CO6430462A2 - Nuevos conjugados, su preparación y su aplicación terapéutica - Google Patents

Nuevos conjugados, su preparación y su aplicación terapéutica

Info

Publication number
CO6430462A2
CO6430462A2 CO11180696A CO11180696A CO6430462A2 CO 6430462 A2 CO6430462 A2 CO 6430462A2 CO 11180696 A CO11180696 A CO 11180696A CO 11180696 A CO11180696 A CO 11180696A CO 6430462 A2 CO6430462 A2 CO 6430462A2
Authority
CO
Colombia
Prior art keywords
group
alkyl
alkyl group
phenyl nucleus
derivative
Prior art date
Application number
CO11180696A
Other languages
English (en)
Inventor
Herve Bouchard
Marie Priscille Brun
Alain Commerçon
Jidong Zhang
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41611078&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6430462(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CO6430462A2 publication Critical patent/CO6430462A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D245/06—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Abstract

La invención se refiere a un agente de selección de la diana al que está unido al menos un derivado de criptoficina de la fórmula (I), en la que: R1 representa un átomo de halógeno y R2 representa un grupo -OH, un grupo acilo derivado de un aminoácido AA o un grupo alcanoiloxi(C1-C4); o bien R1 y R2 forman conjuntamente un motivo epóxido; AA indica un aminoácido natural o no natural; R3 representa un grupo alquilo(C1-C6); R4 y R5 representan los dos H o forman conjuntamente un doble enlace CH=CH entre C13 y C14; R6 y R7 representan independientemente uno de otro H o un grupo alquilo(C1-C6); R8 y R9 representan independientemente uno de otro H o un grupo alquilo(C1-C6); R10 representa al menos un sustituyente del núcleo fenilo elegido entre: H, un grupo OH, alcoxi(C1-C4), un átomo de halógeno o bien un grupo -NH2, -NHalquilo(C1-C6) o -N(alquilo(C1-C6))2; R11 representa al menos un sustituyente del núcleo fenilo elegido entre H o un grupo alquilo(C1-C4); estando unidos el agente de selección de la diana y el derivado de criptoficina de forma covalente, situándose la unión en posición orto (o), meta (m) o para (p) del núcleo fenilo portador del motivo CR1.
CO11180696A 2009-06-29 2011-12-29 Nuevos conjugados, su preparación y su aplicación terapéutica CO6430462A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0903170A FR2947269B1 (fr) 2009-06-29 2009-06-29 Nouveaux composes anticancereux
FR0905651A FR2947271B1 (fr) 2009-06-29 2009-11-25 Nouveaux composes anticancereux

Publications (1)

Publication Number Publication Date
CO6430462A2 true CO6430462A2 (es) 2012-04-30

Family

ID=41611078

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11180696A CO6430462A2 (es) 2009-06-29 2011-12-29 Nuevos conjugados, su preparación y su aplicación terapéutica

Country Status (30)

Country Link
US (1) US8952147B2 (es)
EP (1) EP2448929A1 (es)
JP (1) JP5746692B2 (es)
KR (1) KR101770584B1 (es)
CN (1) CN102482238B (es)
AR (1) AR078131A1 (es)
BR (1) BRPI1015131A2 (es)
CA (1) CA2766762C (es)
CL (1) CL2011003229A1 (es)
CO (1) CO6430462A2 (es)
CR (1) CR20110670A (es)
DO (1) DOP2011000376A (es)
EA (1) EA024627B1 (es)
EC (1) ECSP11011553A (es)
FR (2) FR2947269B1 (es)
HN (1) HN2011003414A (es)
IL (1) IL217208A (es)
MA (1) MA33465B1 (es)
MX (1) MX2011013764A (es)
MY (1) MY156684A (es)
NI (1) NI201100219A (es)
NZ (1) NZ597136A (es)
PE (1) PE20121031A1 (es)
SG (2) SG10201607595WA (es)
SV (1) SV2011004086A (es)
TN (1) TN2011000636A1 (es)
TW (1) TW201110986A (es)
UY (1) UY32745A (es)
WO (1) WO2011001052A1 (es)
ZA (1) ZA201109537B (es)

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Also Published As

Publication number Publication date
CA2766762C (fr) 2017-06-20
IL217208A (en) 2016-02-29
ZA201109537B (en) 2013-03-27
SV2011004086A (es) 2012-05-08
SG10201607595WA (en) 2016-11-29
KR20120101981A (ko) 2012-09-17
FR2947269B1 (fr) 2013-01-18
UY32745A (es) 2011-01-31
US8952147B2 (en) 2015-02-10
PE20121031A1 (es) 2012-08-17
FR2947269A1 (fr) 2010-12-31
NZ597136A (en) 2014-04-30
JP5746692B2 (ja) 2015-07-08
TW201110986A (en) 2011-04-01
TN2011000636A1 (fr) 2013-05-24
AR078131A1 (es) 2011-10-19
BRPI1015131A2 (pt) 2018-12-04
MA33465B1 (fr) 2012-07-03
EP2448929A1 (fr) 2012-05-09
ECSP11011553A (es) 2012-01-31
HN2011003414A (es) 2014-11-10
CR20110670A (es) 2012-02-09
EA024627B1 (ru) 2016-10-31
JP2012531459A (ja) 2012-12-10
CN102482238B (zh) 2015-08-12
MX2011013764A (es) 2012-05-22
KR101770584B1 (ko) 2017-08-24
EA201270096A1 (ru) 2012-07-30
AU2010267917B2 (en) 2016-03-17
FR2947271B1 (fr) 2013-04-05
WO2011001052A1 (fr) 2011-01-06
US20120225089A1 (en) 2012-09-06
CN102482238A (zh) 2012-05-30
FR2947271A1 (fr) 2010-12-31
DOP2011000376A (es) 2012-01-15
MY156684A (en) 2016-03-15
CA2766762A1 (fr) 2011-01-06
IL217208A0 (en) 2012-03-01
SG177419A1 (en) 2012-02-28
CL2011003229A1 (es) 2012-06-29
NI201100219A (es) 2012-05-23
AU2010267917A1 (en) 2012-02-02

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