CN100343229C - 作为选择性PPAR－α激动剂的3－苯基－2－芳基烷基硫代丙酸衍生物 - Google Patents

作为选择性PPAR－α激动剂的3－苯基－2－芳基烷基硫代丙酸衍生物 Download PDF

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Publication number
CN100343229C
CN100343229C CNB028281225A CN02828122A CN100343229C CN 100343229 C CN100343229 C CN 100343229C CN B028281225 A CNB028281225 A CN B028281225A CN 02828122 A CN02828122 A CN 02828122A CN 100343229 C CN100343229 C CN 100343229C
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CN
China
Prior art keywords
phenyl
methylthio
carbamoylmethoxy
dioxo
carbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028281225A
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English (en)
Chinese (zh)
Other versions
CN1620430A (zh
Inventor
E·－L·阿尔斯特马克林斯特德
A·M·P·博伊耶
P·霍尔姆
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AstraZeneca AB
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AstraZeneca AB
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Publication date
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Publication of CN1620430A publication Critical patent/CN1620430A/zh
Application granted granted Critical
Publication of CN100343229C publication Critical patent/CN100343229C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
CNB028281225A 2001-12-19 2002-12-18 作为选择性PPAR－α激动剂的3－苯基－2－芳基烷基硫代丙酸衍生物 Expired - Fee Related CN100343229C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE01043330 2001-12-19
SE0104333A SE0104333D0 (sv) 2001-12-19 2001-12-19 Therapeutic agents

Publications (2)

Publication Number Publication Date
CN1620430A CN1620430A (zh) 2005-05-25
CN100343229C true CN100343229C (zh) 2007-10-17

Family

ID=20286432

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028281225A Expired - Fee Related CN100343229C (zh) 2001-12-19 2002-12-18 作为选择性PPAR－α激动剂的3－苯基－2－芳基烷基硫代丙酸衍生物

Country Status (26)

Country Link
US (1) US7276539B2 (https=)
EP (1) EP1458677B1 (https=)
JP (2) JP3810770B2 (https=)
KR (1) KR20040068589A (https=)
CN (1) CN100343229C (https=)
AR (1) AR038046A1 (https=)
AT (1) ATE428691T1 (https=)
AU (1) AU2002352426A1 (https=)
BR (1) BR0215090A (https=)
CA (1) CA2470066C (https=)
CO (1) CO5590908A2 (https=)
DE (1) DE60232018D1 (https=)
ES (1) ES2324025T3 (https=)
HU (1) HUP0402093A3 (https=)
IL (1) IL162378A0 (https=)
IS (1) IS7303A (https=)
MX (1) MXPA04005992A (https=)
NO (1) NO20043084L (https=)
NZ (1) NZ533365A (https=)
PL (1) PL370623A1 (https=)
RU (1) RU2004117776A (https=)
SE (1) SE0104333D0 (https=)
TW (1) TW200410678A (https=)
UA (1) UA80407C2 (https=)
WO (1) WO2003051826A1 (https=)
ZA (1) ZA200404585B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL375074A1 (en) 2002-06-20 2005-11-14 Astrazeneca Ab Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance
GB0314131D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314134D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314130D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314075D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314260D0 (en) * 2003-06-19 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0427524D0 (en) 2004-12-16 2005-01-19 Astrazeneca Ab Chemical process
GB0427701D0 (en) * 2004-12-17 2005-01-19 Astrazeneca Ab Therapeutic agents
AU2008221673B2 (en) * 2007-03-08 2013-03-28 Albireo Ab 2 -substituted- 3 -phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062872A1 (en) * 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl-2-hydroxypropionic acid derivative (i)
WO1999062871A1 (en) * 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl propionic acid derivatives and analogs

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
US5232945A (en) * 1992-07-20 1993-08-03 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives
WO1999029640A2 (en) 1997-12-05 1999-06-17 Eisai Co., Ltd. Compositions and methods for modulating the activity of fibroblast growth factor
ATE451346T1 (de) * 1998-03-10 2009-12-15 Ono Pharmaceutical Co Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten
SE9801990D0 (sv) 1998-06-04 1998-06-04 Astra Ab New 3-aryl propionic acid derivatives and analogs
GB9822473D0 (en) * 1998-10-16 1998-12-09 Glaxo Group Ltd Chemical compounds
NZ515086A (en) * 1999-04-28 2003-10-31 Aventis Pharma Gmbh Di-aryl acid derivatives as PPAR receptor ligands
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
TW574193B (en) 1999-12-03 2004-02-01 Astrazeneca Ab Novel phenalkyloxy-phenyl derivatives, pharmaceutical composition containing the same and their uses
SE9904421D0 (sv) 1999-12-03 1999-12-03 Astra Ab New compounds
SE0000772D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab Chemical compounds
KR20020081424A (ko) 2000-03-09 2002-10-26 아벤티스 파마 도이칠란트 게엠베하 Ｐｐａｒ 매개인자의 치료학적 용도
SE0003766D0 (sv) 2000-10-18 2000-10-18 Astrazeneca Ab Novel formulation
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
SE0101978D0 (sv) 2001-06-01 2001-06-01 Astrazeneca Ab New compounds
GB0121337D0 (en) 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
GB0121621D0 (en) * 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
GB0121622D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
TWI331143B (en) * 2001-09-08 2010-10-01 Astrazeneca Uk Ltd Benzothiadiazepine derivatives, process for preparing them, and pharmaceutical composition comprising them
GB0229931D0 (en) 2002-12-21 2003-01-29 Astrazeneca Ab Therapeutic agents
SE0104334D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
GB0213669D0 (en) 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
SE0201937D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
SE0201936D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
PL375074A1 (en) 2002-06-20 2005-11-14 Astrazeneca Ab Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance
GB0314078D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314075D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314129D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314136D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314130D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314131D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314260D0 (en) 2003-06-19 2003-07-23 Astrazeneca Ab Therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062872A1 (en) * 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl-2-hydroxypropionic acid derivative (i)
WO1999062871A1 (en) * 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl propionic acid derivatives and analogs

Also Published As

Publication number Publication date
JP2006241162A (ja) 2006-09-14
CA2470066C (en) 2007-04-10
EP1458677B1 (en) 2009-04-15
HUP0402093A2 (hu) 2005-02-28
CO5590908A2 (es) 2005-12-30
WO2003051826A1 (en) 2003-06-26
SE0104333D0 (sv) 2001-12-19
MXPA04005992A (es) 2004-09-27
HUP0402093A3 (en) 2008-08-28
AR038046A1 (es) 2004-12-22
NZ533365A (en) 2006-05-26
CN1620430A (zh) 2005-05-25
EP1458677A1 (en) 2004-09-22
AU2002352426A1 (en) 2003-06-30
JP2005511785A (ja) 2005-04-28
ATE428691T1 (de) 2009-05-15
US7276539B2 (en) 2007-10-02
KR20040068589A (ko) 2004-07-31
DE60232018D1 (de) 2009-05-28
ES2324025T3 (es) 2009-07-29
UA80407C2 (en) 2007-09-25
RU2004117776A (ru) 2006-01-10
HK1068866A1 (en) 2005-05-06
ZA200404585B (en) 2005-10-26
CA2470066A1 (en) 2003-06-26
NO20043084L (no) 2004-07-16
IL162378A0 (en) 2005-11-20
PL370623A1 (en) 2005-05-30
IS7303A (is) 2004-06-08
US20050215630A1 (en) 2005-09-29
BR0215090A (pt) 2004-11-16
JP3810770B2 (ja) 2006-08-16
TW200410678A (en) 2004-07-01

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20071017

Termination date: 20121218