CR20210267A - Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9) para el tratamiento de trastornos metabólicos - Google Patents
Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9) para el tratamiento de trastornos metabólicosInfo
- Publication number
- CR20210267A CR20210267A CR20210267A CR20210267A CR20210267A CR 20210267 A CR20210267 A CR 20210267A CR 20210267 A CR20210267 A CR 20210267A CR 20210267 A CR20210267 A CR 20210267A CR 20210267 A CR20210267 A CR 20210267A
- Authority
- CR
- Costa Rica
- Prior art keywords
- sub
- pcsk9
- inhibitors
- treatment
- metabolic disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
- C07K5/126—Tetrapeptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862772030P | 2018-11-27 | 2018-11-27 | |
| US201962924828P | 2019-10-23 | 2019-10-23 | |
| PCT/IB2019/060201 WO2020110009A1 (en) | 2018-11-27 | 2019-11-26 | Cyclic tetramer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20210267A true CR20210267A (es) | 2021-08-16 |
Family
ID=68808460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20210267A CR20210267A (es) | 2018-11-27 | 2019-11-26 | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9) para el tratamiento de trastornos metabólicos |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11026993B2 (https=) |
| EP (1) | EP3887365A1 (https=) |
| JP (1) | JP7577656B2 (https=) |
| KR (1) | KR20210096154A (https=) |
| CN (1) | CN113166114B (https=) |
| AU (1) | AU2019387294B2 (https=) |
| BR (1) | BR112021009857A2 (https=) |
| CA (1) | CA3115960A1 (https=) |
| CL (1) | CL2021001365A1 (https=) |
| CO (1) | CO2021006895A2 (https=) |
| CR (1) | CR20210267A (https=) |
| CU (1) | CU20210043A7 (https=) |
| DO (1) | DOP2021000100A (https=) |
| EC (1) | ECSP21036194A (https=) |
| IL (1) | IL283374A (https=) |
| JO (1) | JOP20210120A1 (https=) |
| MA (1) | MA54284A (https=) |
| MX (1) | MX2021006069A (https=) |
| PE (1) | PE20211658A1 (https=) |
| PH (1) | PH12021551049A1 (https=) |
| PY (1) | PY1998404A (https=) |
| SG (1) | SG11202103807WA (https=) |
| TW (1) | TW202038990A (https=) |
| UY (1) | UY38485A (https=) |
| WO (1) | WO2020110009A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11882610B2 (en) * | 2020-08-13 | 2024-01-23 | Qualcomm Incorporated | Establishing connections using multiple subscriber identity modules via a single communication link |
| CN114163343A (zh) * | 2021-12-10 | 2022-03-11 | 许昌学院 | 含氟氨基酸及衍生物含氟多肽的制备方法以及应用 |
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| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US5114946A (en) | 1987-06-12 | 1992-05-19 | American Cyanamid Company | Transdermal delivery of pharmaceuticals |
| US4818541A (en) | 1987-08-19 | 1989-04-04 | Schering Corporation | Transdermal delivery of enantiomers of phenylpropanolamine |
| ATE164852T1 (de) | 1990-01-24 | 1998-04-15 | Douglas I Buckley | Glp-1-analoga verwendbar in der diabetesbehandlung |
| US5155100A (en) | 1991-05-01 | 1992-10-13 | Ciba-Geigy Corporation | Phosphono/biaryl substituted dipeptide derivatives |
| IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| DE122010000020I1 (de) | 1996-04-25 | 2010-07-08 | Prosidion Ltd | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| IT1291776B1 (it) | 1997-02-07 | 1999-01-21 | Menarini Ricerche Spa | Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista |
| IT1304888B1 (it) | 1998-08-05 | 2001-04-05 | Menarini Ricerche Spa | Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono |
| CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
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| HUP0301335A3 (en) | 2000-04-12 | 2006-02-28 | Novartis Ag | Combination of organic compounds |
| EP1297826A1 (en) | 2001-09-27 | 2003-04-02 | Menarini Ricerche S.p.A. | Nasal pharmaceutical compositions containing a NK-2 antagonist |
