MX2019013421A - Enlazadores peptidicos y conjugados de criptoficina, utiles en la terapia, y su preparacion. - Google Patents
Enlazadores peptidicos y conjugados de criptoficina, utiles en la terapia, y su preparacion.Info
- Publication number
- MX2019013421A MX2019013421A MX2019013421A MX2019013421A MX2019013421A MX 2019013421 A MX2019013421 A MX 2019013421A MX 2019013421 A MX2019013421 A MX 2019013421A MX 2019013421 A MX2019013421 A MX 2019013421A MX 2019013421 A MX2019013421 A MX 2019013421A
- Authority
- MX
- Mexico
- Prior art keywords
- conjugates
- therapy
- useful
- preparation
- cryptophycin
- Prior art date
Links
- 229930188224 Cryptophycin Natural products 0.000 title abstract 3
- 108010006226 cryptophycin Proteins 0.000 title abstract 3
- PSNOPSMXOBPNNV-VVCTWANISA-N cryptophycin 1 Chemical compound C1=C(Cl)C(OC)=CC=C1C[C@@H]1C(=O)NC[C@@H](C)C(=O)O[C@@H](CC(C)C)C(=O)O[C@H]([C@H](C)[C@@H]2[C@H](O2)C=2C=CC=CC=2)C/C=C/C(=O)N1 PSNOPSMXOBPNNV-VVCTWANISA-N 0.000 title abstract 3
- PSNOPSMXOBPNNV-UHFFFAOYSA-N cryptophycin-327 Natural products C1=C(Cl)C(OC)=CC=C1CC1C(=O)NCC(C)C(=O)OC(CC(C)C)C(=O)OC(C(C)C2C(O2)C=2C=CC=CC=2)CC=CC(=O)N1 PSNOPSMXOBPNNV-UHFFFAOYSA-N 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000003636 chemical group Chemical group 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente divulgación se refiere a compuestos de la fórmula (I): RCG1-L-P (I) en donde RCG1 representa un grupo químico reactivo que es reactivo respecto de un grupo químico presente en un polipéptido como un anticuerpo; P representa H, OH o un O activado; y L representa un enlazador específico. La divulgación también se refiere a cargas útiles de criptoficina, así como a conjugados de criptoficina, a composiciones que los contienen y a su uso terapéutico, en especial como agentes anticancerígenos. La divulgación también se refiere al proceso para preparar estos conjugados.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305531 | 2017-05-10 | ||
| PCT/EP2018/061989 WO2018206635A1 (en) | 2017-05-10 | 2018-05-09 | Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019013421A true MX2019013421A (es) | 2020-02-05 |
Family
ID=58873750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019013421A MX2019013421A (es) | 2017-05-10 | 2018-05-09 | Enlazadores peptidicos y conjugados de criptoficina, utiles en la terapia, y su preparacion. |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20200093934A1 (es) |
| EP (1) | EP3621658A1 (es) |
| JP (2) | JP2020519610A (es) |
| KR (1) | KR20200005580A (es) |
| CN (1) | CN110831633A (es) |
| AR (1) | AR111781A1 (es) |
| AU (2) | AU2018265333C1 (es) |
| BR (1) | BR112019023336A2 (es) |
| CA (1) | CA3062977A1 (es) |
| CO (1) | CO2019012108A2 (es) |
| EA (1) | EA201992667A1 (es) |
| EC (1) | ECSP19078277A (es) |
| IL (1) | IL270507B2 (es) |
| MA (1) | MA50764A (es) |
| MX (1) | MX2019013421A (es) |
| PH (1) | PH12019550230A1 (es) |
| TN (1) | TN2019000303A1 (es) |
| TW (1) | TWI778059B (es) |
| UY (1) | UY37728A (es) |
| WO (1) | WO2018206635A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN110366428B (zh) | 2016-12-30 | 2024-05-17 | Vaxcyte公司 | 具有非天然氨基酸的多肽-抗原缀合物 |
| JP2020519610A (ja) | 2017-05-10 | 2020-07-02 | サノフイＳａｎｏｆｉ | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
| CN111154133B (zh) * | 2020-01-03 | 2022-07-12 | 万华化学集团股份有限公司 | 一种环氧树脂发泡剂，环氧树脂组合物及环氧发泡材料的制备方法和用途 |
| WO2022022649A1 (zh) * | 2020-07-30 | 2022-02-03 | 成都科岭源医药技术有限公司 | 一种双药链接组装单元及双药靶向接头-药物偶联物 |
| CN115105607A (zh) * | 2021-03-22 | 2022-09-27 | 成都科岭源医药技术有限公司 | 一种用于adc的双药-接头的制备方法及其用途 |
| WO2023161291A1 (en) | 2022-02-22 | 2023-08-31 | Araris Biotech Ag | Peptide linkers comprising two or more payloads |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995017093A1 (en) | 1993-12-21 | 1995-06-29 | University Of Hawaii | New cryptophycins |
| EA001913B1 (ru) * | 1996-08-30 | 2001-10-22 | Эли Лилли Энд Компани | Фармацевтические соединения |
| US20020128185A1 (en) | 1998-02-25 | 2002-09-12 | Chuan Shih | Pharmaceutical compounds |
| US7230101B1 (en) | 2002-08-28 | 2007-06-12 | Gpc Biotech, Inc. | Synthesis of methotrexate-containing heterodimeric molecules |
| US20050175619A1 (en) | 2004-02-05 | 2005-08-11 | Robert Duffy | Methods of producing antibody conjugates |
| WO2007127440A2 (en) | 2006-04-27 | 2007-11-08 | Intezyne Technologies, Inc. | Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof |
| CA2658276A1 (en) | 2006-07-18 | 2008-01-24 | Sanofi-Aventis | Antagonist antibody for the treatment of cancer |
| FR2947269B1 (fr) * | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
| US8953557B2 (en) | 2009-06-30 | 2015-02-10 | Alcatel Lucent | Roaming method for a mobile terminal in WLAN, related access controller and access point device |
| AR078470A1 (es) | 2009-10-02 | 2011-11-09 | Sanofi Aventis | Anticuerpos que se unen especificamente al receptor epha2 |
| AU2014337555C1 (en) | 2013-10-15 | 2021-01-28 | Seagen Inc. | PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics |
| US10836821B2 (en) * | 2013-10-15 | 2020-11-17 | Sorrento Therapeutics, Inc. | Drug-conjugates with a targeting molecule and two different drugs |
| EP3068443B1 (en) * | 2013-11-12 | 2019-04-10 | Centre for Probe Development and Commercialization | Residualizing linkers and uses thereof |
| US10736974B2 (en) | 2014-10-22 | 2020-08-11 | The Johns Hopkins University | Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy |
| CN113209306A (zh) * | 2014-12-09 | 2021-08-06 | 艾伯维公司 | 具有细胞渗透性的bcl-xl抑制剂的抗体药物缀合物 |
| AU2016250537A1 (en) * | 2015-04-21 | 2018-11-08 | Abbvie Stemcentrx Llc | Calicheamicin constructs and methods of use |
| TWI714661B (zh) | 2015-11-05 | 2021-01-01 | 法商賽諾菲公司 | 新穎念珠藻素化合物及接合物、其製備與其治療用途 |
| CN108066772B (zh) * | 2016-11-14 | 2021-07-13 | 中国科学院上海药物研究所 | 靶向tacstd2的抗体与药物偶联体(adc)分子 |
| JP2020519610A (ja) | 2017-05-10 | 2020-07-02 | サノフイＳａｎｏｆｉ | 治療において有用な、ペプチド性リンカーおよびクリプトフィシンコンジュゲート、ならびにこれらの製造 |
-
2018
- 2018-05-09 JP JP2019561911A patent/JP2020519610A/ja active Pending
- 2018-05-09 CN CN201880044816.0A patent/CN110831633A/zh active Pending
- 2018-05-09 TN TNP/2019/000303A patent/TN2019000303A1/en unknown
- 2018-05-09 AR ARP180101213A patent/AR111781A1/es unknown
- 2018-05-09 TW TW107115718A patent/TWI778059B/zh active
- 2018-05-09 CA CA3062977A patent/CA3062977A1/en active Pending
- 2018-05-09 EP EP18722557.8A patent/EP3621658A1/en active Pending
- 2018-05-09 US US16/612,090 patent/US20200093934A1/en active Pending
- 2018-05-09 MX MX2019013421A patent/MX2019013421A/es unknown
- 2018-05-09 BR BR112019023336-9A patent/BR112019023336A2/pt unknown
- 2018-05-09 EA EA201992667A patent/EA201992667A1/ru unknown
- 2018-05-09 MA MA050764A patent/MA50764A/fr unknown
- 2018-05-09 US US15/975,423 patent/US20180369401A1/en not_active Abandoned
- 2018-05-09 WO PCT/EP2018/061989 patent/WO2018206635A1/en unknown
- 2018-05-09 AU AU2018265333A patent/AU2018265333C1/en active Active
- 2018-05-09 KR KR1020197035740A patent/KR20200005580A/ko not_active Application Discontinuation
- 2018-05-09 UY UY0001037728A patent/UY37728A/es not_active Application Discontinuation
-
2019
- 2019-10-29 CO CONC2019/0012108A patent/CO2019012108A2/es unknown
- 2019-10-31 EC ECSENADI201978277A patent/ECSP19078277A/es unknown
- 2019-11-04 US US16/673,367 patent/US11007275B2/en active Active
- 2019-11-05 PH PH12019550230A patent/PH12019550230A1/en unknown
