat
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
JPS57177985U (ja) * 1981-04-30 1982-11-11
US4510241A (en) * 1981-09-03 1985-04-09 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
US4406832A (en) * 1981-09-03 1983-09-27 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
ATE17262T1 (de) * 1981-11-02 1986-01-15 Pentapharm Ag Verfahren zur quantitativen bestimmung von blutgerinnungsfaktor xii in humanplasma.
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
NL8201987A (nl) * 1982-05-13 1983-12-01 Tno Werkwijze voor het bepalen van de activiteit van plasminogeenactivator van het weefseltype, alsmede voor gebruik bij deze werkwijze geschikte combinatie van het "kit"-type.
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
EP0182929A1 (de) * 1984-11-26 1986-06-04 American Hospital Supply Corporation Koaktivator zur Aktivierung von Protein C
DE3536903A1 (de) * 1985-10-16 1987-04-16 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung von protein c
JPS62126196A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規なα1−アンチトリプシン測定用化合物
DE3710937A1 (de) * 1987-04-01 1988-10-13 Boehringer Mannheim Gmbh Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate
JPH01112157A (ja) * 1987-07-10 1989-04-28 Yamanouchi Pharmaceut Co Ltd 組織プラスミノーゲンアクチベーター活性の測定法,測定具及び測定用キット
JPH0383093U (ja) * 1989-12-09 1991-08-23
AU4634896A (en) * 1995-01-10 1996-07-31 Hendrik Coenraad Hemker Methods of determining endogenous thrombin potential (etp) and thrombin substrates for use in said methods
US20220364141A1 (en) * 2019-09-05 2022-11-17 National University Corporation Tokyo University Of Agriculture And Technology Tryptase Activity Measurement Substrate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
CH622286A5 (ja) * 1975-06-23 1981-03-31 Pentapharm Ag

Also Published As

Publication number Publication date
CH622285A5 (ja) 1981-03-31
ATA464076A (de) 1978-09-15
DE2629067C2 (ja) 1989-08-03
FI762009A (ja) 1977-01-12
DD127320A5 (ja) 1977-09-14
SE407571B (sv) 1979-04-02
BE843969A (fr) 1976-11-03
NL187693B (nl) 1991-07-16
DK312776A (da) 1977-01-12
US4214049A (en) 1980-07-22
GB1510925A (en) 1978-05-17
CA1081212A (en) 1980-07-08
AU497546B2 (en) 1978-12-14
FI56524C (fi) 1980-02-11
DK146937C (da) 1984-07-30
JPS5615238B2 (ja) 1981-04-09
ZA763585B (en) 1977-05-25
NO142812B (no) 1980-07-14
FR2317278B1 (ja) 1981-01-30
AT349648B (de) 1979-04-10
IL49830A (en) 1978-12-17
FR2317278A1 (fr) 1977-02-04
AU1530476A (en) 1978-01-05
IL49830A0 (en) 1976-08-31
NL187693C (nl) 1991-12-16
FI56524B (fi) 1979-10-31
IT1062604B (it) 1984-10-20
SE7507974L (sv) 1977-01-12
SU700060A3 (ru) 1979-11-25
ES449738A1 (es) 1977-12-16
DE2629067A1 (de) 1977-01-13
PL103098B1 (pl) 1979-05-31
NO142812C (no) 1980-10-22
DK146937B (da) 1984-02-20
NL7607433A (nl) 1977-01-13
NO762406L (ja) 1977-01-12
JPS5224581A (en) 1977-02-24

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