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| WO2003104200A1 (en) | 2002-06-07 | 2003-12-18 | Glaxo Group Limited | N-mercaptoacyl phenyalanine derivatives, process for their preparation, and pharmaceutical compositions containing them |
| DK1537114T3 (da) | 2002-08-07 | 2006-11-13 | Novartis Ag | Organiske forbindelser som midler til behandling af aldosteronmedierede tilstande |
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| TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| SMT201700306T1 (it) | 2012-06-08 | 2017-07-18 | Theravance Biopharma R&D Ip Llc | Inibitori di neprilisina |
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| DK2964616T3 (en) | 2013-03-05 | 2017-08-28 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
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-
2019
- 2019-11-22 PY PY201901998404A patent/PY1998404A/es unknown
- 2019-11-22 UY UY0001038485A patent/UY38485A/es not_active Application Discontinuation
- 2019-11-25 TW TW108142721A patent/TW202038990A/zh unknown
- 2019-11-26 MX MX2021006069A patent/MX2021006069A/es unknown
- 2019-11-26 US US16/695,843 patent/US11026993B2/en active Active
- 2019-11-26 JO JOP/2021/0120A patent/JOP20210120A1/ar unknown
- 2019-11-26 MA MA054284A patent/MA54284A/fr unknown
- 2019-11-26 CR CR20210267A patent/CR20210267A/es unknown
- 2019-11-26 KR KR1020217019281A patent/KR20210096154A/ko not_active Ceased
- 2019-11-26 JP JP2021529266A patent/JP7577656B2/ja active Active
- 2019-11-26 CU CU2021000043A patent/CU20210043A7/es unknown
- 2019-11-26 SG SG11202103807WA patent/SG11202103807WA/en unknown
- 2019-11-26 BR BR112021009857-7A patent/BR112021009857A2/pt not_active Application Discontinuation
- 2019-11-26 WO PCT/IB2019/060201 patent/WO2020110009A1/en not_active Ceased
- 2019-11-26 EP EP19816905.4A patent/EP3887365A1/en active Pending
- 2019-11-26 CA CA3115960A patent/CA3115960A1/en active Pending
- 2019-11-26 CN CN201980076002.XA patent/CN113166114B/zh active Active
- 2019-11-26 PE PE2021000749A patent/PE20211658A1/es unknown
- 2019-11-26 AU AU2019387294A patent/AU2019387294B2/en not_active Ceased
-
2021
- 2021-03-12 US US17/200,471 patent/US11813306B2/en active Active
- 2021-05-06 PH PH12021551049A patent/PH12021551049A1/en unknown
- 2021-05-21 EC ECSENADI202136194A patent/ECSP21036194A/es unknown
- 2021-05-23 IL IL283374A patent/IL283374A/en unknown
- 2021-05-24 DO DO2021000100A patent/DOP2021000100A/es unknown
- 2021-05-25 CL CL2021001365A patent/CL2021001365A1/es unknown
- 2021-05-25 CO CONC2021/0006895A patent/CO2021006895A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN113166114B (zh) | 2025-01-03 |
| JOP20210120A1 (ar) | 2021-05-26 |
| CL2021001365A1 (es) | 2022-01-14 |
| BR112021009857A2 (pt) | 2021-08-17 |
| ECSP21036194A (es) | 2021-06-30 |
| US20210252103A1 (en) | 2021-08-19 |
| MA54284A (fr) | 2022-03-02 |
| TW202038990A (zh) | 2020-11-01 |
| CO2021006895A2 (es) | 2021-06-10 |
| US20200164024A1 (en) | 2020-05-28 |
| JP7577656B2 (ja) | 2024-11-05 |
| WO2020110009A1 (en) | 2020-06-04 |
| PY1998404A (es) | 2021-06-17 |
| SG11202103807WA (en) | 2021-06-29 |
| CA3115960A1 (en) | 2020-06-04 |
| UY38485A (es) | 2020-06-30 |
| US11026993B2 (en) | 2021-06-08 |
| DOP2021000100A (es) | 2021-06-30 |
| MX2021006069A (es) | 2021-07-06 |
| PE20211658A1 (es) | 2021-08-24 |
| CN113166114A (zh) | 2021-07-23 |
| CU20210043A7 (es) | 2022-01-13 |
| JP2022507957A (ja) | 2022-01-18 |
| AU2019387294A1 (en) | 2021-05-13 |
| AU2019387294B2 (en) | 2022-09-08 |
| KR20210096154A (ko) | 2021-08-04 |
| US11813306B2 (en) | 2023-11-14 |
| IL283374A (en) | 2021-07-29 |
| PH12021551049A1 (en) | 2021-12-06 |
| EP3887365A1 (en) | 2021-10-06 |
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