AR078131A1 - Conjugados su preparacion y su aplicacion terapeutica - Google Patents
Conjugados su preparacion y su aplicacion terapeuticaInfo
- Publication number
- AR078131A1 AR078131A1 ARP100102290A ARP100102290A AR078131A1 AR 078131 A1 AR078131 A1 AR 078131A1 AR P100102290 A ARP100102290 A AR P100102290A AR P100102290 A ARP100102290 A AR P100102290A AR 078131 A1 AR078131 A1 AR 078131A1
- Authority
- AR
- Argentina
- Prior art keywords
- gcr1
- cr15r16
- cr13r14
- group
- piperidinyl
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 101150039048 GCR1 gene Proteins 0.000 abstract 56
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 11
- PSNOPSMXOBPNNV-VVCTWANISA-N cryptophycin 1 Chemical class C1=C(Cl)C(OC)=CC=C1C[C@@H]1C(=O)NC[C@@H](C)C(=O)O[C@@H](CC(C)C)C(=O)O[C@H]([C@H](C)[C@@H]2[C@H](O2)C=2C=CC=CC=2)C/C=C/C(=O)N1 PSNOPSMXOBPNNV-VVCTWANISA-N 0.000 abstract 6
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- -1 -OH Chemical group 0.000 abstract 1
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 abstract 1
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000002118 epoxides Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D245/06—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicacion 1: Un derivado de criptoficina de la formula (2) en la que R1 representa un átomo de halogeno y R2 representa un grupo -OH, un grupo acilo derivado de un aminoácido AA o un grupo alcanoiloxi C1-4; o bien R1 y R2 forman conjuntamente un motivo epoxido; AA indica un aminoácido natural o no natural; R3 representa un grupo alquilo C1-6; R4 y R5 representan los dos H o forman conjuntamente un doble enlace CH=CH entre C13 y C14; R6 y R7 representan independientemente uno de otro H o un grupo alquilo C1-6; R8 y R9 representan independientemente uno de otro H o un grupo alquilo C1-6; R10 representa al menos un sustituyente del nucleo fenilo elegido entre: H, un grupo OH, alcoxi C1-4, un átomo de halogeno o bien un grupo -NH2, -NHalquilo(C1-6) o -N(alquilo(C1-6))2; R11 representa al menos un sustituyente del nucleo fenilo elegido entre H o un grupo alquilo C1-4; L representa un conector en posicion orto (o), meta (rn) o para (p), con preferencia para, del nucleo fenilo portador del motivo GCR1 elegido entre: -G'X(CR13R14)t(OCH2CH2)y(CR15R16)u Q GCR1; -G'X(CR13R14)t(OCH2CH2)y-Y'-(CR15R16)u Q GCR1; -G'X(CR13R14)t(CR17=CR18)(CR15R16)u(OCH2CH2)y Q GCR1; -G'X(CR13R14)t(OCH2CH2)y(CR17=CR18)(CR15R16)u Q GCR1; -G'X(CR13R14)t-fenil-(CR15R16)u Y' Q GCR1; -G'X(CR13R14)t-furil-(CR15R16)u Y' Q GCR1; -G'X(CR13R14)t-oxazolil-(CR15R16)u Y' Q GCR1; -G'X(CR13R14)t-tiazolil-(CR15R16)u Y' Q GCR1; -G'X (CR13R14)t-tienil-(CR15R16)u Y' Q GCR1; -G'X(CR13R14)t-imidazolil-(CR15R16)u Y' Q GCR1; -G'X(CR13R14)t-piperazinil-CO(CR15R16)u Y' Q GCR1; -G'X(CR13R14)t-piperidinil-metil-NR12-CO(CR15R16)u Y' Q GCR1; -G'X(CR13R14)t-piperidinil-(CR15R16)u Y' Q GCR1; -G'X (CR13R14)t-piperidinil-NR12-(CR15R16)u Y' Q GCR1; -G'X(CR13R14)t-triazoIil-(CR15R16)u Y' Q GCR1; -G'X(CR13R14)t-triazolil-(CR15R16)u Y' Q GCR1; -G'X(CR13R14)t-fenil(CR15R16)u Q GCR1; -G'X(CR13R14)t-furil-(CR15R16)u Q GCR1; -G'X (CR13R14)t-oxazolil-(CR15R16)u Q GCR1; -G'X(CR13R14)t-tiazolil-(CR15R16)u Q GCR1; -G'X(CR13R14)t-tienil-(CR15R16)u Q GCR1; -G'X (CR13R14)t-imidazolil-(CR15R16)u Q GCR1; -G'X(CR13R14)t-piperazinil-(CR15R16)u Q GCR1; -G'X(CR13R14)t-piperidinil-(CR15R16)u Q GCR1; -G'X (CR13R14)t-piperidinil-metil-NR12-(CR15R16)u Q GCR1; -G'X(CR13R14)t-piperidinil-NR12-(CR15R16)u Q