CO6900140A2 - Compuestos y composiciones como inhibidores de la quinasa c-kit - Google Patents
Compuestos y composiciones como inhibidores de la quinasa c-kitInfo
- Publication number
- CO6900140A2 CO6900140A2 CO14043411A CO14043411A CO6900140A2 CO 6900140 A2 CO6900140 A2 CO 6900140A2 CO 14043411 A CO14043411 A CO 14043411A CO 14043411 A CO14043411 A CO 14043411A CO 6900140 A2 CO6900140 A2 CO 6900140A2
- Authority
- CO
- Colombia
- Prior art keywords
- compositions
- compounds
- kinase inhibitors
- kit kinase
- kit
- Prior art date
Links
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 title 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161530028P | 2011-09-01 | 2011-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6900140A2 true CO6900140A2 (es) | 2014-03-20 |
Family
ID=46829898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14043411A CO6900140A2 (es) | 2011-09-01 | 2014-02-28 | Compuestos y composiciones como inhibidores de la quinasa c-kit |
Country Status (42)
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| CN103797011B (zh) | 2011-09-01 | 2016-03-30 | 诺华股份有限公司 | 作为c-Kit激酶抑制剂的化合物和组合物 |
| CN104619709B (zh) | 2012-07-13 | 2016-11-09 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的咪唑并吡啶衍生物 |
| EP3007689B1 (en) | 2013-01-10 | 2018-03-07 | Pulmokine, Inc. | Non-selective kinase inhibitors |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| US9925184B2 (en) | 2013-10-11 | 2018-03-27 | Pulmokine, Inc. | Spray-dry formulations |
| CA2932482A1 (en) * | 2013-12-05 | 2015-06-11 | Bayer Pharma Aktiengesellschaft | Aryl- and hetaryl-substituted imidazo[1,2-a]pyridine-3-carboxamides and use thereof |
| CN103965190A (zh) * | 2014-05-20 | 2014-08-06 | 定陶县友帮化工有限公司 | 一种咪唑并[1,2-a]吡啶-3-甲酸的合成方法 |
| UA125171C2 (uk) | 2015-07-02 | 2022-01-26 | Янссен Саєнсиз Айрленд Юсі | Антибактеріальні сполуки |
| US10059708B2 (en) * | 2016-04-26 | 2018-08-28 | Northwestern University | Therapeutic targeting of the interleukin 1 receptor-associated kinase 4 (IRAK4) in leukemias characterized by rearrangements in the mixed lineage leukemia gene (MLL-r) |
| US20200308169A1 (en) | 2016-06-16 | 2020-10-01 | Janssen Sciences Ireland Unlimited Company | Heterocyclic compounds as antibacterials |
| JP2019518046A (ja) | 2016-06-16 | 2019-06-27 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | 抗菌薬としての複素環式化合物 |
| RU2763525C2 (ru) | 2016-10-27 | 2021-12-30 | Пульмокин, Инк. | Комбинированная терапия для лечения легочной гипертензии |
| KR20190121315A (ko) | 2017-03-01 | 2019-10-25 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 병용 요법 |
| CN111039946A (zh) * | 2018-10-15 | 2020-04-21 | 上海轶诺药业有限公司 | 一类咪唑并芳环类化合物的制备和应用 |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| MA55976A (fr) * | 2019-05-13 | 2022-03-23 | Novartis Ag | Formes cristallines de n-(5-(5-((1r, 2s)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl) imidazo [1,2-a] pyridine-3-carboxamide |
| US20220340564A1 (en) | 2019-09-13 | 2022-10-27 | Janssen Sciences Ireland Unlimited Company | Antibacterial compounds |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| DK4122923T3 (da) * | 2020-03-17 | 2025-12-15 | Sumitomo Pharma Co Ltd | Oxadiazolderivat |
| JP2023534963A (ja) * | 2020-07-15 | 2023-08-15 | サード ハーモニック バイオ， インコーポレイテッド | 選択的ｃ－ｋｉｔキナーゼ阻害剤の結晶質形態 |
