CR20110065A - Derivados de pirazolo (3,4) pirimidin-4-ilo y sus usos para el tratamiento de la diabetes y la obesidad - Google Patents

Derivados de pirazolo (3,4) pirimidin-4-ilo y sus usos para el tratamiento de la diabetes y la obesidad

Info

Publication number
CR20110065A
CR20110065A CR20110065A CR20110065A CR20110065A CR 20110065 A CR20110065 A CR 20110065A CR 20110065 A CR20110065 A CR 20110065A CR 20110065 A CR20110065 A CR 20110065A CR 20110065 A CR20110065 A CR 20110065A
Authority
CR
Costa Rica
Prior art keywords
treatment
pirazolo
pirimidin
ilo
obesity
Prior art date
Application number
CR20110065A
Other languages
English (en)
Inventor
Norman Lile Bennett Stuart
Gustaf Bonn Peter
Dan Brink Mikael
John Butlin Roger
Campbell Leonie
Darren Morse Davies Robert
Richard Faberhag Jonar
Jurva Ulrik
Claire Pointon Helen
Richard Robb Graeme
Schnecke Volker
Marie Svensson Henriksson Anette
Peter Walker Rolf
James Waring Michael
Ralf Westerlund Christer
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CR20110065A publication Critical patent/CR20110065A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto de fórmula (I) es útil en el tratamiento o prevención de una enfermedad o afección mediada por glucoquinasa (GLK o GK), que conduce a una reducción del umbral de glucosa para la secreción de insulina.
CR20110065A 2008-08-04 2011-02-04 Derivados de pirazolo (3,4) pirimidin-4-ilo y sus usos para el tratamiento de la diabetes y la obesidad CR20110065A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8591908P 2008-08-04 2008-08-04
US16804809P 2009-04-09 2009-04-09

Publications (1)

Publication Number Publication Date
CR20110065A true CR20110065A (es) 2011-05-10

Family

ID=41563374

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20110065A CR20110065A (es) 2008-08-04 2011-02-04 Derivados de pirazolo (3,4) pirimidin-4-ilo y sus usos para el tratamiento de la diabetes y la obesidad

Country Status (23)

Country Link
US (1) US8143263B2 (es)
EP (1) EP2324028A2 (es)
JP (1) JP2011529955A (es)
KR (1) KR20110052676A (es)
CN (1) CN102171213A (es)
AR (1) AR072900A1 (es)
AU (1) AU2009278929B2 (es)
BR (1) BRPI0917589A2 (es)
CA (1) CA2732165A1 (es)
CL (1) CL2011000249A1 (es)
CO (1) CO6351730A2 (es)
CR (1) CR20110065A (es)
DO (1) DOP2011000047A (es)
EA (1) EA201100097A1 (es)
EC (1) ECSP11010809A (es)
IL (1) IL210778A0 (es)
MX (1) MX2011001333A (es)
PE (1) PE20110568A1 (es)
SV (1) SV2011003829A (es)
TW (1) TW201011026A (es)
UY (1) UY32032A (es)
WO (1) WO2010015849A2 (es)
ZA (1) ZA201101663B (es)

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WO2010116176A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
WO2010116177A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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US10538522B2 (en) 2015-05-14 2020-01-21 The Regents Of The University Of California Brassinosteroid mimetics
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CN106361753A (zh) * 2016-11-13 2017-02-01 曹艳 一种别嘌醇衍生物及其在制备抗肿瘤药物中的用途
CN106749265A (zh) * 2016-11-13 2017-05-31 曹艳 一种别嘌醇衍生物及其在制备抗肿瘤药物中的用途
CN106749263A (zh) * 2016-11-13 2017-05-31 曹艳 一种别嘌醇衍生物及其在制备抗肿瘤药物中的用途
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CN108033966A (zh) * 2018-01-05 2018-05-15 天津药明康德新药开发有限公司 7-叔丁基3-乙基8-甲基5,6二氢三唑并吡嗪3,7(8h)二甲酸基酯的合成方法
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Also Published As

Publication number Publication date
AR072900A1 (es) 2010-09-29
PE20110568A1 (es) 2011-09-07
ECSP11010809A (es) 2011-03-31
CL2011000249A1 (es) 2011-07-15
WO2010015849A3 (en) 2010-04-01
AU2009278929B2 (en) 2012-07-05
DOP2011000047A (es) 2011-02-28
KR20110052676A (ko) 2011-05-18
CA2732165A1 (en) 2010-02-11
MX2011001333A (es) 2011-03-15
US20100093757A1 (en) 2010-04-15
CN102171213A (zh) 2011-08-31
EA201100097A1 (ru) 2011-10-31
UY32032A (es) 2010-03-26
US8143263B2 (en) 2012-03-27
TW201011026A (en) 2010-03-16
SV2011003829A (es) 2011-07-01
EP2324028A2 (en) 2011-05-25
WO2010015849A2 (en) 2010-02-11
ZA201101663B (en) 2011-11-30
AU2009278929A1 (en) 2010-02-11
AU2009278929A8 (en) 2011-03-10
BRPI0917589A2 (pt) 2015-11-17
CO6351730A2 (es) 2011-12-20
JP2011529955A (ja) 2011-12-15
IL210778A0 (en) 2011-03-31

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