CO6351783A2 - Derivados de indazoles sustituidos con fenilo o piridinilo - Google Patents

Derivados de indazoles sustituidos con fenilo o piridinilo

Info

Publication number
CO6351783A2
CO6351783A2 CO10137241A CO10137241A CO6351783A2 CO 6351783 A2 CO6351783 A2 CO 6351783A2 CO 10137241 A CO10137241 A CO 10137241A CO 10137241 A CO10137241 A CO 10137241A CO 6351783 A2 CO6351783 A2 CO 6351783A2
Authority
CO
Colombia
Prior art keywords
derivatives
indazols
piridinyl
phenyll
replaced
Prior art date
Application number
CO10137241A
Other languages
English (en)
Inventor
Markus Berger
Jan Dahmen
Hartmut Rehwinkel
Stinabritt Nilsson
Matti Lepisto
Henrik Johansson
Nafizal Hossain
Martin Hemmerling
Thomas Hansson
Karl Edman
Original Assignee
Astrazeneca Ab
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41340347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6351783(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Bayer Schering Pharma Ag filed Critical Astrazeneca Ab
Publication of CO6351783A2 publication Critical patent/CO6351783A2/es

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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

Un compuesto de fórmula la:La presente invención se refiere a nuevos derivados de indazolilo, a composiciones farmacéuticas que comprenden tales derivados, a procesos para preparar dichos nuevos derivados y al uso de tales derivados como medicamentos.
CO10137241A 2008-05-20 2010-11-04 Derivados de indazoles sustituidos con fenilo o piridinilo CO6351783A2 (es)

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CO10137241A CO6351783A2 (es) 2008-05-20 2010-11-04 Derivados de indazoles sustituidos con fenilo o piridinilo
CO10137238A CO6331310A2 (es) 2008-05-20 2010-11-04 Derivados de indazol sustituidos con fenilo y benzodioxinilo

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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2754B1 (en) 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
WO2009120717A2 (en) * 2008-03-24 2009-10-01 Medivation Technologies, Inc. Pyrido [3, 4-b] indoles and methods of use
SA109300309B1 (ar) 2008-05-20 2013-01-22 باير شيرنج فارما ايه جي مشتقات فينيل وبنزو داي أوكسينيل إندازول بها استبدال
ES2524970T3 (es) 2009-04-30 2014-12-16 Basf Se Procedimiento de preparación de compuestos de isoxazolina sustituidos y sus precursores
WO2011061527A1 (en) * 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
FR2955105B1 (fr) 2010-01-11 2012-04-20 Arkema France Procede de preparation d'aminoethyl imidazolidone ou de son thiocarbonyle
BR112012032496A2 (pt) 2010-06-23 2015-09-15 Basf Se processos para produzir um composto de carbonila da fórmula i e de imina da fórmula iii, compostos de imina da fórmula (iii), composições agrícolas e veterinária, uso de um composto de imina da fórmula iii e material de propagação de planta
CN103282345A (zh) 2010-11-03 2013-09-04 巴斯夫欧洲公司 制备取代的异噁唑啉化合物及其前体4-氯-、4-溴-或4-碘苯甲醛肟的方法
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
JP2014505737A (ja) 2011-02-18 2014-03-06 メディベイション テクノロジーズ， インコーポレイテッド 糖尿病を処置する化合物および方法
US9974759B2 (en) 2013-05-31 2018-05-22 Indiana University Research And Technology Corporation Beta 2 adrenoceptor antagonists for treating orthostatic hypotension
WO2016046260A1 (en) * 2014-09-26 2016-03-31 Astrazeneca 1-alkyl-6-oxo-1,6-dihydropyridin-3-yl compounds and use as sgrm modulators
WO2016124722A1 (en) * 2015-02-06 2016-08-11 Astrazeneca Ab A process for the preparation of 3-5-{[(1r,2s)-2-[(2,2-difluoropropanyl)amino]-1 -(2,3-dihydro-1,4-benzodioxin-6-yl]propyl]oxy}-1h-indazol-1-yl)-n-[(3r)-tetrahydrofuran-3-yl] benzamide
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
JP6749399B2 (ja) * 2015-09-15 2020-09-02 レオ ファーマ アクティーゼルスカブ 局所薬物送達のための非ステロイド性グルココルチコイド受容体モジュレーター
WO2017161518A1 (en) * 2016-03-23 2017-09-28 Astrazeneca Ab New physical form
KR20180128020A (ko) 2016-03-24 2018-11-30 아스트라제네카 아베 결정형
CN106083837B (zh) * 2016-05-27 2018-08-31 浙江普洛得邦制药有限公司 一种噁唑烷酮类抗菌药物及其中间体的制备方法
EA202091429A1 (ru) 2017-12-18 2020-10-27 Грюненталь Гмбх Замещенные амиды i пирролидина
TW201927769A (zh) 2017-12-18 2019-07-16 德商歌林達有限公司 經取代之吡咯啶醯胺ｉｉ
CA3125929A1 (en) * 2019-01-11 2020-07-16 Grunenthal Gmbh Substituted pyrrolidine amides iii
WO2020254552A2 (en) 2019-06-19 2020-12-24 Grünenthal GmbH Substituted pyrrolidine amides v
WO2020254551A1 (en) 2019-06-19 2020-12-24 Grünenthal GmbH Substituted pyrrolidine amides iv
CN114929684B (zh) * 2019-12-31 2023-08-18 南京明德新药研发有限公司 苯并吡唑类化合物
US20230265078A1 (en) 2020-07-09 2023-08-24 Gruenenthal Gmbh Substituted pyrrolidine amines and amides vi
WO2023274040A1 (zh) * 2021-06-28 2023-01-05 南京明德新药研发有限公司 一种三唑并吡啶取代的吲唑类化合物的晶型及其制备方法
KR102571432B1 (ko) * 2023-02-08 2023-08-29 주식회사 에스씨엘테라퓨틱스 인다졸릴에스테르 및 아미드 유도체를 포함하는 암 치료용 조성물

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB607840A (en) 1946-02-12 1948-09-06 Bristol Aeroplane Co Ltd Improvements in or relating to means for feeding ammunition to automatic fire arms
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
DE3000377A1 (de) 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3514696A1 (de) 1985-04-24 1986-11-06 Bayer Ag, 5090 Leverkusen N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
DE3535167A1 (de) * 1985-10-02 1987-04-09 Boehringer Mannheim Gmbh Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel
DE3632329A1 (de) 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
TW224462B (es) 1992-02-24 1994-06-01 Squibb & Sons Inc
NZ247440A (en) 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
CA2114981A1 (en) 1993-02-09 1994-08-10 Kazumi Ogata Quinolonecarboxylic acid derivatives
DE4323916A1 (de) 1993-07-16 1995-01-19 Basf Ag Substituierte 2-Phenylpyridine
DE69431470T2 (de) 1993-07-26 2003-08-14 Eisai Co., Ltd. Sulfonamide und sulfonsäure-ester mit je einem trizyclischen heteroring
JPH09505375A (ja) 1993-08-30 1997-05-27 エアフロー リサーチ マニュファクチュアリング コーポレーション 帯付き軸流ファンと共に使用するための再循環制御を伴うハウジング
GB9504854D0 (en) * 1994-03-31 1995-04-26 Zeneca Ltd Nitrogen derivatives
US5545669A (en) 1994-06-02 1996-08-13 Adams; Jerry L. Anti-inflammatory compounds
GB9417532D0 (en) 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
WO1996036595A1 (en) 1995-05-19 1996-11-21 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
TW523506B (en) 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
TW542822B (en) 1997-01-17 2003-07-21 Ajinomoto Kk Benzamidine derivatives
AR014195A1 (es) 1997-12-29 2001-02-07 Ortho Mcneil Pharm Inc Compuestos de trifenilpropanamida utiles para el tratamiento de procesos inflamatorios, composiciones anti-inflamatorias que los comprenden, ymetodos para prepararlos
US6200995B1 (en) 1998-01-29 2001-03-13 Tularik Inc. PPAR-γ modulators
DE19856475A1 (de) * 1998-11-27 2000-05-31 Schering Ag Nichtsteroidale Entzündungshemmer
WO2001024786A1 (fr) 1999-05-13 2001-04-12 Shionogi & Co., Ltd. Principes actifs destines au soin ou a la prevention de diabetes
US6569885B1 (en) 1999-12-23 2003-05-27 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
ES2230353T3 (es) 2000-09-11 2005-05-01 Pfizer Products Inc. Derivados de resorcinol.
FR2815030A1 (fr) 2000-10-05 2002-04-12 Lipha Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments
US6838074B2 (en) * 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
EP1432693A2 (en) 2001-10-01 2004-06-30 Taisho Pharmaceutical Co. Ltd. Mch receptor antagonists
KR20050044581A (ko) 2001-11-22 2005-05-12 오노 야꾸힝 고교 가부시키가이샤 피페리딘-2-온 유도체 화합물 및 그 화합물을 유효성분으로서 함유하는 약제
JP4725945B2 (ja) 2002-03-13 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体
CA2481320A1 (en) 2002-04-11 2003-10-23 Merck & Co., Inc. 1h-benzo[f]indazol-5-yl derivatives as selective glucocorticoid receptor modulators
NZ536504A (en) 2002-05-24 2008-04-30 Millennium Pharm Inc CCR9 inhibitors and methods of use thereof
JP2004059116A (ja) 2002-07-31 2004-02-26 Sharp Corp ディスプレイ用基板収納用トレイ及びディスプレイ用基板の取り出し機構並びにディスプレイ用基板の取り出し方法
US20050113450A1 (en) 2002-08-23 2005-05-26 Atli Thorarensen Antibacterial agents
EP1539141B1 (en) 2002-08-29 2010-07-14 Boehringer Ingelheim Pharmaceuticals Inc. 3-(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
US6894061B2 (en) 2002-12-04 2005-05-17 Wyeth Substituted dihydrophenanthridinesulfonamides
EP1610753A4 (en) 2003-02-20 2007-07-04 Encysive Pharmaceuticals Inc UROTENSIN-II RECEPTOR ANTAGONISTS OF PHENYLENEDIAMINE AND ANTAGONISTS OF CCR-9
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7297709B2 (en) * 2003-05-22 2007-11-20 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
US20040235892A1 (en) * 2003-05-22 2004-11-25 Yujia Dai Indazole and benzisoxazole kinase inhibitors
BRPI0411275A (pt) 2003-06-10 2006-08-01 Kalypsys Inc compostos de carbonila como inibidores de histona deacetilase para tratamento de doenças; composição farmacêutica; método de modular a atividade catalìtica de hdac; método de tratar doença em um indivìduo; utilização de um composto ou composição; método de inibir hdac
US7393873B2 (en) 2003-07-02 2008-07-01 Merck & Co., Inc. Arylsulfonamide derivatives
AU2004305321A1 (en) 2003-12-19 2005-07-07 Pfizer Inc. Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-hsd-1) for the treatment of diabetes and obesity
JP2005263787A (ja) 2004-02-17 2005-09-29 Ishihara Sangyo Kaisha Ltd アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
US20050250820A1 (en) 2004-03-08 2005-11-10 Amgen Inc. Therapeutic modulation of PPARgamma activity
DE102004028862A1 (de) 2004-06-15 2005-12-29 Merck Patent Gmbh 3-Aminoindazole
SE0402636D0 (sv) * 2004-10-29 2004-10-29 Astrazeneca Ab Chemical compounds
KR20070068432A (ko) 2004-10-29 2007-06-29 아스트라제네카 아베 염증 질환의 치료를 위한 글루코코르티코이드 수용체조절제로서의 신규 술폰아미드 유도체
SE0402635D0 (sv) 2004-10-29 2004-10-29 Astrazeneca Ab Chemical compounds
EP1869003B1 (en) 2005-04-14 2013-05-15 Glaxo Group Limited Indazoles as glucocorticoid receptor ligands
RU2007148225A (ru) 2005-06-10 2009-07-20 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Глюкокортикоидные миметики, способы их получения, фармацевтические композиции и их применение
US7888381B2 (en) 2005-06-14 2011-02-15 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
TW200815361A (en) 2005-10-20 2008-04-01 Astrazeneca Ab Chemical compounds
GB0522880D0 (en) 2005-11-09 2005-12-21 Glaxo Group Ltd Novel compounds
WO2007114763A1 (en) 2006-03-31 2007-10-11 Astrazeneca Ab Sulphonamide derivates as modulators of the glucocorticoid receptor
CA2649509A1 (en) * 2006-04-20 2007-11-01 Glaxo Group Limited Novel compounds
GB0607840D0 (en) 2006-04-20 2006-05-31 Glaxo Group Ltd Novel compounds
WO2008008882A2 (en) 2006-07-14 2008-01-17 Eli Lilly And Company Glucocorticoid receptor modulator and methods of use
GB0620385D0 (en) 2006-10-13 2006-11-22 Glaxo Group Ltd Novel compounds
GB0620406D0 (en) 2006-10-13 2006-11-22 Glaxo Group Ltd Novel compounds
CA2667007A1 (en) 2006-10-23 2008-05-02 Merck & Co., Inc. 2-[1-phenyl-5-hydroxy or methoxy-4alpha-methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives as glucocorticoid receptor ligands
EP2094692B1 (en) 2006-11-01 2012-11-28 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1 and/or nf-kappab activity and use thereof
JP2010508358A (ja) 2006-11-01 2010-03-18 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性の調節剤、並びにその使用
US20120065173A1 (en) 2006-11-23 2012-03-15 Markus Berger Chemical compounds
TW200829578A (en) * 2006-11-23 2008-07-16 Astrazeneca Ab Chemical compounds 537
WO2008070507A2 (en) 2006-12-06 2008-06-12 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
JO2754B1 (en) * 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
WO2008079073A1 (en) 2006-12-22 2008-07-03 Astrazeneca Ab Indazolyl sulphonamide derivatives for the treatment of glucocorticoid receptor mediated disorders
CA2683647A1 (en) 2007-04-10 2008-10-16 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US20100048950A1 (en) 2007-04-10 2010-02-25 Boehringer Ingelheim International Gmbh Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof
GB0708858D0 (en) 2007-05-08 2007-06-13 Glaxo Group Ltd Novel compounds
DE102007029419A1 (de) 2007-06-26 2009-01-02 Emsland-Stärke GmbH Filamentfaserschlichtemittel und Verwendung desselben
GB0720549D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720544D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720557D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720556D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720546D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0722211D0 (en) 2007-11-12 2007-12-27 Glaxo Group Ltd Novel compounds
GB0724254D0 (en) 2007-12-12 2008-01-23 Glaxo Group Ltd Novel compounds
JP2011513313A (ja) 2008-02-26 2011-04-28 メルク・シャープ・エンド・ドーム・コーポレイション 選択的グルココルチコイド受容体調節剤としてのヘキサヒドロシクロペンチル［ｆ］インダゾールカルボキサミドおよびこの誘導体
WO2009111214A1 (en) 2008-03-06 2009-09-11 Merck & Co., Inc. Hexahydrocyclopentyl[f]indazole sulfonamides and derivatives thereof as selective glucocorticoid receptor modulators
SA109300309B1 (ar) 2008-05-20 2013-01-22 باير شيرنج فارما ايه جي مشتقات فينيل وبنزو داي أوكسينيل إندازول بها استبدال

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CN102112449A (zh) 2011-06-29
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DK2291369T3 (en) 2016-02-01
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EA018629B8 (ru) 2013-12-30
WO2009142569A1 (en) 2009-11-26
EA018629B1 (ru) 2013-09-30
BRPI0912878A2 (pt) 2020-08-18
AR071857A1 (es) 2010-07-21
CA2724584A1 (en) 2009-11-26
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