| US20220175740A1 (en) * | 2020-11-19 | 2022-06-09 | Novartis Ag | Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same |
| US11744823B2 (en) | 2020-11-19 | 2023-09-05 | Third Harmonic Bio, Inc. | Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same |
| WO2022182982A1 (en) * | 2021-02-26 | 2022-09-01 | Third Harmonic Bio, Inc. | Methods for treating c-kit kinase mediated diseases and disorders using a selective c-kit kinase inhibitor |
| MX2023010947A (es) | 2021-03-16 | 2023-11-29 | Janssen Sciences Ireland Unlimited Co | Compuestos antibacterianos. |
| MX2023010941A (es) | 2021-03-17 | 2023-11-28 | Janssen Sciences Ireland Unlimited Co | Compuestos antibacterianos. |
| CA3211592A1 (en) | 2021-03-17 | 2022-09-22 | Jerome Emile Georges Guillemont | Antibacterial compounds |
| EP4423097A1 (en) | 2021-10-28 | 2024-09-04 | Janssen Sciences Ireland Unlimited Company | Imidazopyridine amides and related compounds for use in the treatment of bacterial infections |
| WO2024089170A1 (en) | 2022-10-27 | 2024-05-02 | Janssen Sciences Ireland Unlimited Company | Antibacterial compounds |
| JP2025540958A (ja) | 2022-11-30 | 2025-12-17 | ブループリント メディシンズ コーポレイション | 蕁麻疹の治療のための野生型ｃ－ｋｉｔキナーゼ阻害剤としてのＮ－フェニル－ピラゾロ［１，５－Ａ］ピリジン－３－カルボキサミド誘導体 |
| AU2023390239A1 (en) * | 2022-12-07 | 2025-07-24 | Third Harmonic Bio, Inc. | Compounds and compositions as c-kit kinase inhibitors |
| WO2024123966A1 (en) * | 2022-12-07 | 2024-06-13 | Third Harmonic Bio, Inc. | Compounds and compositions as c-kit kinase inhibitors |
| WO2024223859A1 (en) | 2023-04-26 | 2024-10-31 | Janssen Pharmaceutica Nv | Antibacterial compounds |
| US20250042898A1 (en) * | 2023-07-25 | 2025-02-06 | Enanta Pharmaceuticals, Inc. | Pharmaceutical Compounds And Compositions As c-Kit Kinase Inhibitors |
| TW202523302A (zh) | 2023-11-02 | 2025-06-16 | 美商阿克思生物科學有限公司 | 噻唑化合物及其使用方法 |
| TW202542157A (zh) * | 2024-01-04 | 2025-11-01 | 大陸商上海翰森生物醫藥科技有限公司 | 多環類衍生物抑制劑、其製備方法和應用 |
| WO2025256552A1 (zh) * | 2024-06-11 | 2025-12-18 | 上海翰森生物医药科技有限公司 | 吡唑类衍生物抑制剂、其制备方法和应用 |
| WO2025259929A1 (en) * | 2024-06-13 | 2025-12-18 | Third Harmonic Bio, Inc. | COMPOUNDS AND COMPOSITIONS AS c-Kit KINASE INHIBITORS |
| WO2025256609A1 (en) * | 2024-06-13 | 2025-12-18 | Third Harmonic Bio, Inc. | Crystalline forms of a selective c-kit kinase inhibitor |
| CN121181581A (zh) * | 2024-06-21 | 2025-12-23 | 上海美悦生物科技发展有限公司 | 一种稠杂环化合物、其制备方法和用途 |
| CN121426815A (zh) * | 2024-07-30 | 2026-01-30 | 上海美悦生物科技发展有限公司 | 一种杂环化合物、其制备方法和用途 |
| WO2026032333A1 (zh) * | 2024-08-06 | 2026-02-12 | 上海美悦生物科技发展有限公司 | 一种杂环化合物、其制备方法和用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9518993D0 (en) * | 1995-09-16 | 1995-11-15 | Agrevo Uk Ltd | Fungicides |
| US20070072861A1 (en) * | 2000-03-27 | 2007-03-29 | Barbara Roniker | Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| AU2003251561A1 (en) | 2002-06-20 | 2004-01-06 | Beacon Looms, Inc. | Knitted electrical conductor fabric |
| US7754717B2 (en) | 2005-08-15 | 2010-07-13 | Amgen Inc. | Bis-aryl amide compounds and methods of use |
| WO2008058037A1 (en) * | 2006-11-03 | 2008-05-15 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| AU2011329233A1 (en) * | 2010-11-15 | 2013-05-23 | Abbvie Deutschland Gmbh & Co Kg | NAMPT and ROCK inhibitors |
