CO5590908A2 - Derivados de acido 3-fenil-2-arilalquiltiopropionico como antagonistas selectivos de ppar-alfa - Google Patents
Derivados de acido 3-fenil-2-arilalquiltiopropionico como antagonistas selectivos de ppar-alfaInfo
- Publication number
- CO5590908A2 CO5590908A2 CO04068143A CO04068143A CO5590908A2 CO 5590908 A2 CO5590908 A2 CO 5590908A2 CO 04068143 A CO04068143 A CO 04068143A CO 04068143 A CO04068143 A CO 04068143A CO 5590908 A2 CO5590908 A2 CO 5590908A2
- Authority
- CO
- Colombia
- Prior art keywords
- ethyl
- methylsulfonyl
- thio
- phenoxy
- oxy
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 2
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 235000019260 propionic acid Nutrition 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 2
- HFLYCKJGBPCISD-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)ethylsulfanyl]-3-[4-[2-(4-methylsulfonyloxyphenoxy)ethyl]phenyl]propanoic acid Chemical compound C1=CC(OS(=O)(=O)C)=CC=C1OCCC(C=C1)=CC=C1CC(C(O)=O)SCCC1=CC=C(Cl)C=C1 HFLYCKJGBPCISD-UHFFFAOYSA-N 0.000 abstract 1
- GYEWMDUUKDWGNS-UHFFFAOYSA-N 2-[2-(4-fluorophenyl)ethylsulfanyl]-3-[4-[2-(4-methylsulfonyloxyphenoxy)ethyl]phenyl]propanoic acid Chemical compound C1=CC(OS(=O)(=O)C)=CC=C1OCCC(C=C1)=CC=C1CC(C(O)=O)SCCC1=CC=C(F)C=C1 GYEWMDUUKDWGNS-UHFFFAOYSA-N 0.000 abstract 1
- PGZGQQFVPOZCAQ-UHFFFAOYSA-N 2-[2-(4-hydroxyphenyl)ethylsulfanyl]-3-[4-[2-(4-methylsulfonyloxyphenoxy)ethyl]phenyl]propanoic acid Chemical compound C1=CC(OS(=O)(=O)C)=CC=C1OCCC(C=C1)=CC=C1CC(C(O)=O)SCCC1=CC=C(O)C=C1 PGZGQQFVPOZCAQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0104333A SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5590908A2 true CO5590908A2 (es) | 2005-12-30 |
Family
ID=20286432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04068143A CO5590908A2 (es) | 2001-12-19 | 2004-07-16 | Derivados de acido 3-fenil-2-arilalquiltiopropionico como antagonistas selectivos de ppar-alfa |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7276539B2 (https=) |
| EP (1) | EP1458677B1 (https=) |
| JP (2) | JP3810770B2 (https=) |
| KR (1) | KR20040068589A (https=) |
| CN (1) | CN100343229C (https=) |
| AR (1) | AR038046A1 (https=) |
| AT (1) | ATE428691T1 (https=) |
| AU (1) | AU2002352426A1 (https=) |
| BR (1) | BR0215090A (https=) |
| CA (1) | CA2470066C (https=) |
| CO (1) | CO5590908A2 (https=) |
| DE (1) | DE60232018D1 (https=) |
| ES (1) | ES2324025T3 (https=) |
| HU (1) | HUP0402093A3 (https=) |
| IL (1) | IL162378A0 (https=) |
| IS (1) | IS7303A (https=) |
| MX (1) | MXPA04005992A (https=) |
| NO (1) | NO20043084L (https=) |
| NZ (1) | NZ533365A (https=) |
| PL (1) | PL370623A1 (https=) |
| RU (1) | RU2004117776A (https=) |
| SE (1) | SE0104333D0 (https=) |
| TW (1) | TW200410678A (https=) |
| UA (1) | UA80407C2 (https=) |
| WO (1) | WO2003051826A1 (https=) |
| ZA (1) | ZA200404585B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL375074A1 (en) | 2002-06-20 | 2005-11-14 | Astrazeneca Ab | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
| GB0314131D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314134D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314130D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314075D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314260D0 (en) * | 2003-06-19 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0427524D0 (en) | 2004-12-16 | 2005-01-19 | Astrazeneca Ab | Chemical process |
| GB0427701D0 (en) * | 2004-12-17 | 2005-01-19 | Astrazeneca Ab | Therapeutic agents |
| AU2008221673B2 (en) * | 2007-03-08 | 2013-03-28 | Albireo Ab | 2 -substituted- 3 -phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| US5232945A (en) * | 1992-07-20 | 1993-08-03 | Pfizer Inc. | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives |
| WO1999029640A2 (en) | 1997-12-05 | 1999-06-17 | Eisai Co., Ltd. | Compositions and methods for modulating the activity of fibroblast growth factor |
| ATE451346T1 (de) * | 1998-03-10 | 2009-12-15 | Ono Pharmaceutical Co | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
| SE9801990D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
| SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
| MA26634A1 (fr) * | 1998-06-04 | 2004-12-20 | Astra Ab | Nouveaux derives de l'acide 3-aryl propionique et analogues |
| GB9822473D0 (en) * | 1998-10-16 | 1998-12-09 | Glaxo Group Ltd | Chemical compounds |
| NZ515086A (en) * | 1999-04-28 | 2003-10-31 | Aventis Pharma Gmbh | Di-aryl acid derivatives as PPAR receptor ligands |
| TWI262185B (en) | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| TW574193B (en) | 1999-12-03 | 2004-02-01 | Astrazeneca Ab | Novel phenalkyloxy-phenyl derivatives, pharmaceutical composition containing the same and their uses |
| SE9904421D0 (sv) | 1999-12-03 | 1999-12-03 | Astra Ab | New compounds |
| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| KR20020081424A (ko) | 2000-03-09 | 2002-10-26 | 아벤티스 파마 도이칠란트 게엠베하 | Ｐｐａｒ 매개인자의 치료학적 용도 |
| SE0003766D0 (sv) | 2000-10-18 | 2000-10-18 | Astrazeneca Ab | Novel formulation |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
| SE0101978D0 (sv) | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | New compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) * | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| TWI331143B (en) * | 2001-09-08 | 2010-10-01 | Astrazeneca Uk Ltd | Benzothiadiazepine derivatives, process for preparing them, and pharmaceutical composition comprising them |
| GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| SE0104334D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| SE0201937D0 (sv) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | Therapeutic agents |
| SE0201936D0 (sv) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | Therapeutic agents |
| PL375074A1 (en) | 2002-06-20 | 2005-11-14 | Astrazeneca Ab | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
| GB0314078D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314075D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314129D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314136D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314130D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314131D0 (en) | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| GB0314260D0 (en) | 2003-06-19 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
-
2001
- 2001-12-19 SE SE0104333A patent/SE0104333D0/xx unknown
-
2002
- 2002-12-18 CA CA002470066A patent/CA2470066C/en not_active Expired - Fee Related
- 2002-12-18 AT AT02788144T patent/ATE428691T1/de not_active IP Right Cessation
- 2002-12-18 CN CNB028281225A patent/CN100343229C/zh not_active Expired - Fee Related
- 2002-12-18 IL IL16237802A patent/IL162378A0/xx unknown
- 2002-12-18 KR KR10-2004-7009348A patent/KR20040068589A/ko not_active Withdrawn
- 2002-12-18 PL PL02370623A patent/PL370623A1/xx unknown
- 2002-12-18 MX MXPA04005992A patent/MXPA04005992A/es not_active Application Discontinuation
- 2002-12-18 AU AU2002352426A patent/AU2002352426A1/en not_active Abandoned
- 2002-12-18 RU RU2004117776/04A patent/RU2004117776A/ru not_active Application Discontinuation
- 2002-12-18 EP EP02788144A patent/EP1458677B1/en not_active Expired - Lifetime
- 2002-12-18 HU HU0402093A patent/HUP0402093A3/hu unknown
- 2002-12-18 JP JP2003552714A patent/JP3810770B2/ja not_active Expired - Fee Related
- 2002-12-18 UA UA20040604534A patent/UA80407C2/uk unknown
- 2002-12-18 DE DE60232018T patent/DE60232018D1/de not_active Expired - Lifetime
- 2002-12-18 US US10/499,042 patent/US7276539B2/en not_active Expired - Fee Related
- 2002-12-18 ES ES02788144T patent/ES2324025T3/es not_active Expired - Lifetime
- 2002-12-18 TW TW091136517A patent/TW200410678A/zh unknown
- 2002-12-18 NZ NZ533365A patent/NZ533365A/en unknown
- 2002-12-18 WO PCT/GB2002/005743 patent/WO2003051826A1/en not_active Ceased
- 2002-12-18 BR BR0215090-5A patent/BR0215090A/pt not_active IP Right Cessation
- 2002-12-19 AR ARP020105003A patent/AR038046A1/es not_active Application Discontinuation
-
2004
- 2004-06-08 IS IS7303A patent/IS7303A/is unknown
- 2004-06-09 ZA ZA200404585A patent/ZA200404585B/en unknown
- 2004-07-16 NO NO20043084A patent/NO20043084L/no not_active Application Discontinuation
- 2004-07-16 CO CO04068143A patent/CO5590908A2/es not_active Application Discontinuation
-
2006
- 2006-03-20 JP JP2006077296A patent/JP2006241162A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006241162A (ja) | 2006-09-14 |
| CA2470066C (en) | 2007-04-10 |
| EP1458677B1 (en) | 2009-04-15 |
| CN100343229C (zh) | 2007-10-17 |
| HUP0402093A2 (hu) | 2005-02-28 |
| WO2003051826A1 (en) | 2003-06-26 |
| SE0104333D0 (sv) | 2001-12-19 |
| MXPA04005992A (es) | 2004-09-27 |
| HUP0402093A3 (en) | 2008-08-28 |
| AR038046A1 (es) | 2004-12-22 |
| NZ533365A (en) | 2006-05-26 |
| CN1620430A (zh) | 2005-05-25 |
| EP1458677A1 (en) | 2004-09-22 |
| AU2002352426A1 (en) | 2003-06-30 |
| JP2005511785A (ja) | 2005-04-28 |
| ATE428691T1 (de) | 2009-05-15 |
| US7276539B2 (en) | 2007-10-02 |
| KR20040068589A (ko) | 2004-07-31 |
| DE60232018D1 (de) | 2009-05-28 |
| ES2324025T3 (es) | 2009-07-29 |
| UA80407C2 (en) | 2007-09-25 |
| RU2004117776A (ru) | 2006-01-10 |
| HK1068866A1 (en) | 2005-05-06 |
| ZA200404585B (en) | 2005-10-26 |
| CA2470066A1 (en) | 2003-06-26 |
| NO20043084L (no) | 2004-07-16 |
| IL162378A0 (en) | 2005-11-20 |
| PL370623A1 (en) | 2005-05-30 |
| IS7303A (is) | 2004-06-08 |
| US20050215630A1 (en) | 2005-09-29 |
| BR0215090A (pt) | 2004-11-16 |
| JP3810770B2 (ja) | 2006-08-16 |
| TW200410678A (en) | 2004-07-01 |
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