AR064327A1 - Un metodo para preparar montelukast e intermediarios utilizados en el mismo - Google Patents
Un metodo para preparar montelukast e intermediarios utilizados en el mismoInfo
- Publication number
- AR064327A1 AR064327A1 ARP070105594A ARP070105594A AR064327A1 AR 064327 A1 AR064327 A1 AR 064327A1 AR P070105594 A ARP070105594 A AR P070105594A AR P070105594 A ARP070105594 A AR P070105594A AR 064327 A1 AR064327 A1 AR 064327A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- montelukast
- same
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Reivindicacion 1: Un método para reparar montelukast o su sal de sodio de la formula (1) que comprende las etapas de: (a) permitir que un compuesto halofosfato de la formula (5) reaccione con el compuesto diol de la formula (4) en un solvente en presencia de una base para producir un compuesto fosfato de la formula (3) y (b) acoplar el compuesto fosfato de la formula (3) con un compuesto ácido tiocarboxílico de la formula (2) en un solvente en presencia de una base: en donde, R es H o Na; R1 es H, metilo, o etilo; R2 es metilo, etilo, o fenilo; X es halogeno; Y es azufre u oxígeno. Reivindicacion 11: Un compuesto fosfato de la formula (3), el cual es utilizado como un intermediario para producir montelukast o su sal de sodio de acuerdo con la reivindicacion 1: en donde, R2 es metilo, etil, o fenilo; Y es azufre u oxígeno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020060127942A KR100774088B1 (ko) | 2006-12-14 | 2006-12-14 | 몬테루카스트의 제조방법 및 이에 사용되는 중간체 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR064327A1 true AR064327A1 (es) | 2009-03-25 |
Family
ID=39061099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070105594A AR064327A1 (es) | 2006-12-14 | 2007-12-13 | Un metodo para preparar montelukast e intermediarios utilizados en el mismo |
Country Status (12)
Country | Link |
---|---|
US (1) | US8217174B2 (es) |
EP (1) | EP2114889B1 (es) |
JP (1) | JP5017696B2 (es) |
KR (1) | KR100774088B1 (es) |
CN (1) | CN101558042B (es) |
AR (1) | AR064327A1 (es) |
CA (1) | CA2673098C (es) |
ES (1) | ES2446016T3 (es) |
MX (1) | MX2009005164A (es) |
RU (1) | RU2408583C1 (es) |
TW (1) | TWI382017B (es) |
WO (1) | WO2008072872A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2358923T3 (es) | 2005-07-05 | 2011-05-16 | Teva Pharmaceutical Industries, Ltd. | Purificación de montelukast. |
KR101072896B1 (ko) | 2007-10-09 | 2011-10-17 | 한미홀딩스 주식회사 | 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법 |
WO2009138993A1 (en) * | 2008-05-13 | 2009-11-19 | Macleods Pharmaceuticals Limited | A process for preparation of montelukast sodium salt |
KR101123292B1 (ko) * | 2008-09-26 | 2012-03-19 | 주식회사 엘지생명과학 | 몬테루카스트 나트륨염의 제조방법 |
KR100893756B1 (ko) * | 2009-01-14 | 2009-04-22 | 주식회사 메디켐코리아 | 몬테루카스트의 효율적 제조방법 |
EP2552892A1 (en) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
HUP1000425A2 (en) | 2010-08-11 | 2012-03-28 | Richter Gedeon Nyrt | Process for the production of montelukast sodium |
WO2014081616A1 (en) * | 2012-11-21 | 2014-05-30 | Merck Sharp & Dohme Corp. | Preparation of precursors for leukotriene antagonists |
CN104293850B (zh) * | 2014-08-12 | 2017-08-04 | 江苏恒盛药业有限公司 | 孟鲁司特钠的制备工艺及其中间产物 |
CN106831863B (zh) * | 2017-01-20 | 2018-09-21 | 山东百诺医药股份有限公司 | 孟鲁司特钠中间体及其制备方法和应用 |
CA3111275A1 (en) | 2018-09-06 | 2020-03-12 | Innopharmascreen Inc. | Methods and compositions for treatment of asthma or parkinson's disease |
CN111892535B (zh) * | 2020-08-27 | 2023-04-11 | 鲁南制药集团股份有限公司 | 一种孟鲁司特钠的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW448160B (en) * | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
JP2001514660A (ja) * | 1997-03-13 | 2001-09-11 | メルク エンド カンパニー インコーポレーテッド | キノリンロイコトリエン拮抗薬 |
US5952347A (en) | 1997-03-13 | 1999-09-14 | Merck & Co., Inc. | Quinoline leukotriene antagonists |
CN1420113A (zh) * | 2001-11-16 | 2003-05-28 | 北京上地新世纪生物医药研究所 | 孟鲁司特钠的制备方法及其制备中间体 |
DE602005015174D1 (de) | 2004-04-21 | 2009-08-13 | Teva Pharma | Verfahren zur herstellung von montelukast-natrium |
EP1812394B1 (en) | 2004-07-19 | 2011-03-02 | Matrix Laboratories Ltd | Process for the preparation of montelukast and its salts |
WO2006058545A1 (en) | 2004-11-30 | 2006-06-08 | Medichem, S.A. | New process for the preparation of a leukotriene antagonist |
-
2006
- 2006-12-14 KR KR1020060127942A patent/KR100774088B1/ko active IP Right Grant
-
2007
- 2007-12-11 EP EP07851395.9A patent/EP2114889B1/en not_active Not-in-force
- 2007-12-11 ES ES07851395.9T patent/ES2446016T3/es active Active
- 2007-12-11 CA CA2673098A patent/CA2673098C/en not_active Expired - Fee Related
- 2007-12-11 RU RU2009126769/04A patent/RU2408583C1/ru not_active IP Right Cessation
- 2007-12-11 WO PCT/KR2007/006424 patent/WO2008072872A1/en active Application Filing
- 2007-12-11 JP JP2009540174A patent/JP5017696B2/ja not_active Expired - Fee Related
- 2007-12-11 US US12/518,213 patent/US8217174B2/en not_active Expired - Fee Related
- 2007-12-11 MX MX2009005164A patent/MX2009005164A/es active IP Right Grant
- 2007-12-11 CN CN200780045692XA patent/CN101558042B/zh not_active Expired - Fee Related
- 2007-12-13 AR ARP070105594A patent/AR064327A1/es unknown
- 2007-12-13 TW TW096147639A patent/TWI382017B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US8217174B2 (en) | 2012-07-10 |
US20100099876A1 (en) | 2010-04-22 |
MX2009005164A (es) | 2009-05-27 |
CN101558042A (zh) | 2009-10-14 |
JP5017696B2 (ja) | 2012-09-05 |
JP2010512309A (ja) | 2010-04-22 |
WO2008072872A1 (en) | 2008-06-19 |
TW200831466A (en) | 2008-08-01 |
CN101558042B (zh) | 2011-05-18 |
ES2446016T3 (es) | 2014-03-06 |
RU2408583C1 (ru) | 2011-01-10 |
EP2114889A1 (en) | 2009-11-11 |
CA2673098C (en) | 2011-10-04 |
KR100774088B1 (ko) | 2007-11-06 |
CA2673098A1 (en) | 2008-06-19 |
EP2114889B1 (en) | 2014-01-22 |
TWI382017B (zh) | 2013-01-11 |
EP2114889A4 (en) | 2010-12-22 |
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Legal Events
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FB | Suspension of granting procedure |