| US20150051206A1 (en) * | 2011-09-01 | 2015-02-19 | Irm Llc | Compounds and compositions as c-kit kinase inhibitors |
| CN103797011B (zh) * | 2011-09-01 | 2016-03-30 | 诺华股份有限公司 | 作为c-Kit激酶抑制剂的化合物和组合物 |
| EA201490537A1 (ru) * | 2011-09-01 | 2014-07-30 | АйАрЭм ЭлЭлСи | СОЕДИНЕНИЯ И КОМПОЗИЦИИ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ C-Kit |
-
2012
- 2012-08-27 US US13/595,575 patent/US9199981B2/en active Active
- 2012-08-28 SI SI201231624T patent/SI2751102T1/sl unknown
- 2012-08-28 PL PL12756879T patent/PL2751102T3/pl unknown
- 2012-08-28 EA EA201490540A patent/EA024293B1/ru not_active IP Right Cessation
- 2012-08-28 JP JP2014528513A patent/JP6117208B2/ja active Active
- 2012-08-28 PT PT12756879T patent/PT2751102T/pt unknown
- 2012-08-28 DK DK12756879.8T patent/DK2751102T3/da active
- 2012-08-28 PH PH1/2014/500351A patent/PH12014500351B1/en unknown
- 2012-08-28 TR TR2019/09189T patent/TR201909189T4/tr unknown
- 2012-08-28 ES ES12756879T patent/ES2732671T3/es active Active
- 2012-08-28 AP AP2014007494A patent/AP2014007494A0/xx unknown
- 2012-08-28 KR KR1020147008106A patent/KR101959590B1/ko active Active
- 2012-08-28 HR HRP20191140TT patent/HRP20191140T1/hr unknown
- 2012-08-28 LT LTEP12756879.8T patent/LT2751102T/lt unknown
- 2012-08-28 CN CN201280042763.1A patent/CN103764653B/zh active Active
- 2012-08-28 AU AU2012300248A patent/AU2012300248B2/en active Active
- 2012-08-28 BR BR112014004504-6A patent/BR112014004504B1/pt active IP Right Grant
- 2012-08-28 EP EP12756879.8A patent/EP2751102B1/en active Active
- 2012-08-28 MY MYPI2014000347A patent/MY167245A/en unknown
- 2012-08-28 RS RS20190784A patent/RS59025B1/sr unknown
- 2012-08-28 SG SG2014011050A patent/SG2014011050A/en unknown
- 2012-08-28 PE PE2014000294A patent/PE20141033A1/es active IP Right Grant
- 2012-08-28 CA CA2845159A patent/CA2845159C/en active Active
- 2012-08-28 WO PCT/US2012/052621 patent/WO2013033070A1/en not_active Ceased
- 2012-08-28 MX MX2014002482A patent/MX342329B/es active IP Right Grant
- 2012-08-28 ME MEP-2019-183A patent/ME03395B/me unknown
- 2012-08-28 UA UAA201401136A patent/UA110841C2/uk unknown
- 2012-08-28 HU HUE12756879 patent/HUE044373T2/hu unknown
- 2012-08-29 UY UY0001034300A patent/UY34300A/es active IP Right Grant
- 2012-08-30 JO JOP/2012/0246A patent/JOP20120246B1/ar active
- 2012-08-31 TW TW101131940A patent/TWI543981B/zh active
- 2012-08-31 AR ARP120103222A patent/AR087752A1/es active IP Right Grant
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2014
- 2014-02-10 TN TNP2014000061A patent/TN2014000061A1/en unknown
- 2014-02-13 ZA ZA2014/01113A patent/ZA201401113B/en unknown
- 2014-02-27 CU CUP2014000023A patent/CU20140023A7/es unknown
- 2014-02-27 GT GT201400036A patent/GT201400036A/es unknown
- 2014-02-27 CL CL2014000494A patent/CL2014000494A1/es unknown
- 2014-02-27 IL IL231226A patent/IL231226A/en active IP Right Grant
- 2014-02-28 CO CO14043411A patent/CO6900140A2/es active IP Right Grant
- 2014-02-28 CR CR20140106A patent/CR20140106A/es unknown
- 2014-03-28 MA MA36863A patent/MA35459B1/fr unknown
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2019
- 2019-06-27 CY CY20191100671T patent/CY1121695T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |