BR0317099A - Método in vitro para inibir a função e/ou proliferação de uma janus tirosina quinase 3, método de teste in vitro para auxiliar na identificação de substâncias que são úteis como imunossupressores terapêuticos, método in vitro para auxiliar na identificação de um novo medicamento imunossupressor, método in vitro para inibir a função e/ou proliferação de uma célula expressando a janus tirosina quinase 3, uso de pelo menos um composto, composto quìmico isolado ou purificado e composição farmacêutica - Google Patents
Método in vitro para inibir a função e/ou proliferação de uma janus tirosina quinase 3, método de teste in vitro para auxiliar na identificação de substâncias que são úteis como imunossupressores terapêuticos, método in vitro para auxiliar na identificação de um novo medicamento imunossupressor, método in vitro para inibir a função e/ou proliferação de uma célula expressando a janus tirosina quinase 3, uso de pelo menos um composto, composto quìmico isolado ou purificado e composição farmacêuticaInfo
- Publication number
- BR0317099A BR0317099A BR0317099-3A BR0317099A BR0317099A BR 0317099 A BR0317099 A BR 0317099A BR 0317099 A BR0317099 A BR 0317099A BR 0317099 A BR0317099 A BR 0317099A
- Authority
- BR
- Brazil
- Prior art keywords
- vitro
- function
- proliferation
- tyrosine kinase
- inhibit
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
- C07C225/08—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
- C07C225/12—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings with doubly-bound oxygen atoms bound to carbon atoms being part of rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
- G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"MéTODO IN VITRO PARA INIBIR A FUNçãO E/OU PROLIFERAçãO DE UMA JANUS TIROSINA QUINASE 3, MéTODO DE TESTE IN VITRO PARA AUXILIAR NA IDENTIFICAçãO DE SUBSTâNCIAS QUE SãO úTEIS COMO IMUNOSSUPRESSORES TERAPêUTICOS, MéTODO IN VITRO PAPA AUXILIAR NA IDENTIFICAçãO DE UM NOVO MEDICAMENTO IMUNOSSUPRESSOR, MéTODO IN VITRO PARA INIBIR A FUNçãO E/OU PROLIFERAçãO DE UMA CéLULA EXPRESSANDO A JANUS TIROSINA QUINASE 3, USO DE PELO MENOS UM COMPOSTO, COMPOSTO QUìMICO ISOLADO OU PURIFICADO E COMPOSIçãO FARMACêUTICA". São descritos métodos para inibir ou romper a Janus tirosina quinase 3 (Jak3), dependente da função das células de origem linfóide ou mielóide, especialmente para bloquear a proliferação e função dos linfóticos (p.ex., células-T, células-B). é empregado um composto base de Mannich, ou um derivativo ou composto modificado, que é capaz de seletivamente inibir Jak3, enquanto afetando outras atividades da proteína tirosina quinase em uma menor extensão ou não em absoluto, para fornecer efeitos benéficos, tais como mitigação de rejeição de transplante e alívio de respostas alérgicas, com menos efeitos colaterais do que com os agentes imunossupressores convencionais.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43185102P | 2002-12-09 | 2002-12-09 | |
PCT/US2003/038993 WO2004052359A1 (en) | 2002-12-09 | 2003-12-09 | Methods for selectively inhibiting janus tyrosine kinase 3 (jak3) |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0317099A true BR0317099A (pt) | 2005-10-25 |
Family
ID=32507812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0317099-3A BR0317099A (pt) | 2002-12-09 | 2003-12-09 | Método in vitro para inibir a função e/ou proliferação de uma janus tirosina quinase 3, método de teste in vitro para auxiliar na identificação de substâncias que são úteis como imunossupressores terapêuticos, método in vitro para auxiliar na identificação de um novo medicamento imunossupressor, método in vitro para inibir a função e/ou proliferação de uma célula expressando a janus tirosina quinase 3, uso de pelo menos um composto, composto quìmico isolado ou purificado e composição farmacêutica |