GCR1; -G' X(CR13R14)t-triazolil-(CR15R16)u Q GCR1; o -Gö Y (CR13R14)t(OCH2CH2)y(CR15R16)u Q GCR1; -Gö Y (CR13R14)t(OCH2CH2)y-Y'-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t(CR17=CR18)(CR15R16)u(OCH2CH2)y Q GCR1; -Gö Y (CR13R14)t(OCH2CH2)(CR17=CR18)(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-fenil-(CR15R16)u Y' Q GCR1; -Gö Y (CR13R14)t-furil-(CR15R16)u Y' Q GCR1; -Gö Y (CR13R14)t-oxazolil-(CR15R16)u Y' Q GCR1; -Gö Y (CR13R14)t-tiazolil-(CR15R16)u Y' Q GCR1; -Gö Y (CR13R14)t-tienil-(CR15R16)u Y' Q GCR1; -Gö Y (CR13R14)t-imidazolil-(CR15R16)u Y' Q GCR1; -Gö Y (CR13R14)t-piperazinil-(CR15R16)u Y' Q GCR1; -Gö Y (CR13R14)t-piperidinil-metil-NR12-CO(CR15R16)u Y' Q GCR1; -Gö Y (CR13R14)t-piperidinil-(CR15R16)u Y' Q GCR1; -Gö Y (CR13R14)t-piperidinil-NR12-(CR15R16)u Y' Q GCR1; -Gö Y (CR15R14)t-triazolil-(CR15R16)u Y' Q GCR1; -Gö Y (CR13R14)t-fenil-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-furil-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-oxazolil-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-tiazolil-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-tienil-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-imidazolil-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-piperazinil-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-piperazinil-(CR15R16)u Q CCR1; -Gö Y (CR13R14)t-piperidinil-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-piperidinil-metil-NR12-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-piperidinil-NR12-(CR15R16)u Q GCR1; -Gö Y (CR13R14)t-triazolil-(CR15R16)u Q GCR1; formulas en las que: G' representa un grupo -CH=CH- o -(CH2)n-; Gö representa un grupo -(CH2)n-; n representa un numero entero que va de 1 a 6; X representa un enlace simple o un grupo -CO-, -COO-, o -CONR12-, estando el grupo CO unido a G'; Y representa un grupo -O-, -OCO, -OCOO, -OCONR12-, -NR12-, -NR12CO-, -NR12CONR'12-, -NR12COO-, o -S(O)q-, estando el átomo O o el grupo NR12 unidos a Gö; q representa un numero entero que puede valer 0, 1 o 2; Y', representa un grupo -O-, -OCO, -OCOO, -OCONR12-, -NR12-, -NR12CO-, -NR12CONR'12-, -NR12COO-; -S(O)q-, -CO-, -COO-, o -CONR12-; R12, R'12, R13, R14, R15, R16, R17 y R18 representan independientemente uno de otro H o un grupo alquilo C1-6; t, u e y representan numeros enteros que pueden ir cada uno de 0 a 20 y tales que t+u+y sea superior o igual a 1; en el caso del conector de la formula -Gö Y (CR13R14)t(OCH2CH2)y-Y'-(CR15R16)u Q GCR1, si y vale 0 y cuando Q representa un enlace simple, entonces u no puede valer 0; Q representa un enlace simple, un grupo alquileno C1-10 o un grupo (OCH2CH2)i, representando i un numero entero que va de 1 a 20, más particularmente de 1 a 10, más particularmente aun de 1 a 8, o de 1 a 6 y aun más particularmente de 2 a 5; GCR1 representa -SZa, -C(=O)-ZbRb, formulas (3) o (4) con R12 representando H o alquilo C1-6, más particularmente el grupo metilo; o bien L se elige entre las formulas (5) formulas en las que el resto (1) representa uno de los 9 grupos de formulas (6) o n representa un numero entero que va de 1 a 6; ALK representa un grupo alquileno C1-12; R12 y R'12 representan independientemente uno de otro H o un grupo alquilo C1-6, más particularmente el grupo metilo; i representa un numero entero que va de 1 a 20, más particularmente de 1 a 10, más particularmente aun de 1 a 8, o de 1 a 6 y aun más particularmente de 2 a 5; 5 o bien L es un conector de la formula (7) en la que (AA)w, representa una cadena de w aminoácidos AA unidos entre sí por enlaces peptídicos; w representa un numero entero que va de 1 a 12, con preferencia de 1 a 6; n representa un numero entero que va de 1 a 6; D representa uno de los D1 a D3 para los que R12 representa H o un grupo alquilo C1-6; R19, R20, R21, R22 representan independientemente uno de otro H, un átomo de halogeno, -OH, -CN o un grupo alquilo C1-4; T unido a (CH2)n representa NR12 u O; V1 representa O, S, NR12; V2 representa CR22 o N; V3, V4, V5 se eligen independientemente uno de otro entre CR22 o N; Za representa H o el grupo -SRa, con Ra representando un grupo alquilo C1-6, cicloalquilo C3-7, arilo, heteroarilo o heterocicloalquilo C3-7; Zb representa un enlace simple, -O- o -NH-, con Rb representando H o un grupo alquilo C1-6, cicloalquilo C3-7, arilo, heteroarilo o heterocicloalquilo C3-7. Reivindicacion 17: Un procedimiento de preparacion de un agente de seleccion de la diana al que está unido al menos un derivado de criptoficina, denominado conjugado, que consiste en: (i) poner en contacto y dejar reaccionar una solucion acuosa de un agente de seleccion de la diana eventualmente tamponada y una solucion del derivado de criptoficina tal como se ha definido en una de las reivindicaciones 1 a 16; (ii) después separar opcionalmente el conjugado formado en la etapa (i) del derivado de criptoficina y/o del agente de seleccion de la diana que no haya reaccionado y/o de los agregados que se hayan formado. Reivindicacion 26: La utilizacion de un derivado de criptoficina de la formula (3) en la que G representa un grupo -CH=CH2 o -(CH2)nY, que se situa en posicion orto (o), meta (m) o para (p) del nucleo fenilo portador del motivo CR1, con preferencia en posicion para; Y representa -OH; -CI; N3 -NH2 -SH; -COOH; -NR12-CH2-C:::CH en el que R12 representa H o un grupo alquilo C1-6, más particularmente el grupo metilo; -OGP en el que GP indica un grupo saliente; -OC(=O)-O-(4-nitrofenilo); -maleimido, o de la formula (8) teniendo los grupos R1 a R11, los mismos significados que en las reivindicaciones 1, 11 o 12 y siendo n un numero entero que va de 1 a 6, para la preparacion de un agente de seleccion de la diana al que está unido al menos uno de dichos derivados de criptoficina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0903170A FR2947269B1 (fr) | 2009-06-29 | 2009-06-29 | Nouveaux composes anticancereux |
| FR0905651A FR2947271B1 (fr) | 2009-06-29 | 2009-11-25 | Nouveaux composes anticancereux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078131A1 true AR078131A1 (es) | 2011-10-19 |
Family
ID=41611078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102290A AR078131A1 (es) | 2009-06-29 | 2010-06-28 | Conjugados su preparacion y su aplicacion terapeutica |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8952147B2 (es) |
| EP (1) | EP2448929A1 (es) |
| JP (1) | JP5746692B2 (es) |
| KR (1) | KR101770584B1 (es) |
| CN (1) | CN102482238B (es) |
| AR (1) | AR078131A1 (es) |
| BR (1) | BRPI1015131A2 (es) |
| CA (1) | CA2766762C (es) |
| CL (1) | CL2011003229A1 (es) |
| CO (1) | CO6430462A2 (es) |
| CR (1) | CR20110670A (es) |
| DO (1) | DOP2011000376A (es) |
| EA (1) | EA024627B1 (es) |
| EC (1) | ECSP11011553A (es) |
| FR (2) | FR2947269B1 (es) |
| HN (1) | HN2011003414A (es) |
| IL (1) | IL217208A (es) |
| MA (1) | MA33465B1 (es) |
| MX (1) | MX2011013764A (es) |
| MY (1) | MY156684A (es) |
| NI (1) | NI201100219A (es) |
| NZ (1) | NZ597136A (es) |
| PE (1) | PE20121031A1 (es) |
| SG (2) | SG177419A1 (es) |
| SV (1) | SV2011004086A (es) |
| TN (1) | TN2011000636A1 (es) |
| TW (1) | TW201110986A (es) |
| UY (1) | UY32745A (es) |
| WO (1) | WO2011001052A1 (es) |
| ZA (1) | ZA201109537B (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL305084A (en) | 2005-08-24 | 2023-10-01 | Immunogen Inc | A process for preparing purified drug compounds |
| LT2437790T (lt) | 2009-06-03 | 2019-06-10 | Immunogen, Inc. | Konjugavimo būdai |
| NZ597050A (en) | 2009-06-29 | 2014-02-28 | Incyte Corp | Pyrimidinones as pi3k inhibitors |
| US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| EP2558463A1 (en) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Fused derivatives as i3 inhibitors |
| WO2011163195A1 (en) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Fused pyrrole derivatives as pi3k inhibitors |
| AR084366A1 (es) | 2010-12-20 | 2013-05-08 | Incyte Corp | N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| KR20220009505A (ko) | 2011-03-29 | 2022-01-24 | 이뮤노젠 아이엔씨 | 일-단계 방법에 의한 메이탄시노이드 항체 접합체의 제조 |
| BR122019020716B1 (pt) | 2011-09-02 | 2021-02-17 | Incyte Holdings Corporation | heterociclilaminas como inibidores de pi3k e composição farmacêutica que as compreende |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| SG11201502429YA (en) | 2012-10-04 | 2015-04-29 | Immunogen Inc | Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates |
| CN105593238B (zh) | 2013-07-11 | 2020-09-08 | 诺华股份有限公司 | 使用微生物转谷氨酰胺酶进行赖氨酸特异性化学酶法蛋白质修饰 |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| CR20170111A (es) * | 2014-09-03 | 2017-05-23 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
| GB201416960D0 (en) | 2014-09-25 | 2014-11-12 | Antikor Biopharma Ltd | Biological materials and uses thereof |
| MD3262046T2 (ro) | 2015-02-27 | 2021-03-31 | Incyte Corp | Săruri de inhibitori ai PI3K și procedee pentru prepararea lor |
| EP3069734A1 (en) * | 2015-03-17 | 2016-09-21 | Exiris S.r.l. | Cryptophycin-based antibody-drug conjugates with novel self-immolative linkers |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| TWI660741B (zh) | 2015-11-03 | 2019-06-01 | 財團法人工業技術研究院 | 抗體藥物複合物及其製造方法 |
| TWI714661B (zh) * | 2015-11-05 | 2021-01-01 | 法商賽諾菲公司 | 新穎念珠藻素化合物及接合物、其製備與其治療用途 |
| WO2017136769A1 (en) * | 2016-02-04 | 2017-08-10 | Eisai R&D Management Co., Ltd. | Peptide drug conjugates |
| WO2018178277A1 (en) | 2017-03-29 | 2018-10-04 | Avicenna Oncology Gmbh | New targeted cytotoxic isocombretaquinoline derivatives and conjugates thereof |
| MA50764A (fr) | 2017-05-10 | 2020-03-18 | Sanofi Sa | Linkers peptidiques et conjugués de cryptophycine, utiles en thérapie, et leur préparation |
| EP3665161B1 (en) | 2017-08-09 | 2023-09-27 | Helmholtz-Zentrum für Infektionsforschung GmbH | New targeted cytotoxic ratjadone derivatives and conjugates thereof |
| CA3085600A1 (en) * | 2017-12-22 | 2019-06-27 | Cornell University | 18f-labeled peptide ligands useful in pet and cerenkov luminescene imaging |
| CA3108289A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| SG11202100934PA (en) | 2018-08-02 | 2021-02-25 | Dyne Therapeutics Inc | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| FR3085952B1 (fr) | 2018-09-17 | 2020-10-30 | Centre Nat Rech Scient | Conjugue anticorps-medicament comprenant des derives de quinoline |
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- 2010-05-20 WO PCT/FR2010/050986 patent/WO2011001052A1/fr active Application Filing
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