- 2019-11-07 IL IL270507A patent/IL270507B2/en unknown
-
2021
- 2021-03-23 US US17/210,072 patent/US11998611B2/en active Active
-
2022
- 2022-06-30 AU AU2022204711A patent/AU2022204711B2/en active Active
-
2023
- 2023-04-06 JP JP2023061810A patent/JP2023085475A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US11007275B2 (en) | 2021-05-18 |
| JP2023085475A (ja) | 2023-06-20 |
| TW201907957A (zh) | 2019-03-01 |
| AU2018265333C1 (en) | 2023-08-17 |
| AU2018265333A1 (en) | 2019-11-28 |
| EP3621658A1 (en) | 2020-03-18 |
| KR20200005580A (ko) | 2020-01-15 |
| TN2019000303A1 (en) | 2021-05-07 |
| CA3062977A1 (en) | 2018-11-15 |
| US20200093934A1 (en) | 2020-03-26 |
| IL270507A (es) | 2019-12-31 |
| CO2019012108A2 (es) | 2020-02-28 |
| UY37728A (es) | 2019-01-02 |
| IL270507B1 (en) | 2023-04-01 |
| US20200054760A1 (en) | 2020-02-20 |
| US11998611B2 (en) | 2024-06-04 |
| TWI778059B (zh) | 2022-09-21 |
| WO2018206635A1 (en) | 2018-11-15 |
| EA201992667A1 (ru) | 2020-03-10 |
| PH12019550230A1 (en) | 2020-07-06 |
| US20210228726A1 (en) | 2021-07-29 |
| MA50764A (fr) | 2020-03-18 |
| CN110831633A (zh) | 2020-02-21 |
| BR112019023336A2 (pt) | 2020-06-16 |
| ECSP19078277A (es) | 2019-11-30 |
| AU2022204711A1 (en) | 2022-07-21 |
| IL270507B2 (en) | 2023-08-01 |
| US20180369401A1 (en) | 2018-12-27 |
| AU2022204711B2 (en) | 2024-01-04 |
| JP2020519610A (ja) | 2020-07-02 |
| AR111781A1 (es) | 2019-08-21 |
| AU2018265333B2 (en) | 2022-07-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12019550230A1 (en) | Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation | |
| PH12019501056A1 (en) | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers | |
| MX2019010804A (es) | Compuestos de benzazepina, conjugados y usos de los mismos. | |
| TN2015000177A1 (en) | Anti-ceacam5 antibodies and uses thereof | |
| WO2017177149A3 (en) | Methods and compositions for car t cell therapy | |
| WO2015187596A3 (en) | Antibody-drug conjugates, their preparation and their therapeutic use | |
| AR078470A1 (es) | Anticuerpos que se unen especificamente al receptor epha2 | |
| MX2013011201A (es) | Proceso para la elaboracion de conjugados de mejor homogeneidad. | |
| PH12018500852A1 (en) | Novel cryptophycin compounds and conjugates, their preparation and their therapeutic use | |
| WO2015012904A3 (en) | Antibody-sn-38 immunoconjugates with a cl2a linker | |
| MX2018013952A (es) | Marcadores selectivamente desregulados en celulas t reguladoras, infiltrantes de tumores. | |
| MX339927B (es) | Preparacion de conjugados de maitansinoides y anticuerpos mediante un proceso de una etapa. | |
| WO2015095301A3 (en) | Cytotoxic peptides and conjugates thereof | |
| NZ612161A (en) | Radiolabled her2 binding peptides | |
| MX2015005124A (es) | Conjugados de farmaco-proteina. | |
| WO2008103693A3 (en) | Chemical linkers with single amino acids and conjugates thereof | |
| MY193985A (en) | Antibody drug conjugates for ablating hematopoietic stem cells | |
| MX2011011661A (es) | Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750. | |
| MY171008A (en) | Preparation of maytansinoid antibody conjugates by a one-step process | |
| MX2019007347A (es) | Anticuerpo anti-cd3 y moleculas que comprenden el anticuerpo. | |
| NZ594480A (en) | Methods and compositions for diagnosis and treatment of cancer | |
| ZA202203201B (en) | Therapeutic conjugates | |
| AR077972A1 (es) | Anticuerpos contra cdcp1 destinados al tratamiento del cancer | |
| WO2019125154A3 (en) | Transition metal-based functional moieties for preparing cell targeting conjugates | |
| MX2019008773A (es) | Derivados de caliqueamicina y conjugados anticuerpo-farmaco de los mismos. |