Country Status (17)
Country | Link |
---|---|
US (2) | US7365096B2 (pt) |
EP (1) | EP1578411A4 (pt) |
JP (1) | JP2006514021A (pt) |
KR (1) | KR20050084224A (pt) |
CN (1) | CN1747729A (pt) |
AU (1) | AU2003297740B2 (pt) |
BR (1) | BR0317099A (pt) |
CA (1) | CA2506432A1 (pt) |
EC (1) | ECSP055843A (pt) |
HU (1) | HUP0500844A2 (pt) |
MX (1) | MXPA05006133A (pt) |
NO (1) | NO20052497L (pt) |
NZ (1) | NZ540427A (pt) |
PL (1) | PL376844A1 (pt) |
RU (1) | RU2005121672A (pt) |
WO (1) | WO2004052359A1 (pt) |
ZA (1) | ZA200504163B (pt) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004087673A2 (en) | 2003-03-28 | 2004-10-14 | Sloan-Kettering Institute For Cancer Research | Migrastatin analogs and uses thereof |
EP1755680A1 (en) * | 2004-05-03 | 2007-02-28 | Novartis AG | Combinations comprising a s1p receptor agonist and a jak3 kinase inhibitor |
JP5149001B2 (ja) | 2004-05-25 | 2013-02-20 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | 癌の処置におけるマイグラスタチンアナログ |
WO2006034478A2 (en) * | 2004-09-23 | 2006-03-30 | Sloan-Kettering Institute For Cancer Research | Isomigrastatin analogs in the treatment of cancer |
GB0507918D0 (en) | 2005-04-19 | 2005-05-25 | Novartis Ag | Organic compounds |
WO2007027238A2 (en) * | 2005-05-03 | 2007-03-08 | Rigel Pharmaceuticals, Inc. | Jak kinase inhibitors and their uses |
TR201802449T4 (tr) | 2005-10-26 | 2018-03-21 | Novartis Ag | Ailesel akdeniz hummasının anti ıl-1beta antikorları ile tedavisi. |
NZ568182A (en) | 2005-11-21 | 2010-08-27 | Novartis Ag | Neuroendocrine tumor treatment using MTOR inhibitors |
GB0601744D0 (en) | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
JP2010528086A (ja) | 2007-05-29 | 2010-08-19 | ノバルティス アーゲー | 抗il−1治療に関する新しい適応症 |
JP2011515068A (ja) | 2007-11-08 | 2011-05-19 | ノバルティス アーゲー | 慢性/硬化性同種移植腎症に対する遺伝子発現シグネチャー |
US8268834B2 (en) | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
US9752191B2 (en) | 2009-07-09 | 2017-09-05 | The Scripps Research Institute | Gene expression profiles associated with chronic allograft nephropathy |
US8791100B2 (en) | 2010-02-02 | 2014-07-29 | Novartis Ag | Aryl benzylamine compounds |
UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
WO2012012737A2 (en) | 2010-07-23 | 2012-01-26 | The University Of Toledo | Stable tregs and related materials and methods |
CN103608349A (zh) | 2011-06-27 | 2014-02-26 | 诺瓦提斯公司 | 四氢-吡啶并-嘧啶衍生物的固体形式和盐 |
MX2014000338A (es) | 2011-07-08 | 2014-05-01 | Novartis Ag | Derivados de pirrolo-pirimidina novedoso. |
WO2013057711A1 (en) | 2011-10-21 | 2013-04-25 | Novartis Ag | Quinazoline derivatives as pi3k modulators |
WO2013082282A1 (en) | 2011-12-02 | 2013-06-06 | lNOVARTIS AG | Anti-il-1beta (interleukin-1beta) antibody-based prophylactic therapy to prevent complications leading to vaso-occlusion in sickle cell disease. |
DK2790705T3 (en) | 2011-12-15 | 2018-03-12 | Novartis Ag | Use of inhibitors of the activity or function of PI3K |
JO3398B1 (ar) | 2011-12-22 | 2019-10-20 | Novartis Ag | مشتقات 2،3- ثانى هيدرو- بنزو[1,4] أوكسازين والمركبات المتعلقة بها كمثبطات كيناز فسفواينوسيتيد-3 (pi3k) لمعالجة على سبيل المثال التهاب المفاصل الروماتيدي |
WO2013093850A1 (en) | 2011-12-22 | 2013-06-27 | Novartis Ag | Quinoline derivatives |
WO2013148638A2 (en) * | 2012-03-26 | 2013-10-03 | Ep Pharma, Inc. | Compositions and methods related to inhibitors of jak kinase |
TW201422625A (zh) | 2012-11-26 | 2014-06-16 | Novartis Ag | 二氫-吡啶并-□衍生物之固體形式 |
WO2014128612A1 (en) | 2013-02-20 | 2014-08-28 | Novartis Ag | Quinazolin-4-one derivatives |
UY35675A (es) | 2013-07-24 | 2015-02-27 | Novartis Ag | Derivados sustituidos de quinazolin-4-ona |
WO2015179773A1 (en) | 2014-05-22 | 2015-11-26 | The Scripps Research Institute | Tissue molecular signatures of kidney transplant rejections |
