CS184291A3 - Radioactive pharmaceuticals, process of their preparation and application - Google Patents

Radioactive pharmaceuticals, process of their preparation and application Download PDF

Info

Publication number
CS184291A3
CS184291A3 CS911842A CS184291A CS184291A3 CS 184291 A3 CS184291 A3 CS 184291A3 CS 911842 A CS911842 A CS 911842A CS 184291 A CS184291 A CS 184291A CS 184291 A3 CS184291 A3 CS 184291A3
Authority
CS
Czechoslovakia
Prior art keywords
acid
ligand
complex
composition according
radiopharmaceutical composition
Prior art date
Application number
CS911842A
Other languages
Czech (cs)
English (en)
Inventor
Jaime Simon
Joseph R Garlich
Keith R Frank
Kenneth Mcmillan
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of CS184291A3 publication Critical patent/CS184291A3/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
CS911842A 1990-06-18 1991-06-14 Radioactive pharmaceuticals, process of their preparation and application CS184291A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53887190A 1990-06-18 1990-06-18

Publications (1)

Publication Number Publication Date
CS184291A3 true CS184291A3 (en) 1992-02-19

Family

ID=24148781

Family Applications (1)

Application Number Title Priority Date Filing Date
CS911842A CS184291A3 (en) 1990-06-18 1991-06-14 Radioactive pharmaceuticals, process of their preparation and application

Country Status (32)

Country Link
US (1) US5762907A (hu)
EP (1) EP0462787B1 (hu)
JP (2) JP3636728B2 (hu)
KR (1) KR100219964B1 (hu)
CN (1) CN1033143C (hu)
AT (1) ATE123955T1 (hu)
AU (2) AU651112B2 (hu)
BR (2) BR9102579A (hu)
CA (1) CA2044812C (hu)
CS (1) CS184291A3 (hu)
CY (1) CY1891A (hu)
DE (1) DE69110554T2 (hu)
DK (1) DK0462787T3 (hu)
EG (1) EG19862A (hu)
ES (1) ES2073678T3 (hu)
FI (1) FI101044B (hu)
GR (1) GR3017430T3 (hu)
HK (1) HK80496A (hu)
HU (1) HU226897B1 (hu)
IE (1) IE71023B1 (hu)
IL (1) IL98536A (hu)
IS (1) IS1704B (hu)
MC (1) MC2260A1 (hu)
NO (1) NO302510B1 (hu)
NZ (1) NZ238547A (hu)
PH (1) PH30975A (hu)
PL (1) PL165699B1 (hu)
PT (1) PT97996B (hu)
RU (1) RU2095085C1 (hu)
SA (1) SA92120343B1 (hu)
SK (1) SK279598B6 (hu)
ZA (1) ZA914615B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
US5405601A (en) * 1993-07-02 1995-04-11 Mallinckrodt Medical Inc. Functionalized tripodal ligands for imaging applications
CN1065769C (zh) * 1997-07-03 2001-05-16 中国原子能科学研究院 一种放射性药物制剂的制备方法
CN1092962C (zh) * 1998-01-26 2002-10-23 贾伟 一种减轻骨及骨关节疾病疼痛的药物
WO2000076556A2 (en) * 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
WO2002062398A2 (en) 2001-01-08 2002-08-15 Neorx Corporation Radioactively labelled conjugates of phosphonates
US6567492B2 (en) 2001-06-11 2003-05-20 Eastern Isotopes, Inc. Process and apparatus for production of F-18 fluoride
WO2004043497A1 (en) 2002-11-05 2004-05-27 Ion Beam Applications S.A. Stabilzation of radiopharmceuticals labeled with 18-f
US7018614B2 (en) * 2002-11-05 2006-03-28 Eastern Isotopes, Inc. Stabilization of radiopharmaceuticals labeled with 18-F
CA2911414C (en) 2013-05-13 2018-09-11 Vision Global Holdings Ltd. Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging
DK3054996T3 (da) * 2013-10-07 2023-07-10 Igl Pharma Inc Fremgangsmåde til fremstilling af terapeutiske knoglemidler af høj renhed
US10660966B2 (en) 2014-12-04 2020-05-26 Ge Healthcare Limited Method for removing acetaldehyde
RU2593017C1 (ru) * 2015-04-23 2016-07-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения радиофармацевтического препарата "астат-211"
EP3297684B1 (en) * 2015-05-21 2020-12-23 Actinium Pharmaceuticals, Inc. Infusion administration of conjugated monoclonal antibodies
US20180104366A1 (en) * 2015-05-25 2018-04-19 Isotherapeutics Group, Llc Dotmp kit formulations for radioisotopes
RU2757258C1 (ru) * 2020-09-28 2021-10-12 федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский ядерный университет "МИФИ" (НИЯУ МИФИ) Способ получения радиофармацевтического препарата с галлием-68 для визуализации метастазов скелета методом пэт

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018883A (en) * 1975-03-10 1977-04-19 Nichols Institute For Endocrinology Thyroxine (T4) radioimmunoassay
US4111656A (en) * 1975-06-26 1978-09-05 Mallinckrodt, Inc. Radioimmunoassay methods for the determination of l-triiodothyronine and thyroxine
US4301140A (en) * 1979-12-14 1981-11-17 G. D. Searle & Co. Radiopharmaceutical method for monitoring kidneys
US4341755A (en) * 1980-07-15 1982-07-27 Immuno Nuclear Corporation Parathyroid radioimmunoassay
US4457602A (en) * 1981-04-20 1984-07-03 Olympus Optical Company Ltd. Multiple light emission control system utilizing electronic flashes
US4411881A (en) * 1982-07-12 1983-10-25 New England Nuclear Corporation Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines
ZA852799B (en) * 1984-06-04 1986-12-30 Dow Chemical Co Organic amine phosphonic acid complexes for the treatment of calcific tumors
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
GB8510726D0 (en) * 1985-04-26 1985-06-26 Amersham Int Plc Stabilised radio-labelled compounds
US4752464A (en) * 1985-06-07 1988-06-21 Cadema Medical Products, Inc. Treatment of arthritis, including rheumatoid arthritis, with radioactive isotopes
NZ222304A (en) * 1987-05-18 1990-10-26 Dow Chemical Co Suppression of bone marrow using samarium-153, gadolinium-159 or holmium-166 complexes
US4853209A (en) * 1987-05-18 1989-08-01 The Dow Chemical Company Bone marrow suppressing agents
WO1989000052A1 (en) * 1987-06-30 1989-01-12 Mallinckrodt, Inc. Method for enhancing the safety of metal-ligand chelates as magnetic resonants imaging agents and x-ray contrast agents
US4882142A (en) * 1988-12-19 1989-11-21 The Dow Chemical Company Bone marrow suppressing agents
US4937333A (en) * 1989-08-04 1990-06-26 The Dow Chemical Company Method for purifying aminomethylenephosphonic acids for pharmaceutical use
US5219556A (en) * 1990-07-09 1993-06-15 Mallinckrodt Medical, Inc. Stabilized therapeutic radiopharmaceutical complexes

Also Published As

Publication number Publication date
CA2044812C (en) 2002-12-31
RU2095085C1 (ru) 1997-11-10
AU665911B2 (en) 1996-01-18
IE912057A1 (en) 1991-12-18
CA2044812A1 (en) 1991-12-19
HUT57994A (en) 1992-01-28
PT97996A (pt) 1992-03-31
MC2260A1 (fr) 1993-04-26
AU7847091A (en) 1991-12-19
IL98536A (en) 1996-10-31
GR3017430T3 (en) 1995-12-31
SA92120343B1 (ar) 2004-01-25
AU651112B2 (en) 1994-07-14
HU226897B1 (en) 2010-01-28
EG19862A (en) 1996-06-30
PL165699B1 (pl) 1995-01-31
CY1891A (en) 1996-08-30
CN1063615A (zh) 1992-08-19
EP0462787A1 (en) 1991-12-27
PH30975A (en) 1997-12-23
JP2002114712A (ja) 2002-04-16
SK279598B6 (sk) 1999-01-11
FI101044B (fi) 1998-04-15
IS1704B (is) 1998-12-10
JP3636728B2 (ja) 2005-04-06
NO912345L (no) 1991-12-19
US5762907A (en) 1998-06-09
AU6455994A (en) 1994-08-04
NZ238547A (en) 1994-05-26
EP0462787B1 (en) 1995-06-21
DE69110554D1 (de) 1995-07-27
NO302510B1 (no) 1998-03-16
FI912933A (fi) 1991-12-19
ZA914615B (en) 1993-02-24
FI912933A0 (fi) 1991-06-17
HK80496A (en) 1996-05-17
IE71023B1 (en) 1997-01-15
DE69110554T2 (de) 1995-12-14
DK0462787T3 (da) 1995-10-30
NO912345D0 (no) 1991-06-17
CN1033143C (zh) 1996-10-30
KR100219964B1 (ko) 1999-09-01
BR1101169A (pt) 2000-08-08
ES2073678T3 (es) 1995-08-16
BR9102579A (pt) 1992-01-21
PT97996B (pt) 1998-11-30
IS3717A7 (is) 1991-12-19
ATE123955T1 (de) 1995-07-15
HU912011D0 (en) 1991-12-30
IL98536A0 (en) 1992-07-15
KR920000334A (ko) 1992-01-29
PL290717A1 (en) 1992-02-24
JPH04230224A (ja) 1992-08-19

Similar Documents

Publication Publication Date Title
CS184291A3 (en) Radioactive pharmaceuticals, process of their preparation and application
JP7376481B2 (ja) 鉛またはトリウム放射性核種に連結されたｐｓｍａ標的化化合物を含む錯体
AU656915B2 (en) Stabilized therapeutic radiopharmaceutical complexes
JP2003501488A (ja) 骨髄抑制のための高投与量放射性核種錯体
KR0175305B1 (ko) 방사능의약품 조성물의 제조방법
ES2314977T3 (es) Agentes radioterapeuticos que contienen estaño-117m.
AU650944B2 (en) Method of treating and/or diagnosing soft tissue tumors
JPH05271102A (ja) 放射性薬剤の制菌剤
JPH0513929B2 (hu)
WO2011149844A1 (en) Delivery of high dose therapeutic radioisotopes to bone
EP1292338B1 (en) Stabiliser for radiopharmaceuticals
AU2001264133A1 (en) Stabiliser for radiopharmaceuticals
EP1438076B1 (en) Radiopharmaceutical agent for the treatment of early stage cancer
RU2817970C1 (ru) Лиофилизат на основе лигандов к простат-специфическому мембранному антигену (ПСМА) для приготовления радиофармацевтической композиции в форме раствора для инъекций для лечения рака предстательной железы, радиофармацевтическая композиция на ее основе для лечения рака предстательной железы и способ приготовления радиофармацевтической композиции
US20220273828A1 (en) Dotmp kit formulations for radioisotopes
AU654169B2 (en) Compositions and method for soft tissue tumors
RU2162714C1 (ru) Радиофармацевтическая композиция
Sajid et al. LABELLING OF M-TRIMETHYL SILYLPHENYL)-ETHYLIDENE-1, 1-BISPHOSPHONATE WITH 99mTc AND ITS EVALUATION AS AN IMAGING AGENT
Zolle et al. 12.7. 2 99mTc-Diphosphonates
JPH01283229A (ja) Ｔｃ‐９９ｍ‐ω‐アルキルホスフイニコ‐１‐ヒドロキシアルカン‐１，１‐ジホスホネート含有生成物

Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic