AR071856A1 - Derivados de indazoles sustituidos con fenilo o piridinilo, un proceso para su preparacion, una composicion farmaceutica que los comprende y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por el receptor de glucocorticoides. - Google Patents

Derivados de indazoles sustituidos con fenilo o piridinilo, un proceso para su preparacion, una composicion farmaceutica que los comprende y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por el receptor de glucocorticoides.

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Publication number
AR071856A1
AR071856A1 ARP090101814A ARP090101814A AR071856A1 AR 071856 A1 AR071856 A1 AR 071856A1 AR P090101814 A ARP090101814 A AR P090101814A AR P090101814 A ARP090101814 A AR P090101814A AR 071856 A1 AR071856 A1 AR 071856A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
heteroaryl
aryl
optionally substituted
Prior art date
Application number
ARP090101814A
Other languages
English (en)
Inventor
Henrik Johansson
Nafizal Hossain
Markus Berger
Thomas Hansson
Matti Lepistoe
Jan Dahmen
Stinabritt Nilsson
Martin Hemmerling
Karl Edman
Hartmut Rehwinkel
Original Assignee
Astrazeneca Ab
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41340347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR071856(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Bayer Schering Pharma Ag filed Critical Astrazeneca Ab
Publication of AR071856A1 publication Critical patent/AR071856A1/es

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente se refiere a derivados de indazolilo, a composiciones farmaceuticas que comprenden tales derivados, a procesos para preparar dichos nuevos derivados y al uso de tales derivados como medicamentos. Reivindicacion 1: Un compuesto caracterizado porque es de la formula (1) donde: A es alquilo C1-6, alcoxi C1-6, cicloalquilo C3-7, haloalquilo C1-6, alquiltio C1-6, alquil C1-6C(O), alquiloxi C1-6C(O), NR5R6, NR5R6C(O) o heteroarilo C5-10, todos opcionalmente sustituidos con uno o m s sustituyentes seleccionados independientemente entre halo, ciano, hidroxilo, alquilo C1-4, alcoxi C1-4 y haloalquilo C1-4; R5 y R6 se seleccionan independientemente de hidrogeno, alquilo C1-6, cicloalquilo C3-7, alquiI C1-6C(O) y cicloalquil C3-7C(O), o R5 y R6 pueden formar un anillo con el nitrogeno al cual est n unidos; R1 es hidrogeno, alquilo C1-4, hidroxialquilo C1-4, alquil C1-4O-alquilo C1-4, alquiltio C1-4-alquilo C1-4 o haloalquilo C1-4; R3 es arilo C5-10, aril C5-10-alquilo C1-4, aril C5-10-O, aril C5-10-alcoxi C1-4, ariloxi C5-10-alquilo C1-4, heteroarilo C5-10, heteroaril C5-10-alquilo C1-4, heteroaril C5-10-alcoxi C1-4 o heteroariloxi C5-10-alquilo C1-4, todos los cuales est n sin sustituir o opcionalmente sustituidos con uno o m s sustituyentes seleccionados independientemente de B; B es hidroxilo, halo, ciano, alquilo C1-4, alcoxi C1-4, hidroxialquilo C1-3, alcoxi C1-4-alquilo C1-4, cicloalquiloxi C3-6-alquilo C1-4, cicloalquil C3-6O, cicloalquiltio C3-6-alquilo C1-4, cicloalquiltio C3-6, aIquil C1-3S(O)k-alquilo C1-4, alquil C1-3S(O)k, haloalquilo C1-4 o haloalcoxi C1-4, o B es uno de los grupos siguientes que est n unidos a carbonos adyacentes en un anillo arilo o heteroarilo (CH2)tOalqueniI C1-4O(CH2)v o (CH2)tO(CH2)v; k es 0, 1; t y v son, independientemente, 0, 1, 2 o 3, y t y v no son ambos 0; X es O o NH; W es fenilo sustituido con uno o m s sustituyentes seleccionados independientemente entre (CH2)nC(O)NR7R8, (CH2)nNR9C(O)R8 o (CH2)nC(O)NR9(CR14R15)C(O)NR7R8; y W est  adem s opcionalmente sustituido con halogeno o alquilo c1-4; R7 es hidrogeno o alquilo C1-4; R8 y R9 son, independientemente, hidrogeno, alquilo C1-4 (opcionalmente sustituido con uno o dos grupos seleccionados entre hidroxilo, alcoxi C1-4, NH2, oxo, C(O)NR10R11, NR10alquilo C1-4, C(O)NR10alquilo c1-4, NR10C(O)alquilo C1-4, alquiltio C1-4, heterociclilo C5-10, arilo C5-10 o heteroarilo C5-10), cicloalquilo C3-7 (opcionalmente sustituido con C(O)NH2), heterociclilo C5-10, arilo C5-10, heteroarilo C5-10 o C(O)NR10R11; donde arilo C5-10 o heteroarilo C5-10 est n opcionalmente sustituidos con halogeno, alquilo C1-4, alcoxi C1-4, CF3, OCF3, hidroxi o ciano; y donde cualquier heterociclilo est  opcionalmente sustituido con alquilo C1-4, alcoxi C1-4-alquilo C1-4, oxo o hidroxilo; o R7 y R8, junto con el nitrogeno al cual est n unidos, forman un anillo de 5 o 6 miembros que comprende opcionalmente un segundo  tomo de nitrogeno en el anillo, donde el anillo est  opcionalmente sustituido con uno o dos grupos seleccionados entre oxo, hidroxilo, hidroxialquilo C1-4, alquilo C1-4, alcoxi C1-4-alquilo C1-4 o (CH2)pC(O)NR12R13, R10, R11, R12 y R13 son, independientemente, hidrogeno o alquilo C1-4; n y p son, independientemente, 0, 1, 2, 3 o 4; e Y es hidrogeno, halo, alquilo C1-4 o haloalquilo C1-4; o una de sus sales farmaceuticamente aceptables.
ARP090101814A 2008-05-20 2009-05-20 Derivados de indazoles sustituidos con fenilo o piridinilo, un proceso para su preparacion, una composicion farmaceutica que los comprende y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por el receptor de glucocorticoides. AR071856A1 (es)

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