SG11201600028YA (en) | 2013-09-22 | 2016-02-26 | Calitor Sciences Llc | Substituted aminopyrimidine compounds and methods of use |
US9512084B2 (en) | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
BR112016024484A2 (pt) | 2014-04-24 | 2017-08-15 | Novartis Ag | derivados de aminopiridina como inibidores de fosfatidilinositol 3-quinase |
EP3134395B1 (en) | 2014-04-24 | 2018-01-31 | Novartis AG | Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
EA032075B1 (ru) | 2014-04-24 | 2019-04-30 | Новартис Аг | Производные аминопиразина в качестве ингибиторов фосфатидилинозитол-3-киназы |
US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
CN104090115B (zh) * | 2014-07-10 | 2016-01-13 | 上海益诺思生物技术有限公司 | 次级t细胞依赖抗体反应检测外源性化合物免疫抑制方法 |
US10751339B2 (en) | 2018-01-20 | 2020-08-25 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine compounds and methods of use |
WO2020067887A1 (en) | 2018-09-24 | 2020-04-02 | Erasmus University Medical Center Rotterdam | Specific inhibition of janus kinase 3 (jak3) for modulating anti-tumor immune responses |
WO2020234779A1 (en) | 2019-05-23 | 2020-11-26 | Novartis Ag | Crystalline forms of a btk inhibitor |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA712187A (en) * | 1965-06-22 | J. C. Buisson Paul | 2-(2'-oxo-1'-cyclododecyl) acetic acid, the salts thereof, and process of preparing same | |
FR1466205A (fr) * | 1960-04-01 | 1967-01-20 | Chimie Atomistique | Acide 1-cétocyclododécyl-2-acétique, ses sels et leur procédé de préparation |
AU566673B2 (en) * | 1983-09-15 | 1987-10-29 | F. Hoffmann-La Roche Ag | Phenethylamine derivatives |
US6136595A (en) * | 1993-07-29 | 2000-10-24 | St. Jude Children's Research Hospital | Jak kinases and regulations of cytokine signal transduction |
IL141434A0 (en) | 1998-08-21 | 2002-03-10 | Parker Hughes Inst | Quinazoline derivatives |
US6080747A (en) * | 1999-03-05 | 2000-06-27 | Hughes Institute | JAK-3 inhibitors for treating allergic disorders |
CA2392554A1 (en) * | 1999-11-30 | 2001-06-28 | Parker Hughes Institute | Inhibitors of thrombin induced platelet aggregation |
MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
CA2326952A1 (en) * | 2000-11-27 | 2002-05-27 | The Hospital For Sick Children | T cell protein tyrosine phosphatase |
-
2003
- 2003-12-09 MX MXPA05006133A patent/MXPA05006133A/es unknown
- 2003-12-09 JP JP2004559442A patent/JP2006514021A/ja active Pending
- 2003-12-09 EP EP03796805A patent/EP1578411A4/en not_active Withdrawn
- 2003-12-09 NZ NZ540427A patent/NZ540427A/en unknown
- 2003-12-09 PL PL376844A patent/PL376844A1/pl not_active Application Discontinuation
- 2003-12-09 US US10/731,769 patent/US7365096B2/en not_active Expired - Fee Related
- 2003-12-09 HU HU0500844A patent/HUP0500844A2/hu unknown
- 2003-12-09 CN CNA2003801054687A patent/CN1747729A/zh active Pending
- 2003-12-09 CA CA002506432A patent/CA2506432A1/en not_active Abandoned
- 2003-12-09 WO PCT/US2003/038993 patent/WO2004052359A1/en active Application Filing
- 2003-12-09 BR BR0317099-3A patent/BR0317099A/pt not_active IP Right Cessation
- 2003-12-09 AU AU2003297740A patent/AU2003297740B2/en not_active Ceased
- 2003-12-09 RU RU2005121672/15A patent/RU2005121672A/ru not_active Application Discontinuation
- 2003-12-09 KR KR1020057010469A patent/KR20050084224A/ko not_active Application Discontinuation
-
2005
- 2005-05-23 ZA ZA200504163A patent/ZA200504163B/en unknown
- 2005-05-24 NO NO20052497A patent/NO20052497L/no not_active Application Discontinuation
- 2005-06-08 EC EC2005005843A patent/ECSP055843A/es unknown
-
2007
- 2007-11-05 US US11/935,147 patent/US7928062B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ZA200504163B (en) | 2007-03-28 |
US7928062B2 (en) | 2011-04-19 |
CA2506432A1 (en) | 2004-06-24 |
ECSP055843A (es) | 2005-11-22 |
AU2003297740A2 (en) | 2004-06-30 |
HUP0500844A2 (en) | 2007-08-28 |
NZ540427A (en) | 2008-04-30 |
EP1578411A1 (en) | 2005-09-28 |
US20080167220A1 (en) | 2008-07-10 |
KR20050084224A (ko) | 2005-08-26 |
NO20052497L (no) | 2005-09-02 |
US7365096B2 (en) | 2008-04-29 |
MXPA05006133A (es) | 2006-03-09 |
JP2006514021A (ja) | 2006-04-27 |
US20050203177A1 (en) | 2005-09-15 |
CN1747729A (zh) | 2006-03-15 |
RU2005121672A (ru) | 2005-11-20 |
PL376844A1 (pl) | 2006-01-09 |
NO20052497D0 (no) | 2005-05-24 |
AU2003297740A1 (en) | 2004-06-30 |
WO2004052359A1 (en) | 2004-06-24 |
EP1578411A4 (en) | 2007-05-02 |
AU2003297740B2 (en) | 2008-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0317099A (pt) | Método in vitro para inibir a função e/ou proliferação de uma janus tirosina quinase 3, método de teste in vitro para auxiliar na identificação de substâncias que são úteis como imunossupressores terapêuticos, método in vitro para auxiliar na identificação de um novo medicamento imunossupressor, método in vitro para inibir a função e/ou proliferação de uma célula expressando a janus tirosina quinase 3, uso de pelo menos um composto, composto quìmico isolado ou purificado e composição farmacêutica | |
SV2003001148A (es) | Derivados de benzamida tiazol y composciones farmaceuticas para inhibir la proliferacion de celulas, y metodos para su utilizacion ref. no.0097-01-sv | |
EA199700280A1 (ru) | Ингибиторы протеинкиназы с | |
ES2161291T3 (es) | N-(indol-2-carbonil)amidas y derivados como inhibidores de la glucogeno fosforilasa. | |
BR0312464A (pt) | Inibidores de tirosina quinases | |
ECSP055701A (es) | Nuevos derivados de pirimidinamida y el uso de los mismos | |
ES2124793T3 (es) | Derivados de rapamicina alquilados en o y su uso, particularmente como inmunosupresores. | |
BRPI0519148A2 (pt) | inibidores de homodimerizaÇço de myd88 | |
BR0014973A (pt) | Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38 | |
MX9308199A (es) | Inhibidores de enzima. | |
BR0306785A (pt) | Deazapurinas e seus usos | |
EA199800119A1 (ru) | Ингибиторы адгезии клеток | |
BRPI0514102B8 (pt) | composto para inibição da enzima de proteassoma e composição farmacêutica compreendendo dito composto | |
EA200001176A1 (ru) | Гетероциклические ингибиторы p38 | |
BRPI0514750A (pt) | derivados amida de 7-amino-3-fenil-diidropirimido[4, 5-d]pirimidinonas, sua fabricação e uso como inibidores de proteìna cinase | |
AR003140A1 (es) | Nuevos compuestos utiles para inhibir las interacciones de las tirosinaquinasas/proteinas adaptadoras, composiciones farmaceuticas que lascontienen y metodos de aplicacion de dichos compuestos para inhibir dichas interacciones. | |
TR199900048T2 (xx) | Protein tirozin kinaz inhibit�rleri olarak bisiklik heteroaromatik bile�ikler | |
Schroecksnadel et al. | Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells | |
BR0010716A (pt) | Compostos de fenila substituìdos com atividade imunossupressora e composições farmacêuticas | |
AR024138A1 (es) | Inhibidores de la proliferacion celular | |
ATE425142T1 (de) | Inhibitoren von c-jun n-terminal kinasen (jnk) | |
BR0315662A (pt) | Derivados de 1-(4-benzil-piperazin-1-il)-3-fenil-propenona | |
MXPA03004209A (es) | Composicion farmaceutica o cosmetica y uso de un inhbidor de proteina cinasa c con un inhibidor de metaloproteasas de la matriz para inhibir la migracion de celulas de langerhans. | |
BR0304963A (pt) | Compostos, composição farmacêutica, e, métodos para modular a atividade de adenosina em um mamìfero, e para tratar um mamìfero sofrendo de ou suscetìvel às doenças | |
ES2171743T3 (es) | Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 8A. ANUIDADE(S), |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |