AR080102A1 - Compuestos de aril-bencil-amina y su utilizacion en el tratamiento de trastornos mediados por las interacciones de los linfocitos - Google Patents

Compuestos de aril-bencil-amina y su utilizacion en el tratamiento de trastornos mediados por las interacciones de los linfocitos

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Publication number
AR080102A1
AR080102A1 ARP110100336A ARP110100336A AR080102A1 AR 080102 A1 AR080102 A1 AR 080102A1 AR P110100336 A ARP110100336 A AR P110100336A AR P110100336 A ARP110100336 A AR P110100336A AR 080102 A1 AR080102 A1 AR 080102A1
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AR
Argentina
Prior art keywords
carbon atoms
halogen
alkyl
optionally substituted
alkoxy
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ARP110100336A
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English (en)
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Novartis Ag
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Publication date
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Publication of AR080102A1 publication Critical patent/AR080102A1/es

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    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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Abstract

Compuestos de aril-bencil-amina sustituida, a procesos para su produccion, a su uso como productos farmacéuticos, y a composiciones farmacéuticas que los comprenden. Reivindicacion 1: Un compuesto de la formula (1), o una sal farmacéuticamente aceptable del mismo; en donde: R1 es hidrogeno, halogeno, o alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno; R2 es halogeno, alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno, ciano, o alcoxilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno; o R1 y R2, junto con los átomos de carbono con los que están unidos, forman un anillo de arilo con 6 a 10 átomos de carbono, el cual puede estar opcionalmente sustituido por 1 a 4 sustituyentes seleccionados a partir de ciano, alquilo de 1 a 4 átomos de carbono opcionalmente sustituido por halogeno, alcoxilo de 1 a 4 átomos de carbono opcionalmente sustituido por halogeno, y halogeno; R3 es hidrogeno, halogeno, o alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno; R4 es hidrogeno, cicloalquilo de 3 a 6 átomos de carbono, o alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno; R5 es hidrogeno o alquilo de 1 a 6 átomos de carbono; R6 y R7 se seleccionan independientemente a partir de H y alquilo de 1 a 6 átomos de carbono, o pueden formar, junto con el átomo de carbono con el que están unidos, un anillo carbocíclico saturado de 3 a 7 miembros; R8 y R9 se seleccionan independientemente a partir de H y alquilo de 1 a 6 átomos de carbono, o R8 y R9 pueden formar, junto con los átomos con los que están unidos, un anillo heterocíclico de 4 a 7 miembros, opcionalmente sustituido una o más veces por alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno, trifluoro-metilo, hidroxilo, o amino; n = 1, 2, 3 o 4; R10 es hidrogeno, alquilo de 1 a 6 átomos de carbono, amino, hidroxilo o alcoxilo de 1 a 6 átomos de carbono; R se selecciona a partir de H; fenilo que está opcionalmente sustituido por alquilo de 1 a 6 átomos de carbono, alcoxilo de 1 a 6 átomos de carbono, halogeno o hidroxilo; y alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por alcoxilo de 1 a 6 átomos de carbono, halogeno, hidroxilo, o fenilo opcionalmente sustituido por alquilo de 1 a 6 átomos de carbono, alcoxilo de 1 a 6 átomos de carbono, halogeno o hidroxilo, X1, X2, X3 y X4, se seleccionan cada uno independientemente a partir de N o CR11, R11 en cada caso se selecciona independientemente a partir de H, halogeno, ciano, alcoxilo de 1 a 6 átomos de carbono, alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por halogeno, o -SO2-alqujlo de 1 a 6 átomos de carbono; e Y representa independientemente en cada presentacion CR12R13, en donde R12 y R13 se seleccionan independientemente a partir de H y alquilo de 1 a 6 átomos de carbono.
ARP110100336A 2010-02-02 2011-02-01 Compuestos de aril-bencil-amina y su utilizacion en el tratamiento de trastornos mediados por las interacciones de los linfocitos AR080102A1 (es)

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US (1) US8791100B2 (es)
EP (1) EP2531487B1 (es)
JP (1) JP5876419B2 (es)
CN (1) CN102741227B (es)
AR (1) AR080102A1 (es)
ES (1) ES2504090T3 (es)
TW (1) TW201130811A (es)
UY (1) UY33214A (es)
WO (1) WO2011095452A1 (es)

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KR20160122260A (ko) 2014-02-28 2016-10-21 깃세이 야쿠힌 고교 가부시키가이샤 신규한 아닐린 유도체, 그것을 함유하는 의약 조성물 및 그것들의 용도
CN111548257B (zh) * 2020-05-28 2022-11-15 安道麦马克西姆有限公司 一种（4-异丙氧基-2-甲基）苯基异丙基酮的制备方法

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
AU7686891A (en) 1990-04-05 1991-10-30 American National Red Cross, The A protein family related to immediate-early protein expressed by human endothelial cells during differentiation
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
US6060272A (en) 1997-05-07 2000-05-09 Human Genome Sciences, Inc. Human G-protein coupled receptors
US6310078B1 (en) * 1998-04-20 2001-10-30 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
WO2000011166A1 (en) 1998-08-19 2000-03-02 Millennium Pharmaceuticals, Inc. 14274 receptor, a g-protein coupled receptor related to the edg receptor family
DE19846979A1 (de) 1998-09-11 2000-03-23 Max Delbrueck Centrum G-Protein gekoppelter Rezeptor EDG6 und seine Verwendung
NZ510712A (en) 1998-10-13 2004-11-26 Arena Pharm Inc Non-endogenous, constitutively activated human G protein-coupled receptors
EP1133559B1 (en) 1998-11-20 2005-08-10 Arena Pharmaceuticals, Inc. Human orphan g protein-coupled receptor rup3
US6323333B1 (en) 1999-04-05 2001-11-27 Smithkline Beecham Corporation Mouse EDG1
WO2001004139A2 (en) 1999-07-13 2001-01-18 Smithkline Beecham Corporation Human axor29 receptor
GB9923890D0 (en) 1999-10-08 1999-12-08 Pfizer Ltd Novel polypeptide
EP1259611A2 (en) 2000-03-03 2002-11-27 Incyte Genomics, Inc. G-protein coupled receptors
US20010041355A1 (en) 2000-03-24 2001-11-15 Shyam Ramakrishnan Regulation of human nerve growth factor-related G protein-coupled receptor
WO2001073021A1 (fr) 2000-03-28 2001-10-04 Takeda Chemical Industries, Ltd. Nouvelle proteine receptrice couplee a une proteine g et adn associe
MXPA02010241A (es) 2000-04-26 2004-09-06 Aventis Pharma Gmbh Receptor edg8, su preparacion y uso.
DE10028901A1 (de) 2000-06-10 2001-12-20 Michael Brues Arminosäuresequenz
WO2002006446A2 (en) 2000-07-17 2002-01-24 Genaissance Pharmaceuticals, Inc. Haplotypes of the edg6 gene
AU2001288563A1 (en) 2000-08-31 2002-03-13 University Of Connecticut Regulation of angiogenesis via modulation of edg receptor mediated signal transduction comprising sphingosine-1-phosphate administration
PE20020544A1 (es) 2000-11-07 2002-07-30 Novartis Ag Derivados de indolilmaleimida
US7521192B2 (en) * 2001-04-18 2009-04-21 Rigel Pharmaceuticals, Inc. EDG: modulators of lymphocyte activation and migration
EP1425023A1 (en) 2001-08-10 2004-06-09 Wyeth G protein-coupled receptor assay
JP4430941B2 (ja) 2002-01-18 2010-03-10 メルク エンド カムパニー インコーポレーテッド Ｅｄｇ受容体作動薬
TW200918046A (en) 2002-04-03 2009-05-01 Novartis Ag Indolylmaleimide derivatives
US20030225288A1 (en) 2002-04-12 2003-12-04 Millennium Pharmaceuticals, Inc. Imidazolidine compounds
CA2466288A1 (en) 2002-07-18 2004-01-29 Sri International Methods of treating conditions associated with an edg-1 receptor
AU2003263402A1 (en) 2002-09-20 2004-04-08 Pfizer Products Inc. Amide and sulfonamide ligands for the estrogen receptor
AU2003279915A1 (en) 2002-10-15 2004-05-04 Merck And Co., Inc. Process for making azetidine-3-carboxylic acid
