CO5630026A2 - Sales de amina de acido (-)-2-{[2-(4-hidroxifenil)etil]tio}-3-[4-(2-{4-[metilsulfonil)oxi]fenoxi}etil)fenil]propanoico y su uso en medicina - Google Patents

Sales de amina de acido (-)-2-{[2-(4-hidroxifenil)etil]tio}-3-[4-(2-{4-[metilsulfonil)oxi]fenoxi}etil)fenil]propanoico y su uso en medicina

Info

Publication number
CO5630026A2
CO5630026A2 CO06001009A CO06001009A CO5630026A2 CO 5630026 A2 CO5630026 A2 CO 5630026A2 CO 06001009 A CO06001009 A CO 06001009A CO 06001009 A CO06001009 A CO 06001009A CO 5630026 A2 CO5630026 A2 CO 5630026A2
Authority
CO
Colombia
Prior art keywords
salt
ethyl
hydroxyphenyl
phenoxy
phenyl
Prior art date
Application number
CO06001009A
Other languages
English (en)
Inventor
Matti Ahlqvist
Mikael Ulf Johan Dahlstrom
Bengt Ohlsson
Richard Anthony Storey
Nigel Philip Taylor
Rebeca Woods
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5630026A2 publication Critical patent/CO5630026A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1.- Una sal de terc-butilamina, una sal de piperazina, una sal de colina, una sal de tris(hidroximetil)metilamina, una sal de lisina o una sal de adamantilamina de ácido (-)-2-{[2-(4-hidroxifenil)etil]tio}-3-[4-(2-{4[(metilsulfonil) oxi]fenoxi} etil )fenil]propanoico.2.- Una sal de acuerdo con la reivindicación 1 seleccionada de una sal de terc-butilamina, una sal de piperazina, una sal de colina, una sal de tris(hidroximetil)metilamina, una sal de lisina o una sal de adamantilamina de ácido ( - )-2-{[2-(4-hidroxifenil)etil]tio }-3-[4-(2-{4-[(metilsulfonil) oxi] fenoxi} etil)fenil]propanoico.3.- Una sal de acuerdo con la reivindicación 1 que es una sal de terc-butilamina.4.- Una sal de acuerdo con la reivindicación 1 que es una sal de piperazina.5.- Una sal de acuerdo con la reivindicación 1 que es una sal de colina.6.- Una sal de acuerdo con la reivindicación 1 que es una sal de tris(hidroximetil)metilamina.7.- Una sal de acuerdo con la reivindicación 1 que es una sal de lisina.8.- Una sal de acuerdo con la reivindicación 1 que es una sal de adamantilamina.9.- Una sal como se reivindica en una cualquiera de las reivindicaciones 1 a 8 la cual puede ser un solvato, un hidrato, un solvato/hidrato mixto, un ansolvato o un anhidrato.
CO06001009A 2003-06-18 2006-01-05 Sales de amina de acido (-)-2-{[2-(4-hidroxifenil)etil]tio}-3-[4-(2-{4-[metilsulfonil)oxi]fenoxi}etil)fenil]propanoico y su uso en medicina CO5630026A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0314130.6A GB0314130D0 (en) 2003-06-18 2003-06-18 Therapeutic agents

Publications (1)

Publication Number Publication Date
CO5630026A2 true CO5630026A2 (es) 2006-04-28

Family

ID=27636789

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06001009A CO5630026A2 (es) 2003-06-18 2006-01-05 Sales de amina de acido (-)-2-{[2-(4-hidroxifenil)etil]tio}-3-[4-(2-{4-[metilsulfonil)oxi]fenoxi}etil)fenil]propanoico y su uso en medicina

Country Status (20)

Country Link
US (1) US20070099928A1 (es)
EP (1) EP1638930A1 (es)
JP (1) JP3927594B2 (es)
KR (1) KR20060023165A (es)
CN (1) CN1835919A (es)
AR (1) AR044826A1 (es)
AU (1) AU2004249483A1 (es)
BR (1) BRPI0411580A (es)
CA (1) CA2529544A1 (es)
CO (1) CO5630026A2 (es)
GB (1) GB0314130D0 (es)
IL (1) IL172633A0 (es)
IS (1) IS8224A (es)
MX (1) MXPA05013718A (es)
NO (1) NO20056006L (es)
RU (1) RU2005141061A (es)
TW (1) TW200503671A (es)
UY (1) UY28372A1 (es)
WO (1) WO2004113283A1 (es)
ZA (1) ZA200510263B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0104333D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
ATE386013T1 (de) 2002-06-20 2008-03-15 Astrazeneca Ab Ortho-substituierte benzoesäurederivate zur behandlung von insulinresistenz
GB0314075D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314131D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0427524D0 (en) 2004-12-16 2005-01-19 Astrazeneca Ab Chemical process
GB0427701D0 (en) * 2004-12-17 2005-01-19 Astrazeneca Ab Therapeutic agents
US20120142766A1 (en) * 2007-11-21 2012-06-07 Evolva Sa Substituted 1,3-dioxanes and their uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA26634A1 (fr) * 1998-06-04 2004-12-20 Astra Ab Nouveaux derives de l'acide 3-aryl propionique et analogues
SE9801992D0 (sv) * 1998-06-04 1998-06-04 Astra Ab New 3-aryl-2-hydroxypropionic acid derivative I
SE0104333D0 (sv) * 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents

Also Published As

Publication number Publication date
AU2004249483A1 (en) 2004-12-29
MXPA05013718A (es) 2006-06-27
WO2004113283A1 (en) 2004-12-29
US20070099928A1 (en) 2007-05-03
NO20056006L (no) 2006-02-24
EP1638930A1 (en) 2006-03-29
CN1835919A (zh) 2006-09-20
IL172633A0 (en) 2006-04-10
KR20060023165A (ko) 2006-03-13
TW200503671A (en) 2005-02-01
BRPI0411580A (pt) 2006-08-08
JP3927594B2 (ja) 2007-06-13
GB0314130D0 (en) 2003-07-23
JP2006527749A (ja) 2006-12-07
CA2529544A1 (en) 2004-12-29
UY28372A1 (es) 2005-01-31
AR044826A1 (es) 2005-10-05
IS8224A (is) 2006-01-10
ZA200510263B (en) 2007-02-28
RU2005141061A (ru) 2006-08-27

Similar Documents

Publication Publication Date Title
CO5630026A2 (es) Sales de amina de acido (-)-2-{[2-(4-hidroxifenil)etil]tio}-3-[4-(2-{4-[metilsulfonil)oxi]fenoxi}etil)fenil]propanoico y su uso en medicina
KR890701567A (ko) 헤테로사이클릭 화합물
AR052866A1 (es) Fenil-metanonas monociclicas sustituidas
PE20090757A1 (es) Formulaciones que contienen triazinonas y hierro
BRPI0410922A (pt) processo para a formação de um composto, e, composto
CO6210692A2 (es) Derivados de hidantoina usados como inhibidores de mmp
AR057874A1 (es) Aminopirimidinas utiles como inhibidores de quinasa
AR057909A1 (es) Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
AR053774A1 (es) Derivados de sulfonilbencimidazol. composiciones farmaceuticas.
AR029919A1 (es) Fenil sulfamoil carboxamidas sustituidas con uracilo
NO20080325L (no) Forbindelser og deres salter som er spesifikke overfor PPAR-reseptorer og EGF-reseptorer samt deres anvendelse innen medisin
AR064327A1 (es) Un metodo para preparar montelukast e intermediarios utilizados en el mismo
AR051577A1 (es) Derivados eter sustituidos por hexafluorisopropanol
AR039690A1 (es) Difenilazetidinonas sustituidas por grupos acidos, medicamentos que comprenden estos compuestos y su uso
CO4700469A1 (es) 3-[4-(4(4-cianofenil)-1-piperazinanil)butil]-5]ciannoindol y su proceso de obtencion .
AR012732A1 (es) Derivados de fenilquinolinas, procedimientos para su preparacion, composiciones farmaceuticas, y su uso para la fabricacion de medicamentos
NO881306D0 (no) 4-(4-(4-(4-( (2,4-difluorfenyl)-2-(1h-azolylmetyl)-1,3-dioxolan-4-yl)metoksy)fenyl)-1-piperazinyl)fenyl)triazoloner.
HUP0303245A2 (hu) Herbicid készítmény
EA200600760A1 (ru) Новые соединения фенилпиридилпиперазина, способ их получения и фармацевтические композиции, содержащие их
BRPI0412910A (pt) derivados de nicotinamida úteis como inibidores de pde4
CO5590908A2 (es) Derivados de acido 3-fenil-2-arilalquiltiopropionico como antagonistas selectivos de ppar-alfa
PE20080554A1 (es) Formulacion acuosa del acido 4-[((4-carboxibutil)-{2-[(4-fenetilbencil)oxi]fenil}amino)metil]benzoico
DK155996C (da) Analogifremgangsmaade til fremstilling af substituerede beta-oxo-alfa-phenylcarbamoyl-pyrrolpropionitriler eller deres enolform eller enol-c(1-4)-alkylethere eller enol-c(1-4)-alkanoylestere deraf eller salte deraf med baser
AR053409A1 (es) 4-(2,4-dicloro-5-metoxifenil)amino-6-metoxi-7-((5-(amino-sustituido)metil)-3-furil)-3-quinolincarbonitrilos como inhibidores de quinasa. procesos de obtencion y composiciones farmaceuticas.
DE60326720D1 (de) Sulfonsäuresalze von Mandelsäurederivaten

Legal Events

Date Code Title Description
FC Application refused