ES2125611T3 - Nuevos derivados de dioxadiazol como agentes antihiperglicemicos. - Google Patents

Nuevos derivados de dioxadiazol como agentes antihiperglicemicos.

Info

Publication number
ES2125611T3
ES2125611T3 ES95915677T ES95915677T ES2125611T3 ES 2125611 T3 ES2125611 T3 ES 2125611T3 ES 95915677 T ES95915677 T ES 95915677T ES 95915677 T ES95915677 T ES 95915677T ES 2125611 T3 ES2125611 T3 ES 2125611T3
Authority
ES
Spain
Prior art keywords
dioxadiazol
derivatives
new
trifluoroalkoxy
trifluoroalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95915677T
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Cynthia Lee Palka
Iwan Gunawan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2125611T3 publication Critical patent/ES2125611T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVAS 2-4-(5-SUSTITUIDO-1,2,4OXADIAZOL-3-ILMETOXI)BENCIL-1,2,5-OXADIAZOLIDIN-3,5-DIONAS QUE HAN DEMOSTRADO TENER ACTIVIDAD ANTIHIPERGLICEMICA EN RATONES DIABETICOS (OB/OB Y DB/DB), MODELOS GENETICOS ANIMALES DE DIABETES MELLITUS NO INSULINO-DEPENDIENTES (NDDM O DIABETES TIPO II). ESTOS COMPUESTOS SE REPRESENTAN MEDIANTE LA FORMULA (I), DONDE R{SUP,1} ES UN ARILO C{SUB,6}-C{SUB,10}, OPCIONALMENTE SUSTITUIDO POR UNO A TRES SUSTITUYENTES INDEPENDIENTEMENTE SELECCIONADOS DE LOS GRUPOS ALQUILO C{SUB,1}-C{SUB,6}, ALCOXI C{SUB,1}-C{SUB,6}, FLUORO, CLORO, BROMO, IODO, TRIFLUOROALQUILO C{SUB,1}-C{SUB,3}, TRIFLUOROALCOXI C{SUB,1}-C{SUB,3}; Y R{SUP,2} SE SELECCIONA DEL GRUPO CONSISTENTE EN HIDROGENO, ALQUILO C{SUB,1}-C{SUB,6}, ALCOXI C{SUB,1}-C{SUB,6}, FLUORO, CLORO, BROMO, IODO, TRIFLUOROALQUILO C{SUB,1}-C{SUB,3}, TRIFLUOROALCOXI C{SUB,1}-C{SUB,3}, O SUS SALES FARMACEUTICAMENTE ACEPTABLES.
ES95915677T 1994-05-10 1995-04-13 Nuevos derivados de dioxadiazol como agentes antihiperglicemicos. Expired - Lifetime ES2125611T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/241,116 US5420146A (en) 1994-05-10 1994-05-10 Di-oxadiazolidine derivatives as antihyperglycemic agents

Publications (1)

Publication Number Publication Date
ES2125611T3 true ES2125611T3 (es) 1999-03-01

Family

ID=22909322

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95915677T Expired - Lifetime ES2125611T3 (es) 1994-05-10 1995-04-13 Nuevos derivados de dioxadiazol como agentes antihiperglicemicos.

Country Status (16)

Country Link
US (1) US5420146A (es)
EP (1) EP0759912B1 (es)
JP (1) JPH10502907A (es)
KR (1) KR970702859A (es)
CN (1) CN1151736A (es)
AT (1) ATE173729T1 (es)
CA (1) CA2190017A1 (es)
DE (1) DE69506244T2 (es)
DK (1) DK0759912T3 (es)
ES (1) ES2125611T3 (es)
GR (1) GR3029359T3 (es)
HU (1) HUT76059A (es)
MX (1) MX9605434A (es)
NZ (1) NZ283991A (es)
WO (1) WO1995030664A1 (es)
ZA (1) ZA953603B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0696585T3 (da) * 1993-04-30 1999-08-23 Yamanouchi Pharma Co Ltd Nyt bisoxadiazolidinderivat
US5703096A (en) * 1994-10-07 1997-12-30 Sankyo Company, Limited Oxime derivatives, their preparation and their therapeutic use
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
IL118474A (en) * 1995-06-01 2001-08-08 Sankyo Co Benzimideol derivatives and pharmaceutical preparations containing them
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
CZ298812B6 (cs) 1996-07-01 2008-02-13 Dr. Reddy's Laboratories Limited Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US7351726B2 (en) * 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7141592B2 (en) * 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
TW200815377A (en) * 2006-04-24 2008-04-01 Astellas Pharma Inc Oxadiazolidinedione compound
TW200932219A (en) 2007-10-24 2009-08-01 Astellas Pharma Inc Oxadiazolidinedione compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670338A1 (de) * 1966-03-14 1972-08-10 Heyden Chem Fab Verfahren zur Herstellung von antimikrobiell wirksamen Nitrofuranderivaten
DE1910895C3 (de) * 1969-03-04 1978-11-02 Bayer Ag, 5090 Leverkusen Heterocyclisch-substituierte 13,4-Thiadiazol-Derivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Herbizide
DE2405324A1 (de) * 1974-02-05 1975-08-14 Basf Ag 1,2,4-oxdiazolin-5-on-derivate
IT1138425B (it) * 1981-06-16 1986-09-17 Stigler Otis S P A Complesso elettro-fluidodinamico per l'azionamento di una cabina di un impianto ascensore
JPS59186979A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd テトラヒドロベンゾチアゾ−ル誘導体及び該誘導体を含有する除草剤
FR2612186B1 (fr) * 1987-03-09 1989-07-21 Poudres & Explosifs Ste Nale Carbonyl 2,2' bis (alkyl-4 oxadiazolidines-1,2,4-diones-3,5), leur procede de preparation et leur utilisation comme intermediaires de synthese dans la preparation de carbamates
ATE116971T1 (de) * 1990-08-23 1995-01-15 Pfizer Hypoglykämische hydroxyharnstoffderivate.

Also Published As

Publication number Publication date
NZ283991A (en) 1999-03-29
HU9603106D0 (en) 1997-01-28
CN1151736A (zh) 1997-06-11
DK0759912T3 (da) 1999-08-09
DE69506244D1 (de) 1999-01-07
AU680135B2 (en) 1997-07-17
JPH10502907A (ja) 1998-03-17
EP0759912B1 (en) 1998-11-25
WO1995030664A1 (en) 1995-11-16
DE69506244T2 (de) 1999-04-29
MX9605434A (es) 1997-12-31
GR3029359T3 (en) 1999-05-28
ATE173729T1 (de) 1998-12-15
EP0759912A1 (en) 1997-03-05
AU2247795A (en) 1995-11-29
KR970702859A (ko) 1997-06-10
HUT76059A (en) 1997-06-30
CA2190017A1 (en) 1995-11-16
US5420146A (en) 1995-05-30
ZA953603B (en) 1996-11-04

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