BR0317099A (pt) 2002-12-09 2005-10-25 Boardd Of Regents Of The Unive Método in vitro para inibir a função e/ou proliferação de uma janus tirosina quinase 3, método de teste in vitro para auxiliar na identificação de substâncias que são úteis como imunossupressores terapêuticos, método in vitro para auxiliar na identificação de um novo medicamento imunossupressor, método in vitro para inibir a função e/ou proliferação de uma célula expressando a janus tirosina quinase 3, uso de pelo menos um composto, composto quìmico isolado ou purificado e composição farmacêutica
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
AU2004251146A1 (en) 2003-05-19 2005-01-06 Irm, Llc Immunosuppressant compounds and compositions
US7501538B2 (en) 2003-08-08 2009-03-10 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
CN101407471A (zh) * 2003-08-29 2009-04-15 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
ES2754221T3 (es) 2003-08-29 2020-04-16 Ono Pharmaceutical Co Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo
JPWO2005028667A1 (ja) 2003-09-19 2006-11-30 独立行政法人理化学研究所 ヒト肥満細胞で発現するｇ蛋白質共役型受容体を標的とした薬剤およびそのスクリーニング方法
EP1524265A1 (en) 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors
JP2007513082A (ja) * 2003-11-10 2007-05-24 シエーリング アクチエンゲゼルシャフト Ｃｃｒ−５アンタゴニストとして有用なベンジルエーテルアミン化合物
ZA200602666B (en) 2004-01-12 2007-09-26 Cytopia Res Pty Ltd Selective kinase inhibitors
US20060057559A1 (en) * 2004-06-23 2006-03-16 Rigel Pharmaceuticals, Inc. High-throughput cell migration screening assay
US7611851B2 (en) 2004-07-27 2009-11-03 Merck & Co., Inc. Canis sphingosine 1-phosphate receptor isoform 1
WO2006058316A1 (en) 2004-11-29 2006-06-01 Novartis Ag Dosage regimen of an s1p receptor agonist
CN101119714A (zh) * 2005-02-14 2008-02-06 弗吉尼亚大学专利基金会 含有由氨基和苯基取代的环烷基和5元杂环的1-磷酸鞘氨醇激动剂
CA2626549A1 (en) 2005-10-21 2007-04-26 University Of Alabama At Birmingham Small molecule inhibitors of hiv-1 capsid assembly
WO2007139946A2 (en) 2006-05-25 2007-12-06 University Of Tennessee Research Foundation Gpcr ligands identified by computational modeling
US7655396B1 (en) * 2006-09-29 2010-02-02 Allergan, Inc. Methods for detecting receptor modulator activity
US20080108077A1 (en) * 2006-11-07 2008-05-08 Stephanie Chissoe Genes associated with rheumatoid arthritis
JP2009007341A (ja) * 2007-06-01 2009-01-15 Mitsubishi Tanabe Pharma Corp 医薬組成物
MX2010002885A (es) * 2007-09-20 2010-04-01 Amgen Inc Derivados de acido 1-(4-(bencilbenzamido)-bencil)-azetidin-3-carbo xilico y compuestos relacionados como moduladores de receptores de s1p para el tratamiento de trastornos inmunitarios.
WO2009053481A1 (en) 2007-10-25 2009-04-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compositions and methods for modulating nk and t cell trafficking
GB0723794D0 (en) 2007-12-05 2008-01-16 Lectus Therapeutics Ltd Potassium ion channel modulators and uses thereof
EP2247591A1 (en) 2008-02-06 2010-11-10 Novartis AG Pyrrolo [2, 3-d]pyridines and use thereof as tyrosine kinase inhibitors
US20100324086A1 (en) 2008-02-19 2010-12-23 Novasaid Ab Compounds and methods
US8703811B2 (en) 2008-05-07 2014-04-22 Genzyme Corporation Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
US20100168079A1 (en) 2008-12-23 2010-07-01 Daniela Angst Biaryl Benzylamine Derivatives

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EP2531487A1 (en) 2012-12-12
WO2011095452A1 (en) 2011-08-11
CN102741227B (zh) 2014-07-30
JP2013518846A (ja) 2013-05-23
CN102741227A (zh) 2012-10-17
JP5876419B2 (ja) 2016-03-02
ES2504090T3 (es) 2014-10-08
TW201130811A (en) 2011-09-16

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